Mayo, FL

Travel Guide

A calm river surrounded by trees with Spanish moss, reflecting the clear blue sky.
A calm river with trees and a clear blue sky.
A swampy area with trees and water.
A calm river surrounded by trees reflecting in the water.
A calm river with trees reflecting the sunlight.
Cindys Motel

Cindys Motel

2.5 out of 5
487 W Main St Mayo FL
$90 nightly
The price is $96 total per night from Nov 5 to Nov 6
$96 total
Nov 5 - Nov 6
Total with taxes and fees
Stay at this motel in Mayo. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions Veteran's ...
8.8/10 Excellent! (140 reviews)
"Old and dark. A little smells in the room. One light bulb is out of order. Water super hot and dangerous for kids"

Reviewed on Nov 1, 2026

Cindys Motel
Suwannee River Rendezvous

Suwannee River Rendezvous

2.5 out of 5
828 NE Primrose Rd Mayo FL
$123 nightly
The price is $131 total per night from Nov 5 to Nov 6
$131 total
Nov 5 - Nov 6
Total with taxes and fees
Stay at this resort in Mayo. Enjoy free WiFi, free parking, and 3 outdoor pools. Popular attractions Wes Skiles Peacock Springs State Park and Telford Spring ...
8.6/10 Excellent! (34 reviews)
"Very run down, old towels and beddings."

Reviewed on Oct 25, 2026

Suwannee River Rendezvous
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
$77 nightly
The price is $82 total per night from Nov 16 to Nov 17
$82 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this cabin in Mayo. Enjoy free WiFi, a garden, and patios. Popular attraction Allen Mill Pond Spring is located nearby.
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
See all 509 properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
Stay at this cabin in Mayo. Enjoy free WiFi, a garden, and patios. Popular attraction Allen Mill Pond Spring is located nearby.
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
The Best memories are made on the Suwannee River

The Best memories are made on the Suwannee River

Mayo FL
Stay at this vacation home in Mayo. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lafayette Blue Springs State Park and Perry Spring ...
9.8/10 Exceptional! (59 reviews)
"Very easy check in/check out. Plenty of kitchen pans, dishes, utensils, and small appliances. Comfortable rooms and beds. The location is a gem! Quiet and peaceful river setting and convenient for short drives to many great places for fishing, beaches, springs. We plan on visiting again. Host has ..."

Reviewed on Oct 19, 2026

The Best memories are made on the Suwannee River
Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping

Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping

Mayo FL
Stay at this cabin in Mayo. Enjoy a garden, patios, and air conditioning. Popular attraction Allen Mill Pond Spring is located nearby.
Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping
See all properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mayo attractions

Lafayette Blue Springs State Park

8.0/10 (6 reviews)
You can take time to visit Lafayette Blue Springs State Park during your travels to Mayo. While you're in the area, wander around the parks.
See properties

Frequently asked questions

Is Mayo worth visiting?
Mayo is worth visiting for its natural attractions, including Lafayette Blue Springs State Park and Perry Spring, which offer travelers opportunities for outdoor recreation. The area also provides diverse dining options, with local establishments serving North American and Latin American cuisine.
When is the best time to visit Mayo?
The best time to visit Mayo is from November through March, when conditions are typically pleasant for exploring. For fewer crowds and better value, the warmer months of June through August are a good bet, offering a more relaxed experience.
What is Mayo known for?
Mayo is known for Lafayette Blue Springs State Park and Perry Spring, offering travelers natural springs to explore. The destination also features the Lafayette County Library, providing insight into the local community.
What is a good itinerary length for Mayo?
A good itinerary length for Mayo is one to two days to experience its natural attractions like Lafayette Blue Springs State Park and Perry Spring. An extended stay of three to four days allows travelers to enjoy the area's springs and explore local spots like the Lafayette County Library, plus sample diverse cuisine.
What are the top things to do in and around Mayo?
Mayo offers natural springs, parks, and local landmarks for travelers to explore:

  • Explore Lafayette Blue Springs State Park
  • Visit Perry Spring
  • See the Lafayette County Library
  • Enjoy Allen Mill Pond Spring
  • Wander through Veteran's Memorial Park of Mayo

How do I plan a trip to Mayo?
To plan your trip to Mayo, search for places to stay and book flights in advance. Consider a rental car for exploring the area's attractions. Plan to visit Lafayette Blue Springs State Park and Perry Spring. For outdoor activities, aim for early morning or late afternoon. Also, be sure to check out Lafayette County Library.
What cuisines can you find in Mayo?
In Mayo you can find Japanese cuisine, featuring popular dishes such as sushi, ramen, tempura, and teriyaki. Travelers can also enjoy a variety of international flavors, including North American comfort food, vibrant Latin American dishes, diverse Asian options, and classic Italian fare.
Can I book a refundable hotel in Mayo?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Mayo by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Mayo with Expedia?
Expedia makes it easier to plan your Mayo trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Mayo?
The best choice depends on your travel style. Hotels in Mayo can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Mayo trip on Expedia?
Once you've booked your Mayo trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Mayo trip?
Expedia offers customer support before, during, and after your Mayo trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Mayo?
If it's your first trip to Mayo, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Mayo hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Mayo hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Cities near Mayo

A park with large trees and a grassy area.

Live Oak

An aerial view of a coastal town with historic buildings, a prominent church, and a marina with boats.

Old Town

A clear, turquoise pool surrounded by wooden decks and dense forest.

Branford

A calm river with clear water, surrounded by dense trees and rocky banks.

O Brien

Explore a world of travel with Expedia