
Santa Croce Vacations from $969
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Your Santa Croce Vacation
Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.
The Latest Santa Croce Vacation Packages

Aurum Firenze
Reviewed on Jun 19, 2026

Aurum Uffizi
Reviewed on Jun 5, 2026

Precise Tale Poggio Alla Sala
Reviewed on Jun 19, 2026

The Moon Boutique Hotel & Spa
Reviewed on Jun 8, 2026

Bernini Palace
Reviewed on Jun 18, 2026
Where to stay in Santa Croce

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santa Croce Hotel Deals

FH55 Grand Hotel Mediterraneo
"The property was within walking distance of everything, as long as you don’t mind and a little extra walk. The breakfast was delicious, getting a taxi to the airport was really tough due to other activities, but that probably wasn’t the hotel’s fault."
Reviewed on Jun 20, 2026

Aurum Uffizi
"Location was excellent! Highly recommended."
Reviewed on Jun 17, 2026

Plaza Hotel Lucchesi
"Beautiful property, nice rooftop"
Reviewed on Jun 6, 2026
Discover the most popular places to visit in Santa Croce

Piazza Santa Croce
Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Basilica of Santa Croce
Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.
Church of Sant'Ambrogio
After visiting Church of Sant'Ambrogio, make a plan to see the other sights and activities in Florence. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.
Things to do

City Sightseeing Florence Hop-on Hop-off Bus Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour























