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Our top choices for Puxico hotels

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
"My room is almost always pretty clean. I stay here quite often in my travels."
United States
Robyn
2 days ago
$65 nightly
The price is $69
Apr 12 - Apr 13
Total with taxes and fees
Motel 6 Poplar Bluff, MO

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,001 reviews)
"The guy at the front desk provided all the first aid supplies we needed."
United States
Lindsey
10 days ago
$94 nightly
The price is $106
Apr 19 - Apr 20
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (884 reviews)
"The room has been intentionally created to be comfortable. We arrived last night."
United States
Rose Alice
November 6th, 2025
$110 nightly
The price is $124
Apr 11 - Apr 12
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (816 reviews)
"Breakfast is well stocked. This Hampton Inn is clean. The staff was super kind."
United States
Jose
2 days ago
$93 nightly
The price is $105
Apr 19 - Apr 20
Total with taxes and fees
Hampton Inn Poplar Bluff

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (727 reviews)
"The staff was really friendly. The breakfast was surprisingly good from the voucher they gave."
United States
Kaitlyn
December 16th, 2025
$101 nightly
The price is $114
Apr 12 - Apr 13
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (400 reviews)
"This place was very nice and clean and the people that work there."
United States
Tammy
27 days ago
$92 nightly
The price is $103
Apr 12 - Apr 13
Total with taxes and fees
Travelodge by Wyndham Dexter

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (18 reviews)
"The rooms are very large and super clean!"
United States
Sara
March 5th, 2026
$98 nightly
The price is $110
Apr 19 - Apr 20
Total with taxes and fees
Hampton Inn By Hilton Dexter

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (85 reviews)
"Parking was easy. Room was nice. The staff were super friendly."
United States
Mehdi
16 days ago
$87 nightly
The price is $95
Apr 12 - Apr 13
Total with taxes and fees
EC Reed's Mercantile and Hotel

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (639 reviews)
"Staff was friendly everything was quiet pleasant experience for an easy one night stay."
United States
Markay
October 29th, 2025
$56 nightly
The price is $63
May 4 - May 5
Total with taxes and fees
Super 8 by Wyndham Poplar Bluff Missouri

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (410 reviews)
"Room was clean and staff was great! Also, breakfast was great!"
United States
Michael
December 22nd, 2025
$88 nightly
The price is $100
Apr 19 - Apr 20
Total with taxes and fees
Comfort Inn Poplar Bluff North

Dexter Inn

Dexter Inn
2.5 star property
Dexter
6.8 out of 10, (341 reviews)
"Older hotel going through updates. The staff was very accommodating."
United States
patricia
October 20th, 2025
$55 nightly
The price is $61
Apr 20 - Apr 21
Total with taxes and fees
Dexter Inn

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (137 reviews)
"Well maintained space with good comfort. Service quality was consistent."
United States
Ronan
December 28th, 2025
$65 nightly
The price is $72
Apr 9 - Apr 10
Total with taxes and fees
OYO Hickory House Inn

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (260 reviews)
"Staff was very friendly. Room was very clean with excellent pillows."
United States
Anonymous traveler
$51 nightly
The price is $57
May 8 - May 9
Total with taxes and fees
Econo Lodge Dexter

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (213 reviews)
"Accommodation was very good. We will stay again."
United States
Penny
Bullwinkles Rustic Lodge

OYO Malden Airport Inn

OYO Malden Airport Inn
2.5 star property
Malden
6.8 out of 10, (69 reviews)
"The staff was very nice and professional. The room was very clean."
United States
Everette
$70 nightly
The price is $75
Apr 13 - Apr 14
Total with taxes and fees
OYO Malden Airport Inn

SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly

SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly
Poplar Bluff
SOLAR ECLIPSE! Lodge on10ac open field. 4 bed, 1 bath. Family/Pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Puxico

Check out the local area in Puxico—home to attractions like Mark Twain National Forest and Mingo Wilderness.

Photo by Mike McClain
Open Photo by Mike McClain

Top Puxico Hotel Reviews

More cheap stays in Puxico

Hotels in Puxico with star-rating

Frequently asked questions

What is the best area to stay in Puxico?
The best area to stay in Puxico is the central part of town, particularly around the intersection of Highway 51 and Highway 67.

This area is the heart of Puxico, offering convenient access to local businesses and community gathering spots. You'll find the town's main park, public services, and local eateries within easy reach. It's a straightforward layout, making it simple to navigate for visitors.

For families, staying in this central area is ideal due to its proximity to the community park, which often hosts local events and provides open spaces for recreation.
When is the best time to go to Puxico?
The best time to visit Puxico, Missouri, is during the spring (April to June) and fall (September to October) when the weather is most pleasant.

Spring offers mild temperatures, making it comfortable for outdoor activities like exploring the nearby Mingo National Wildlife Refuge. You'll find the local flora blooming and wildlife more active during these months. It's a great time for nature enthusiasts and those looking for a peaceful getaway.

Fall also provides agreeable weather with cooler temperatures and the added beauty of changing leaves. This season is ideal for enjoying scenic drives through the surrounding countryside and participating in local harvest festivals if they are scheduled.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Puxico.
How can I save on a Puxico hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Puxico hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Puxico hotel?
Prices for hotels in Puxico often vary, but you can find a great deal from $57 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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