A calm river with clear water, surrounded by dense trees and rocky banks.

O Brien Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for O Brien vacation rentals

A covered porch with wooden railings, a table, and four chairs.

1. Suwannee Music Park about 30 mins away. Royal Springs across the street.

Suwannee Music Park about 30 mins away. Royal Springs across the street.
O'Brien
9.6 out of 10, Exceptional, (7 reviews)
"Ideal for weekend getaways, a quiet place to forget about the stress of the city, the house is so cozy. "
Mexico
Maria Josefina
$257 nightly
The price is $280
Oct 5 - Oct 6
Total with taxes and fees
Suwannee Music Park about 30 mins away. Royal Springs across the street.
Cozy tiny home living area with leather sofa and loft.

2. Nook at the Springs | Tiny Home • Full Kitchen

Nook at the Springs | Tiny Home • Full Kitchen
Fort White
9.8 out of 10, Exceptional, (10 reviews)
"Excellent place "
United States
Linay
$154 nightly
The price is $166
Sep 29 - Sep 30
Total with taxes and fees
Nook at the Springs | Tiny Home • Full Kitchen
A covered outdoor seating area with wicker chairs and a table, surrounded by a wooden deck and railing.

3. Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River

Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River
Branford
10.0 out of 10, Exceptional, (12 reviews)
"Hosts are awesome, and there's enough amenities to keep any family busy for as long as they'd like. "
United States
James S.
$180 nightly
The price is $196
Sep 29 - Sep 30
Total with taxes and fees
Rustic River Cabin 2-bedroom cabin in Branford near Santa Fe River
A cabin with a cozy interior, a dining area, and a view of the forest.

4. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (285 reviews)
"Great accommodations! We enjoyed our stay and will be back!"
United States
Michael
$198 nightly
The price is $218
Oct 28 - Oct 29
Total with taxes and fees
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
A modern kitchen with wooden cabinets, a central island with stools, a stove, and a dining area with chairs.

5. The Riverhead | Springs • Pavilion • Grill

The Riverhead | Springs • Pavilion • Grill
Fort White
9.4 out of 10, Exceptional, (16 reviews)
"Very close to springs and other attractions. Property was clean and very inviting on the inside. The beds were comfortable and the decor was very homey. Ample coffee and tea was provided and the kitchen was very equipped for cooking. Overall a really great way to enjoy the nearby springs. "
United States
Nicole
$272 nightly
The price is $294
Oct 11 - Oct 12
Total with taxes and fees
The Riverhead | Springs • Pavilion • Grill
Private kitchen

6. Cozy Lake House, Hot Tub & Close to FL Springs

Cozy Lake House, Hot Tub & Close to FL Springs
Branford
10.0 out of 10, Exceptional, (1 review)
"Juan was so welcoming. The house was clean and had everything we needed for a fun family getaway - and then some! Would love to stay here again. "
United States
Ashley L.
$245 nightly
The price is $261
Oct 5 - Oct 6
Total with taxes and fees
Cozy Lake House, Hot Tub & Close to FL Springs
A laundry area with a washing machine, dryer, and shelves with baskets.

7. Nature Cabin Itchetucknee Springs Private Access

Nature Cabin Itchetucknee Springs Private Access
Columbia County
10.0 out of 10, Exceptional, (1 review)
"Charming place to stay and enjoy the local rivers!"
United States
Shawn
$239 nightly
The price is $239
Oct 4 - Oct 5
Total with taxes and fees
Nature Cabin Itchetucknee Springs Private Access
A wooden deck with two benches and a table, surrounded by a wooden fence and trees.

8. SpringHouse at Convict Springs

SpringHouse at Convict Springs
Mayo
10.0 out of 10, Exceptional, (1 review)
$130 nightly
The price is $138
Sep 29 - Sep 30
Total with taxes and fees
SpringHouse at Convict Springs
A living room with a grey sofa, a wooden coffee table with vases, a framed picture on the wall, and a view of a grassy area through a door.

9. Stylish Cabin - Nearby Springs

Stylish Cabin - Nearby Springs
Lake City
10.0 out of 10, Exceptional, (5 reviews)
"Amazing place"
United States
Ernesto Randhel
$181 nightly
The price is $196
Sep 30 - Oct 1
Total with taxes and fees
Stylish Cabin - Nearby Springs
A kitchen with wooden cabinets, a stainless steel refrigerator, and a window overlooking greenery.

10. The Loft Private Cabin Near Hulaween & Spirit of the Suwannee

The Loft Private Cabin Near Hulaween & Spirit of the Suwannee
Live Oak
10.0 out of 10, Exceptional, (36 reviews)
"Fantastic place, super clean and dreamy! We had an amazing stay"
United States
Maria C.
$161 nightly
The price is $175
Oct 5 - Oct 6
Total with taxes and fees
The Loft Private Cabin Near Hulaween & Spirit of the Suwannee
A wooden cabin interior with a dining area, kitchen, and large windows.

11. Sweetwater on the Range | Cozy Cabin • Firepit

Sweetwater on the Range | Cozy Cabin • Firepit
High Springs
8.8 out of 10, Excellent, (13 reviews)
"Not pet friendly but accommodating."
United States
Lawrence
Sweetwater on the Range | Cozy Cabin • Firepit
A compact, well-lit room with a bed, a small sink, a potted plant, and a window with a view of the outdoors.

12. The Happy House Tiny Guest House

The Happy House Tiny Guest House
Live Oak
8.6 out of 10, Excellent, (8 reviews)
"very nice tiny house style accommodation"
United States
Cara B.
$134 nightly
The price is $145
Sep 29 - Sep 30
Total with taxes and fees
The Happy House Tiny Guest House
Screened-In Lanai | Dining Table | Bar Area | Private Pool (Not Heated)

13. Suwannee River Retreat: Pet Friendly, Private Dock

Suwannee River Retreat: Pet Friendly, Private Dock
Branford
9.8 out of 10, Exceptional, (8 reviews)
"I had the pleasure of celebrating my birthday at the Bucks River Retreat. We had a group of 8 adults and 2 kids staying there and there was plenty of room for every one. The house is clean and cozy with a fun cabin vibe. The property is absolutely gorgeous! Plenty of room to park, party, cook out, swim and of course enjoy the Suwannee river. The dock is newly redone and fun place to hang out. I can’t wait to go back and stay at the Bucks again. It had every thing you need and so much more."
United States
Hayley
$540 nightly
The price is $575
Sep 29 - Sep 30
Total with taxes and fees
Suwannee River Retreat: Pet Friendly, Private Dock
Interior

14. Suwannee River Retreat: Pet Friendly, Private Dock

Suwannee River Retreat: Pet Friendly, Private Dock
3.0 star property
Branford
$567 nightly
The price is $606
Sep 29 - Sep 30
Total with taxes and fees
Suwannee River Retreat: Pet Friendly, Private Dock
A garden with a small pond, surrounded by various plants and a wooden structure.

15. Kokomo Farms - Cozy Cottage on the Farm

Kokomo Farms - Cozy Cottage on the Farm
Live Oak
9.8 out of 10, Exceptional, (15 reviews)
"Great place for nature!"
United States
Stephen
$154 nightly
The price is $167
Sep 29 - Sep 30
Total with taxes and fees
Kokomo Farms - Cozy Cottage on the Farm
A compact kitchen with wooden cabinets, a microwave, and a sink.

16. Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Mayo
9.6 out of 10, Exceptional, (19 reviews)
"Fantastic property very quiet with very friendly animals."
United States
Hevrard
$92 nightly
The price is $97
Sep 29 - Sep 30
Total with taxes and fees
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
A residential street lined with mature trees and a well-maintained lawn.

17. "The Loft" on the 11th Tee. No pets! No smoking!

"The Loft" on the 11th Tee. No pets! No smoking!
Lake City
10.0 out of 10, Exceptional, (17 reviews)
"This property is exactly as advertised - cozy, clean and well maintained in a beautiful neighborhood. We very much enjoyed staying there."
United States
Gerald S.
$148 nightly
The price is $164
Sep 29 - Sep 30
Total with taxes and fees
"The Loft" on the 11th Tee. No pets! No smoking!
A living room with a television on a wooden stand, a wicker chair, a dark sofa, and a door to another room.

18. O'LE LADYBUG COTTAGE

O'LE LADYBUG COTTAGE
Lake City
9.6 out of 10, Exceptional, (57 reviews)
"Everything was great will stay again if I’m ever in the area"
United States
regina
$186 nightly
The price is $207
Sep 29 - Sep 30
Total with taxes and fees
O'LE LADYBUG COTTAGE
A single-story mobile home with a covered porch and a fenced entrance.

19. Three Rivers Retreat

Three Rivers Retreat
Fort White
$254 nightly
The price is $283
Oct 4 - Oct 5
Total with taxes and fees
Three Rivers Retreat
A kitchen with a black induction cooktop, hanging utensils, and a small shelf with kitchen items.

20. Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.

Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.
Lake City
9.0 out of 10, Wonderful, (6 reviews)
"Amenities were surprisingly good, glad to have coffee available "
United States
Cindy M.
$158 nightly
The price is $175
Sep 29 - Sep 30
Total with taxes and fees
Your Cozy Farmhouse Inspired Retreat. Just 5 minutes to I-75. Pets Welcomed.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top O Brien Hotel Reviews

Tru by Hilton Lake City

Tru by Hilton Lake City

10/10 Excellent
"All good, staff especially!"
Bonita 2-night trip
Posted 2 hours ago
Tru by Hilton Lake City

Find out more about O Brien

Everything you need to know about O Brien vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the O Brien vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect O Brien vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

O Brien vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in O Brien. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit O Brien in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $97 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on O Brien rentals

At Expedia, we put the best O Brien vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top O Brien rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream O Brien vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around O Brien. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in O Brien?

Yes, we offer vacation rentals close to well known points of interest in O Brien, or you can go with a more secluded option if you're looking for a relaxing stay.

What's the top vacation rental that O Brien has to offer?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Another good choice for your trip to O Brien is MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY.

How many vacation rentals are there in O Brien?

Expedia has 4 vacation rentals for your stay in O Brien.

What’s there to see and do in O Brien?

Suwannee River and Ichetucknee River are a couple of lovely local spots to get outside and enjoy nature. Ichetucknee Springs State Park and Lafayette Blue Springs State Park are a couple of places you'll find in the larger area.

What’s a vacation rental in O Brien like?

Vacation rentals are private properties you can stay in for several days or longer in O Brien. Vacation rentals offer amenities like WiFi and washers and dryers so you'll have everything you need. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a popular choice for small groups.