San Francesco Vacations from $620

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Your San Francesco Vacation

Organizing your next adventure just got a whole lot simpler with a vacation package to San Francesco. Experience everything this neighborhood has to offer while making wonderful memories you'll replay for years. Can't wait to get out and see the sights during your trip to San Francesco? Be sure to check out nearby attractions like Tonnarella, Piazza Plebiscito and Piazza della Repubblica. Stop daydreaming and start doing. When it's time to lock in your next vacation to San Francesco, Expedia is here to help.

The Latest San Francesco Vacation Packages

Price found within the past 48 hours. Click for updated prices.
B&B Essenze

B&B Essenze

3 out of 5
Politeama
Price was $785, price is now $620 per person
$620
per person
Jan 18 - Jan 23
found 17 hours ago
Roundtrip flight included
Boston (BOS) to Palermo (PMO)
8.6/10 Excellent! (18 reviews)
Tutto perfetto, ospiti gentilissimi che ti fanno sentire a casa. Torneremo!

Reviewed on Sep 8, 2024

Eurostars Centrale Palace

Eurostars Centrale Palace

4 out of 5
Palermo Historical Center
Price was $796, price is now $649 per person
$649
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to Palermo (PMO)
8.4/10 Very Good! (1,004 reviews)
Room clean and great service..

Reviewed on Nov 6, 2025

Grand Hotel et Des Palmes

Grand Hotel et Des Palmes

5 out of 5
Politeama
Price was $1,377, price is now $1,150 per person
$1,150
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to Palermo (PMO)
8.4/10 Very Good! (1,002 reviews)
Very elegant, spotless and classic, very helpful staff. Great location!

Reviewed on Nov 10, 2025

Hotel Plaza Opera

Hotel Plaza Opera

4 out of 5
Politeama
Price was $854, price is now $738 per person
$738
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to Palermo (PMO)
8.6/10 Excellent! (584 reviews)
Would definitely recommend and would stay here again

Reviewed on Nov 7, 2025

Porta di Castro Boutique Hotel & Spa

Porta di Castro Boutique Hotel & Spa

1 out of 5
Palermo Historical Center
Price was $852, price is now $742 per person
$742
per person
Jan 20 - Jan 24
found 1 day ago
Roundtrip flight included
Boston (BOS) to Palermo (PMO)
9.4/10 Exceptional! (388 reviews)
Fantastic quirky hotel with great attentive friendly staff

Reviewed on Nov 11, 2025

Where to stay in San Francesco

Find the best San Francesco areas and neighborhoods for the activities you enjoy most. Learn more about San Francesco
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Giudecca

Though Giudecca might not have many top sights, you can venture to the surrounding area to see attractions like Royal Saint Nicholas and Piazza della Repubblica.

Find hotels in Giudecca

San Francesco Hotel Deals

Le Porte Del Tempo Dimora Storica

Le Porte Del Tempo Dimora Storica

Via Bagno 2, Mazara del Vallo, TP
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $96 total per night from Nov 24 to Nov 25
$96 total
Nov 24 - Nov 25
Total with taxes and fees
10/10 Exceptional! (5 reviews)
The room was lovely and spacious. The building itself is a delight with real charm and history and definitely part of the Old Town vibe. Breakfast was very good too.

Reviewed on Nov 10, 2025

Le Porte Del Tempo Dimora Storica
Grand Hotel Palace

Grand Hotel Palace

5 out of 5
Via Lungomare Mediterraneo, 57, Marsala, TP
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $114 total per night from Nov 26 to Nov 27
$114 total
Nov 26 - Nov 27
Total with taxes and fees
8/10 Very Good! (282 reviews)
Hotel was a bit "tired" but a good value for the price

Reviewed on Oct 16, 2025

Grand Hotel Palace
Baitan Hotel

Baitan Hotel

Contrada Spagnola, Marsala, TP
$69 nightly
The price is $76 total per night from Nov 16 to Nov 17
$76 total
Nov 16 - Nov 17
Total with taxes and fees
9.4/10 Exceptional! (37 reviews)
everything is wonderful

Reviewed on Oct 6, 2025

Baitan Hotel
See all 1,107 properties in San Francesco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Discover the most popular places to visit in San Francesco

St. Vitus on the Sea

Learn about the local history of Mazara del Vallo when you take a trip to St. Vitus on the Sea. Discover the area's countryside and monuments.

St. Vitus on the Sea

Royal Saint Nicholas

You can learn about the history of Mazara del Vallo with a trip to Royal Saint Nicholas. Discover the area's countryside and monuments.

Royal Saint Nicholas

Museum Satiro

You can spend time studying the exhibits at Museum Satiro in Mazara del Vallo. Make time to visit the monuments and churches while you're in the area.

Museum Satiro

Things to do

DonnaGiacoma Experience

DonnaGiacoma Experience

$21
per adult
DonnaGiacoma Experience
Quad ATV excursion

Quad tour between vineyards and the sea with a glass of wine.

$151
per traveler
Quad tour between vineyards and the sea with a glass of wine.
Marsala: Guided Salt Pans Walk Tour with Windmill Visit

Marsala: Guided Salt Pans Walk Tour with Windmill Visit

$19
per adult
Marsala: Guided Salt Pans Walk Tour with Windmill Visit
See all activities in Mazara del Vallo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.