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Our top choices for Puxico hotels

1. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"The hotel offers evening buffet dinner. Helen were very friendly."
United States
Doyle
7 days ago
$93 nightly
The price is $105
Aug 22 - Aug 23
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

2. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
"Provided us a convenient place spend the night. It was clean."
United States
Doug
14 days ago
$78 nightly
The price is $87
Aug 7 - Aug 8
Total with taxes and fees
Motel 6 Poplar Bluff, MO

3. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (910 reviews)
"The property was very well maintained. Staff was very friendly."
United States
Aluce
2 days ago
$93 nightly
The price is $105
Aug 9 - Aug 10
Total with taxes and fees
Hampton Inn Poplar Bluff

4. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (943 reviews)
"I absolutely love staying at Fairfield. The staff is extremely nice."
United States
Tequilla
18 days ago
$101 nightly
The price is $114
Aug 9 - Aug 10
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

5. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (754 reviews)
"Staff was very friendly. There is an attached restaurant serving breakfast."
United States
Terry
June 21st, 2026
$87 nightly
The price is $98
Aug 30 - Aug 31
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG

6. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.8 out of 10, Exceptional, (59 reviews)
"Staff are very helpful. I lived the new property."
United States
Vanessa
1 day ago
$98 nightly
The price is $110
Aug 9 - Aug 10
Total with taxes and fees
Hampton Inn By Hilton Dexter

7. Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (660 reviews)
"The rooms was clean. Staff friendly and for breakfast they have waffle. Yogurt and coffee."
United States
Diana
10 days ago
$67 nightly
The price is $75
Aug 7 - Aug 8
Total with taxes and fees
Super 8 by Wyndham Poplar Bluff Missouri

8. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (105 reviews)
"This boutique hotel is awesome. It has a really good restaurant."
United States
Farhan
June 16th, 2026
$85 nightly
The price is $92
Aug 25 - Aug 26
Total with taxes and fees
EC Reed's Mercantile and Hotel

9. Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (358 reviews)
"Air conditioning was great. I ate fresh made waffles every morning."
United States
Cynthia
11 days ago
$56 nightly
The price is $63
Aug 10 - Aug 11
Total with taxes and fees
Dexter Inn

10. Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (418 reviews)
"It is a real 1950 s era diner which serves breakfast."
United States
Joey
April 14th, 2026
$87 nightly
The price is $98
Aug 1 - Aug 2
Total with taxes and fees
Travelodge by Wyndham Dexter

11. Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (430 reviews)
"Hot tub, pool and entire staff!!!!"
United States
Christy
24 days ago
$80 nightly
The price is $90
Aug 23 - Aug 24
Total with taxes and fees
Comfort Inn Poplar Bluff North

12. OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (140 reviews)
"Well maintained space with good comfort. Service quality was consistent."
United States
Ronan
$59 nightly
The price is $66
Aug 7 - Aug 8
Total with taxes and fees
OYO Hickory House Inn

13. Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (273 reviews)
"Staff was very friendly. Room was very clean with excellent pillows."
United States
Anonymous traveler
$51 nightly
The price is $57
Aug 29 - Aug 30
Total with taxes and fees
Econo Lodge Dexter

14. OYO Malden Airport Inn

OYO Malden Airport Inn
2.5 star property
Malden
6.4 out of 10, (78 reviews)
"Clean room, cleaning staff friendly, AC working, overflowing dumpster."
United States
James
28 days ago
$59 nightly
The price is $63
Aug 5 - Aug 6
Total with taxes and fees
OYO Malden Airport Inn

15. Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (213 reviews)
"Accommodation was very good. We will stay again."
United States
Penny
Bullwinkles Rustic Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay near Puxico

Discover the charm of Puxico, where outdoor adventures and scenic landscapes await. Explore nearby towns for family-friendly excursions, romantic spots, and rich cultural experiences, all set in a welcoming atmosphere perfect for your vacation getaway. Enjoy the tranquility and beauty this region has to offer!

Wappapello

Discover Wappapello, a charming destination perfect for families and nature lovers seeking a rejuvenating getaway. With its stunning Lake Wappapello and the scenic Lake Wappapello State Park, visitors can indulge in outdoor activities while enjoying picturesque landscapes. The nearby Eagle Point Recreation Area offers additional opportunities for adventure and relaxation. Located about 6 miles from Puxico, Wappapello is an excellent choice for travelers looking to immerse themselves in nature and create lasting memories.

Dexter

Experience the charm of Dexter, a delightful hub for families and nature enthusiasts looking for outdoor adventures and scenic beauty. This welcoming city offers a range of attractions, such as the Dexter Welcome Center Depot and Museum for history buffs, the picturesque Mingo Wilderness nature reserve for nature lovers, and nearby lakes perfect for relaxation. Just about 17 miles by car from Puxico, Dexter is an excellent choice for your stay, combining affordability with a variety of enriching experiences.

Sturdivant

Families and nature enthusiasts will love Sturdivant, known for its serene outdoor experiences and budget-friendly accommodations. This charming city offers easy access to the Mingo Wilderness, perfect for exploring nature, and the Eagle Point Recreation Area, ideal for picnics and relaxation. History buffs will appreciate a visit to The Heritage House, a glimpse into the past. Located about 11 miles from Puxico, Sturdivant makes for a smart stay during your Missouri getaway.

Dudley

Dudley stands out as a prime spot for travelers seeking a family-friendly getaway immersed in nature. With attractions like the Heritage House and the Dexter Welcome Center Depot and Museum, visitors can explore the rich history of the area. Outdoor enthusiasts will appreciate the nearby urban park and lake, perfect for a day of relaxation or recreation. Located about 12 miles from Puxico, Dudley is a smart choice for those looking to enjoy both city life and outdoor adventures.

Fisk

Travelers visiting the area often choose Fisk, especially families and nature enthusiasts seeking a budget-friendly vacation. This charming city offers access to a variety of outdoor activities and scenic spots, including a picturesque lake, a serene river, and the expansive national state park. With attractions like the Black River Coliseum for entertainment, the Margaret Harwell Art Museum for culture, and the Mo-Ark Regional Railroad Museum for history, Fisk provides a delightful experience. Located about 12 miles from Puxico, Fisk is a smart choice for your getaway.

Stay near popular attractions around Puxico

Discover the charm of Puxico, where lush parks and serene nature reserves invite you to unwind and connect with the great outdoors. Perfect for families and couples alike, this hidden gem offers a refreshing escape into picturesque scenery and eco-friendly adventures.

Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

A night scene with a clear sky, a crescent moon, and two silhouetted trees against a twilight sky.
Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

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Hotels in Puxico with star-rating

Frequently asked questions

What is the best area to stay in Puxico?
The best area to stay in Puxico is the central part of town, particularly around the intersection of Highway 51 and Highway 67.

This area is the heart of Puxico, offering convenient access to local businesses and community gathering spots. You'll find the town's main park, public services, and local eateries within easy reach. It's a straightforward layout, making it simple to navigate for visitors.

For families, staying in this central area is ideal due to its proximity to the community park, which often hosts local events and provides open spaces for recreation.
When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (April to June) and fall (September to October) when the weather is most pleasant.

Spring offers mild temperatures, making it comfortable for outdoor activities like exploring the nearby Mingo National Wildlife Refuge. You'll find the local flora blooming and wildlife more active during these months. It's a great time for nature enthusiasts and those looking for a peaceful getaway.

Fall also provides agreeable weather with cooler temperatures and the added beauty of changing leaves. This season is ideal for enjoying scenic drives through the surrounding countryside and participating in local harvest festivals if they are scheduled.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Puxico.
How much is the nightly rate at a Puxico hotel?
Prices for hotels in Puxico often vary, but you can find a great deal from $57 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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