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Sikeston Vacation Rentals

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Check prices for these dates

In two weeks
Jul 31 - Aug 2
In two months
Sep 11 - Sep 13
In three months
Oct 9 - Oct 11
In four months
Nov 6 - Nov 8

Our top choices for Sikeston vacation rentals

Coffee/tea maker, fridge, microwave, oven

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
$145 nightly
The price is $155
Jul 26 - Jul 27
Total with taxes and fees
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Living area

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very Good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
$101 nightly
The price is $108
Jul 21 - Jul 22
Total with taxes and fees
Little Blue Cottage on Spanish
Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (159 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
$229 nightly
The price is $248
Jul 24 - Jul 25
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space
Outdoor dining

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"I loved the location and the staff was wonderful. The bed was comfortable. I loved that King size bed!"
United States
Melvin
$160 nightly
The price is $167
Jul 20 - Jul 21
Total with taxes and fees
Studio Apt | King Bed, Full Kitchen · By KeenStays
Exterior

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very Good, (35 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
$200 nightly
The price is $215
Jul 26 - Jul 27
Total with taxes and fees
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Interior

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (12 reviews)
"It was great. "
United States
Benjamin Q.
$172 nightly
The price is $181
Jul 22 - Jul 23
Total with taxes and fees
Villa B offers peace and quiet with beautiful views of the countryside.
Property grounds

Vibrant Lofted Tiny Home

Vibrant Lofted Tiny Home
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The tiny house was adorable, clean, and everything we expected. We can’t wait to stay in the others. We definitely recommend staying here. Lisa and Holly have done a wonderful job. Holly was great at getting back to me. Loved everything about our stay and the trip. Thank you so much"
United States
Kim K.
$224 nightly
The price is $235
Jul 20 - Jul 21
Total with taxes and fees
Vibrant Lofted Tiny Home
Coffee/tea maker, fridge, microwave, oven

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (36 reviews)
"Clean and cozy cottage. Quiet and peaceful. Lots of space. Would definitely would stay again."
United States
Jean B.
$171 nightly
The price is $180
Jul 20 - Jul 21
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
Interior

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (24 reviews)
"Very peaceful"
United States
Gloria M.
$292 nightly
The price is $307
Jul 20 - Jul 21
Total with taxes and fees
Charming Secluded Getaway Cabin within minutes of amenities
Property grounds

European Inspired Lofted Cottage in Tiny Home Village

European Inspired Lofted Cottage in Tiny Home Village
Cape Girardeau
$218 nightly
The price is $229
Jul 26 - Jul 27
Total with taxes and fees
European Inspired Lofted Cottage in Tiny Home Village
TV, fireplace

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (4 reviews)
"This was the coolest place! Our family absolutely loved it. Plenty of space, bathrooms, sitting areas outside were plenty as well as fireplaces and fire pit. The bedrooms are spacious- the area where the two twin beds are is downstairs and the beds are smaller but just know that going in. Beautiful area. We’d love to stay again."
United States
Victoria
$313 nightly
The price is $313
Jul 23 - Jul 24
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (41 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
$301 nightly
The price is $316
Jul 23 - Jul 24
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
1 bedroom, desk, iron/ironing board, WiFi

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$197 nightly
The price is $197
Jul 20 - Jul 21
Total with taxes and fees
The Cottage, Rusted Route Farms
Interior

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Nice, quiet, close to shopping & restaurants"
United States
Jaime M.
$299 nightly
The price is $314
Jul 27 - Jul 28
Total with taxes and fees
The Twisted Sassafras Treehouse
1 bedroom, WiFi (free), bed sheets

Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
$197 nightly
The price is $207
Jul 20 - Jul 21
Total with taxes and fees
Purple Tiny House with Fire pit & Nature
Terrace/patio

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
Cape Girardeau
$216 nightly
The price is $227
Jul 23 - Jul 24
Total with taxes and fees
Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
TV, offices

Fresh & Cozy Retreat w/ King Bed · By KeenStays

Fresh & Cozy Retreat w/ King Bed · By KeenStays
Cape Girardeau
$160 nightly
The price is $167
Aug 9 - Aug 10
Total with taxes and fees
Fresh & Cozy Retreat w/ King Bed · By KeenStays
Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
$526 nightly
The price is $552
Jul 23 - Jul 24
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Outdoor dining

A-Frame Cottage with Deck in Charming Inspiration Village

A-Frame Cottage with Deck in Charming Inspiration Village
Cape Girardeau
$231 nightly
The price is $242
Jul 20 - Jul 21
Total with taxes and fees
A-Frame Cottage with Deck in Charming Inspiration Village
Coffee/tea maker, fridge, microwave, oven

Modern Boho Getaway 1BR Apartment By KeenStays

Modern Boho Getaway 1BR Apartment By KeenStays
Cape Girardeau
$160 nightly
The price is $167
Aug 2 - Aug 3
Total with taxes and fees
Modern Boho Getaway 1BR Apartment By KeenStays
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"I stayed for six days at Pear Tree while my daughter was doing camp at SEMO. They offer a discount for SEMO parents if you call direct, be sure to ask for it. You also get extra Drury reward points if you choose to not have housekeeping during your stay so that is something to know too. Main SEMO campus is 15 min away, Riverside is about 20 and an easy drive. Breakfast every morning was a delight. Linda was working during my entire stay and she was wonderful to chat with in the morning. Everything was kept fresh and full. I loved having coffee and sodas available to me plus the water bottle refill and ice were great since it was hot and humid. Popcorn was available in the afternoon for snacking which was nice. The Outback Steakhouse is a 2 min walk next door if you want fancy, but there are a million other options within a 5 min drive. Walmart is also 5 min away if you forgot anything. The hotel also has a kind of pantry with snacks, food items and health and beauty things you can purchase. Of course prices are a bit steep but beats running out at 10pm if you forgot your toothpaste. There is also a laundry for guests to use and the common areas offer lots of space outside of your room to work on read. Already booked my next stay for my student moving in."
Shawn 6-night trip
Posted 7 hours ago
Pear Tree Inn Cape Girardeau West

Find out more about Sikeston

Everything you need to know about Sikeston vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Sikeston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Sikeston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Sikeston vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Sikeston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Sikeston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $131 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Sikeston rentals

At Expedia, we put the best Sikeston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Sikeston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Sikeston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Sikeston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

Beautiful location in the secluded woods : Visitors like this Sikeston vacation home rental. It offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.