Find hotels in Puxico, MO from $60

The best area to stay in Puxico is the central part of town, particularly around the intersection of Highway 51 and Highway 67.This area is the heart of Puxico, offering convenient access to local businesses and community gathering spots. You'll find the town's main park, public services, and local eateries within easy reach. It's a straightforward layout, making it simple to navigate for visitors.For families, staying in this central area is ideal due to its proximity to the community park, which often hosts local events and provides open spaces for recreation.

The best time to visit Puxico, Missouri, is during the spring (April to June) and fall (September to October) when the weather is most pleasant.Spring offers mild temperatures, making it comfortable for outdoor activities like exploring the nearby Mingo National Wildlife Refuge. You'll find the local flora blooming and wildlife more active during these months. It's a great time for nature enthusiasts and those looking for a peaceful getaway.Fall also provides agreeable weather with cooler temperatures and the added beauty of changing leaves. This season is ideal for enjoying scenic drives through the surrounding countryside and participating in local harvest festivals if they are scheduled.

With Expedia, you earn OneKeyCash™* on eligible Puxico hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.