Defiance Vacation Rentals

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    Upfront pricing

    We're not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Sep 12 - Sep 14
In one month
Sep 26 - Sep 28
In two months
Oct 24 - Oct 26
In three months
Nov 21 - Nov 23

Vacation Rentals in Defiance

Our top choices for Defiance vacation rentals

Stunning 1890's Home - Sleeps 8!
Microwave, oven, stovetop, dishwasher

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (75)
"The house is beautiful, in a great location, and has all the amenities of home. Definitely glad we stayed here instead of a nearby hotel."
$367 nightly
The price is $375
Sep 2 - Sep 3
Total with taxes and fees
Stunning 1890's Home - Sleeps 8!
St. Charles 1860's Gem - Sleeps 6!
Fridge, microwave, oven, stovetop

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (119)
"Everything was great!"
$239 nightly
The price is $239
Sep 1 - Sep 2
Total with taxes and fees
St. Charles 1860's Gem - Sleeps 6!
Residence on the Roundabout
Interior

Residence on the Roundabout

9.6 out of 10, Exceptional, (135)
"We loved it. Had everything we needed and more. Very clean and comfortable "
Residence on the Roundabout
Overlook Main St. in this 2 Bedroom Owners Suite!
Fridge, microwave, oven, stovetop

Overlook Main St. in this 2 Bedroom Owners Suite!

4.0 star property
9.4 out of 10, Exceptional, (32)
"Perfect place for a visit to St Charles! Hope to return and stay here again!"
Overlook Main St. in this 2 Bedroom Owners Suite!
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Dining

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.8 out of 10, Exceptional, (46)
"Lovely stay, very sweet house in a cute neighborhood. Great for traveling with kids! Thank you!"
$345 nightly
The price is $345
Sep 1 - Sep 2
Total with taxes and fees
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
The St. Charles Guest House, lovely historic home, fun for families and groups
Outdoor dining

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (132)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
The St. Charles Guest House, lovely historic home, fun for families and groups
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Outdoor dining

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (205)
"The riverside guest house was a perfect find for our two day getaway. Would definitely stay again. Perfect location. "
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Studio Condo on the Water @ Innsbrook
Bar (on property)

Studio Condo on the Water @ Innsbrook

9.8 out of 10, Exceptional, (27)
"Had a good golf day wonderful place to stay "
$177 nightly
The price is $183
Sep 2 - Sep 3
Total with taxes and fees
Studio Condo on the Water @ Innsbrook
Madison House 1 -Walk to Main St
2 bedrooms, desk, iron/ironing board, travel crib

Madison House 1 -Walk to Main St

9.0 out of 10, Wonderful, (11)
"Comfy fun stay!"
$209 nightly
The price is $235
Sep 1 - Sep 2
Total with taxes and fees
Madison House 1 -Walk to Main St
The Lewis & Clark Hangout
Fridge, microwave, oven, stovetop

The Lewis & Clark Hangout

9.0 out of 10, Wonderful, (17)
"Enjoyed are stay"
$417 nightly
The price is $468
Sep 1 - Sep 2
Total with taxes and fees
The Lewis & Clark Hangout
Peaceful chalet - *new* private beach, WIFI, kayaks
Fridge, microwave, oven, stovetop

Peaceful chalet - *new* private beach, WIFI, kayaks

10.0 out of 10, Exceptional, (69)
"Great place. Very clean and relaxing. "
Peaceful chalet - *new* private beach, WIFI, kayaks
Home Near Main Street-Covered Patio-Hot Tub!
Fridge, microwave, oven, stovetop

Home Near Main Street-Covered Patio-Hot Tub!

10.0 out of 10, Exceptional, (22)
"Great place to stay. They had plenty of games and seating for an extended family. Walked the neighborhood a bit very quiet. "
Home Near Main Street-Covered Patio-Hot Tub!
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
3 bedrooms, WiFi, bed sheets

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

9.6 out of 10, Exceptional, (65)
"Comfy beds, plenty of towels, good location."
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
Adorable Augusta Cabin
1 bedroom, free WiFi, bed sheets

Adorable Augusta Cabin

9.6 out of 10, Exceptional, (5)
"Absolutely beautiful area. Cabin is so cozy"
$196 nightly
The price is $218
Sep 7 - Sep 8
Total with taxes and fees
Adorable Augusta Cabin
Rustic Augusta Cabin by StayLage
TV

Rustic Augusta Cabin by StayLage

10.0 out of 10, Exceptional, (3)
"I booked this place wit spend some homely time with my kids and it was amazing, the place was clean they even dropped off some extra towels without us having to ask, it was truly amazing. Will definitely stay there again. "
$294 nightly
The price is $328
Sep 8 - Sep 9
Total with taxes and fees
Rustic Augusta Cabin by StayLage
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Outdoor spa tub

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

10.0 out of 10, Exceptional, (63)
"Cute little house. Beautiful deck surrounded by woods and a gorgeous view of the lake. Cozy weekend get-a-way! All that we wanted. "
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
The Lofts of North Main Street
Dining

The Lofts of North Main Street

9.6 out of 10, Exceptional, (146)
"Perfect location!"
$235 nightly
The price is $251
Sep 1 - Sep 2
Total with taxes and fees
The Lofts of North Main Street
Cowboy Cabin, come sit under the trees
Outdoor dining

Cowboy Cabin, come sit under the trees

10.0 out of 10, Exceptional, (201)
"The cabin offered amazing porch/deck time with lots of privacy in the trees. Great for a relaxing weekend!"
Cowboy Cabin, come sit under the trees
The Otter Suite at Divine Otter
2 bedrooms, desk, iron/ironing board, free WiFi

The Otter Suite at Divine Otter

8.0 out of 10, Very Good, (1)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
The Otter Suite at Divine Otter
The Original Custom House!
Fridge, microwave, oven, stovetop

The Original Custom House!

9.8 out of 10, Exceptional, (30)
"We enjoyed our stay in this historic setting with modern touches. Cute decorating, they included coffee, large televisions for evening relaxation, and prompt replies for questions and very clean house. We could walk everywhere! "
$349 nightly
The price is $385
Sep 2 - Sep 3
Total with taxes and fees
The Original Custom House!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Find out more about Defiance

Find out more about Defiance

Everything you need to know about Defiance vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Defiance vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Defiance vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Defiance vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Defiance. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Defiance in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $183 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Defiance rentals

At Expedia, we put the best Defiance vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Defiance rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Defiance vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Defiance. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway: This vacation home rental outside of Defiance is located on a lake and has a furnished patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.