Santa Croce Vacations from $764

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Your Santa Croce Vacation

Our Santa Croce vacation packages are a fast and practical way to plan and reserve your next adventure. Uncover the true character of this unique neighborhood without the hassle of having to organize everything yourself. Some top nearby attractions to see during your trip to Santa Croce include Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia can put your plans into action. Book your ultimate Santa Croce vacation now.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Florence Boutique
Palazzo Firenze by Baglioni Hotels & Resorts
Aurum Uffizi
Aurum Firenze
Glance Hotel In Florence

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce

Santa Croce Hotel Deals

Plaza Hotel Lucchesi

Plaza Hotel Lucchesi

4 out of 5
Lungarno Della Zecca Vecchia 38, Florence, FI
Fully refundableReserve now, pay when you stay
$267 nightly
The price is $311 total per night from Aug 30 to Aug 31
$311 total
Aug 30 - Aug 31
Total with taxes and fees
9.2/10 Wonderful! (975 reviews)
Will Come Back
"Wonderful hotel, perfect location for easy walking around in Florence. Great breakfast as well, staff were always friendly. Nice view of Arno River. The room I stayed in I was given a free book and lovely lotion (150mL which I used everyday during my stay). I would love to hear again next time I ..."

Reviewed on Aug 23, 2025

Plaza Hotel Lucchesi
FH55 Grand Hotel Mediterraneo

FH55 Grand Hotel Mediterraneo

4 out of 5
Lungarno del Tempio, 44, Florence, FI
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $126 total per night from Aug 30 to Aug 31
$126 total
Aug 30 - Aug 31
Total with taxes and fees
8/10 Very Good! (909 reviews)
"Nice hotel just on the outside of square"

Reviewed on Aug 23, 2025

FH55 Grand Hotel Mediterraneo
Hotel Balestri

Hotel Balestri

4 out of 5
Piazza Mentana 7, Florence, FI
Fully refundableReserve now, pay when you stay
$246 nightly
The price is $286 total per night from Aug 31 to Sep 1
$286 total
Aug 31 - Sep 1
Total with taxes and fees
9.2/10 Wonderful! (978 reviews)
Short break in Florence
"Its an amazing hotel very close to shops and restaurant. Highly recommended"

Reviewed on Aug 21, 2025

Hotel Balestri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Santa Croce

Things to do

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.