North Santee Vacations from $354

Book a Hotel + Flight or Car together to unlock savings

Your North Santee Vacation

The adventure-filled city of North Santee is calling. Discover its hot spots and hidden treasures with a North Santee vacation package that's customized to you. Hopsewee Plantation is just one of the big-ticket attractions to check off your sightseeing agenda during a trip to North Santee. A few clicks is all it takes to put together your dream North Santee vacation on Expedia.

The Latest North Santee vacation packages

Price found within the past 48 hours. Click for updated prices.
Westgate Myrtle Beach Oceanfront Resort

Westgate Myrtle Beach Oceanfront Resort

3.5 out of 5
Save 100% on your flight
Price was $769, price is now $354 per person
$354
per person
Dec 15 - Dec 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
8.6/10 Excellent! (1,504 reviews)

Sands Beach Club

Sands Beach Club

2.5 out of 5
Save 100% on your flight
Price was $584, price is now $378 per person
$378
per person
Jan 11 - Jan 16
found 1 day ago
Roundtrip flight included
Islip (ISP) to Myrtle Beach (MYR)
8.8/10 Excellent! (145 reviews)
Always love our stays here!

Reviewed on Oct 22, 2026

Marina Inn Grande Dunes Condos & Suites

Marina Inn Grande Dunes Condos & Suites

5 out of 5
Price was $612, price is now $405 per person
$405
per person
Jan 8 - Jan 11
just found
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
9.4/10 Exceptional! (229 reviews)

Jade Tree Cove

Jade Tree Cove

3 out of 5
Save 100% on your flight
Price was $602, price is now $401 per person
$401
per person
Jan 11 - Jan 16
found 1 day ago
Roundtrip flight included
Islip (ISP) to Myrtle Beach (MYR)
9.6/10 Exceptional! (416 reviews)

Marina Inn At Grande Dunes

Marina Inn At Grande Dunes

4.5 out of 5
Price was $588, price is now $394 per person
$394
per person
Jan 8 - Jan 11
just found
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
9.4/10 Exceptional! (1,884 reviews)

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What to do in North Santee

Murrells Inlet Sunset Cruise: Scenic Views & Wildlife

Murrells Inlet Sunset Cruise

$32
per adult
Murrells Inlet Sunset Cruise
Myrtle Beach: Children’s Pirate Daytime or Sunset Adventure

Myrtle Beach: Children’s Pirate Daytime or Sunset Adventure

$32
per adult
Myrtle Beach: Children’s Pirate Daytime or Sunset Adventure
Myrtle Beach to Charleston with Horse & Carriage Ride, Harbor Cruise, Boone Hall

Myrtle Beach to Charleston with Horse & Carriage Ride, Harbor Cruise, Boone Hall

$215
per adult
86% of travellers recommend
Myrtle Beach to Charleston with Horse & Carriage Ride, Harbor Cruise, Boone Hall
See all activities in North Santee

North Santee Hotel Deals

The George Hotel

The George Hotel

3.5 out of 5
615 Front Street Georgetown SC
Fully refundableReserve now, pay when you stay
$168 nightly
The price is $186 total per night from Nov 8 to Nov 9
$186 total
Nov 8 - Nov 9
Total with taxes and fees
9.8/10 Exceptional! (624 reviews)
"The only thing I could suggest that could use improvement is the water pressure in the room shower could be better if possible but all in all we had a wonderful stay"

Reviewed on Oct 30, 2026

The George Hotel
Motel 6 Georgetown, SC - Marina

Motel 6 Georgetown, SC - Marina

2 out of 5
120 Church St Georgetown SC
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $72 total per night from Nov 9 to Nov 10
$72 total
Nov 9 - Nov 10
Total with taxes and fees
5/10 (524 reviews)
"No shower supplies like shampoo or body wash. No hair dryer. Internet kept failing. No streaming TV channels."

Reviewed on Oct 20, 2026

Motel 6 Georgetown, SC - Marina
Quality Inn & Suites Georgetown

Quality Inn & Suites Georgetown

2.5 out of 5
210 Church St Georgetown SC
Fully refundable
$70 nightly
The price is $77 total per night from Nov 29 to Nov 30
$77 total
Nov 29 - Nov 30
Total with taxes and fees
5.8/10 (558 reviews)
"Nice room for the price. Website said pets stay free this is not the case."

Reviewed on Oct 23, 2026

Quality Inn & Suites Georgetown
See all 460 properties in North Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best North Santee Vacation Packages

North Santee Essential Information

Language
English
Currency
U.S dollars
Top Sights
Georgetown County Museum, Hampton Plantation State Historic Site and Hopsewee Plantation

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Frequently asked questions

How much does a North Santee vacation package cost?
You can grab a vacation package to this popular destination from $354 on Expedia. However, how much your vacation to North Santee costs will depend on your hotel choice, length of stay and season.
What are the cheapest months to go to North Santee?
If you're hoping to snag a cheap North Santee vacation package, consider traveling in January, October and November. You'll generally find lower prices on airfares and hotels during these quieter months — ideal for a budget-friendly break.
How many days is enough for North Santee?
The ideal length for your North Santee vacation depends on what you'd like to do. Generally, a few days to a week will give you enough time to tick off all the main attractions and explore some hidden treasures along the way.
How to find the best North Santee package deals?
Use Expedia's filter tool to find some terrific North Santee package deals. When you start your search, simply set your maximum budget and then order the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for North Santee package deals in the low season. Switch up your travel dates and you may score even bigger discounts. As a rule of thumb, it's usually best to book your vacation package well in advance.
Is it cheaper to book a North Santee vacation as a package?
You can enjoy significant savings on your North Santee retreat by booking a customized vacation package. Click on the "Package" heading, then enter your destination and travel dates to see the best hotel and flight prices. Bundling can save travelers hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to North Santee?
If you have your North Santee travel dates confirmed, book as soon as you can to snap up some unbeatable deals. With Expedia, you can often reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for impromptu escapes.
Does Expedia offer Book Now, Pay Later North Santee vacation packages?
Your North Santee trip is meant to be an escape from your busy life, not a source of money-related stress. So to allow you more flexibility, we've partnered with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there are no hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.