A stone bridge with arches spanning a waterfall.

Wilkes Vacations from $418

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Your Wilkes Vacation

Say farewell to the worries of planning and hello to a Wilkes vacation package. With your travel details organized before you go, you can focus on discovering this city, starting with Mississippi District, which is good for shopping, nightlife and bars and pubs. Cascade Station, The Grotto and Edgefield Winery are just a few of the attractions you'll want to see during your trip to Wilkes. Stop daydreaming and start traveling. Explore the broad range of options on Expedia today and put your Wilkes vacation plans in motion!

The Latest Wilkes Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • The Mark Spencer Hotel entrance with a clear view of the building's facade, including the entrance canopy and the American flag.
    Jan 29 - Feb 1

    Mark Spencer Hotel + Flight

    Downtown Portland
    3 nights
    3.0 star property
    9.2/10 - Wonderful (2,554 reviews)
    "Quick check in, nice staff, everything was good."
    Reviewed November 11, 2026
    Roundtrip • Burbank (BUR) - Portland (PDX)
    BUR - PDX • Nonstop PDX - BUR • Nonstop
    $585
    $418
    per traveler
    found 1 day ago
    Mark Spencer Hotel
  • A spacious lobby with a central staircase, seating areas, and hanging light fixtures.
    Jan 21 - Jan 24

    The Ritz-Carlton, Portland + Flight

    Downtown Portland
    3 nights
    5.0 star property
    9.4/10 - Exceptional (373 reviews)
    "Staff was wonderful and very helpful. Nice atmosphere throughout."
    Reviewed November 7, 2026
    Roundtrip • Los Angeles (LAX) - Portland (PDX)
    LAX - PDX • Nonstop PDX - LAX • Nonstop
    $1,087
    $706
    per traveler
    found 12 hours ago
    The Ritz-Carlton, Portland
  • A stately building with a symmetrical facade, large windows, and a central entrance.
    Jan 22 - Jan 25

    Portland's White House + Flight

    Northeast Portland
    3 nights
    3.0 star property
    8.0/10 - Very good (2 reviews)
    "The property was absolutely gorgeous. We would give 5 stars all the way around, except there really was no staff or amenities. There were several times we would have like to speak with staff regarding locations, food or if there had been some extras offered we might have stayed on property. All in all the home is absolutely gorgeous!"
    Reviewed October 27, 2026
    Roundtrip • Los Angeles (LAX) - Portland (PDX)
    LAX - PDX • Nonstop PDX - LAX • Nonstop
    $735
    $550
    per traveler
    found 1 day ago
    Portland's White House
  • A modern house with a stone chimney, large windows, and a wooden deck.
    Dec 25 - Dec 29

    Skamania Lodge + Flight

    Stevenson
    4 nights
    3.5 star property
    9.2/10 - Wonderful (1,091 reviews)
    Roundtrip • Dallas (DFW) - Portland (PDX)
    DFW - PDX • Nonstop PDX - DFW • 1 stop
    $1,042
    $782
    per traveler
    found 10 hours ago
    Skamania Lodge
  • A spacious living area with a high ceiling, a dining area, and a kitchen with a view of the outdoors.
    Jan 26 - Jan 30

    Chapman Cove by Avantstay Gorgeous Beach Bungalow w/ Sauna + Flight

    Cannon Beach
    4 nights
    3.0 star property
    Roundtrip • Dallas (DFW) - Portland (PDX)
    DFW - PDX • Nonstop PDX - DFW • Nonstop
    Save 100% on your flight
    $1,799
    $1,358
    per traveler
    found 1 day ago
    Chapman Cove by Avantstay Gorgeous Beach Bungalow w/ Sauna

Where to stay in Wilkes

Find the best Wilkes areas and neighborhoods for the activities you enjoy most.
A theater marquee with 'Portland' and 'An Evening with Crosby, Stills & Nash' written on it.

Downtown Portland

Explore the Portland Art Museum, Oregon Historical Society, and Tom McCall Waterfront Park in this central business district with high-rise buildings. Enjoy walkable streets, and easily access public transportation like MAX light rail and Portland Streetcar.

The Moda Center with a clear sky, trees, and a pedestrian area.

Northeast Portland

Inner Northeast Portland boasts shopping areas like Lloyd District and Alberta Arts District, while the area near Burnside Bridge offers a lively nightlife with bars such as The Chesterfield and music venues like The Doug Fir Lounge.

A street with a modern building featuring large murals, parked cars, and a café with outdoor seating.

Pearl District

Discover art galleries like Elizabeth Leach Gallery, dine at diverse restaurants, and unwind in public plazas such as Jamison Square. Easily navigate with the Portland Streetcar and explore nearby iconic Powell's City of Books.

A large industrial building with a prominent red chimney and the letters "QMS" on its side.

Southeast Portland

Stretching from the Willamette River to Gresham, Southeast Portland boasts the scenic Mt. Tabor Park and the quirky Hawthorne district with its subculturally oriented shops. Don't miss exploring Reed College campus!

A cable car system, a cityscape with high-rise buildings, a river, and a mountain in the background.

Southwest Portland

Downtown Portland boasts cultural, educational, and retail hotspots, with attractions like Tom McCall Waterfront Park, Portland Art Museum, and Pioneer Place mall. Enjoy pedestrian-friendly streets and unique residential areas in Southwest Portland.

Wilkes Hotel Deals

A hotel room with a bed, a sofa, a TV, a dresser, and a microwave.

Oyo Hotel Portland Or Near Airport

Oyo Hotel Portland Or Near Airport
2.5 star property
Wilkes
6.2 out of 10, (80 reviews)
$75 nightly
The price is $86
Nov 15 - Nov 16
Total with taxes and fees
Oyo Hotel Portland Or Near Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Wilkes
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.