
Santa Croce Vacations from $1,153
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Your Santa Croce Vacation
Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.
The Latest Santa Croce Vacation Packages

Aurum Firenze
Reviewed on May 1, 2026

Aurum Uffizi
Reviewed on May 2, 2026

Eurostars Florence Boutique
Reviewed on Dec 13, 2025

Hotel Duomo Firenze
Reviewed on May 4, 2026

Hotel Villani
Reviewed on May 2, 2026
Where to stay in Santa Croce

Historic Centre of Florence
Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.
Santa Croce Hotel Deals

FH55 Grand Hotel Mediterraneo
Very friendly staff and breakfast had good selection! We had a flight at 7 and had to leave the hotel at 5am. We thought there was going to be no staff but luckily a guy was there to help us and had called us a taxi that arrived in 2 minutes. Room was nice and always cleaned everyday. We were left ...
Reviewed on Apr 28, 2026

Plaza Hotel Lucchesi
Internet struggles when in the rooms, but the rooftop bar/pool area has strong wifi and it's a much better place to setup if you have to do some light work. The views are stunning from the rooftop, you can watch the sun set and skip the tourist trap spots for that. The staff is incredibly kind and ...
Reviewed on Apr 25, 2026

Hotel Balestri
Excellent location, beautiful hotel, highly recommended
Reviewed on Apr 17, 2026
Discover the most popular places to visit in Santa Croce

Piazza Santa Croce
Italy’s most famous soccer game takes place here once a year, but the square is better known as a nighttime hangout of choice for young people.

Basilica of Santa Croce
Glorious tombs mark the resting place of Michelangelo, Galileo and many other Italian greats in the largest Franciscan church in the world.
National Central Library of Florence
Find out about the history of Florence when you take a trip to National Central Library of Florence. Discover the area's beautiful sunsets and churches.
Things to do

City Sightseeing Florence Hop-on Hop-off Bus Tour

Small-Group Wine Tasting Experience in the Tuscan Countryside























