Mayo Vacations

Book a Hotel + Flight or Car together to unlock savings

Your Mayo Vacation

Experience the unique character and personality of Mayo with a customized Mayo vacation package. From its rural countryside to its spectacular views, you'll never have a dull moment in this city. If seeing the sights is on your to-do list during your trip to Mayo, check out major attractions such as Lafayette Blue Springs State Park. Don't put off exploring this destination any longer. Your perfect Mayo vacation is a couple of clicks away with Expedia.

Mayo Hotel Deals

Suwannee River Rendezvous

Suwannee River Rendezvous

2.5 out of 5
828 NE Primrose Rd Mayo FL
$40 nightly
The price is $43 total per night from May 17 to May 18
$43 total
May 17 - May 18
Total with taxes and fees
8.6/10 Excellent! (28 reviews)
No, no,no, 11 feral cats loose on property. When there's Nothing good to say about a place or person it's more Honorable to say Nothing.

Reviewed on Apr 3, 2026

Suwannee River Rendezvous
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
$64 nightly
The price is $67 total per night from May 9 to May 10
$67 total
May 9 - May 10
Total with taxes and fees
9.8/10 Exceptional! (9 reviews)
Great host and property. After one night, I have booked another 6 nights. I am in Mayo for work and needed a relaxing place to stay. After testing motels in Mayo and Perry this place is my favorite. Quiet, well maintained, excellent host and the right price. Remote work-no problem your Internet connection ...

Reviewed on May 5, 2026

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Cindys Motel

Cindys Motel

2.5 out of 5
487 W Main St Mayo FL
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $95 total per night from May 14 to May 15
$95 total
May 14 - May 15
Total with taxes and fees
8.8/10 Excellent! (130 reviews)
Easy parking. Friendly staff. We extended our stay and had to switch rooms. The 1st kingsize bad was great. But when we changed rooms the queen size bed sagged in the middle.

Reviewed on Mar 11, 2026

Cindys Motel
See all 481 properties in Mayo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mayo Vacation Packages

Mayo Essential Information

Language
English
Currency
U.S dollars
Population
1,250
Max Temp Winter
65ºF
Max Temp Summer
90ºF
Top Sights
Lafayette Blue Springs State Park and Troy Spring State Park

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Frequently asked questions

How much does a Mayo vacation package cost?
You'll find cheap prices on Expedia for your Mayo break. However, a range of factors like the hotel choice, length of stay and season will determine how much your vacation to Mayo costs.
What are the cheapest months to go to Mayo?
February, June and November are great times to search for cheap Mayo vacation packages. Traveling in less busy periods means you can typically find better prices on flights and hotels.
How many days is enough for Mayo?
With a well-organized travel plan, you can easily tick off the main Mayo attractions in a few days. But if you'd like to explore off the beaten track or go on day trips, consider booking your Mayo vacation for longer.
How to find the best Mayo package deals?
Use Expedia's handy filters to help you find some tempting Mayo package deals. When you start your search, just set your maximum budget and then order the results by "Price: low to high." If you want to save, plan your trip for midweek, or browse for Mayo package deals in the off-season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Mayo vacation as a package?
You can enjoy significant savings on your Mayo retreat by booking a personalized vacation package. Check the "Package" heading, then enter your destination and travel dates to see the best airfares and hotel prices. Bundle everything into a neat package and you can save hundreds of dollars. Consider adding a car rental and you may land a better deal.
When to book a vacation package to Mayo?
If you've got your Mayo travel dates finalized, book as early as you can to bag some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for jetting off on a whim.
Does Expedia offer Book Now, Pay Later Mayo vacation packages?
Set off on your dream trip to Mayo with help from Expedia's Book Now, Pay Later vacations. No need to save like crazy or hold off until the next payday — we've teamed up with online lender Affirm to give you flexibility and choice. Our vacation packages with payment plans let you spread the total cost across 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stick to your budget and snap up cheap deals while they last.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.