Medical District Vacations from $420

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Medical District Vacation

Our Medical District vacation packages are an easy and handy way to plan and book your next break. Discover the heart and soul of this unique neighborhood without the stress of having to plan everything yourself. Can't wait to explore the sights during your trip to Medical District? Don't miss nearby attractions like University of Texas at Austin, Zilker Park and Texas State Capitol. Expedia can help you turn your ideal Medical District vacation into reality, whatever your travel plans or budget.

The Latest Medical District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Comfort Suites Buda - Austin South

Comfort Suites Buda - Austin South

2.5 out of 5
Save 100% on your flight
Price was $653, price is now $420 per person
$420
per person
Feb 28 - Mar 7
found 5 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Austin (AUS)
8.4/10 Very Good! (1,000 reviews)
The size of the room was larger than expected.

Reviewed on Nov 25, 2025

Frame Hotel - Treehouse

Frame Hotel - Treehouse

3.5 out of 5
South Congress
Price was $982, price is now $577 per person
$577
per person
Feb 20 - Feb 24
found 5 hours ago
Roundtrip flight included
Chicago (CHI) to Austin (AUS)
9.8/10 Exceptional! (209 reviews)
Treehouse Frame Hotel is an absolute hidden gem. Wonderfully appointed, it was very relaxing and tranquil. Since it was such a small boutique property, it was much more enjoyable than a standard hotel. The bed was amazingly comfortable and the room amenities were excellent. South Congress was just a block over so very walkable. Even though there are some bars near by, we didn’t hear them from our room. We will definitely stay at Frame Hotel again. Unbelievably pleasantly surprised. Well done.

Reviewed on Sep 27, 2025

Austin Proper Hotel, a Member of Design Hotels

Austin Proper Hotel, a Member of Design Hotels

5 out of 5
Downtown Austin
Save 100% on your flight
Price was $1,290, price is now $788 per person
$788
per person
Feb 14 - Feb 17
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Austin (AUS)
9.2/10 Wonderful! (340 reviews)
Antonio and Giulio !! The best in this hotel

Reviewed on Dec 8, 2025

The Carpenter Hotel

The Carpenter Hotel

3.5 out of 5
Zilker
Price was $849, price is now $561 per person
$561
per person
Jan 28 - Feb 1
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Austin (AUS)
9.4/10 Exceptional! (807 reviews)
The staff here is always amazing, super nice, and accommodating. The rooms are always very clean. It’s a great location. Only good things to say about this place.

Reviewed on Dec 6, 2025

Hotel Viata

Hotel Viata

4.5 out of 5
Save 100% on your flight
Price was $720, price is now $481 per person
$481
per person
Feb 5 - Feb 10
found 22 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Austin (AUS)
9.2/10 Wonderful! (680 reviews)
Staff were exceptional!

Reviewed on Dec 11, 2025

Where to stay in Medical District

Find the best Medical District areas and neighborhoods for the activities you enjoy most. Learn more about Medical District
Downtown Austin showing street scenes and an administrative buidling

Downtown Austin

4 out of top 10 points of interest in this area
4/5(3,367 area reviews)

Central business district with high-rise buildings, Downtown Austin offers shopping at Second Street District and Sixth Street, art at Contemporary Austin Jones Center, and sights like Texas State Capitol. Accessible via Capital MetroRail.

Find hotels in Downtown Austin

Medical District Hotel Deals

Holiday Inn Express & Suites Austin Downtown - University by IHG

Holiday Inn Express & Suites Austin Downtown - University by IHG

2.5 out of 5
805 Neches Street Austin TX
Fully refundable
$80 nightly
The price is $95 total per night from Dec 23 to Dec 24
$95 total
Dec 23 - Dec 24
Total with taxes and fees
8.6/10 Excellent! (1,933 reviews)
Very friendly staff at the front desk, I had a great room with city view and a wonderful breakfast in the morning.

Reviewed on Dec 9, 2025

Holiday Inn Express & Suites Austin Downtown - University by IHG
Hyatt House Austin/Downtown

Hyatt House Austin/Downtown

3.5 out of 5
901 Neches Street Austin TX
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $119 total per night from Dec 20 to Dec 21
$119 total
Dec 20 - Dec 21
Total with taxes and fees
8.8/10 Excellent! (2,253 reviews)
Good

Reviewed on Dec 9, 2025

Hyatt House Austin/Downtown
Omni Austin Hotel

Omni Austin Hotel

4 out of 5
700 San Jacinto Blvd Austin TX
Fully refundableReserve now, pay when you stay
$218 nightly
The price is $261 total per night from Dec 20 to Dec 21
$261 total
Dec 20 - Dec 21
Total with taxes and fees
9.2/10 Wonderful! (1,930 reviews)
The room was spotless, beautifully maintained, and thoughtfully designed for both comfort and convenience. The bed was comfortable, the amenities were modern, and housekeeping consistently exceeded expectations throughout my stay.

Reviewed on Dec 10, 2025

Omni Austin Hotel
See all 8,349 properties in Medical District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Medical District

Frank Erwin Center

Frank Erwin Center

4.5/5(158 reviews)

Catch an event at Frank Erwin Center, and enjoy other activities in Austin such as biking. Experience the entertainment choices and acclaimed art scene in this vibrant area.

Frank Erwin Center
Waterloo Park

Waterloo Park

4.5/5(3 reviews)

Waterloo Park is just one of the places to see in Austin, so why not enjoy the other things to explore during your travels? Experience the acclaimed art scene and great live music in this vibrant area.

Waterloo Park
Austin

University of Texas at Austin

4.5/5(1,545 reviews)

Tour this campus to discover architectural wonders and public art displays. Visit captivating museums and witness the passion of a college football match.

University of Texas at Austin

Things to do

Cruise through Little Venice

Lake Austin Sunset Boat Cruise – 1 - Hour Scenic Tour BYOB

$35
per adult
100% of travellers recommend
Lake Austin Sunset Boat Cruise – 1 - Hour Scenic Tour BYOB
Lake Austin is fun to explore!

Scenic 2HR Austin Guided Lake Tour: Small Group & Full Sun Shade

$84
per adult
96% of travellers recommend
Scenic 2HR Austin Guided Lake Tour: Small Group & Full Sun Shade
Delicious lunch at Salt Lick

From Austin: Hill Country BBQ & Wine Shuttle

$62
per adult
94% of travellers recommend
From Austin: Hill Country BBQ & Wine Shuttle
See all activities in Austin
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.