Find hotels in Puxico, MO

  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Puxico hotels

40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!
3.0 star property
Poplar Bluff
10.0 out of 10, Exceptional, (3 reviews)
"Beautiful place enjoyed our stay"
United States
Anonymous traveler
40-acre Poplar Bluff Nature Lovers Paradise!

Lake Wappapello

Lake Wappapello
2.0 star property
Williamsville
10.0 out of 10, Exceptional, (1 review)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
United States
Dyann
Lake Wappapello

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (986 reviews)
"Great location and room "
United States
Curtis
$94 nightly
The price is $106
Feb 6 - Feb 7
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

'the Lakehouse' Lovely Wappapello Country Home!

'the Lakehouse' Lovely Wappapello Country Home!
3.0 star property
Wappapello
'the Lakehouse' Lovely Wappapello Country Home!

Spacious & Secluded Shook Home w/ Private Hot Tub!

Spacious & Secluded Shook Home w/ Private Hot Tub!
3.0 star property
Lowndes
Spacious & Secluded Shook Home w/ Private Hot Tub!

Waterfront Home Near Mark Twain National Forest

Waterfront Home Near Mark Twain National Forest
3.5 star property
Poplar Bluff
Waterfront Home Near Mark Twain National Forest

Private Getaway on 270 Acres w/ Lake: Swim & Canoe

Private Getaway on 270 Acres w/ Lake: Swim & Canoe
2.0 star property
Advance
Private Getaway on 270 Acres w/ Lake: Swim & Canoe

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (719 reviews)
"Amazing place"
United States
Mladen
$114 nightly
The price is $129
Feb 7 - Feb 8
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (872 reviews)
"The size of the room. The staff were great. The room was very clean. Will definitely stay there again."
United States
Brenda
$108 nightly
The price is $122
Feb 12 - Feb 13
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,003 reviews)
"Very clean and staff was very friendly!"
United States
Sherry
$57 nightly
The price is $60
Feb 3 - Feb 4
Total with taxes and fees
Motel 6 Poplar Bluff, MO

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (10 reviews)
"Great stay "
United States
Ashley
$98 nightly
The price is $110
Feb 9 - Feb 10
Total with taxes and fees
Hampton Inn By Hilton Dexter

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (800 reviews)
"Would stay again"
United States
David
$107 nightly
The price is $120
Feb 9 - Feb 10
Total with taxes and fees
Hampton Inn Poplar Bluff

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (84 reviews)
"Cute room, great food, fun soda fountain and friendly owners! Will return! "
United States
Leslie
$85 nightly
The price is $93
Feb 10 - Feb 11
Total with taxes and fees
EC Reed's Mercantile and Hotel

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (393 reviews)
"Clean room, friendly staff and quiet stay."
United States
Margo
$92 nightly
The price is $103
Feb 16 - Feb 17
Total with taxes and fees
Travelodge by Wyndham Dexter

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (404 reviews)
"Everything is fine "
United States
Bob
$96 nightly
The price is $109
Feb 14 - Feb 15
Total with taxes and fees
Comfort Inn Poplar Bluff North

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (333 reviews)
"Room was nice and spacious."
United States
Rebecca
$79 nightly
The price is $89
Feb 3 - Feb 4
Total with taxes and fees
Dexter Inn

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (213 reviews)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (633 reviews)
"Very clean and staff was great"
United States
Dawn
$53 nightly
The price is $60
Feb 9 - Feb 10
Total with taxes and fees
Super 8 by Wyndham Poplar Bluff Missouri

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (253 reviews)
"Room was clean, staff was AMAZING breakfast was false advertising as they don’t have hot breakfast just things like cereal."
United States
Jessica
$59 nightly
The price is $67
Mar 4 - Mar 5
Total with taxes and fees
Econo Lodge Dexter

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (135 reviews)
"We enjoyed every moment of our stay. Wonderful service—everyone was friendly and helpful."
United States
Albert
$57 nightly
The price is $63
Mar 4 - Mar 5
Total with taxes and fees
OYO Hickory House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

Great place for sunrises, Bald Eagles in the winter, and Milkyway shots.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

Hotels in Puxico with star-rating

Frequently asked questions

What is the best area to stay in Puxico?
The best area to stay in Puxico is the central part of town, particularly around the intersection of Highway 51 and Highway 67.

This area is the heart of Puxico, offering convenient access to local businesses and community gathering spots. You'll find the town's main park, public services, and local eateries within easy reach. It's a straightforward layout, making it simple to navigate for visitors.

For families, staying in this central area is ideal due to its proximity to the community park, which often hosts local events and provides open spaces for recreation.
When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (April to June) and fall (September to October) when the weather is most pleasant.

Spring offers mild temperatures, making it comfortable for outdoor activities like exploring the nearby Mingo National Wildlife Refuge. You'll find the local flora blooming and wildlife more active during these months. It's a great time for nature enthusiasts and those looking for a peaceful getaway.

Fall also provides agreeable weather with cooler temperatures and the added beauty of changing leaves. This season is ideal for enjoying scenic drives through the surrounding countryside and participating in local harvest festivals if they are scheduled.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Puxico.
How can I save on a Puxico hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Puxico hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Puxico hotel?
Prices for hotels in Puxico often vary, but you can find a great deal on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia