Mayo Vacations

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Your Mayo Vacation

Experience the unique character and personality of Mayo with a customized Mayo vacation package. From its rural countryside to its spectacular views, you'll never have a dull moment in this city. If seeing the sights is on your to-do list during your trip to Mayo, check out major attractions such as Lafayette Blue Springs State Park. Don't put off exploring this destination any longer. Your perfect Mayo vacation is a couple of clicks away with Expedia.

Stay near popular Mayo attractions

Lafayette Blue Springs State Park

8.0/10 (6 reviews)
Dive into this first-magnitude spring's crystal-clear waters flowing beneath a natural limestone bridge. Explore underwater caves or paddle to the iconic Suwannee River amid moss-draped oaks.
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Mayo Hotel Deals

Cindys Motel

Cindys Motel

2.5 out of 5
487 W Main St Mayo FL
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $96 total per night from Oct 29 to Oct 30
$96 total
Oct 29 - Oct 30
Total with taxes and fees
Cindys Motel
Suwannee River Rendezvous

Suwannee River Rendezvous

2.5 out of 5
828 NE Primrose Rd Mayo FL
$123 nightly
The price is $131 total per night from Oct 29 to Oct 30
$131 total
Oct 29 - Oct 30
Total with taxes and fees
8.6/10 Excellent! (34 reviews)
"Very run down, old towels and beddings."

Reviewed on Oct 25, 2026

Suwannee River Rendezvous
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
$85 nightly
The price is $90 total per night from Nov 2 to Nov 3
$90 total
Nov 2 - Nov 3
Total with taxes and fees
9.6/10 Exceptional! (20 reviews)
"Great place to stay! Pet friendly and plenty of playing space! Highly recommend"

Reviewed on Oct 26, 2026

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
See all 512 properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo Vacation Packages

Mayo Essential Information

Language
English
Currency
U.S dollars
Population
1,250
Max Temp Winter
65ºF
Max Temp Summer
90ºF
Top Sights
Lafayette Blue Springs State Park and Troy Spring State Park

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Frequently asked questions

What's the best vacation package for Mayo?
For travelers seeking a Mayo vacation package focused on value, or those preferring an independent stay, Cindys Motel is a strong option. Rated 8.8 out of 10, this motel provides amenities like a kitchenette and free WiFi, making it convenient for preparing your own meals. Travelers frequently praise its clean rooms and great staff.

Families and outdoor enthusiasts looking to explore Mayo's natural attractions will find a package with a stay at Cindys Motel well-suited. It's located about 6 miles from Lafayette Blue Springs State Park, and its kitchenette can be particularly useful for family trips. Guests often highlight the clean rooms and helpful staff.

If you're planning a Mayo vacation package and traveling with pets, Cindys Motel is a pet-friendly choice. This property, rated 8.8 out of 10, offers comfortable accommodations with air conditioning and free WiFi, with guests consistently noting the clean rooms and great staff.
How can I save money on a Mayo vacation package?
When you bundle, you can save up to 30%*. To save money on a Mayo package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What are the top things to do in Mayo?
A Mayo vacation offers plenty of outdoor and nature-focused activities, from exploring natural springs to enjoying family-friendly attractions:

Browse and book things to do in Mayo on Expedia.
Do you need to rent a car in Mayo, or is public transport enough?
For Mayo vacation packages with flights, a rental car is highly recommended for exploring the area. As an outdoor and nature destination outside a major city, Mayo has many attractions that are spread out. For instance, natural springs like Lafayette Blue Springs State Park are about 6 miles away, and family attractions like Wild Adventures are about 19 miles from central Mayo. While you can fly into JAX-Jacksonville Intl. Airport (JAX), which is about 94 miles from Mayo, a car provides the flexibility to visit these natural attractions and other points of interest at your own pace.
Are Mayo vacation package hotels conveniently located?
Mayo vacation package hotels offer convenient access to the town center and nearby natural attractions. For example, Cindys Motel, rated 8.8 out of 10 by travelers, is located about a 10-minute walk from central Mayo. This central location makes it easy to explore the local area and access the region's outdoor activities.
Can I change or cancel my Mayo vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Mayo vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Mayo vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mayo vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Mayo?
To find last-minute vacation packages to Mayo, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Mayo vacation packages?
Free cancellation on a Mayo vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Mayo vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Mayo getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Mayo vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.