Medical Center Vacations
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Your Medical Center Vacation
Your next big adventure is just around the corner with a vacation package to Medical Center. Entertainment, relaxation and good times — you're bound to find it in this neighborhood. When it's time to take in the sights, you'll find loads of top attractions nearby including Creighton University, University of Nebraska-Omaha and CHI Health Center Omaha. Tick off one, two or all during your trip to Medical Center. Expedia will help you turn your dream Medical Center vacation into reality, whatever your travel plans or budget.
- Travel Inn By OYO Omaha
Jul 2 - Jul 6Travel Inn By OYO Omaha + Flight
South Central Omaha4 nights6.0/10 - (178 reviews)"Stairs were dirty. The tv didn't work right. There dirt in the vent bathroom and light Don't stay run."Reviewed May 29, 2026Roundtrip • Phoenix (PHX) - Omaha (OMA)PHX - OMA • Nonstop OMA - PHX • Nonstop$551$486found 1 day agoper traveler - Holiday Inn Express & Suites Yankton by IHG
Aug 16 - Aug 19Holiday Inn Express & Suites Yankton by IHG + Flight
Yankton3 nights9.2/10 - Wonderful (434 reviews)"A positive regular hotel stay. Property was updated and clean. Breakfast was good, fully stocked and friendly staff. They let me park my bike under the canopy while a big storm was coming through. The mexican restaurant near the property (unrelated to Holiday Inn) made both my spouse and I sick."Reviewed May 26, 2026Roundtrip • Dallas (DFW) - Sioux Falls (FSD)DFW - FSD • 1 stop FSD - DFW • 1 stop$1,177$787found 1 day agoper traveler - Home2 Suites by Hilton Omaha I-80 at 72nd Street, NE
Aug 7 - Aug 10Home2 Suites by Hilton Omaha I-80 at 72nd Street, NE + Flight
South Central Omaha3 nights9.4/10 - Exceptional (302 reviews)"Great place with great service and amenities!"Reviewed May 10, 2026Roundtrip • Dallas (DAL) - Omaha (OMA)DAL - OMA • 1 stop OMA - DFW • 1 stop$642$556found 1 day agoper traveler - Americas Best Value Inn Missouri Valley
Jul 2 - Jul 6Americas Best Value Inn Missouri Valley + Flight
Missouri Valley4 nights7.2/10 - Good (351 reviews)"Sure it’s an older hotel but the bed was comfortable, the young lady at the front desk was nice and it’s incredibly chesp"Reviewed May 25, 2026Roundtrip • Phoenix (PHX) - Omaha (OMA)PHX - OMA • Nonstop OMA - PHX • Nonstop$564$493found 1 day agoper traveler - Hampton Inn Omaha West-Lakeside
Jul 2 - Jul 6Hampton Inn Omaha West-Lakeside + Flight
West Omaha4 nights9.2/10 - Wonderful (1,709 reviews)"Early checking is available if a room is ready. The front desk staff are extremely helpful in providing suggestions if needed. The breakfast staff is more than accommodating. Their pleasant smile makes your day start perfectly. Highly recommend staying at this lication."Reviewed May 29, 2026Roundtrip • Phoenix (PHX) - Omaha (OMA)PHX - OMA • Nonstop OMA - PHX • Nonstop$682$597found 1 day agoper traveler
Where to stay in Medical Center
Downtown Omaha
Explore the historic core of Omaha, where you'll find the Old Market Historic District, offering boutique shops, dining, and cultural activities. Don't miss the Orpheum Theater and Omaha Children's Museum nearby.
Medical Center Hotel Deals
Hampton Inn by Hilton Omaha UN Medical Center Area
"Staff was not helpful- was overcharge"
Reviewed on May 29, 2026
Home2 Suites by Hilton Omaha UN Medical Ctr Area
"The hotel lobby and all areas in general were very nice and modern. The biggest complaint was they had a sign that the room would be cleaned every other day. We had to ask on day 3 to have it cleaned but it was not. We once again had to ask on day 4 to clean it and it finally was. There was very ..."
Reviewed on May 26, 2026
Days Inn by Wyndham Omaha NE
"The rooms were nice and clean, the staff were extremely friendly and helpful. Breakfast was very good."
Reviewed on May 27, 2026
Discover the most popular places to visit in Medical Center
Henry Doorly Zoo and Aquarium
Journey through the world’s biggest indoor desert, spot magnificent creatures in the aquarium and explore indoor rainforests and swamps in Nebraska’s premier zoo.
Lauritzen Gardens
Wander through the diverse woodland areas, admire the charming waterfall and inspect the model railway system in this botanical park.
Heartland of America Park
Gaze up at the stunning light and water show at the fountain and hold hands on a romantic stroll through this charming park.