Mesi Vacations from $1,634

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Your Mesi Vacation

Lock in a Mesi vacation package and get set to experience this exciting city the stress-free way. Consider staying in the neighborhood of Myli, which is great for views and hiking. If your trip to Mesi includes a little sightseeing, check out renowned attractions like Rethymnon Town Hall, Rethymnon Lighthouse and Arkadi Monastery. Check out Expedia's wide range of travel options and begin planning your dream vacation to Mesi today.

The Latest Mesi Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • Jan 18 - Jan 25

    Infinity City Boutique Hotel + Flight

    Heraklion
    6 nights
    4.0 star property
    8.8/10 - Excellent (357 reviews)
    "5 starts for newly renovated stylish hotel beautiful job! Duvet, extra pillows, new comfortable beds. Black out drapes, patio, and 55 inch flat screen TVs with apps for Prime Netflix Disney YouTube watch in your language. Huge bonus! Quiet central friendly staff. Beautiful stylish with mood back lighting. Top notch! Breakfast good. Felt spoiled. Stayed at 2 other hotels in the city looked like prison cells on comparison :)"
    Reviewed November 5, 2026
    Roundtrip • Boston (BOS) - Heraklion (HER)
    BOS - HER • 2 stops HER - BOS • 2 stops
    $1,819
    $1,634
    per traveler
    found 1 day ago
    Infinity City Boutique Hotel
  • Dec 25 - Jan 1

    Lagon Life Spirit Design Villas - Adults Only + Flight

    Chania
    6 nights
    4.0 star property
    9.8/10 - Exceptional (18 reviews)
    "From the moment we arrived, the staff was amazing and very helpful. The property is new, very clean, quiet, and everything you need for a very relaxing vacation. We are looking forward to staying at the Villa again soon. We couldn't have asked for a more warm welcome and great hospitality."
    Reviewed October 28, 2026
    Roundtrip • Boston (BOS) - Chania (CHQ)
    BOS - HER • 1 stop HER - BOS • 2 stops
    $3,753
    $2,990
    per traveler
    found 2 hours ago
    Lagon Life Spirit Design Villas - Adults Only
  • Jan 18 - Jan 25

    Vespera City Hotel + Flight

    Heraklion
    6 nights
    3.0 star property
    9.2/10 - Wonderful (46 reviews)
    Roundtrip • Boston (BOS) - Heraklion (HER)
    BOS - HER • 2 stops HER - BOS • 2 stops
    $2,046
    $1,637
    per traveler
    found 1 day ago
    Vespera City Hotel
  • Jan 18 - Jan 25

    Dimargio Luxury Hotel & Spa + Flight

    Heraklion
    6 nights
    5.0 star property
    9.8/10 - Exceptional (61 reviews)
    "Wonderful front desk staff and beautiful place"
    Reviewed October 20, 2026
    Roundtrip • Boston (BOS) - Heraklion (HER)
    BOS - HER • 2 stops HER - BOS • 2 stops
    $1,933
    $1,716
    per traveler
    found 1 day ago
    Dimargio Luxury Hotel & Spa
  • Dec 25 - Jan 1

    Domus Renier Boutique Hotel, Member of Domus Elegance Collection + Flight

    Old Town Chania
    6 nights
    4.0 star property
    10/10 - Exceptional (254 reviews)
    "If I could give more than five stars I would. I loved it here!"
    Reviewed November 6, 2026
    Roundtrip • Boston (BOS) - Chania (CHQ)
    BOS - HER • 1 stop HER - BOS • 2 stops
    $3,411
    $3,063
    per traveler
    found 2 hours ago
    Domus Renier Boutique Hotel, Member of Domus Elegance Collection

Mesi Hotel Deals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently Asked Questions

How much does a Mesi vacation package cost?

Offering excellent value package deals from $1,634 on Expedia, you'll be thrilled with how little a vacation to Mesi costs! Expedia's packages make travel planning easier and your savings go further.

What are the cheapest months to go to Mesi?

You can typically find lower prices and better availability in November, December and January. Browse our cheap Mesi vacation packages and you could get some excellent off-season deals.

How many days is enough for Mesi?

The ideal duration for your Mesi vacation depends on what you'd like to see. Generally, a few days to a week will give you plenty of time to check out all the major attractions and explore some hidden gems along the way.

How to find the best Mesi package deals?

Use Expedia's handy filters to help you find some great Mesi package deals. When you start your search, simply set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your break for midweek, or search for Mesi package deals in the off-season. Play around with your travel dates and you may score even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.

Is it cheaper to book a Mesi vacation as a package?

You can enjoy significant savings on your next Mesi break by booking a customized vacation package. Check the "Package" heading, then select your travel dates and destination to view the best airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.

When to book a vacation package to Mesi?

If you've got your Mesi vacation dates locked in, book early to snap up some fantastic deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous getaways? Our last-minute deals are great for jetting off on a whim.

Does Expedia offer Book Now, Pay Later Mesi vacation packages?

If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the overall cost of your Mesi break over 3, 6 or 12 months. There are also no hidden costs or late payment fees, so you can secure great vacation packages with payment plans as soon as you see them.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.