The view of Manatee Springs and Suwannee River. Manatee Springs State Park is in Chiefland, Florida

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Our top choices for Mayo hotels

Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (135 reviews)
"Wonderful, quiet, a hide a way for a fun stay."
United States
Diane
9 days ago
$84 nightly
The price is $89
Jul 10 - Jul 11
Total with taxes and fees
Cindys Motel

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very Good, (844 reviews)
"The location is great and the pool area was nice and clean."
United States
Janaina
3 days ago
$114 nightly
The price is $125
Jul 12 - Jul 13
Total with taxes and fees
Holiday Inn Express & Suites Live Oak by IHG

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.8 out of 10, Excellent, (32 reviews)
"This is a lovely place to visit."
United States
Beth
24 days ago
$41 nightly
The price is $44
Jun 29 - Jun 30
Total with taxes and fees
Suwannee River Rendezvous

Royal Inn Motel

Royal Inn Motel
2.0 star property
Perry
8.8 out of 10, Excellent, (1,001 reviews)
"Very friendly staff. Rooms need a coffee pot."
United States
Debra
2 days ago
$79 nightly
The price is $88
Jun 26 - Jun 27
Total with taxes and fees
Royal Inn Motel

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (677 reviews)
"Sarah the leader of the facility was very helpful. Made sure her staff were professional."
United States
Anthony
28 days ago
$65 nightly
The price is $71
Jul 20 - Jul 21
Total with taxes and fees
Quality Inn White Springs Suwanee

Good Times Motel and Marina

Good Times Motel and Marina
2.0 star property
Steinhatchee
9.4 out of 10, Exceptional, (163 reviews)
"Absolutely loved our stay. The kids didn't want to leave."
United States
Dacy
16 days ago
$201 nightly
The price is $221
Jun 28 - Jun 29
Total with taxes and fees
Good Times Motel and Marina

Holiday Inn Express Hotel & Suites PERRY by IHG

Holiday Inn Express Hotel & Suites PERRY by IHG
2.5 star property
Perry
8.6 out of 10, Excellent, (756 reviews)
"My overnight stay was great. Staff was friendly. This hotel was by far the best."
United States
Gregory D
2 days ago
$125 nightly
The price is $140
Jul 26 - Jul 27
Total with taxes and fees
Holiday Inn Express Hotel & Suites PERRY by IHG

Best Western Plus Madison

Best Western Plus Madison
2.5 star property
Madison
8.2 out of 10, Very Good, (617 reviews)
"This is place is always the best in that town property clean staff friendly beds are comfortable love here Thank you Tammy for being perfessional at the front desk."
United States
Kesha
May 25th, 2026
$104 nightly
The price is $117
Jun 28 - Jun 29
Total with taxes and fees
Best Western Plus Madison

Putnam Lodge Hotel and Spa

Putnam Lodge Hotel and Spa
2.5 star property
Cross City
9.2 out of 10, Wonderful, (379 reviews)
"It's a perfect location for us to visit family."
United States
Debra
May 23rd, 2026
$160 nightly
The price is $176
Jun 26 - Jun 27
Total with taxes and fees
Putnam Lodge Hotel and Spa

Hampton Inn Perry

Hampton Inn Perry
2.5 star property
Perry
8.6 out of 10, Excellent, (766 reviews)
"Property needs updated. Staff is exceptional. Bed was comfortable."
United States
Jennifer
11 days ago
$108 nightly
The price is $121
Jul 26 - Jul 27
Total with taxes and fees
Hampton Inn Perry

Days Inn by Wyndham Madison

Days Inn by Wyndham Madison
2.0 star property
Madison
7.0 out of 10, Good, (623 reviews)
"Good quiet location. Building maintenance can be improved specially the door locks."
United States
Gavin
11 days ago
$76 nightly
The price is $86
Jun 28 - Jun 29
Total with taxes and fees
Days Inn by Wyndham Madison

Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.2 out of 10, Good, (570 reviews)
"Staff was awesome. Friendly and helpful. Room was clean and quiet."
United States
Patricia
15 days ago
$79 nightly
The price is $87
Jun 29 - Jun 30
Total with taxes and fees
Quality Inn & Suites Live Oak I-10 Exit 283

Super 8 by Wyndham Madison

Super 8 by Wyndham Madison
2.0 star property
Madison
7.4 out of 10, Good, (678 reviews)
"My room was very clean. Nice tv and comfortable bed will stay again."
United States
Angelina
16 days ago
$76 nightly
The price is $86
Jun 28 - Jun 29
Total with taxes and fees
Super 8 by Wyndham Madison

Steinhatchee River Inn

Steinhatchee River Inn
2.0 star property
Steinhatchee
9.4 out of 10, Exceptional, (404 reviews)
"Gift store with a restaurant inside for breakfast."
United States
Kathleen
19 days ago
$259 nightly
The price is $289
Jul 6 - Jul 7
Total with taxes and fees
Steinhatchee River Inn

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (309 reviews)
"The room, pool, and breakfast area were clean and well maintained."
United States
Michael
15 days ago
$77 nightly
The price is $85
Jun 28 - Jun 29
Total with taxes and fees
Econo Lodge Live Oak

Regency Inn

Regency Inn
2.5 star property
Perry
5.2 out of 10, (257 reviews)
"The room was clean. I had a great stay at Regency Inn."
United States
Reginald
February 28th, 2026
$80 nightly
The price is $89
Jul 5 - Jul 6
Total with taxes and fees
Regency Inn

Carriage Inn Motel

Carriage Inn Motel
2.0 star property
Cross City
5.8 out of 10, (138 reviews)
"Staff excellent. Room clean hot watet."
United States
Sharon
February 17th, 2026
$95 nightly
The price is $104
Jul 24 - Jul 25
Total with taxes and fees
Carriage Inn Motel

Royal Inn

Royal Inn
2.0 star property
Live Oak
6.2 out of 10, (57 reviews)
"The best thing was the bed, which was comfortable."
United States
Michael
$57 nightly
The price is $63
Jun 28 - Jun 29
Total with taxes and fees
Royal Inn

Charming Hill Top Room 17 in Mayo with WiFi, AC, fitness room

Charming Hill Top Room 17 in Mayo with WiFi, AC, fitness room
Mayo
Charming Hill Top Room 17 in Mayo with WiFi, AC, fitness room
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Mayo attractions

Learn more about Mayo

Paddle through crystal-clear waters at Lafayette Blue Springs State Park where swimming and snorkeling reveal underwater caves and limestone formations. Explore the peaceful Suwannee River by kayak or visit Perry Spring, where locals gather for refreshing dips during hot summer afternoons.

kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top Mayo Hotel Reviews

More cheap stays in Mayo

Hotels in Mayo with star-rating

Find out more about Mayo

Top reasons to visit Mayo

  • Outdoor Adventures: Mayo offers thrilling outdoor activities, including water sports and hiking in stunning natural settings.
  • Scenic Rivers: Explore beautiful rivers perfect for fishing, kayaking, and relaxing by the water.
  • State Parks: Enjoy tranquility and nature in nearby state parks, ideal for picnicking and wildlife watching.
  • Family-Friendly Experiences: Mayo provides activities suitable for all ages, making it a great destination for families.
  • Comfortable Accommodations: Choose from a variety of motels and hotels that cater to diverse traveler needs.

Find great hotels near Mayo

Discover the perfect blend of comfort and hospitality in Mayo, Florida, where a variety of motels and hotels cater to every traveler's needs. Whether you're seeking a pet-friendly stay, an adventurous getaway, or a business-friendly environment, you'll find the right accommodations to enhance your vacation experience. Explore the best hotels in Mayo for a memorable stay tailored to your preferences.

  • Holiday Inn Express & Suites Live Oak by IHG: This budget-friendly hotel with a guest rating of 8.4 is perfect for business travelers seeking comfort and convenience. Located 23 miles from Mayo, it offers a range of amenities including complimentary breakfast, high-speed Wi-Fi, and a well-equipped business center. Guests appreciate the modern rooms that provide a relaxing atmosphere after a busy day. The property also features a fitness center and an outdoor pool, making it an excellent choice for those looking to unwind.
  • Royal Inn Motel: With a guest rating of 8.8, the Royal Inn Motel is an inviting budget-friendly option located 25 miles away from Mayo. This cozy motel emphasizes entertainment with features such as Cable TV and LCD TVs in every room. Guests enjoy the simplicity and comfort of the accommodations, along with convenient parking and easy access to local attractions. It's an ideal spot for travelers who prioritize value and accessibility in their stay.
  • Quality Inn & Suites Live Oak I-10 Exit 283: This pet-friendly hotel, rated 8.0, is situated just 22 miles from Mayo and caters to both business and leisure travelers. Quality Inn & Suites offers a welcoming environment for those traveling with pets, providing specific amenities such as pet-friendly policies and designated areas for furry companions. The hotel features a complimentary breakfast, an outdoor pool, and a fitness center, ensuring guests have a comfortable and enjoyable stay.

Where to stay in and around Mayo

Mayo, Florida, is a hidden gem perfect for outdoor enthusiasts and families alike. With its fresh air and beautiful scenery, visitors can enjoy adventure activities and explore the surrounding natural landscapes. The warmer months invite travelers to engage in outdoor fun, while nearby attractions add to the charm of this excellent location. Whether you're seeking adventure or a peaceful retreat, Mayo offers something for everyone looking to make lasting memories.

  • Day: Nestled in the heart of Mayo, Day is a charming village that attracts visitors year-round, especially during the bustling months of March and June to July. Known for its outdoor, family-friendly, and beach experiences, Day offers a plethora of activities for adventure seekers. From exhilarating underwater sports to relaxing days at the beach, there's something for everyone. Travelers can explore local landmarks such as beautiful family beaches and parks, making it a perfect spot for those looking to unwind in nature while enjoying recreational activities.
  • O Brien: Located 14 miles from Mayo, O Brien is a vibrant city that offers a moderately seasonal travel experience, with peak visits during June to August. This city is renowned for its stunning scenery and adventurous spirit. Visitors can partake in various outdoor activities, including exploring recreational areas and indulging in thrilling underwater sports. Key attractions nearby include serene rivers, a national state park, and picturesque water features, making O Brien a delightful destination for nature lovers and adventure enthusiasts alike.
  • Dowling Park: Just 14 miles from Mayo, Dowling Park is a quaint village known for its highly seasonal travel patterns, with peak arrival times in April, July, and September. This village offers breathtaking scenery and a variety of outdoor adventures, including an amusement park and recreational areas. Visitors will find themselves surrounded by natural beauty, with nearby attractions such as a scenic river, a national state park, and a tranquil lake, making it an ideal spot for those seeking to connect with nature and enjoy fun-filled outdoor activities.

Things to do in Mayo

Mayo, Florida, is perfect for outdoor enthusiasts seeking adventure and stunning scenery. Visitors can enjoy various recreational opportunities, including thrilling underwater sports and other adventure activities in the area's beautiful natural settings. Whether you're looking to relax or get your adrenaline pumping, Mayo offers an array of activities to make your vacation memorable.

Shopping

Mayo has a few charming local shops for unique gifts and souvenirs, perfect for a cozy shopping experience. If you're up for a drive, visit the nearby Lake City Mall, located 30 miles away, featuring a variety of retail stores, dining options, and entertainment for a full day of shopping.

Recreation

Experience tranquility at the Mayo Wellness Center, where you can indulge in yoga and meditation sessions surrounded by nature. For outdoor fun, explore the nearby Suwannee River for kayaking and fishing, immersing yourself in the serene beauty of Florida's landscapes.

Adventure

In Mayo, Florida, explore the scenic Suwannee River with kayaking and fishing adventures. Trek through the nearby parks for hiking and wildlife spotting. For a unique experience, visit the local springs for swimming and snorkeling in crystal-clear waters, immersing yourself in the area's natural beauty.

Nightlife

Mayo, Florida, offers a laid-back nightlife atmosphere with cozy bars and local hangouts. Enjoy live music at the local tavern, or unwind at a nearby lakeside pub. The friendly community vibe makes it perfect for a relaxed evening out, mingling with locals and savoring southern hospitality.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Mayo

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Mayo are December to February, where the prices are slightly lower. This is in comparison to June to August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Mayo is Monday. The most expensive day to stay in Mayo is Friday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to refine your choices based on your budget, preferred location, and desired hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly hotels that are currently available. To find the best prices and offers, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by booking an Expedia package that combines your Mayo hotel, flights, and activities all in one convenient deal.

Find the best attractions in and around Mayo

Mayo, Florida, is an ideal destination for outdoor enthusiasts and adventure seekers, offering stunning scenery and family-friendly experiences. Visitors can explore the area's beautiful rivers, enjoy the tranquility of local state parks, and even visit the library for a quiet retreat. Whether you’re looking for thrilling outdoor activities or a peaceful escape, Mayo's attractions promise to create lasting memories.

  • Lafayette Blue Springs State Park: This beautiful park offers stunning natural scenery and a variety of outdoor adventures. Enjoy swimming in the crystal-clear spring water, hiking scenic trails, or simply relaxing in a serene environment surrounded by lush greenery.
  • Suwannee River: Located 16 miles from Mayo, the Suwannee River is perfect for outdoor enthusiasts. Experience kayaking or canoeing while taking in breathtaking views of the riverbanks and wildlife, making it an ideal spot for nature lovers.
  • Baker Park: Situated 18 miles away, Baker Park is a family-friendly urban park. Enjoy picnicking, walking trails, and playgrounds, all while soaking up the vibrant city atmosphere and outdoor vibes.

Best time to go to Mayo

The best time to visit Mayo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.4°F (11.9°C)Light RainMostly SunnyAverageSlightly Low
February57.9°F (14.4°C)Light RainMostly SunnySlightly LowSlightly Low
March62.8°F (17.1°C)Light RainMostly SunnySlightly HighAverage
April69.1°F (20.6°C)Light RainMostly SunnySlightly HighAverage
May75.4°F (24.1°C)Light RainMostly SunnyAverageAverage
June80.2°F (26.8°C)Light RainMostly SunnyAverageSlightly High
July81.5°F (27.5°C)Light RainMostly SunnyAverageSlightly High
August81.3°F (27.4°C)Light RainMostly SunnySlightly LowSlightly High
September77.9°F (25.5°C)Light RainMostly SunnySlightly HighAverage
October70.9°F (21.6°C)No RainMostly SunnyAverageAverage
November61.9°F (16.6°C)Light RainMostly SunnyAverageAverage
December57.4°F (14.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Mayo

To visit Mayo, Florida, you can fly into several major airports. Jacksonville International Airport (JAX) is 94 miles away, with nearby hotels like the 4-star Hyatt Regency Jacksonville, located 12 miles from the airport, and the DoubleTree by Hilton Hotel Jacksonville Airport, just 0.3 miles away. Tallahassee International Airport (TLH) is 74 miles from Mayo, offering hotel options such as the 4-star DoubleTree by Hilton Hotel Tallahassee and Hotel Duval, both 5 miles away. Gainesville Regional Airport (GNV) is 59 miles away, featuring the 4-star DoubleTree by Hilton Gainesville, located 8 miles from the airport. Each airport has convenient access to nearby accommodations for your stay.

Frequently asked questions

What is the best area to stay in Mayo?
The best area to stay in Mayo, Florida, is in the heart of downtown Mayo, particularly around Main Street (US-27).

This central area is the hub of local activity, featuring Mayo's few local businesses, dining options, and access to services. It's a small, walkable area centered around the intersection of Main Street and Lafayette Street, making it easy to access everything the town offers.

For solo travelers or couples seeking a quiet, authentic small-town experience, staying downtown provides convenient access to local eateries and shops.
What are the best hotels in Mayo that travelers recommend?
Two of the best hotels in Mayo that travelers recommend are Suwannee River Rendezvous and Cindys Motel.

Suwannee River Rendezvous, with an 8.6 rating, is a great option for guests seeking a resort experience with extensive pool facilities including sun loungers and an outdoor pool. Many guests appreciate the beautiful scenery and the kind staff, and it is conveniently located just 13.2 miles from the Suwannee River.

Another highly recommended choice is Cindys Motel, which boasts an impressive 9.0 rating. This motel offers practical amenities such as air conditioning, free self-parking, and complimentary RV, bus, and truck parking. Guests consistently praise the clean and great rooms, and it is very close to local attractions, being only 0.1 miles from Veteran's Memorial Park of Mayo and 0.4 miles from Lafayette County Library.
What are the best family hotels in Mayo?
For a family-friendly hotel in Mayo, consider the Suwannee River Rendezvous.

This hotel, with an 8.6 rating, is much-loved by families and offers a variety of pool options, including an outdoor pool and a shared, secured pool area. Connecting rooms are available, as are kid's meals, making it convenient for families. Guests frequently mention the beautiful scenery and kind staff. It is located 13.2 miles from the Suwannee River.
What are the top pet-friendly hotels in Mayo?
For pet-friendly hotels in Mayo, consider Cindys Motel or Suwannee River Rendezvous.

Cindys Motel, with a 9.0 rating, is an excellent choice for travelers with dogs, as it specifically permits dogs and offers complimentary WiFi. Guests frequently mention the clean rooms, and the hotel provides free self-parking as well as free parking for RVs, buses, and trucks. It is conveniently located near Veteran's Memorial Park of Mayo, just 0.1 miles away, and the Lafayette County Library, which is 0.4 miles away.

Another highly-rated option is Suwannee River Rendezvous, with an 8.6 rating. This hotel welcomes pets and features a dedicated dog exercise area, making it ideal for pet owners. Guests appreciate the beautiful scenery and kind staff. The property also boasts an outdoor pool with sun loungers, offering a pleasant relaxation spot. It is located 13.2 miles from the Suwannee River. See more pet-friendly hotels in Mayo
What are the best budget hotels in Mayo?
For budget-friendly accommodations in Mayo, consider Cindys Motel or Suwannee River Rendezvous.

Cindys Motel, with a 9.0 rating, offers convenient amenities such as free WiFi and complimentary self-parking, including space for RVs, buses, and trucks. Guests often describe the rooms as clean and great. It is also very close to Veteran's Memorial Park of Mayo, just 0.1 miles away.

Another good option is Suwannee River Rendezvous, rated 8.6. This hotel provides free self-parking, free WiFi, and a selection of pool amenities including an outdoor pool with sun loungers. Travelers frequently mention the beautiful scenery and kind staff. It is located about 13.2 miles from the Suwannee River. View all budget hotels in Mayo
What are the most romantic hotels in Mayo for couples?
For couples seeking a romantic getaway in Mayo, the Suwannee River Rendezvous is an excellent choice.

This highly-rated accommodation, with an 8.6 review score, offers a serene setting great for couples. Guests frequently praise the beautiful scenery and the kind staff, ensuring a pleasant stay. The property features an outdoor pool with sun loungers, providing a relaxing spot to unwind together. Additionally, it is conveniently located just 13.2 miles from the Suwannee River, offering opportunities for scenic strolls or other romantic activities.
What are the best hotels in Mayo near Suwannee River?
For hotels in Mayo near the Suwannee River, Suwannee River Rendezvous is a good option.

Suwannee River Rendezvous, with an 8.6 rating, is located approximately 13.2 miles from the Suwannee River. This hotel offers a variety of pool options, including an outdoor pool, and features connecting rooms, which can be convenient for families. Guests often mention the beautiful scenery.
When is the best time to go to Mayo?
The best time to go to Mayo, Florida, is during the spring and fall months, specifically from March to May and September to November. These periods offer the most pleasant weather conditions for exploring the area.

During spring, you'll find comfortable temperatures, typically ranging from the low 70s to high 80s Fahrenheit, with lower humidity. This makes it ideal for outdoor activities like visiting local springs or exploring the nearby Suwannee River. It's a great time for travelers who enjoy hiking, kayaking, or simply relaxing outdoors without the intense summer heat.

Fall also provides agreeable weather, with temperatures mirroring those of spring and generally less rainfall than the summer. This season is superb for couples or solo travelers looking for a tranquil getaway, as the cooler air is conducive to enjoying nature trails and local events without large crowds.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Mayo.
How can I save on a Mayo hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Mayo hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Mayo hotel?
Prices for hotels in Mayo often vary, but you can find a great deal from $44 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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