Santo Domingo Vacations from $649

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Your Santo Domingo Vacation

Experience all the fabulous things this neighborhood has to offer with a tailor-made Santo Domingo vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. When it's time to head out and explore, you'll find loads of top attractions nearby including Tepozteco Pyramid, El Tepozteco National Park and Artisan Market of Tepoztlán. Visit one or all during your trip to Santo Domingo. Stop dreaming and start doing. When you're ready to book your vacation to Santo Domingo, Expedia will help you get there.

The Latest Santo Domingo Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel PF

Hotel PF

3.5 out of 5
Reforma
Price was $1,060, price is now $649 per person
$649
per person
Oct 19 - Oct 25
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9/10 Wonderful! (1,973 reviews)
Overall the stay was ok. The lady at the front desk when we checked in was not very friendly. At first she refused to give us 2 room keys even though we were 2 guests. Someone else came and gave us the cards. The maintenance lady was super nice and friendly and so was everyone else. Breakfast was good and the staff was amazing! Hôtel is close to everything which is nice. Lots of bars and restaurants around however only Mexican, Korean or junk food. Selection is much better in Roma Norte or Condesa in terms of variety and just a few minutes walk.

Reviewed on Aug 27, 2025

Apartamento en La Condesa

Apartamento en La Condesa

4.5 out of 5
La Condesa
Save 100% on your flight
Price was $2,433, price is now $1,346 per person
$1,346
per person
Oct 15 - Oct 22
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Mexico City (MEX)
7.6/10 Good! (4 reviews)
Fantastic location and great space. Wish the TV was a little bigger lol but for the money this place was outstanding. Thanks again.

Reviewed on Aug 11, 2025

Hotel & Suites PF

Hotel & Suites PF

3.5 out of 5
Reforma
Save 100% on your flight
Price was $1,253, price is now $737 per person
$737
per person
Oct 22 - Oct 27
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8.6/10 Excellent! (2,001 reviews)
I felt like home, but I was missing a refrigerator and sometimes a microwave. Staff was very nice.

Reviewed on Aug 31, 2025

HOTEL LUCA

HOTEL LUCA

4 out of 5
Roma Norte
Save 100% on your flight
Price was $1,566, price is now $969 per person
$969
per person
Oct 10 - Oct 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.2/10 Wonderful! (272 reviews)
Fantastic boutique hotel, highly recommended! Will stay again!

Reviewed on Aug 22, 2025

Historico Central Hotel

Historico Central Hotel

4 out of 5
Historic Center
Save 100% on your flight
Price was $1,367, price is now $848 per person
$848
per person
Oct 19 - Oct 25
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.8/10 Exceptional! (2,335 reviews)
Customer service was perfect Breakfast 100% awesome

Reviewed on Sep 2, 2025

Where to stay in Santo Domingo

Find the best Santo Domingo areas and neighborhoods for the activities you enjoy most. Learn more about Santo Domingo
Tepoztlan as well as an individual femail

San Miguel

3 out of top 10 points of interest in this area
5/5(5 area reviews)

While visiting San Miguel, you might make a stop by sights like Artisan Market of Tepoztlán and Ex-Convent of the Nativity.

Find hotels in San Miguel

Santo Domingo Hotel Deals

Hotel Amomoxtli

Hotel Amomoxtli

4 out of 5
Prolongacion Matamoros 115, Barrio Santo Domingo, Valle de Atongo, Tepoztlán, MOR
$253 nightly
The price is $298 total per night from Sep 8 to Sep 9
$298 total
Sep 8 - Sep 9
Total with taxes and fees
9.2/10 Wonderful! (594 reviews)
"Wonderful spot and service. Spectacular view of the mountains."

Reviewed on Aug 26, 2025

Hotel Amomoxtli
Finca Catalina Hotel Boutique

Finca Catalina Hotel Boutique

2.5 out of 5
1 Prol. Albino Ortega Santo Domingo, Tepoztlán, Mor.
Fully refundableReserve now, pay when you stay
$107 nightly
The price is $128 total per night from Sep 17 to Sep 18
$128 total
Sep 17 - Sep 18
Total with taxes and fees
Finca Catalina Hotel Boutique
Hotel Zaragoza Tepoztlan

Hotel Zaragoza Tepoztlan

3 out of 5
Calle Zaragoza 35B, Barrio Santo Domingo, Tepoztlán, MOR
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $148 total per night from Sep 17 to Sep 18
$148 total
Sep 17 - Sep 18
Total with taxes and fees
Hotel Zaragoza Tepoztlan
See all 823 properties in Santo Domingo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santo Domingo

Tepozteco Pyramid featuring tranquil scenes and landscape views

Tepozteco Pyramid

Examine the reliefs engraved on the walls of this temple where you can learn about the Aztec empire and admire the panoramic hilltop vista of the town.

Tepozteco Pyramid
Tepoztlan featuring markets as well as a small group of people

Artisan Market of Tepoztlán

Dramatic green mountains create a sensational background to the multiple market stalls, shops and restaurants of the central plaza.

Artisan Market of Tepoztlán
Tepoztlan featuring heritage architecture and a garden as well as a family

Ex-Convent of the Nativity

Learn about the Chinelo dance and pre-Hispanic people in the museums of a 16th-century convent with a glorious chapel and courtyard.

Ex-Convent of the Nativity
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.