Defiance Vacation Rentals

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Jul 12 - Jul 13
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Jul 13 - Jul 14
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Jul 18 - Jul 20
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Jul 25 - Jul 27

Vacation Rentals in Defiance

Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!
Enjoy cooking in this well-equipped kitchen with a gas stove, microwave, and refrigerator.

Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

8.6 out of 10, Excellent, (24)
"This was a great experience. Communication was great and I felt safe to have my family there for a small get together. I really appreciate the experience!!"
$484 nightly
The price is $495
Aug 11 - Aug 12
Total includes taxes and fees
Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!
AK's STL Pearl Grey House - Game Room
Enjoy meals in this well-equipped kitchen with a central island, oven, and dining area with a view.

AK's STL Pearl Grey House - Game Room

9.2 out of 10, Wonderful, (5)
"Quiet neighborhood, comfortable house, well-stocked kitchen. We would stay here again."
$470 nightly
The price is $470
Jul 15 - Jul 16
Total includes taxes and fees
AK's STL Pearl Grey House - Game Room
Charming 3-bedroom house with AC, WiFi in amazing St. Louis
Enjoy cooking in this well-equipped kitchen with a granite countertop, stainless steel appliances, and a convenient potted orchid plant.

Charming 3-bedroom house with AC, WiFi in amazing St. Louis

9.0 out of 10, Wonderful, (2)
"Clean and comfortable property close to everywhere we needed to go while there. "
$434 nightly
The price is $470
Jul 21 - Jul 22
Total includes taxes and fees
Charming 3-bedroom house with AC, WiFi in amazing St. Louis
Cozy & Safe - 6 beds - mins from shopping &stores
Relax in this inviting living room with two comfortable sofas, a ceiling fan, and a large window.

Cozy & Safe - 6 beds - mins from shopping &stores

9.4 out of 10, Exceptional, (25)
"House was clean, beds were nice. Close to everything yet far enough away to be from the craziness that can happen close to a big city. "
$344 nightly
The price is $363
Jul 21 - Jul 22
Total includes taxes and fees
Cozy & Safe - 6 beds - mins from shopping &stores
Maison Champignon by StayLage
3 bedrooms, desk, iron/ironing board, free WiFi

Maison Champignon by StayLage

$329 nightly
The price is $362
Jul 16 - Jul 17
Total includes taxes and fees
Maison Champignon by StayLage
Downtown St. Charles • Cozy Historic Home
Kitchen features a central island with stove and oven, flanked by cabinetry and a brick accent wall.

Downtown St. Charles • Cozy Historic Home

10.0 out of 10, Exceptional, (11)
"It was in a great location, beds are comfortable, just overall very, very comfortable home"
$643 nightly
The price is $716
Aug 11 - Aug 12
Total includes taxes and fees
Downtown St. Charles • Cozy Historic Home
The Olive House - Near Main Street- Fully rehabbed
Enjoy cooking in this well-equipped kitchen with a stainless steel stove, microwave, and dining area.

The Olive House - Near Main Street- Fully rehabbed

8.8 out of 10, Excellent, (6)
"Location is very convenient to downtown St Charles and many restaurants, stores and various type of entertainment. House is nice, roomy, clean and owner is always around if you need to contact them. Neighborhood is very quiet and nice. Would recommend this house to anyone."
$304 nightly
The price is $343
Jul 14 - Jul 15
Total includes taxes and fees
The Olive House - Near Main Street- Fully rehabbed
The Original Custom House!
Enjoy cooking in this well-lit kitchen with a central island and cabinetry.

The Original Custom House!

9.8 out of 10, Exceptional, (29)
"Perfect little property to stay and visit Main Street! "
$354 nightly
The price is $390
Jul 16 - Jul 17
Total includes taxes and fees
The Original Custom House!
St. Charles Victorian Gem | Steps to Main Street
Enjoy cooking in this well-equipped kitchen with a central island, stove, and ample counter space.

St. Charles Victorian Gem | Steps to Main Street

9.8 out of 10, Exceptional, (16)
"The house was great. Comfortable, well-equipped, and very roomy."
$646 nightly
The price is $719
Jul 30 - Jul 31
Total includes taxes and fees
St. Charles Victorian Gem | Steps to Main Street
Home Near Main Street-Covered Patio-Hot Tub!
Enjoy cooking in this well-equipped kitchen with an oven and refrigerator.

Home Near Main Street-Covered Patio-Hot Tub!

10.0 out of 10, Exceptional, (21)
"Great place to stay. They had plenty of games and seating for an extended family. Walked the neighborhood a bit very quiet. "
$521 nightly
The price is $534
Jul 16 - Jul 17
Total includes taxes and fees
Home Near Main Street-Covered Patio-Hot Tub!
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Enjoy a spacious living area with a dining table and chairs, a kitchen with modern appliances, and large windows.

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (43)
"Great house. Lots of room. Walkable to main st"
$335 nightly
The price is $335
Jul 17 - Jul 18
Total includes taxes and fees
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Music House · Music House on Main Street at The Wine Garden
Enjoy cooking in this well-equipped kitchen with a dishwasher, stainless steel oven, and microwave.

Music House · Music House on Main Street at The Wine Garden

9.4 out of 10, Exceptional, (13)
"Nice area nice place and communication"
$800 nightly
The price is $898
Jul 13 - Jul 14
Total includes taxes and fees
Music House · Music House on Main Street at The Wine Garden
Stunning 1890's Home - Sleeps 8!
Enjoy cooking in this well-lit kitchen with appliances and a spacious island.

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (66)
"Beautiful house and location."
$392 nightly
The price is $402
Jul 17 - Jul 18
Total includes taxes and fees
Stunning 1890's Home - Sleeps 8!
The Lewis & Clark Hangout
Enjoy cooking in this well-equipped kitchen with a microwave, dishwasher, and stainless steel refrigerator.

The Lewis & Clark Hangout

9.0 out of 10, Wonderful, (15)
"Enjoyed are stay"
$391 nightly
The price is $439
Jul 16 - Jul 17
Total includes taxes and fees
The Lewis & Clark Hangout
Madison House 1 -Walk to Main St
Cozy retreat with a single armchair and brick accent wall, perfect for short stays.

Madison House 1 -Walk to Main St

9.4 out of 10, Exceptional, (10)
"The town house is in a great location and has a cool vibe. It is an older unit, so be aware the windows rattle when windy and there wasnt an outlet by one of the beds upstairs. The sofa seat cushions were stained. The biggest negative is the two sides of the townhomes are connected by a door on the main floor and a door upstairs. Even though locked, that felt strange and we could hear a LOT from the other townhouse. Could hear talking, laughing, the TV, and people walking on the stairs. Also,...
$209 nightly
The price is $235
Jul 14 - Jul 15
Total includes taxes and fees
Madison House 1 -Walk to Main St
Madison House 2 -Walk to Main St
Cozy living space with two sofas arranged around a central coffee table, a fireplace, and a floor lamp.

Madison House 2 -Walk to Main St

9.4 out of 10, Exceptional, (3)
"This property was clean and offered basic amenities, but is a very old historic home and lacks the luster and comfort of most homes, but has needed repairs and improvements to have a 5 star rating. "
$221 nightly
The price is $249
Jul 20 - Jul 21
Total includes taxes and fees
Madison House 2 -Walk to Main St
1st Capitol Mansion - Suite 302
Enjoy the view from this balcony with a wicker sofa, table, and chairs.

1st Capitol Mansion - Suite 302

10.0 out of 10, Exceptional, (1)
"I rushed to find a booking for a trip and seriously lucked out that this unit was available. Everything was excellent, from the patio to the pillows to the shower.Thank you!"
$159 nightly
The price is $178
Jul 14 - Jul 15
Total includes taxes and fees
1st Capitol Mansion - Suite 302
Black & Gold suite 202 -ADA Room
Cozy retreat with a large bed, dresser, and mirror.

Black & Gold suite 202 -ADA Room

$159 nightly
The price is $178
Jul 13 - Jul 14
Total includes taxes and fees
Black & Gold suite 202 -ADA Room
Mansion 301 · 1st Capitol Mansion Boutique Hotel - Suite 301
Enter a serene hallway with a door, window, and a small table near the window.

Mansion 301 · 1st Capitol Mansion Boutique Hotel - Suite 301

8.4 out of 10, Very Good, (10)
"Very cute little place! "
$139 nightly
The price is $156
Jul 13 - Jul 14
Total includes taxes and fees
Mansion 301 · 1st Capitol Mansion Boutique Hotel - Suite 301
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Corridors lead to spacious rooms with large windows and comfortable seating areas.

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

10.0 out of 10, Exceptional, (4)
"The house was everything we needed and the host was very responsive. Great location near historic Main Street."
$209 nightly
The price is $235
Jul 14 - Jul 15
Total includes taxes and fees
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

Stunning 1890's Home - Sleeps 8! : This vacation home rental outside of Defiance has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.