Mayo Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mayo Vacation

Experience the unique character and personality of Mayo with a customized Mayo vacation package. From its rural countryside to its spectacular views, you'll never have a dull moment in this city. If seeing the sights is on your to-do list during your trip to Mayo, check out major attractions such as Lafayette Blue Springs State Park. Don't put off exploring this destination any longer. Your perfect Mayo vacation is a couple of clicks away with Expedia.

Stay near popular Mayo attractions

Lafayette Blue Springs State Park

8.0/10 (6 reviews)
Dive into this first-magnitude spring's crystal-clear waters flowing beneath a natural limestone bridge. Explore underwater caves or paddle to the iconic Suwannee River amid moss-draped oaks.
See properties

Perry Spring

Perry Spring offers crystal-clear 72-degree waters where you can swim from a jumping platform into the Suwannee River. Relax at the covered pavilion with fire pit or lounge on the river deck with floating dock.
See properties

Lafayette County Library

This welcoming community hub offers books, e-books, and resources for all ages. Enjoy free Wi-Fi, participate in book clubs, or attend special seasonal programs that promote literacy and community engagement.
See properties

Allen Mill Pond Spring

This historic second-magnitude spring flows crystal-clear over ancient limestone beneath a canopy of cypress trees. Winter visits offer the best views of the old mill remnants when vegetation thins.
See properties

Veteran's Memorial Park of Mayo

This peaceful memorial park honors veterans with thoughtful monuments and landscaped grounds. Visitors can reflect on service and sacrifice while enjoying the serene atmosphere.
See properties

Mayo Hotel Deals

Cindys Motel

Cindys Motel

487 W Main St Mayo FL
Fully refundableReserve now, pay when you stay
$90 nightly
$96 total
Nov 4 - Nov 5
Total with taxes and fees
8.8/10 Excellent! (138 reviews)
"The staff was very plesent and was very helpful when I had questions about something. Had parking right in front of my room. There is no smoking in the rooms, but they supplied chairs out side of your door with an ash can to use. Not much in the way of shopping but there is a very large nice park ..."

Reviewed on Oct 5, 2026

Cindys Motel
Suwannee River Rendezvous

Suwannee River Rendezvous

828 NE Primrose Rd Mayo FL
$123 nightly
$131 total
Oct 7 - Oct 8
Total with taxes and fees
8.6/10 Excellent! (33 reviews)
"Traveling for a family event in the area. Staff was ok. Room was barely adequate, very run down. Tub wasnt the cleanest and very dingy and old. What was horrible was the room next to me had two large dogs who barked alot and the occupants came in after midnight they were extremely loud, dogs barking, ..."

Reviewed on Jul 12, 2026

Suwannee River Rendezvous
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
$85 nightly
$90 total
Oct 12 - Oct 13
Total with taxes and fees
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
See all 505 properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo Vacation Packages

Mayo Essential Information

Language
English
Currency
U.S dollars
Population
1,250
Max Temp Winter
65ºF
Max Temp Summer
90ºF
Top Sights
Lafayette Blue Springs State Park and Troy Spring State Park

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Frequently asked questions

What's the best vacation package for Mayo?
For travelers seeking a Mayo vacation package focused on value, or those preferring an independent stay, Cindys Motel is a strong option. Rated 8.8 out of 10, this motel provides amenities like a kitchenette and free WiFi, making it convenient for preparing your own meals. Travelers frequently praise its clean rooms and great staff.Families and outdoor enthusiasts looking to explore Mayo's natural attractions will find a package with a stay at Cindys Motel well-suited. It's located about 6 miles from Lafayette Blue Springs State Park, and its kitchenette can be particularly useful for family trips. Guests often highlight the clean rooms and helpful staff.If you're planning a Mayo vacation package and traveling with pets, Cindys Motel is a pet-friendly choice. This property, rated 8.8 out of 10, offers comfortable accommodations with air conditioning and free WiFi, with guests consistently noting the clean rooms and great staff.
How can I save money on a Mayo vacation package?
When you bundle, you can save up to 30%*. To save money on a Mayo package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What are the top things to do in Mayo?
A Mayo vacation offers plenty of outdoor and nature-focused activities, from exploring natural springs to enjoying family-friendly attractions:Browse and book things to do in Mayo on Expedia.
Do you need to rent a car in Mayo, or is public transport enough?
For Mayo vacation packages with flights, a rental car is highly recommended for exploring the area. As an outdoor and nature destination outside a major city, Mayo has many attractions that are spread out. For instance, natural springs like Lafayette Blue Springs State Park are about 6 miles away, and family attractions like Wild Adventures are about 19 miles from central Mayo. While you can fly into JAX-Jacksonville Intl. Airport (JAX), which is about 94 miles from Mayo, a car provides the flexibility to visit these natural attractions and other points of interest at your own pace.
Are Mayo vacation package hotels conveniently located?
Mayo vacation package hotels offer convenient access to the town center and nearby natural attractions. For example, Cindys Motel, rated 8.8 out of 10 by travelers, is located about a 10-minute walk from central Mayo. This central location makes it easy to explore the local area and access the region's outdoor activities.
Can I change or cancel my Mayo vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Mayo vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Mayo vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mayo vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Mayo?
To find last-minute vacation packages to Mayo, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Mayo vacation packages?
Free cancellation on a Mayo vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Mayo vacation as a package or separately?
Booking flights and hotels together can unlock lower overall prices. Better still, you can tailor your Mayo getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Mayo vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.