Puerto Isabela Vacations from $606

Book a Hotel + Flight or Car together to unlock savings

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Puerto Isabela Vacation

Take the stress and hassle out of planning your next adventure by booking a Puerto Isabela vacation package. Take in the sounds and sights of this appealing neighborhood and experience all it has to offer. Hoping to see the sights during your trip to Puerto Isabela? Don't miss nearby attractions such as Centro Olimpico, Quisqueya Stadium and National Palace. Stop daydreaming and start doing. When you're ready to lock in your vacation to Puerto Isabela, Expedia will help you get there.

The Latest Puerto Isabela Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Sybaris Residences

Save 100% on your flight

$606

per person

Nov 27 - Dec 4

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)

8.4/10 Very Good! (126 reviews)

Excellent property, one of the best I’ve been to so far. Beautiful, great pool, attentive personnel, the house has everything you need. Would be great to include some amenities such as golf tour or something else, but great experience

Reviewed on Sep 9, 2026

Coral Costa Caribe Beach Resort - All Inclusive

Villas Del Mar

Save 100% on your flight

$1,571

per person

Dec 21 - Dec 28

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)

8/10 Very Good! (2,708 reviews)

Staff at buffet yarnell was amazing However food quality went down hill coffee sucks Same food served each day very cheap budget menu

Reviewed on Oct 7, 2026

Xeliter Balcones del Atlantico

Save 100% on your flight

$1,049

per person

Dec 7 - Dec 14

found 1 day ago

Roundtrip flight included

New York (JFK) to Santo Domingo (SDQ)

8.2/10 Very Good! (199 reviews)

Me encantó, muy buena limpieza, atenciones y comodidad.

Reviewed on Sep 28, 2026

Wyndham Alltra Samana All-Inclusive Resort

Save 100% on your flight

$923

per person

Nov 13 - Nov 18

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)

8.4/10 Very Good! (524 reviews)

They do not have e buffet everyday. In term of of food there are limitation. Waitress take so long to bring the foods

Reviewed on Oct 6, 2026

Bahia Principe Explore La Romana - Hyatt Inclusive Collection - All Inclusive

Save 100% on your flight

$965

per person

Nov 13 - Nov 18

found 1 day ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Santo Domingo (SDQ)

8.6/10 Excellent! (2,628 reviews)

Someone stole my phone from my room there , unbelievable and I had a sign for the room not to be clean by room service

Reviewed on Oct 5, 2026

Where to stay in Puerto Isabela

Find the best Puerto Isabela areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Isabela

A historic stone archway with a flagpole and a clear blue sky.

Zona Colonial

1 out of top 10 points of interest in this area

A romantic ambiance fills the air of one of the America’s oldest European settlements, a neighborhood known for its architectural masterpieces, bars and parks.

A densely built urban area with numerous high-rise buildings, a large body of water in the background, and some green spaces.

Piantini

2 out of top 10 points of interest in this area

Unique features of Piantini include the shopping and restaurants. Make a stop by Blue Mall or Acropolis Center while you're exploring the area.

A historic building with arches and columns, palm trees, and a paved courtyard.

Downtown Santo Domingo

1 out of top 10 points of interest in this area

Polígono Central boasts a mix of commercial and residential zones, with a high concentration of malls, banks, and international fast food chains. Enjoy daily sports activities at Club Paraiso and Club Naco, or explore the city via Santo Domingo Metro and OMSA bus system.

A historic building with a circular plaza, palm trees, and a clear blue sky.

Ciudad Colonial

Discover the historic heart of Santo Domingo, where cobblestone streets like Calle Las Damas lead to landmarks such as Alcázar de Colón and Catedral de Santa María la Menor. Stroll along pedestrian-only Calle del Conde, and enjoy local shops and restaurants near Plaza de España.

A historic building with arched windows and a statue in front.

Gascue

This leafy residential suburb of Santo Domingo has first-rate museums, performing arts centers and great dining along a stretch of the city’s breezy esplanade.

Puerto Isabela Hotel Deals

Dominican Fiesta Hotel

Av Anacaona 101, Esquina Cibao Oeste Santo Domingo Distrito Nacional

Fully refundableReserve now, pay when you stay

$79 nightly

$102 total

Nov 7 - Nov 8

Total with taxes and fees

Catalonia Santo Domingo

Avenida George Washington No. 500 Santo Domingo Distrito Nacional

Fully refundableReserve now, pay when you stay

$104 nightly

$133 total

Oct 9 - Oct 10

Total with taxes and fees

Radisson Hotel Santo Domingo

Presidente Gonzalez #10 Esq Tiradentes Santo Domingo Distrito Nacional

Fully refundable

$84 nightly

$108 total

Oct 30 - Oct 31

Total with taxes and fees

8.6/10 Excellent! (1,170 reviews)

"The room was clean, but unfortunately, it did not have a mini fridge. I travel with my kids, and my two-year-old still drinks milk, so I had to buy milk every day and throw away what was left because there was no refrigerator to keep it cold. For families traveling with small children, this made ..."

Reviewed on Oct 6, 2026

See all 2,673 properties in Puerto Isabela

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.