A large church with a bell tower and a dome.

Southern Sonora Vacations from $503

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Your Southern Sonora Vacation

When it's time for your next big adventure, our Southern Sonora vacation packages are the answer. Culture and festivals are just a couple of the many things that make this destination truly memorable. With so much to see on a trip to Southern Sonora, it can be hard to know where to start. Kick off your travels in Ciudad Obregón at Nainari Lake and Sendero Plaza — two popular attractions here. Another great city to add to your itinerary is Guaymas. Don't miss Guaymas Malencon and San Carlos Golf Course. Whether you're planning to travel for a week or a month, Expedia are here to help you tailor-make your next Southern Sonora vacation.

The Latest Southern Sonora Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A pool area with lounge chairs, a cactus, and a building with a sign for restrooms.
    Dec 9 - Dec 13

    Hotel Armida Guaymas + Flight

    Guaymas
    4 nights
    2.5 star property
    8.0/10 - Very good (449 reviews)
    "Great place and staff"
    Reviewed November 4, 2026
    Roundtrip • Nuevo Laredo (NLD) - Guaymas (GYM)
    NLD - HMO • 1 stop HMO - NLD • 1 stop
    $535
    $503
    per traveler
    found 1 day ago
    Hotel Armida Guaymas
  • A covered outdoor seating area with wooden chairs and potted plants.
    Dec 9 - Dec 13

    Holiday Inn Express Guaymas by IHG + Flight

    Centro Guaymas
    4 nights
    3.0 star property
    9.4/10 - Exceptional (1,000 reviews)
    Roundtrip • Nuevo Laredo (NLD) - Guaymas (GYM)
    NLD - HMO • 1 stop HMO - NLD • 1 stop
    $555
    $531
    per traveler
    found 1 day ago
    Holiday Inn Express Guaymas by IHG
  • A modern lobby with a sofa, chairs, a coffee table, and a reception desk.
    Dec 9 - Dec 13

    City Express by Marriott Guaymas + Flight

    Guaymas
    4 nights
    3.5 star property
    8.8/10 - Excellent (658 reviews)
    "The venue is very clean. This is also its major drawback: if you have sensitivity to strong scents, the industrial amounts of detergent in public spaces and rooms will get you out of there fast. If that's not a concern for you, you'll find the staff are beyond helpful and you get great value for money."
    Reviewed October 28, 2026
    Roundtrip • Nuevo Laredo (NLD) - Guaymas (GYM)
    NLD - HMO • 1 stop HMO - NLD • 1 stop
    $541
    per traveler
    found 1 day ago
    City Express by Marriott Guaymas

Discover the most popular places to visit in Southern Sonora

An aerial view of a coastal region with a large bay, several islands, and a prominent mountain peak.

Los Algodones

8.8/10 (99 reviews)
Why not spend a lazy afternoon at Los Algodones during your trip to San Carlos? Wander the beautiful beaches in this relaxing area.
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Southern Sonora Hotel Deals

A Holiday Inn Express & Suites with a covered entrance, palm trees, and a clear sky.

Holiday Inn Express & Suites Ciudad Obregon by IHG

Holiday Inn Express & Suites Ciudad Obregon by IHG
3.0 star property
10.7 mi from Southern Sonora
9.4 out of 10, Exceptional, (913 reviews)
"Needs upgrade"
$88 nightly
The price is $105
Nov 16 - Nov 17
Total with taxes and fees
Holiday Inn Express & Suites Ciudad Obregon by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Southern Sonora
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.