Find hotels in O Brien, FL from $65

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Dec 26 - Dec 27
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Dec 27 - Dec 28
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Dec 26 - Dec 28
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Our top choices for O Brien hotels

Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (179)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
$107 nightly
The price is $120
Jan 4 - Jan 5, 2026
Total with taxes and fees
Courtyard By Marriott Lake City
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1013)
"Fantastic stay 10/10"
United States
Michael
$83 nightly
The price is $93
Dec 31 - Jan 1, 2026
Total with taxes and fees
Best Western Plus Lake City
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (169)
"Very clean, friendly staff, safe and quiet "
United States
Amy
$89 nightly
The price is $100
Jan 11 - Jan 12, 2026
Total with taxes and fees
Fairfield Inn & Suites Lake City
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1017)
"Very clean property and a full hot breakfast buffet! "
United States
Julie
$94 nightly
The price is $105
Dec 28 - Dec 29
Total with taxes and fees
La Quinta Inn & Suite by Wyndham Lake City
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1000)
"Great staff"
United States
Alison
$107 nightly
The price is $120
Jan 6 - Jan 7, 2026
Total with taxes and fees
Comfort Suites Lake City
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (618)
"Clean rooms, very friendly staff"
United States
Kristin L
$68 nightly
The price is $75
Jan 11 - Jan 12, 2026
Total with taxes and fees
Quality Inn White Springs Suwanee
Standard Cabin, 1 Queen Bed | Exterior
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (157)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
$179 nightly
The price is $197
Jan 5 - Jan 6, 2026
Total with taxes and fees
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1001)
"Easy check in, friendly staff, hot tub, nice clean rooms. "
United States
Kelsey
$117 nightly
The price is $132
Dec 29 - Dec 30
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (475)
"Staff very helpful- clean updated facility. "
United States
bethany
$106 nightly
The price is $119
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn & Suites Alachua I-75
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1003)
"Clean room, staff, everyone super helpful ."
United States
Devang
$116 nightly
The price is $131
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn & Suites Lake City
Exterior
Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (665)
"It was clean, quiet, safe."
United States
donna
$66 nightly
The price is $75
Dec 30 - Dec 31
Total with taxes and fees
Super 8 by Wyndham Lake City
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1002)
"Great place for a restful night when traveling. "
United States
Peggy
$100 nightly
The price is $113
Jan 4 - Jan 5, 2026
Total with taxes and fees
Tru by Hilton Lake City
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very Good, (83)
"Large room, comfortable bed, clean, pet friendly"
United States
D'Ann
$61 nightly
The price is $69
Dec 31 - Jan 1, 2026
Total with taxes and fees
Motel 6 – Lake City, Fl – Medical Center
Exterior
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1000)
"Nice hotel but a little pricey "
United States
Hilary
$95 nightly
The price is $107
Jan 11 - Jan 12, 2026
Total with taxes and fees
Holiday Inn & Suites Lake City by IHG
Premium bedding, desk, blackout drapes, soundproofing
Palms Garden Inn

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (581)
"Clean and nice staff "
United States
apollo
$65 nightly
The price is $73
Dec 28 - Dec 29
Total with taxes and fees
Palms Garden Inn
1 bedroom, laptop workspace, free WiFi, bed sheets
Vista Verde Farm Retreat

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.6 out of 10, Exceptional, (13)
"This is my second time staying on this property and I love it "
United States
brandie
$156 nightly
The price is $175
Jan 20 - Jan 21, 2026
Total with taxes and fees
Vista Verde Farm Retreat
Pillowtop beds, in-room safe, desk, blackout drapes
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1003)
"Staff was great"
United States
Thomas
$63 nightly
The price is $71
Dec 28 - Dec 29
Total with taxes and fees
Days Inn by Wyndham Lake City I-75
Free daily buffet breakfast
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very Good, (775)
"Have stayed here whenever we are in town. Always god stay."
United States
Gregg
$121 nightly
The price is $133
Jan 11 - Jan 12, 2026
Total with taxes and fees
Holiday Inn Express & Suites Live Oak by IHG
BBQ/picnic area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1000)
"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
$67 nightly
The price is $76
Jan 4 - Jan 5, 2026
Total with taxes and fees
Americas Best Value Inn Lake City
Exterior
The Blanche

The Blanche

The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (164)
"Easy to access building and room with code provided; amazing bed and very clean."
United States
Ruth
$147 nightly
The price is $166
Dec 30 - Dec 31
Total with taxes and fees
The Blanche
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Tru by Hilton Lake City

Tru by Hilton Lake City

10/10 Excellent
"Cleanliness friendly service, very good free breakfast."
Marsha 1-night trip
Posted 2 days ago
Tru by Hilton Lake City

More cheap stays in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
$61 nightly
The price is $69 total per night from Dec 31 to Jan 1
$69 total
Dec 31 - Jan 1, 2026
Total with taxes and fees
8.2/10 Very Good! (83 reviews)

Hotels in O Brien with star-rating

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right O Brien hotel for you.
How can I save on a O Brien hotel booking with Expedia?
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How much is the nightly rate at a O Brien hotel?
Prices for hotels in O Brien often vary, but you can find a great deal from $65 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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