Santa Croce Vacations from $1,161
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Your Santa Croce Vacation
Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.
The Latest Santa Croce Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Precise Tale Poggio Alla Sala
Save 100% on your flight
Price was $3,335, price is now $2,409 per person
$2,409
per person
Sep 16 - Sep 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (154 reviews)
The place it’s an Amazing. Very clean. Is more beautiful than the pictures.
Reviewed on Aug 2, 2026
Where to stay in Santa Croce
Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Historic Centre of Florence
10 out of top 10 points of interest in this area
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santa Croce Hotel Deals
Plaza Hotel Lucchesi
Lungarno Della Zecca Vecchia 38 Florence FI
Fully refundableReserve now, pay when you stay
$236 nightly
The price is $276 total per night from Aug 14 to Aug 15
$276 total
Aug 14 - Aug 15
Total with taxes and fees
FH55 Grand Hotel Mediterraneo
Lungarno del Tempio, 44 Florence FI
Fully refundableReserve now, pay when you stay
$120 nightly
The price is $148 total per night from Aug 9 to Aug 10
$148 total
Aug 9 - Aug 10
Total with taxes and fees
Hotel Balestri
Piazza Mentana 7 Florence FI
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $195 total per night from Aug 21 to Aug 22
$195 total
Aug 21 - Aug 22
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
"Great hotel - quality of room, cleanliness, staff were brilliant and so helpful. Breakfast was excellent. Would definitely stay here again - also great location on the river near the Uffizi."
Reviewed on Jul 31, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Santa Croce attractions
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
$28
per adult
76% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
$21
per adult
80% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
$133
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.