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Our top choices for Puxico hotels

1. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
"Nice clean hotel, reservation was for queen bed actual bed in room was double."
United States
Bruce
5 days ago
$74 nightly
The price is $83
Jun 13 - Jun 14
Total with taxes and fees
Motel 6 Poplar Bluff, MO

2. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,006 reviews)
"Very clean hallways. Hot tub perfect. Great things to say."
United States
Monica
5 days ago
$94 nightly
The price is $106
Jun 14 - Jun 15
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (911 reviews)
"Great place to stay while passing through to Branson!!!"
United States
Julie
8 days ago
$101 nightly
The price is $114
Jun 7 - Jun 8
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

4. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (862 reviews)
"Very reasonably priced. This place is nice throughout."
United States
Lynne
1 day ago
$93 nightly
The price is $105
Jul 5 - Jul 6
Total with taxes and fees
Hampton Inn Poplar Bluff

5. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (746 reviews)
"Great staff especially Ms Wilma at the front desk!"
United States
Denise
1 day ago
$97 nightly
The price is $110
Jun 14 - Jun 15
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG

6. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (409 reviews)
"It is a real 1950 s era diner which serves breakfast."
United States
Joey
April 14th, 2026
$87 nightly
The price is $97
Jun 7 - Jun 8
Total with taxes and fees
Travelodge by Wyndham Dexter

7. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.8 out of 10, Exceptional, (36 reviews)
"Friendly, efficient and helpful staff. Modern and clean hotel."
United States
Thomas
9 days ago
$105 nightly
The price is $118
Jun 14 - Jun 15
Total with taxes and fees
Hampton Inn By Hilton Dexter

8. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (95 reviews)
"It was cute and clean and affordable!"
United States
Linda
10 days ago
$95 nightly
The price is $103
Jun 12 - Jun 13
Total with taxes and fees
EC Reed's Mercantile and Hotel

9. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (647 reviews)
"Staff was friendly everything was quiet pleasant experience for an easy one night stay."
United States
Markay
$59 nightly
The price is $66
Jun 29 - Jun 30
Total with taxes and fees
Super 8 by Wyndham Poplar Bluff Missouri

10. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (415 reviews)
"Room smelt very clean. Breakfast was good."
United States
Lori
29 days ago
$94 nightly
The price is $106
Jun 28 - Jun 29
Total with taxes and fees
Comfort Inn Poplar Bluff North

11. Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (348 reviews)
"Older hotel going through updates. The staff was very accommodating."
United States
patricia
$58 nightly
The price is $65
Jun 15 - Jun 16
Total with taxes and fees
Dexter Inn

12. OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (138 reviews)
"Well maintained space with good comfort. Service quality was consistent."
United States
Ronan
December 28th, 2025
$61 nightly
The price is $68
Jun 17 - Jun 18
Total with taxes and fees
OYO Hickory House Inn

13. Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (263 reviews)
"Staff was very friendly. Room was very clean with excellent pillows."
United States
Anonymous traveler
$51 nightly
The price is $57
Jul 4 - Jul 5
Total with taxes and fees
Econo Lodge Dexter

14. Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (213 reviews)
"Accommodation was very good. We will stay again."
United States
Penny
Bullwinkles Rustic Lodge

15. OYO Malden Airport Inn

OYO Malden Airport Inn
2.5 star property
Malden
6.6 out of 10, (74 reviews)
"The staff was very nice and professional. The room was very clean."
United States
Everette
$64 nightly
The price is $69
Jun 9 - Jun 10
Total with taxes and fees
OYO Malden Airport Inn

16. SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly

SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly
Poplar Bluff
SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

More cheap stays in Puxico

Hotels in Puxico with star-rating

Frequently asked questions

What is the best area to stay in Puxico?
The best area to stay in Puxico is the central part of town, particularly around the intersection of Highway 51 and Highway 67.

This area is the heart of Puxico, offering convenient access to local businesses and community gathering spots. You'll find the town's main park, public services, and local eateries within easy reach. It's a straightforward layout, making it simple to navigate for visitors.

For families, staying in this central area is ideal due to its proximity to the community park, which often hosts local events and provides open spaces for recreation.
When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (April to June) and fall (September to October) when the weather is most pleasant.

Spring offers mild temperatures, making it comfortable for outdoor activities like exploring the nearby Mingo National Wildlife Refuge. You'll find the local flora blooming and wildlife more active during these months. It's a great time for nature enthusiasts and those looking for a peaceful getaway.

Fall also provides agreeable weather with cooler temperatures and the added beauty of changing leaves. This season is ideal for enjoying scenic drives through the surrounding countryside and participating in local harvest festivals if they are scheduled.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Puxico.
How can I save on a Puxico hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Puxico hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Puxico hotel?
Prices for hotels in Puxico often vary, but you can find a great deal from $57 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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