Title: TOP 10 Hotels in O Brien, FL (from $43) 2026 - Competitive Prices | Expedia.com

[O Brien Travel Guide](https://expedia.com/O-Brien.dx3000431472)[Vacation Rentals in O Brien](https://expedia.com/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[Flights to O Brien](https://expedia.com/Cheap-Flights-To-O-Brien.d3000431472.Travel-Guide-Flights)[Car Rentals in O Brien](https://expedia.com/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide)[O Brien Vacation Packages](https://expedia.com/O-Brien.d3000431472.Destination-Travel-Guides)

![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in O Brien

Resort

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&lodging=HOTEL_RESORT)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&lodging=CABIN)

Great for families

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&travelerType=family_friendly)

Pool

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&amenities=POOL)

Pet-friendly

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&amenities=PETS)

Hot tub

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&amenities=HOT_TUB)

Apart­ment

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&lodging=APARTMENT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&lodging=COTTAGE)

Waterpark

[](https://www.expedia.com/Hotel-Search?destination=O+Brien%2C+Florida%2C+United+States+of+America&regionId=3000431472&latLong=30.03829%2C-82.940697&adults=2&startDate=2026-02-24&d1=2026-02-24&endDate=2026-02-26&d2=2026-02-26&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[Feb 10 - Feb 11](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-10&endDate=2026-02-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 11 - Feb 12](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-11&endDate=2026-02-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=3000431472&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for O Brien hotels

![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/758be2b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/a1c39a5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/8f3d1583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

[](https://www.expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

Alachua

9.4/10

Exceptional

(1,003 reviews)

"Staff and hotel were wonderful!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sandra

$108 nightly

$122 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

![3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/994169e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Cabin, Resort View | In-room dining](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/c163ad60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Cabin, Resort View | Terrace/patio](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/d134c1d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic House, 2 Bedrooms, Patio, River View | Terrace/patio](https://images.trvl-media.com/lodging/112000000/111770000/111760600/111760596/9fdd625a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Suwannee River Rendezvous

[](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information)

Mayo

8.8/10

Excellent

(23 reviews)

"Awesome place to stay, beautiful location and great accommodations. Friendly staff and lots to do!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lauren

$40 nightly

$43 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Mayo-Hotels-Suwannee-River-Rendezvous.h111760596.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/0011ea88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/8e94b4a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/c38f0eff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suite by Wyndham Lake City

[](https://www.expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

Lake City

8.8/10

Excellent

(1,074 reviews)

"Excellent place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Donovan

$104 nightly

$116 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/539e711a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/ce51e7f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/3edbfb3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/c1a6f9d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru by Hilton Lake City

[](https://www.expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

Lake City

9.2/10

Wonderful

(1,002 reviews)

"Clean and staff was very kind "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosemary

$107 nightly

$120 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/b55b7c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/6d948429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Non Smoking | Living area | LCD TV](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/5444216f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking | Private kitchen | Fridge, microwave, dishwasher, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/620ea62e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Home2 Suites by Hilton Lake City

[](https://www.expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

Lake City

9.4/10

Exceptional

(760 reviews)

"This is an excellent hotel while you roadtrip:)"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Desiree Moreno

$122 nightly

$138 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/w5753h3835x0y5-8b760fc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/45cc4db7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/5bb0fbdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

Lake City

9.4/10

Exceptional

(1,000 reviews)

"The room was very clean and comfortable. Excellent breakfast and staff was very friendly and helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kenneth

$134 nightly

$151 total

Feb 16 - Feb 17

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/dc8aa87c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/f5ec1000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/fb3e9b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Lake City

[](https://www.expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

Lake City

9.0/10

Wonderful

(1,051 reviews)

"Great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jack

$99 nightly

$111 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds | Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/4fd57c66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/893e3583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/55219bf1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Live Oak by IHG

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

Live Oak

8.4/10

Very Good

(797 reviews)

"The room was clean. Bed was comfortable. Staff very nice. Breakfast was delicious. Great experience "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frank

$121 nightly

$133 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/1d4a6615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/2dd8879c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/35661d50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking | In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/65000000/64480000/64474900/64474824/847fac5d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn & Suites Alachua I-75

[](https://www.expedia.com/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information)

Alachua

9.4/10

Exceptional

(485 reviews)

"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5\. Will definitely stay again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Libbi

$104 nightly

$117 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Hampton-Inn-Suites-Alachua-I-75.h64474824.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/4156d709.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/ec822d01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/737c0544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed with Sofa bed | Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/39f90afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard By Marriott Lake City

[](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

Lake City

9.6/10

Exceptional

(200 reviews)

"Nice and clean. Friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

$107 nightly

$120 total

Feb 22 - Feb 23

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/44a144ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/7c89c912.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/96b8648e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/bff23b3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn & Suites Lake City by IHG

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information)

Lake City

8.6/10

Excellent

(1,000 reviews)

"Great place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

$98 nightly

$110 total

Feb 15 - Feb 16

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information)

![Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/2b2698df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/1d6290c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/90b674ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/bb1585dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information)

Lake City

9.6/10

Exceptional

(1,004 reviews)

"The staff is great"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tana

$117 nightly

$131 total

Feb 16 - Feb 17

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/17e31965.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/c6002627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, pillowtop beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/c572bd7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/d20099d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites Lake City

[](https://www.expedia.com/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information)

Lake City

9.0/10

Wonderful

(194 reviews)

"Friendly staff, convenient location, clean rooms, excellent breakfast"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Keith

$107 nightly

$120 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information)

![1 bedroom, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/a3ee2a3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/42e07503.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Garden view](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/0b12a87b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![40-inch Smart TV with digital channels, Netflix, streaming services](https://images.trvl-media.com/lodging/113000000/112650000/112641200/112641197/86100bd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vista Verde Farm Retreat

[](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information)

Lake City

9.8/10

Exceptional

(16 reviews)

"The property is great and I had a fabulous 3 night stay. Ana was fantastic and gave great suggestions for things to do in the area. Loved the location, pet friendly and beautiful. Would came back again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennie

$164 nightly

$184 total

Feb 12 - Feb 13

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Vista-Verde-Farm-Retreat.h112641197.Hotel-Information)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/74cd9358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/w3837h2160x3y0-2acfd09c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food and drink](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/abc6b8bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/3a18c374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 – Lake City, Fl – Medical Center

[](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

Lake City

8.2/10

Very Good

(107 reviews)

"Dog friendly and price."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

$60 nightly

$68 total

Mar 1 - Mar 2

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

![Fountain](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/dffd0064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Grand Room | Blackout drapes, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/cf88e1e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/4f50db02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/88000000/87680000/87671900/87671816/5794d577.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### BlueGem Motel

[](https://www.expedia.com/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information)

High Springs

9.2/10

Wonderful

(405 reviews)

"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julians

$86 nightly

$97 total

Feb 20 - Feb 21

Total with taxes and fees

[](https://www.expedia.com/High-Springs-Hotels-BlueGem-Motel.h87671816.Hotel-Information)

![Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/a1a4d6c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/5dfe9f55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/918d16cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/10000/7400/7326/2221baa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Alachua Inn

[](https://www.expedia.com/Gainesville-Hotels-Travelodge-By-Wyndham-Alachua.h7326.Hotel-Information)

Alachua

5.8/10

(661 reviews)

"Room was clean and staff were courteous. The place isn't in a good area and, the outside doesn't look the same as the picture, it is worse. Staff were outside smoking and no one was at the front desk. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shirl

$66 nightly

$74 total

Feb 16 - Feb 17

Total with taxes and fees

[](https://www.expedia.com/Gainesville-Hotels-Travelodge-By-Wyndham-Alachua.h7326.Hotel-Information)

![Couples dining](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/7fbbc8b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/51f0a7e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fireplace](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/32ac9bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/16000000/15740000/15732000/15731979/542db1e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Putnam Lodge Hotel and Spa

[](https://www.expedia.com/Chiefland-Hotels-Putnam-Lodge-Hotel-And-Spa.h15731979.Hotel-Information)

Cross City

9.2/10

Wonderful

(367 reviews)

"Historic! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

William

$160 nightly

$176 total

Feb 12 - Feb 13

Total with taxes and fees

[](https://www.expedia.com/Chiefland-Hotels-Putnam-Lodge-Hotel-And-Spa.h15731979.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/f86787e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/w1024h1408x0y128-1c37bc4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Sleeper Sofa | Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/2a6fa58f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/92000000/91100000/91092100/91092031/8b97268c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Blanche 

[](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information)

Lake City

9.2/10

Wonderful

(167 reviews)

"Easy to access building and room with code provided; amazing bed and very clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ruth

$144 nightly

$163 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-The-Blanche.h91092031.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/5edd2e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/31f4ee27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/a54ec91f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/112000000/111230000/111220300/111220251/528c6fdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Lake City

[](https://www.expedia.com/Lake-City-Hotels-TownePlace-Suites-By-Marriott-Lake-City.h111220251.Hotel-Information)

Lake City

9.6/10

Exceptional

(125 reviews)

"Good hotel"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Frank

$169 nightly

$190 total

Feb 16 - Feb 17

Total with taxes and fees

[](https://www.expedia.com/Lake-City-Hotels-TownePlace-Suites-By-Marriott-Lake-City.h111220251.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-25&endDate=2026-02-26&regionId=3000431472&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

[See all hotels in O Brien](https://www.expedia.com/Hotel-Search?startDate=2026-02-25&endDate=2026-02-26&adults=2&regionId=3000431472)

![kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida](https://images.trvl-media.com/place/553248635976197691/42181e6d-fd52-4c3e-bdcb-128d4daebc91.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## Top O Brien Hotel Reviews

![Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110500000/110494400/110494372/fce767a1_y.jpg)

### Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Perfect tiny house experience. Cute, clean and nice for dog walking."

[](https://expedia.com/Postcard-Cabins-Gilchrist-Springs.h110494372.Hotel-Information)

![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg)

### Best Western Plus Lake City

10/10 Excellent

"Yes"

[](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![Super 8 by Wyndham Lake City](https://images.trvl-media.com/lodging/1000000/910000/909400/909334/add6c913_y.jpg)

### Super 8 by Wyndham Lake City

10/10 Excellent

"good"

[](https://expedia.com/Lake-City-Hotels-Super-8-By-Wyndham-Lake-City.h909334.Hotel-Information)

![Home2 Suites by Hilton Lake City](https://images.trvl-media.com/lodging/1000000/30000/25100/25013/47d0ef07_y.jpg)

### Home2 Suites by Hilton Lake City

10/10 Excellent

"Clean room and friendly staff"

[](https://expedia.com/Lake-City-Hotels-Home2-Suites-By-Hilton-Lake-City.h25013.Hotel-Information)

![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg)

### Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent

"The room was clean. Bed was comfortable. Staff very nice. Breakfast was delicious. Great experience "

[](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![Quality Inn Lake City](https://images.trvl-media.com/lodging/1000000/490000/484100/484004/cbec2bb3_y.jpg)

### Quality Inn Lake City

10/10 Excellent

"Friendly staff clean room decent breakfast "

[](https://expedia.com/Lake-City-Hotels-Quality-Inn-Lake-City.h484004.Hotel-Information)

![Americas Best Value Inn Lake City](https://images.trvl-media.com/lodging/2000000/1040000/1039800/1039754/1bfc5692_y.jpg)

### Americas Best Value Inn Lake City

10/10 Excellent

"Everything/everyone was great…breakfast was kinda lacking but had hot coffee "

[](https://expedia.com/Lake-City-Hotels-Americas-Best-Value-Inn-Lake-City.h1039754.Hotel-Information)

![Courtyard By Marriott Lake City](https://images.trvl-media.com/lodging/100000000/99930000/99922700/99922616/9c441019_y.jpg)

### Courtyard By Marriott Lake City

10/10 Excellent

"All good "

[](https://expedia.com/Lake-City-Hotels-Courtyard-By-Marriott-Lake-City.h99922616.Hotel-Information)

![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg)

### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"Room was spotless and staff was great."

[](https://expedia.com/Gainesville-Hotels-Holiday-Inn-Express-Suites-Alachua-Gainesville-Area.h22858269.Hotel-Information)

## More cheap stays in O Brien

![Motel 6 – Lake City, Fl – Medical Center](https://images.trvl-media.com/lodging/120000000/119610000/119606200/119606176/86b658ba_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL

$60 nightly

$68 total

Mar 1 - Mar 2

Total with taxes and fees

8/10 Very Good! (107 reviews)

[](https://expedia.com/Lake-City-Hotels-Motel-6-Lake-City.h119606176.Hotel-Information)

![Best Western Plus Lake City](https://images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

$99 nightly

$111 total

Feb 15 - Feb 16

Total with taxes and fees

9/10 Wonderful! (1,050 reviews)

[](https://expedia.com/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information)

![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### La Quinta Inn & Suite by Wyndham Lake City

165NW CALI DRIVE Lake City FL

$104 nightly

$116 total

Mar 1 - Mar 2

Total with taxes and fees

8.6/10 Excellent! (1,068 reviews)

[](https://expedia.com/Lake-City-Hotels-La-Quinta-Inn-Suite-By-Wyndham-Lake-City.h48281488.Hotel-Information)

![Tru by Hilton Lake City](https://images.trvl-media.com/lodging/35000000/34870000/34865600/34865542/1f67a534_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

$107 nightly

$120 total

Feb 15 - Feb 16

Total with taxes and fees

9/10 Wonderful! (1,001 reviews)

[](https://expedia.com/Lake-City-Hotels-Tru-By-Hilton-Lake-City.h34865542.Hotel-Information)

![Holiday Inn Express & Suites Live Oak by IHG](https://images.trvl-media.com/lodging/1000000/800000/798800/798756/ddd17ce3_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL

$121 nightly

$133 total

Feb 22 - Feb 23

Total with taxes and fees

8.2/10 Very Good! (793 reviews)

[](https://expedia.com/Lake-City-Hotels-Holiday-Inn-Express-Hotel-Suites-LIVE-OAK.h798756.Hotel-Information)

![Hampton Inn & Suites Lake City](https://images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn & Suites Lake City

450 SW Florida Gateway Drive Lake City FL

$134 nightly

$151 total

Feb 16 - Feb 17

Total with taxes and fees

9.4/10 Exceptional! (1,004 reviews)

[](https://expedia.com/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information)

## Hotels in O Brien with star-rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

20 properties

[](https://expedia.com/3Star-O-Brien-Hotels.s30-0-d3000431472.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

65 properties

[](https://expedia.com/2Star-O-Brien-Hotels.s20-0-d3000431472.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in O Brien?

> This area, located directly at the intersection of the two major roadways, provides easy entry to O'Brien and the surrounding region. While O'Brien itself is a small, rural community, this hub offers the most centralized location for exploring the natural springs and outdoor activities North Florida is known for. You'll find the few local businesses and dining options clustered around this intersection.
> 
>   
> For families, staying near this interchange is ideal because it minimizes travel time to popular destinations like the nearby natural springs. Many of these springs offer swimming, snorkeling, and canoeing, making them great for a day out with children. The convenience of quick access to the main roads means less time navigating and more time enjoying the outdoors.
> 
>   
> Solo travelers also benefit from staying in this central location. It provides a practical base for exploring the area's natural beauty, such as kayaking on the Suwannee River or visiting local state parks.

### When is the best time to go to O Brien?

> During these seasons, O'Brien experiences mild temperatures, typically ranging from the low 70s to mid-80s Fahrenheit, with lower humidity than the summer months. This makes it ideal for enjoying the area's natural springs and outdoor recreation without the intense heat or the higher chance of thunderstorms characteristic of summer.
> 
>   
> Travelers looking to explore the natural beauty of the area will find spring and fall particularly appealing. The cooler weather is great for swimming, kayaking, and tubing in the crystal-clear waters of the nearby Ichetucknee Springs State Park or the Suwannee River.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a O Brien hotel booking with Expedia?

> \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

### How much is the nightly rate at a O Brien hotel?

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- [Flights to Branford ](https://www.expedia.com/Cheap-Flights-To-Branford.d6188028.Travel-Guide-Flights)
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- [Ichetucknee Springs State Park ](https://www.expedia.com/Ichetucknee-Springs-State-Park-Florida.d6285986.Vacation-Attraction)
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- [Visit Mayo ](https://www.expedia.com/Mayo.dx6286979)
- [Mayo Vacations ](https://www.expedia.com/Mayo.d6286979.Destination-Travel-Guides)
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- [Wellborn Vacations ](https://www.expedia.com/Wellborn.d172275.Destination-Travel-Guides)
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- [Fort White Vacations ](https://www.expedia.com/Fort-White.d6286968.Destination-Travel-Guides)
- [Bob's River Place ](https://www.expedia.com/Bobs-River-Place-Old-Town.d553248633992473977.Vacation-Attraction)
- [First Federal Sportsplex ](https://www.expedia.com/First-Federal-Sportsplex-Live-Oak.d6185397.Vacation-Attraction)

- [Car rentals near Branford ](https://www.expedia.com/Car-Rentals-In-Branford.d6188028.Car-Rental-Guide)
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- [Car rentals near Ichetucknee Springs State Park ](https://www.expedia.com/Car-Rentals-In-Ichetucknee-Springs-State-Park.d6285986.Car-Rental-Guide)
- [Car rentals near Alton ](https://www.expedia.com/Car-Rentals-In-Alton.d553248635975876473.Car-Rental-Guide)
- [Car rentals near Wes Skiles Peacock Springs State Park ](https://www.expedia.com/Car-Rentals-In-Wes-Skiles-Peacock-Springs-State-Park.d553248621532654050.Car-Rental-Guide)
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- [Enterprise Rental Cars in Live Oak ](https://www.expedia.com/Enterprise-Car-Rentals-In-Live-Oak.d10072-c15.Car-Rental-Guide-Suppliers)

- [Branford Vacation Rentals ](https://www.expedia.com/Branford-Vacation-Rentals.d6188028.Travel-Guide-VacationRentals)
- [Mcalpin Vacation Rentals ](https://www.expedia.com/Mcalpin-Vacation-Rentals.d3000345299.Travel-Guide-VacationRentals)
- [Mayo Vacation Rentals ](https://www.expedia.com/Mayo-Vacation-Rentals.d6286979.Travel-Guide-VacationRentals)
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- [Live Oak Vacation Rentals ](https://www.expedia.com/Live-Oak-Vacation-Rentals.d10072.Travel-Guide-VacationRentals)

- [Things to do in Fort White ](https://www.expedia.com/Things-To-Do-In-Fort-White.d6286968.Travel-Guide-Activities)

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