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Sikeston Vacation Rentals

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Check prices for these dates

In two weeks
Aug 28 - Aug 30
In two months
Oct 9 - Oct 11
In three months
Nov 6 - Nov 8
In four months
Dec 4 - Dec 6

Our top choices for Sikeston vacation rentals

Exterior

1. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very Good, (36 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
$203 nightly
The price is $218
Aug 12 - Aug 13
Total with taxes and fees
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Living area

2. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very Good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
$101 nightly
The price is $108
Aug 12 - Aug 13
Total with taxes and fees
Little Blue Cottage on Spanish
Outdoor dining

3. Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
10.0 out of 10, Exceptional, (2 reviews)
"This is a very safe, comfortable, and relaxing stay. Would definitely recommend"
United States
Krystal K.
$183 nightly
The price is $192
Aug 17 - Aug 18
Total with taxes and fees
Studio Apt | King Bed, Full Kitchen · By KeenStays
1 bedroom, desk, iron/ironing board, WiFi

4. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$200 nightly
The price is $200
Aug 12 - Aug 13
Total with taxes and fees
The Cottage, Rusted Route Farms
Property grounds

5. Vibrant Lofted Tiny Home

Vibrant Lofted Tiny Home
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The tiny house was adorable, clean, and everything we expected. We can’t wait to stay in the others. We definitely recommend staying here. Lisa and Holly have done a wonderful job. Holly was great at getting back to me. Loved everything about our stay and the trip. Thank you so much"
United States
Kim K.
$224 nightly
The price is $235
Aug 12 - Aug 13
Total with taxes and fees
Vibrant Lofted Tiny Home
Interior

6. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (36 reviews)
"Amazing stay! Everything was perfect."
United States
Wayne F.
$302 nightly
The price is $317
Aug 25 - Aug 26
Total with taxes and fees
The Twisted Sassafras Treehouse
Interior

7. Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (25 reviews)
"Very peaceful"
United States
Gloria M.
$292 nightly
The price is $307
Aug 12 - Aug 13
Total with taxes and fees
Charming Secluded Getaway Cabin within minutes of amenities
Terrace/patio

8. Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The property was amazing, and Holly's service was excellent. The community is a collection of tinyish homes that is really cool, with outside communal amenities to enjoy. Close to everything in Cape and Jackson, whether it's a couples getaway or a group experience and you book multiple units, this place would be great for you!"
United States
Dustin T.
$217 nightly
The price is $228
Aug 14 - Aug 15
Total with taxes and fees
Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
TV, offices

9. Fresh & Cozy Retreat w/ King Bed · By KeenStays

Fresh & Cozy Retreat w/ King Bed · By KeenStays
Cape Girardeau
$183 nightly
The price is $192
Aug 23 - Aug 24
Total with taxes and fees
Fresh & Cozy Retreat w/ King Bed · By KeenStays
Coffee/tea maker, fridge, microwave, oven

10. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
$150 nightly
The price is $161
Aug 12 - Aug 13
Total with taxes and fees
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
TV, fireplace

11. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (5 reviews)
"This was the coolest place! Our family absolutely loved it. Plenty of space, bathrooms, sitting areas outside were plenty as well as fireplaces and fire pit. The bedrooms are spacious- the area where the two twin beds are is downstairs and the beds are smaller but just know that going in. Beautiful area. We’d love to stay again."
United States
Victoria
$315 nightly
The price is $315
Aug 12 - Aug 13
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
Property grounds

12. European Inspired Lofted Cottage in Tiny Home Village

European Inspired Lofted Cottage in Tiny Home Village
Cape Girardeau
$218 nightly
The price is $229
Aug 12 - Aug 13
Total with taxes and fees
European Inspired Lofted Cottage in Tiny Home Village
Coffee/tea maker, fridge, microwave, oven

13. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (36 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
$172 nightly
The price is $181
Aug 12 - Aug 13
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
Exterior

14. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (43 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
$301 nightly
The price is $316
Aug 21 - Aug 22
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Coffee/tea maker, fridge, microwave, dishwasher

15. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
$313 nightly
The price is $313
Aug 13 - Aug 14
Total with taxes and fees
Beautifully Renovated Farmhouse in Jackson, MO
Outdoor dining

16. A-Frame Cottage with Deck in Charming Inspiration Village

A-Frame Cottage with Deck in Charming Inspiration Village
Cape Girardeau
$231 nightly
The price is $242
Aug 12 - Aug 13
Total with taxes and fees
A-Frame Cottage with Deck in Charming Inspiration Village
Pool

17. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (10 reviews)
"Nice place, great times"
United States
Jace W.
$526 nightly
The price is $552
Aug 21 - Aug 22
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Interior

18. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (13 reviews)
"Our stay was amazing. Everything was so clean organized, and anything you would possibly need was in the room. We will definitely be staying there again when in the area!!"
United States
Karen P.
$172 nightly
The price is $181
Aug 12 - Aug 13
Total with taxes and fees
Villa B offers peace and quiet with beautiful views of the countryside.
Dining

19. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (42 reviews)
"Peaceful and suited our needs perfectly."
United States
Matthew
$133 nightly
The price is $140
Aug 12 - Aug 13
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
Interior

20. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.6 out of 10, Exceptional, (4 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
$147 nightly
The price is $169
Aug 20 - Aug 21
Total with taxes and fees
The Atrium - A Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

8/10 Good
"Hotel was nice but unfortunately someone decided to smoke in the elevator one night which made it shut down. So, until the repair was completed, everyone one the upper floors had to take the stairs down multiple floors. Usually not that big of an issue, but we were there for a bike ride and had to carry our bikes down three floors in the morning. Thankfully the elevator was fixed by the time we got back. Not really anything the hotel or staff caused, but just repercussions from the act of one person doing something stupid! We will definitely stay here again"
Julie 2-night trip
Posted 18 hours ago
Hampton Inn Sikeston

Find out more about Sikeston

Everything you need to know about Sikeston vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Sikeston vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $143 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Sikeston rentals

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

* On the Wine Trail * Hot Tub * Wi-Fi *: You might want to consider this vacation home rental near Sikeston, which is located on a lake and has a patio, a hot tub, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find Hunter-Dawson State Historic Site and Front Street Studio & Art Gallery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.