Title: Santa Fe de Antioquia Vacation Rentals from $46: Search Short-Term Rentals | Expedia.com

[Santa Fe de Antioquia Travel Guide](https://expedia.com/Santa-Fe-De-Antioquia.dx6143343)[Hotels in Santa Fe de Antioquia](https://expedia.com/Santa-Fe-De-Antioquia-Hotels.d6143343.Travel-Guide-Hotels)[Flights to Santa Fe de Antioquia](https://expedia.com/Cheap-Flights-To-Santa-Fe-De-Antioquia.d6143343.Travel-Guide-Flights)[Things to do in Santa Fe de Antioquia](https://expedia.com/Things-To-Do-In-Santa-Fe-De-Antioquia.d6143343.Travel-Guide-Activities)[Car Rentals in Santa Fe de Antioquia](https://expedia.com/Car-Rentals-In-Santa-Fe-De-Antioquia.d6143343.Car-Rental-Guide)[Santa Fe de Antioquia Vacation Packages](https://expedia.com/Santa-Fe-De-Antioquia.d6143343.Destination-Travel-Guides)

![](https://images.trvl-media.com/place/6143343/03709660-306c-4598-b888-d638aa186980.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Botak Jon

![](https://images.trvl-media.com/place/6143343/03709660-306c-4598-b888-d638aa186980.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6143343&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=6143343&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=6143343&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=6143343&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santa Fe de Antioquia vacation rentals

![Exterior](https://images.trvl-media.com/lodging/120000000/119570000/119565600/119565573/a546314a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room | Free WiFi](https://images.trvl-media.com/lodging/120000000/119570000/119565600/119565573/4a67df51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/120000000/119570000/119565600/119565573/ab281300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room | Free WiFi](https://images.trvl-media.com/lodging/120000000/119570000/119565600/119565573/03d86e13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Finca hotel mi refugio

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Finca-Hotel-Mi-Refugio.h119565573.Hotel-Information)

Santa Fé de Antioquia

$49 nightly

$49 total

Apr 3 - Apr 4

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Finca-Hotel-Mi-Refugio.h119565573.Hotel-Information)

![6 outdoor pools](https://images.trvl-media.com/lodging/109000000/108750000/108747200/108747191/9b39b471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Pool View | Living area](https://images.trvl-media.com/lodging/109000000/108750000/108747200/108747191/6d76c665.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Pool View | Living area](https://images.trvl-media.com/lodging/109000000/108750000/108747200/108747191/94246e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Apartment, Pool View | Living area](https://images.trvl-media.com/lodging/109000000/108750000/108747200/108747191/538e9e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SANTA FE DE ANTIOQUIA

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-SANTA-FE-DE-ANTIOQUIA.h108747191.Hotel-Information)

Santa Fe de Antioquia

8.0/10

Very Good

(1 review)

"Todo Ok"

![Costa Rica](https://a.travel-assets.com/egds/marks/flags/cr.svg)

Nohelys

$88 nightly

$88 total

May 3 - May 4

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-SANTA-FE-DE-ANTIOQUIA.h108747191.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/103000000/102710000/102702200/102702103/w1914h1080x33y0-c4b66405.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/103000000/102710000/102702200/102702103/f6963b82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/103000000/102710000/102702200/102702103/w1543h1080x219y0-792fc333.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/103000000/102710000/102702200/102702103/w1673h1080x154y0-a6fbc9a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### ¡Te va a Encantar! Disole 1104

[](https://www.expedia.com/Vrbo-Property.h102702103.Hotel-Information)

Santa Fé de Antioquia

$119 nightly

$120 total

Apr 5 - Apr 6

[](https://www.expedia.com/Vrbo-Property.h102702103.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/108000000/107040000/107031200/107031122/02884957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/108000000/107040000/107031200/107031122/168278be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/108000000/107040000/107031200/107031122/286e4da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/108000000/107040000/107031200/107031122/bd810d11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Cantaleta Just 3 Block from Old Town

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Cantaleta-Just-3-Block-From-Old-Town.h107031122.Hotel-Information)

Santa Fe de Antioquia

10/10

Exceptional

(1 review)

"everything looks as promised in the app, except for the payment options, I ended up paying cash at the location due to technical communication between the app ant the owner "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Wilson

$372 nightly

$372 total

Apr 3 - Apr 4

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Cantaleta-Just-3-Block-From-Old-Town.h107031122.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/97000000/96520000/96518800/96518795/5963d68a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/97000000/96520000/96518800/96518795/9b5eeaaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/97000000/96520000/96518800/96518795/497c5412.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/97000000/96520000/96518800/96518795/6ac5e734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Jade is the place where your group or family will enjoy it.

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Jade-Is-The-Place-Where-Your-Group-Or-Family-Will-Enjoy-It.h96518795.Hotel-Information)

Santa Fe de Antioquia

$208,800 nightly

$208,800 total

Apr 7 - Apr 8

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Jade-Is-The-Place-Where-Your-Group-Or-Family-Will-Enjoy-It.h96518795.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/128000000/127370000/127363500/127363426/8b02cfb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/128000000/127370000/127363500/127363426/6c828a6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/128000000/127370000/127363500/127363426/90721b5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/128000000/127370000/127363500/127363426/29d29da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Patio Colonial

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Patio-Colonial.h127363426.Hotel-Information)

Zona Colonial

$253 nightly

$253 total

Apr 5 - Apr 6

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Villa-Patio-Colonial.h127363426.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/96000000/95250000/95242000/95241917/4da4e635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95250000/95242000/95241917/decc0749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/96000000/95250000/95242000/95241917/e2f620cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/96000000/95250000/95242000/95241917/caa4c7a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Stunning, Brand-new Apartment with pool, in Santa Fe de Antioquia.

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Stunning.h95241917.Hotel-Information)

Santa Fé de Antioquia

10/10

Exceptional

(1 review)

$160 nightly

$160 total

Apr 5 - Apr 6

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Stunning.h95241917.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/103000000/102400000/102392600/102392539/c3f24a47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/103000000/102400000/102392600/102392539/1a909bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/103000000/102400000/102392600/102392539/a4f5ade3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102400000/102392600/102392539/8c86e221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hacienda with Private Swimming Pool/Air Conditioning/Jacuzzi 

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Hacienda-With-Private-Swimming-PoolAir-ConditioningJacuzzi.h102392539.Hotel-Information)

Santa Fé de Antioquia

$1,180 nightly

$1,180 total

Apr 3 - Apr 4

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Hacienda-With-Private-Swimming-PoolAir-ConditioningJacuzzi.h102392539.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683713/39a8645f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683713/w1290h730x0y0-a29f2986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683713/d3fb4ef9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, stovetop, cookware/dishes/utensils, lobster pot](https://images.trvl-media.com/lodging/127000000/126690000/126683800/126683713/1484d786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### SUMMER APARTMENT IN SANTA FE DE ANTIOQUIA

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Vrbo-Property.h126683713.Hotel-Information)

Santa Fé de Antioquia

$149 nightly

$149 total

Apr 4 - Apr 5

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Vrbo-Property.h126683713.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/87000000/86300000/86292100/86292032/11818e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/87000000/86300000/86292100/86292032/b007bf1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/87000000/86300000/86292100/86292032/818b6ab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's area](https://images.trvl-media.com/lodging/87000000/86300000/86292100/86292032/d2c51ea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Vivanco, A 3 Cuadras Del Parque Principal

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Casa-Vivanco.h86292032.Hotel-Information)

Zona Colonial

$225 nightly

$225 total

Apr 9 - Apr 10

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Casa-Vivanco.h86292032.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/106000000/105760000/105756700/105756636/0dfc1f5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/106000000/105760000/105756700/105756636/ca101b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, toaster, blender, cookware/dishes/utensils](https://images.trvl-media.com/lodging/106000000/105760000/105756700/105756636/de1909c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/106000000/105760000/105756700/105756636/c89457ec_edited_745a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Espectacular Vista, PH Tamarindo

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Espectacular-Vista.h105756636.Hotel-Information)

Santa Fé de Antioquia

2.0/10

(1 review)

"Nunca pude ingresase a la propiedad la persona encargada nunca recibió la reserva aunque el pago se realizó por anticipado "

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Carlos

$130 nightly

$130 total

Apr 5 - Apr 6

[](https://www.expedia.com/Santa-Fe-De-Antioquia-Hotels-Espectacular-Vista.h105756636.Hotel-Information)

![Outdoor spa tub](https://images.trvl-media.com/lodging/109000000/108400000/108394500/108394411/fa140443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108394500/108394411/ff2880b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108400000/108394500/108394411/3914decb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/109000000/108400000/108394500/108394411/3ecdeb44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabaña en la Montaña con Vista a la Ciudad Desde el Jacuzzi

[](https://www.expedia.com/Medellin-Hotels-Vrbo-Property.h108394411.Hotel-Information)

Medellín

10/10

Exceptional

(2 reviews)

"Yes the host was very welcoming. The place was very nice and clean. And the view was amazing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bryan H.

$101 nightly

$101 total

Apr 6 - Apr 7

[](https://www.expedia.com/Medellin-Hotels-Vrbo-Property.h108394411.Hotel-Information)

![Family Cottage, Mountain View | Outdoor dining](https://images.trvl-media.com/lodging/127000000/126620000/126611200/126611108/0fe01747.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cottage, Mountain View | Free WiFi](https://images.trvl-media.com/lodging/127000000/126620000/126611200/126611108/db06c8f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cottage, Mountain View | Exterior](https://images.trvl-media.com/lodging/127000000/126620000/126611200/126611108/1c0c32b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cottage, Mountain View | Bathroom](https://images.trvl-media.com/lodging/127000000/126620000/126611200/126611108/b8b71301.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Onirico Refugio

[](https://www.expedia.com/Medellin-Hotels-Onirico-Refugio.h126611108.Hotel-Information)

Medellín

$86 nightly

$86 total

Apr 6 - Apr 7

[](https://www.expedia.com/Medellin-Hotels-Onirico-Refugio.h126611108.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/84000000/83400000/83396500/83396455/791a523a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![6 bedrooms, desk, free WiFi, wheelchair access](https://images.trvl-media.com/lodging/84000000/83400000/83396500/83396455/79e5260c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83400000/83396500/83396455/c1ca75c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83400000/83396500/83396455/f6300acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Finca/House Las Gemelas - Pool and Sun for vacation

[](https://www.expedia.com/Bouvet-Island-Hotels-FincaHouse-Las-Gemelas-Pool-And-Sun-For-Vacation.h83396455.Hotel-Information)

Antioquia

$232 nightly

$232 total

Apr 5 - Apr 6

[](https://www.expedia.com/Bouvet-Island-Hotels-FincaHouse-Las-Gemelas-Pool-And-Sun-For-Vacation.h83396455.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/112000000/111280000/111279000/111278908/1f95ee51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, Pool View | In-room safe, free WiFi](https://images.trvl-media.com/lodging/112000000/111280000/111279000/111278908/9cc70bb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111280000/111279000/111278908/0c72d9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/112000000/111280000/111279000/111278908/cee3c638.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Gracia Hotel & Spa

[](https://www.expedia.com/San-Jeronimo-Hotels-La-Gracia-Hotel-Spa.h111278908.Hotel-Information)

San Jerónimo

8.8/10

Excellent

(5 reviews)

"Muy bonita la propiedad, limpio, buena comida No me gusto el ruido continuo de otras propiedades"

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Andres

$205 nightly

$205 total

Apr 13 - Apr 14

[](https://www.expedia.com/San-Jeronimo-Hotels-La-Gracia-Hotel-Spa.h111278908.Hotel-Information)

![Apartment, 1 Bedroom, Balcony | Balcony](https://images.trvl-media.com/lodging/120000000/119370000/119365500/119365446/d5a1ceb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 1 Bedroom, Balcony | Interior](https://images.trvl-media.com/lodging/120000000/119370000/119365500/119365446/10b26d3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 1 Bedroom, Balcony | Fitness studio](https://images.trvl-media.com/lodging/120000000/119370000/119365500/119365446/48938d37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 1 Bedroom, Balcony | Pool | Outdoor pool](https://images.trvl-media.com/lodging/120000000/119370000/119365500/119365446/804033dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Stylish 1BR Getaway, Jacuzzi, Fireplace, Gym and AC

[](https://www.expedia.com/Medellin-Hotels-Stylish-1BR-Getaway.h119365446.Hotel-Information)

Medellín

$75 nightly

$75 total

Apr 6 - Apr 7

[](https://www.expedia.com/Medellin-Hotels-Stylish-1BR-Getaway.h119365446.Hotel-Information)

![Classic Studio | In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/127000000/126030000/126028000/126027976/90817505.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment, City View | Living area](https://images.trvl-media.com/lodging/127000000/126030000/126028000/126027976/4967c2a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/127000000/126030000/126028000/126027976/458f7673.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment, City View | Dining](https://images.trvl-media.com/lodging/127000000/126030000/126028000/126027976/07308b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Edificio OA Aparta-suites

[](https://www.expedia.com/Medellin-Hotels-Edificio-OA-Aparta-Suites.h126027976.Hotel-Information)

Laureles - Estadio

$38 nightly

$38 total

Apr 6 - Apr 7

[](https://www.expedia.com/Medellin-Hotels-Edificio-OA-Aparta-Suites.h126027976.Hotel-Information)

![Blackout drapes, free WiFi](https://images.trvl-media.com/lodging/123000000/122760000/122759300/122759216/61fb555b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, free WiFi](https://images.trvl-media.com/lodging/123000000/122760000/122759300/122759216/eb5090ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, free WiFi](https://images.trvl-media.com/lodging/123000000/122760000/122759300/122759216/26398955.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Blackout drapes, free WiFi](https://images.trvl-media.com/lodging/123000000/122760000/122759300/122759216/e9634c8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Otalu Suites

[](https://www.expedia.com/Medellin-Hotels-Otalu-Suites.h122759216.Hotel-Information)

La América

$46 nightly

$46 total

Apr 12 - Apr 13

[](https://www.expedia.com/Medellin-Hotels-Otalu-Suites.h122759216.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/84000000/83020000/83017300/83017235/a22c5753.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/84000000/83020000/83017300/83017235/dc4952eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi](https://images.trvl-media.com/lodging/84000000/83020000/83017300/83017235/c690480b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/83020000/83017300/83017235/4fcb663d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Acogedora Casa Campestre con Chimenea y Espectacular Vista

[](https://www.expedia.com/San-Pedro-Hotels-Acogedora-Casa-Campestre-Con-Chimenea-Y-Espectacular-Vista.h83017235.Hotel-Information)

San Pedro

$84 nightly

$84 total

Apr 3 - Apr 4

[](https://www.expedia.com/San-Pedro-Hotels-Acogedora-Casa-Campestre-Con-Chimenea-Y-Espectacular-Vista.h83017235.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/59000000/58350000/58348000/58347962/d862e56e_edited_75c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/59000000/58350000/58348000/58347962/6690fe2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/59000000/58350000/58348000/58347962/52e01ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/59000000/58350000/58348000/58347962/88ff30fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Log cabin in nature

[](https://www.expedia.com/Medellin-Hotels-Cabana-En-Madera-En-La-Naturaleza.h58347962.Hotel-Information)

San Pedro

$150 nightly

$150 total

Apr 3 - Apr 4

[](https://www.expedia.com/Medellin-Hotels-Cabana-En-Madera-En-La-Naturaleza.h58347962.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-16&endDate=2026-04-17&regionId=6143343&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=VACATION_HOME)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=VILLA)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=APARTMENT)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=COTTAGE)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santa+Fe+de+Antioquia%2C+Antioquia%2C+Colombia&regionId=6143343&latLong=6.55624%2C-75.827766&adults=2&startDate=2026-07-01&d1=2026-07-01&endDate=2026-07-04&d2=2026-07-04&lodging=APART_HOTEL)

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## Top Santa Fe de Antioquia Hotel Reviews

![Hotel San Sebastian del Tonusco](https://images.trvl-media.com/lodging/90000000/89940000/89933300/89933227/95e1a603_y.jpg)

### Hotel San Sebastian del Tonusco

10/10 Excellent

"Excellente todo, habitacion limpia, staff todos muy amables y atentos,"

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Hotel-San-Sebastian-Del-Tonusco.h89933227.Hotel-Information)

![Casa Bixa Hotel Boutique -Santa Fe de Antioquia- Mayores de 12 años](https://images.trvl-media.com/lodging/67000000/66130000/66120500/66120495/6dcc14ca_y.jpg)

### Casa Bixa Hotel Boutique -Santa Fe de Antioquia- Mayores de 12 años

8/10 Good

"Yes, excellent music, bar and relaxing area"

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Casa-Bixa-Hotel-Boutique.h66120495.Hotel-Information)

![Arde La Selva](https://images.trvl-media.com/lodging/109000000/108290000/108283700/108283692/82f0d562_y.jpg)

### Arde La Selva

10/10 Excellent

"Checkout too earlier "

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Arde-La-Selva.h108283692.Hotel-Information)

![Hotel Mariscal Robledo](https://images.trvl-media.com/lodging/5000000/4300000/4294700/4294693/6095aa2d_y.jpg)

### Hotel Mariscal Robledo

10/10 Excellent

"Excelente hotel and nice pool area. Will be back"

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Hotel-Mariscal-Robledo.h4294693.Hotel-Information)

![Casa Al Alma](https://images.trvl-media.com/lodging/101000000/100030000/100027600/100027583/8f88d792_y.jpg)

### Casa Al Alma

6/10 Okay

"The room was ok. The breakfast on the first day was good. Second day terrible. Some of the staff were friendly, second day worse. Not polite."

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Casa-Al-Alma.h100027583.Hotel-Information)

![Selva Maria Hotel Boutique](https://images.trvl-media.com/lodging/103000000/102500000/102498900/102498829/465e97e3_y.jpg)

### Selva Maria Hotel Boutique

10/10 Excellent

"Stayed 2 nights. Small boutique hotel. Great location near plazas and restaurants. Clean rooms and good breakfast. Staff is very professional. "

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Selva-Maria-Hotel-Boutique.h102498829.Hotel-Information)

![Hotel Boutique Al Alma](https://images.trvl-media.com/lodging/97000000/96670000/96661800/96661794/w4987h3330x6y0-4513e902_y.jpg)

### Hotel Boutique Al Alma

10/10 Excellent

"The stunning ambience, decor and customer service make it a unique and wonderful stay."

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Hotel-Boutique-Al-Alma.h96661794.Hotel-Information)

![Finca Hotel Guadalupe](https://images.trvl-media.com/lodging/90000000/89580000/89575600/89575597/820d5046_y.jpg)

### Finca Hotel Guadalupe

10/10 Excellent

"Una finca espectacular con Linda vegetacion, piscina de buen tamaño, staff con excellence servicio , super limpio "

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Guadalupe-Hotel-Boutique.h89575597.Hotel-Information)

![Curazao Hotel](https://images.trvl-media.com/lodging/92000000/91820000/91816900/91816803/9744e233_y.jpg)

### Curazao Hotel

10/10 Excellent

"Location. Staff attitude"

[](https://expedia.com/Santa-Fe-De-Antioquia-Hotels-Curazao-Hotel.h91816803.Hotel-Information)

## Find out more about Santa Fe de Antioquia

**Everything you need to know about Santa Fe de Antioquia vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Fe de Antioquia vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Fe de Antioquia vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Santa Fe de Antioquia vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Santa Fe de Antioquia. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Fe de Antioquia in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $46 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Santa Fe de Antioquia rentals**

At Expedia, we put the best Santa Fe de Antioquia vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Fe de Antioquia rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Fe de Antioquia vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Fe de Antioquia. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Santa Fe de Antioquia

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- [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals)
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- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Santa Fe de Antioquia ](https://expedia.com/Santa-Fe-De-Antioquia-Private-Vacation-Homes.d6143343-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Villas in Santa Fe de Antioquia ](https://expedia.com/Santa-Fe-De-Antioquia-Villas.d6143343-aaVillas.Travel-Guide-Accommodation)
- [Cabin Rentals in Santa Fe de Antioquia ](https://expedia.com/Santa-Fe-De-Antioquia-Cabins.d6143343-aaCabins.Travel-Guide-Accommodation)
- [Hostels in Santa Fe de Antioquia ](https://expedia.com/Santa-Fe-De-Antioquia-Hostels.d6143343-aaHostels.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in Santa Fe de Antioquia?

### What are some of the best vacation home rentals that Santa Fe de Antioquia has to offer?

### How many vacation rentals are there in Santa Fe de Antioquia?

### What can I see and do in Santa Fe de Antioquia?

### What are vacation rentals like in Santa Fe de Antioquia?

### Expedia's Latest Trends

Hotels

- [Apartadó 5 Star Hotels](https://expedia.com/5Star-Apartado-Hotels.s50-0-d404.Travel-Guide-Filter-Hotels)
- [Top Hotels in Guatapé](https://expedia.com/Guatape-Hotels.d6154953.Travel-Guide-Hotels)

Flights

- [Flights to MDE](https://expedia.com/Cheap-Flights-To-Santa-Barbara.d6350769.Travel-Guide-Flights)
- [Flights to MDE](https://expedia.com/Cheap-Flights-To-Guatape.d6154953.Travel-Guide-Flights)
- [Flights to MDE](https://expedia.com/Cheap-Flights-To-Marinilla.d6294332.Travel-Guide-Flights)

Cars

- [Car rentals in Apartadó](https://expedia.com/Car-Rentals-In-Apartado.d404.Car-Rental-Guide)
- [Car rentals in Turbo](https://expedia.com/Car-Rentals-In-Turbo.d3526.Car-Rental-Guide)
- [Car rentals in Rionegro](https://expedia.com/Car-Rentals-In-Rionegro.d181446.Car-Rental-Guide)

Activities

- [Things to do in El Peñol](https://expedia.com/Things-To-Do-In-El-Penol.d6346467.Travel-Guide-Activities)
- [Things to do in Bello](https://expedia.com/Things-To-Do-In-Bello.d6245393.Travel-Guide-Activities)
- [Things to do in Sabaneta](https://expedia.com/Things-To-Do-In-Sabaneta.d6245382.Travel-Guide-Activities)
- [Things to do in Jericó](https://expedia.com/Things-To-Do-In-Jerico.d6350706.Travel-Guide-Activities)
- [Things to do in Fredonia](https://expedia.com/Things-To-Do-In-Fredonia.d3000445158.Travel-Guide-Activities)
- [Things to do in Retiro](https://expedia.com/Things-To-Do-In-Retiro.d6270810.Travel-Guide-Activities)
- [Things to do in Itagüí](https://expedia.com/Things-To-Do-In-Itagui.d6245366.Travel-Guide-Activities)
- [Things to do in Guarne](https://expedia.com/Things-To-Do-In-Guarne.d3000006181.Travel-Guide-Activities)
- [Things to do in Rionegro](https://expedia.com/Things-To-Do-In-Rionegro.d181446.Travel-Guide-Activities)
- [Things to do in Guatapé](https://expedia.com/Things-To-Do-In-Guatape.d6154953.Travel-Guide-Activities)

Packages

- [Guatapé Getaways](https://expedia.com/Guatape.d6154953.Destination-Travel-Guides)
- [Santa Barbara Getaways](https://expedia.com/Santa-Barbara.d6350769.Destination-Travel-Guides)

General

- [Visit Apartadó](https://expedia.com/Apartado.dx404)
- [Visit El Peñol](https://expedia.com/El-Penol.dx6346467)
- [Visit La Ceja](https://expedia.com/La-Ceja.dx6294319)
- [Visit Marinilla](https://expedia.com/Marinilla.dx6294332)
- [Visit Guatapé](https://expedia.com/Guatape.dx6154953)
- [Visit San Jerónimo](https://expedia.com/San-Jeronimo.dx6270869)
- [Visit Jardin](https://expedia.com/Jardin.dx6350777)
- [Visit Caucasia](https://expedia.com/Caucasia.dx773)
- [Visit Sopetrán](https://expedia.com/Sopetran.dx3000006094)
- [Visit Itagüí](https://expedia.com/Itagui.dx6245366)

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