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Our top choices for Santa Rosa hotels

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4706)
"Awesome great place to stay "
United States
Herbert
$114 nightly
The price is $126
Jan 18 - Jan 19, 2026
Total with taxes and fees
Hotel Riu Plaza Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
$224 nightly
The price is $247
Jan 25 - Jan 26, 2026
Total with taxes and fees
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall
4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1002)
"The hotel is conveniently close to the airport and shopping centres. "
United States
Samantha
$110 nightly
The price is $121
Jan 8 - Jan 9, 2026
Total with taxes and fees
Courtyard by Marriott Panama Metromall

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1125)
"The hotel is in a great location in Panama. Great amenities excellent breakfast."
United States
Maria
$98 nightly
The price is $108
Jan 2 - Jan 3, 2026
Total with taxes and fees
Ramada Plaza by Wyndham Panama Punta Pacifica

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (995)
"Was amazing food was delicious and stay was great "
United States
Amanda
$134 nightly
The price is $148
Jan 9 - Jan 10, 2026
Total with taxes and fees
Sheraton Grand Panama

Radisson Hotel Panama Canal

Radisson Hotel Panama Canal
4.5 star property
Amador
8.4 out of 10, Very Good, (1004)
"Wonderful staff and easy checkin!"
United States
Kristin
$80 nightly
The price is $88
Jan 7 - Jan 8, 2026
Total with taxes and fees
Radisson Hotel Panama Canal

Arcadia Condo Suites

Arcadia Condo Suites
2.5 star property
Costa del Este
9.4 out of 10, Exceptional, (167)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
$125 nightly
The price is $137
Dec 26 - Dec 27
Total with taxes and fees
Arcadia Condo Suites

The Executive Hotel

The Executive Hotel
3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1000)
"A nice hotel to stay great location"
United States
angela
$83 nightly
The price is $91
Jan 13 - Jan 14, 2026
Total with taxes and fees
The Executive Hotel

Principe Hotel and Suites

Principe Hotel and Suites
3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1615)
"Friendly staff. "
United States
Thessely
$53 nightly
The price is $58
Jan 15 - Jan 16, 2026
Total with taxes and fees
Principe Hotel and Suites

Renaissance Panama City Hotel

Renaissance Panama City Hotel
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (96)
"Great location and amazing staff"
United States
Aziz
$116 nightly
The price is $128
Jan 2 - Jan 3, 2026
Total with taxes and fees
Renaissance Panama City Hotel

The Westin Panama

The Westin Panama
4.0 star property
Costa del Este
9.0 out of 10, Wonderful, (311)
"Great hotel and services"
United States
Pedro
$214 nightly
The price is $236
Jan 10 - Jan 11, 2026
Total with taxes and fees
The Westin Panama

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1007)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
$116 nightly
The price is $129
Jan 18 - Jan 19, 2026
Total with taxes and fees
Las Americas Golden Tower Panama

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (131)
"Great hotel fair price"
United States
Santiago
$157 nightly
The price is $172
Jan 3 - Jan 4, 2026
Total with taxes and fees
Hyatt Regency Panama City

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1462)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
$110 nightly
The price is $121
Jan 8 - Jan 9, 2026
Total with taxes and fees
Decapolis Hotel Panama City

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
$319 nightly
The price is $351
Jan 10 - Jan 11, 2026
Total with taxes and fees
JW Marriott Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (563)
"Amazing hotel , location , staff and amenities . Clean, elegant , great service. "
United States
Nicole
$378 nightly
The price is $416
Jan 20 - Jan 21, 2026
Total with taxes and fees
Sofitel Legend Casco Viejo, Panama City

Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1000)
"I loved everything about my stay "
United States
Stephanie
$221 nightly
The price is $243
Jan 10 - Jan 11, 2026
Total with taxes and fees
Waldorf Astoria Panama

Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Nice room! Clean. Nice balcony, "
United States
Cassandra
$201 nightly
The price is $222
Jan 2 - Jan 3, 2026
Total with taxes and fees
Hilton Panama

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2136)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
$92 nightly
The price is $102
Jan 5 - Jan 6, 2026
Total with taxes and fees
Plaza Paitilla Inn Hotel

Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama
3.5 star property
Bella Vista
7.4 out of 10, Good, (711)
"The breakfast was great, I love the pool."
United States
Estefani
$51 nightly
The price is $57
Jan 12 - Jan 13, 2026
Total with taxes and fees
Hospedium Princess Hotel Panama
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Frequently asked questions

What is the best area to stay in Santa Rosa?
The best area to stay in Santa Rosa for most travelers is the city center, particularly around Avenida Central and the Parque Central.

This area is the heart of Santa Rosa, offering a convenient base for exploring the city. You'll find a concentration of local businesses, dining options, and access to public transportation. The Parque Central is a key landmark, providing a central gathering spot.

For travelers who appreciate convenience and easy access to local amenities, staying in the city center is ideal.
When is the best time to go to Santa Rosa?
The best time to visit Santa Rosa, Colón, Panama, is during the dry season, which runs from mid-December to mid-April. This period offers the most comfortable weather for exploring.

During these months, you'll experience sunny days with lower humidity and minimal rainfall, making it ideal for outdoor activities like hiking, wildlife viewing, and enjoying the beaches. The clearer skies also provide better conditions for photography and sightseeing.

Travelers looking for a relaxed and pleasant experience will find this time particularly suitable.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Rosa.
How can I save on a Santa Rosa hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Santa Rosa hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Rosa hotel?
Prices for hotels in Santa Rosa often vary, but you can find a great deal from $33 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.