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Our top choices for O Brien hotels

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,001 reviews)
"Everything was awesome! Breakfast was great, rooms were awesome and the staff was top notch!!"
United States
Joanne
10 days ago
$110 nightly
The price is $124
Nov 29 - Nov 30
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

2. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking."
United States
Emory
16 days ago
$94 nightly
The price is $105
Dec 2 - Dec 3
Total with taxes and fees
La Quinta Inn & Suite by Wyndham Lake City

3. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,134 reviews)
"The staff were very helpful. Breakfast was as good or better than most other hotels."
United States
Virginia
1 day ago
$80 nightly
The price is $90
Dec 1 - Dec 2
Total with taxes and fees
Best Western Plus Lake City

4. Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (572 reviews)
"Breakfast buffet was very good with lots of options."
United States
Tara
September 12th, 2026
$108 nightly
The price is $121
Nov 29 - Nov 30
Total with taxes and fees
Hampton Inn & Suites Alachua I-75

5. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,004 reviews)
"The front desk team was very pleasant."
United States
Markisha
3 days ago
$93 nightly
The price is $105
Dec 6 - Dec 7
Total with taxes and fees
Tru by Hilton Lake City

6. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,002 reviews)
"Room was clean and the lobby area was nice."
United States
John
15 hours ago
$94 nightly
The price is $106
Dec 6 - Dec 7
Total with taxes and fees
Comfort Suites Lake City

7. Quality Inn Alachua - Gainesville Area

Quality Inn Alachua - Gainesville Area
2.5 star property
Alachua
7.2 out of 10, Good, (1,009 reviews)
"The housekeepers were very nice."
United States
Aurelia
22 hours ago
$72 nightly
The price is $81
Nov 17 - Nov 18
Total with taxes and fees
Quality Inn Alachua - Gainesville Area

8. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,004 reviews)
"I have stayed here several times. Accommodating properties very clean."
United States
Eileen
16 days ago
$105 nightly
The price is $113
Dec 6 - Dec 7
Total with taxes and fees
Hampton Inn & Suites Lake City

9. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,004 reviews)
"They were very accommodating for our dogs which made us feel comfortable."
United States
John
2 days ago
$101 nightly
The price is $114
Nov 15 - Nov 16
Total with taxes and fees
Holiday Inn & Suites Lake City by IHG

10. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,000 reviews)
"We would stay here again. The staff is friendly."
United States
Bettina
14 days ago
$71 nightly
The price is $80
Dec 1 - Dec 2
Total with taxes and fees
Quality Inn Lake City

11. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
"So nice and clean and quiet!"
United States
sheryl
13 days ago
$116 nightly
The price is $131
Nov 22 - Nov 23
Total with taxes and fees
Courtyard By Marriott Lake City

12. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Great place! Very clean. Awesome breakfast."
United States
Kevin
20 days ago
$94 nightly
The price is $106
Dec 4 - Dec 5
Total with taxes and fees
Fairfield Inn & Suites Lake City

13. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean."
United States
Allan
1 day ago
$61 nightly
The price is $69
Dec 1 - Dec 2
Total with taxes and fees
Super 8 by Wyndham Lake City

14. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"Parking lot is well lite. This is a great hotel for the price."
United States
Brenda
2 days ago
$71 nightly
The price is $80
Nov 11 - Nov 12
Total with taxes and fees
Americas Best Value Inn Lake City

15. Clarion Pointe Alachua - Gainesville Area

Clarion Pointe Alachua - Gainesville Area
2.0 star property
Alachua
8.0 out of 10, Very good, (29 reviews)
"Big beautiful pool, room was very clean, bed was super comfortable, staff was awesome!"
United States
Debra
12 days ago
$72 nightly
The price is $81
Nov 16 - Nov 17
Total with taxes and fees
Clarion Pointe Alachua - Gainesville Area

16. BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (488 reviews)
"Very clean rooms and homey atmosphere!"
United States
Myra
25 days ago
$96 nightly
The price is $108
Dec 8 - Dec 9
Total with taxes and fees
BlueGem Motel

17. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
"Overall stay was good. Good buffet breakfast."
United States
Shanique
5 days ago
$119 nightly
The price is $134
Nov 22 - Nov 23
Total with taxes and fees
Home2 Suites by Hilton Lake City

18. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (900 reviews)
"Lee and all staff were so wonderful. Rooms clean great stay."
United States
KRISTEN
13 days ago
$105 nightly
The price is $116
Dec 6 - Dec 7
Total with taxes and fees
Holiday Inn Express & Suites Live Oak by IHG

19. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.2 out of 10, (999 reviews)
"For the money, no complaints."
United States
Julie
September 19th, 2026
$58 nightly
The price is $65
Nov 11 - Nov 12
Total with taxes and fees
Baymont by Wyndham Lake City I-75

20. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (623 reviews)
"Great location. Rooms were almost spotless. Parking lot was clean."
United States
Robert
15 days ago
$73 nightly
The price is $82
Nov 11 - Nov 12
Total with taxes and fees
Regal Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels recommended for families in O Brien

Where to stay near O Brien

O’Brien, Florida, offers a delightful escape for outdoor enthusiasts and adventure seekers. Explore the stunning scenery and family-friendly atmosphere in the surrounding areas, perfect for eco-friendly vacations and memorable adventures. Enjoy the charm of nature while creating lasting memories with loved ones.

Branford

Discover Branford, a charming destination perfect for families and nature enthusiasts seeking adventure and scenic beauty. With attractions like the Suwannee River for outdoor fun, Troy Spring State Park for exploration, and Sampson Lake for peaceful relaxation, there’s something for everyone. Located about 6 miles by car from O Brien, Branford offers easy access to a variety of recreational activities year-round, making it a smart choice for your vacation stay.

Mcalpin

Plan your stay in Mcalpin, a top-rated choice for families and nature enthusiasts looking for a delightful mix of outdoor adventure and scenic beauty. Explore the nearby Suwannee River, perfect for recreational activities, and discover wildlife at Troy Spring State Park, alongside the relaxing atmosphere of Baker Park. Located about 7 miles by car from O Brien, Mcalpin offers a strategic base to enjoy these attractions while providing a budget-friendly option for your vacation.

Alton

Make your vacation planning effortless by staying in Alton, a haven for nature and adventure enthusiasts thanks to its beautiful scenery and outdoor experiences. Explore the wonders of the nearby Wes Skiles Peacock Springs State Park, unwind at Veteran's Memorial Park of Mayo, or dive into a good book at the Lafayette County Library. Alton is located about 19 miles by car from O Brien, making it a smart choice for a memorable getaway.

Mayo

Immerse yourself in Mayo, where outdoor enthusiasts and families can easily access breathtaking natural beauty and adventure. This charming city is a gateway to Lafayette Blue Springs State Park, perfect for swimming and hiking, while Telford Spring offers refreshing river activities. With a variety of recreational areas nearby, Mayo is ideal for budget-conscious travelers seeking memorable experiences. Located about 14 miles by car from O Brien, Mayo is a smart choice for your next getaway.

Wellborn

Travelers seeking a family-friendly getaway will find Wellborn to be an ideal base for their vacation, featuring scenic outdoor experiences and budget-friendly options. Enjoy the charm of the Stephen Foster Folk Culture Center, explore the serene Blue Sink Canoe Launch, or delve into history at the Stephen Foster State Folk Center. Located about 15 miles by car from O Brien, Wellborn offers easy access to natural attractions like rivers and lakes, making it a smart choice for your stay.

Stay near popular O Brien attractions

O'Brien is a hidden gem for travelers seeking outdoor adventures and stunning scenery. With its picturesque parks and tranquil rivers, you'll find endless opportunities for family fun and exploration. Experience the beauty and charm that make this area a perfect getaway for nature lovers.

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Find out more about O Brien

Top reasons to visit O Brien

  • Outdoor Adventures: O'Brien is perfect for outdoor enthusiasts, offering activities like hiking, fishing, and exploring scenic parks.
  • Scenic Beauty: The area boasts stunning natural landscapes, including local rivers and tranquil nature trails.
  • Community Events: Experience a friendly atmosphere with vibrant community events and local culture.
  • Accommodations for Everyone: O'Brien has a range of welcoming accommodations, from pet-friendly motels to cozy hotels.
  • Family-Friendly Atmosphere: Ideal for families, O'Brien offers a mix of adventure and relaxation for all ages.

Find great hotels near O Brien

Discover a variety of welcoming accommodations in O'Brien, Florida, ideal for every traveler. Whether you’re seeking a pet-friendly motel or a cozy hotel for business travel, you'll find options that provide essential amenities like free Wi-Fi. Enjoy an inclusive atmosphere perfect for LGBTQIA travelers, and explore nearby Branford and Troy Street for additional lodging choices. Your perfect O'Brien getaway awaits.

  • Baymont by Wyndham Lake City I-75: Located 18 miles from O'Brien, Baymont by Wyndham Lake City I-75 offers a budget-friendly stay perfect for families and business travelers alike. This pet-friendly hotel provides a welcoming atmosphere with amenities tailored for children, including complimentary cribs. Guests can enjoy the convenience of bringing their furry friends along, with specific pet policies in place. The hotel fosters a family-oriented environment while ensuring comfort and accessibility for all guests.
  • Americas Best Value Inn Lake City: Just 18 miles from O'Brien, Americas Best Value Inn Lake City boasts a commendable guest rating of 8.6 out of 10. This budget-friendly motel is ideal for pet owners seeking a comfortable getaway. With a focus on affordability and convenience, the hotel permits pets onsite, alongside a waived fee for service animals. Visitors appreciate the warm hospitality and the straightforward amenities that make their stay enjoyable.
  • Comfort Suites Lake City: Situated 18 miles away from O'Brien, Comfort Suites Lake City is a highly rated hotel with an impressive score of 9.6 out of 10. This establishment caters primarily to business travelers, offering spacious suites equipped for productivity and relaxation. Guests can appreciate the well-appointed facilities and a commitment to quality service, ensuring a successful stay for those traveling for work or leisure.

Where to stay near O Brien

O'Brien, Florida, is a hidden gem perfect for outdoor enthusiasts and families alike. With stunning scenery and adventurous activities, you'll find plenty to explore in this charming city. Nearby attractions offer a friendly atmosphere, inviting travelers to enjoy nature trails, local parks, and vibrant community events. Whether you're looking to unwind or embark on an adventure, O'Brien and its surrounding areas promise a memorable vacation experience.

  • Branford: Located a mere 6 miles from O'Brien, Branford is a charming city that attracts visitors year-round, with peak traveler arrivals in April and June to July. This destination is perfect for outdoor enthusiasts and adventure seekers, offering a variety of recreational areas, underwater sports, and breathtaking scenery. You can explore the nearby national state park, meander along the serene river, or partake in exciting adventure activities. Branford's natural beauty and welcoming atmosphere make it a delightful stop for those looking to connect with nature and enjoy thrilling experiences.
  • Mcalpin: Situated 7 miles away from O'Brien, Mcalpin is another appealing city that sees moderate seasonal travel throughout the year, with visitor numbers peaking consistently. It’s an ideal location for those who love the great outdoors, featuring stunning landscapes and an array of adventure activities. Visitors can enjoy recreational areas and partake in underwater sports while discovering the nearby national state park and tranquil river settings. Mcalpin provides a perfect blend of adventure and relaxation, making it a great spot for family outings or solo explorations.
  • Mayo: Located 14 miles from O'Brien, Mayo is a picturesque city that welcomes visitors throughout the year, with peak seasons in March to April and September. Known for its outdoor adventures and scenic views, Mayo offers various recreational activities and underwater sports that thrill adventure seekers. The proximity to a national state park, lush parks, and the scenic river enhances your experience, inviting you to immerse yourself in nature’s splendor. Mayo's small-town charm and vibrant outdoor culture make it a must-visit destination for those looking to escape into nature.

Things to do in O Brien

O'Brien, Florida, is perfect for outdoor enthusiasts seeking adventure and scenic beauty. Popular activities include exploring recreational areas, engaging in underwater sports, and enjoying various adventure activities. It's an ideal destination for fishing enthusiasts and those looking for exciting Florida tours, making it a great spot for an unforgettable vacation filled with exploration and fun.

Shopping

In O'Brien, you can enjoy local shops offering unique souvenirs and gifts. If you're up for a drive, check out the nearby Lake City Mall, where you'll find a variety of retailers, from fashion to home goods, perfect for picking up memorable items from your trip.

Recreation

Experience tranquility at the Suwannee River Retreat, where you can unwind with yoga classes and nature walks along the serene riverbanks. For recreational fun, explore nearby parks for hiking and fishing, or enjoy a peaceful kayak ride on the beautiful waters.

Adventure

In O'Brien, explore the scenic beauty of the nearby Suwannee River, perfect for kayaking and fishing. Experience thrilling airboat rides through the wetlands, offering close encounters with unique wildlife. Don't miss the picturesque trails for hiking and biking, showcasing Florida's lush landscapes and diverse ecosystems.

Nightlife

In O'Brien, Florida, the nightlife is laid-back yet vibrant, featuring local bars and cozy venues. The O'Brien Community Center hosts events, while nearby spots offer live music and friendly gatherings, perfect for unwinding after a day of exploring the area's natural beauty.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for O Brien

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in O Brien are January, August and November, where the prices are slightly lower. This is in comparison to March, May and October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in O Brien is Monday. The most expensive day to stay in O Brien is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool lets you choose your budget, preferred location, and additional criteria. You can organize your results to display prices from lowest to highest, ensuring you see the most affordable hotels first. Additionally, you can refine your options by hotel type—if you select the Eco-certified filter, you'll find sustainable and eco-friendly hotels ready for booking.
  • Consider bundling your trip: You can save money by combining your O'Brien hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near O Brien

O Brien, Florida, is an ideal destination for outdoor enthusiasts and adventure seekers. Visitors can explore scenic national and state parks, enjoy the beauty of local rivers, and visit the library for a taste of local culture. Whether you're looking for thrilling activities or peaceful scenery, O Brien offers a range of attractions that cater to all types of travelers seeking an unforgettable experience in the heart of Florida.

  • Suwannee River: Located 6 miles from O Brien, the Suwannee River offers stunning scenery and a serene outdoor experience. Perfect for kayaking, fishing, or simply enjoying nature's beauty, this river is a fantastic spot for relaxation and adventure.
  • Ichetucknee Springs State Park: Situated 11 miles away, this state park is a gem for outdoor enthusiasts. With lush landscapes, crystal-clear springs, and various recreational activities, you can enjoy tubing, snorkeling, or hiking while soaking up the vibrant scenery.
  • Ichetucknee River: Also located 11 miles from O Brien, the Ichetucknee River provides a picturesque setting for tubing and canoeing. Its tranquil waters and scenic surroundings make it an ideal destination for a leisurely day in nature.

Best time to go to O Brien

The best time to visit O Brien is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

Calendar MonthTemperaturePrecipitationCloudinessOccupancyPricing
January53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly Low
February57.9°F (14.4°C)Light RainMostly SunnyAverageAverage
March62.8°F (17.1°C)Light RainMostly SunnyAverageSlightly High
April69.1°F (20.6°C)Light RainMostly SunnyAverageAverage
May75.4°F (24.1°C)Light RainMostly SunnyModerately LowSlightly High
June80.2°F (26.8°C)Light RainMostly SunnyModerately HighAverage
July81.5°F (27.5°C)Light RainMostly SunnyModerately HighAverage
August81.3°F (27.4°C)Light RainMostly SunnyModerately HighSlightly Low
September77.9°F (25.5°C)Light RainMostly SunnyAverageAverage
October70.9°F (21.6°C)No RainMostly SunnyAverageSlightly High
November61.7°F (16.5°C)Light RainMostly SunnyModerately LowSlightly Low
December57.4°F (14.1°C)Light RainMostly SunnyAverageAverage

The nearest major airports for your trip to O Brien

To visit O'Brien, Florida, you can fly into three major airports. Jacksonville International Airport (JAX) is 81 miles away, with nearby hotels like the 4-star DoubleTree by Hilton Hotel Jacksonville Airport, only 0.3 miles from the terminal. Tallahassee International Airport (TLH) is 87 miles away, offering hotel options such as the 4-star DoubleTree by Hilton Hotel Tallahassee, located 5 miles from the airport. Gainesville Regional Airport (GNV) is the closest at 47 miles, with accommodations including the 4-star DoubleTree by Hilton Gainesville, situated 8 miles away. Each airport provides various transportation services to these hotels for added convenience.

Frequently Asked Questions

What is the best area to stay in O Brien?

The best area to stay in O'Brien, Florida, is near the I-10 and US-129 interchange, as this offers the most convenient access to local attractions and amenities.

This area, located directly at the intersection of the two major roadways, provides easy entry to O'Brien and the surrounding region. While O'Brien itself is a small, rural community, this hub offers the most centralized location for exploring the natural springs and outdoor activities North Florida is known for. You'll find the few local businesses and dining options clustered around this intersection.

For families, staying near this interchange is ideal because it minimizes travel time to popular destinations like the nearby natural springs. Many of these springs offer swimming, snorkeling, and canoeing, making them great for a day out with children. The convenience of quick access to the main roads means less time navigating and more time enjoying the outdoors.

Solo travelers also benefit from staying in this central location. It provides a practical base for exploring the area's natural beauty, such as kayaking on the Suwannee River or visiting local state parks.

When is the best time to go to O Brien?

The best time to visit O'Brien, Florida, is during the spring (March to May) and fall (September to November) for comfortable weather and pleasant outdoor activities.

During these seasons, O'Brien experiences mild temperatures, typically ranging from the low 70s to mid-80s Fahrenheit, with lower humidity than the summer months. This makes it ideal for enjoying the area's natural springs and outdoor recreation without the intense heat or the higher chance of thunderstorms characteristic of summer.

Travelers looking to explore the natural beauty of the area will find spring and fall particularly appealing. The cooler weather is great for swimming, kayaking, and tubing in the crystal-clear waters of the nearby Ichetucknee Springs State Park or the Suwannee River.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in O Brien.

How much is the nightly rate at a O Brien hotel?

Prices for hotels in O Brien often vary, but you can find a great deal from $64 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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