A valley with a town nestled between hills, a winding road, and distant mountains.

Find 4 Star Hotels in Santee, CA from $127

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Check availability on Santee 4 Star Hotels

Tonight
Oct 16 - Oct 17
Tomorrow
Oct 17 - Oct 18
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Santee 4-star hotels

A modern hotel lobby with a blue patterned carpet, multiple seating areas, and large windows offering a view of the cityscape.
A modern room with a stationary bike, a flat-screen TV, and a kitchen area with white cabinets.
A modern hotel room with a large bed, a flat-screen TV, a desk, a sofa, and a view of the sea.
A modern hotel room with a large bed, a flat-screen TV, a sofa, and a view of the city.

1. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
Downtown San Diego
United States
Sarah
$275 nightly
$319 total
Oct 30 - Oct 31
Total with taxes and fees
Manchester Grand Hyatt San Diego
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.
A waterfront hotel with a dock, palm trees, and a view of the water.
An outdoor dining area with tables and chairs, umbrellas, and string lights against a sunset backdrop.
A modern building with a curved roof, surrounded by lush tropical vegetation.

2. Paradise Point Resort & Spa

Paradise Point Resort & Spa
Mission Bay
Canada
Jesse
$239 nightly
$274 total
Nov 1 - Nov 2
Total with taxes and fees
Paradise Point Resort & Spa
A hotel courtyard with outdoor seating, palm trees, and a view of the ocean at dusk.
A high-rise urban area with modern buildings, palm trees, and a clear sky.
A marina with multiple boats docked and tall buildings in the background.
A modern living room with a green sofa, a round glass table, and a flat-screen TV mounted on the wall.

3. Wyndham San Diego Bayside

Wyndham San Diego Bayside
Downtown San Diego
United States
Jonathan
$182 nightly
$211 total
Oct 22 - Oct 23
Total with taxes and fees
Wyndham San Diego Bayside
Poolside bar
A Hard Rock Hotel with a prominent Hard Rock Cafe sign, a large marquee, and a modern building facade.
A modern lobby with a digital display wall, reception desks, and a spacious, well-lit area.
A modern bar area with a circular bar, multiple stools, and a large screen.

4. Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
Downtown San Diego
United States
Christopher
$224 nightly
$259 total
Nov 16 - Nov 17
Total with taxes and fees
Hard Rock Hotel San Diego
A balcony with wicker furniture overlooking a marina and a coastal cityscape.
An outdoor dining area with tables and chairs arranged on a grassy lawn, overlooking a body of water with a sailboat in the distance.
A marina with boats docked, a large white yacht, and a sunset in the background.
A modern restaurant with a view of a marina, featuring geometric wall panels, patterned flooring, and contemporary pendant lighting.

5. Sheraton San Diego Resort

Sheraton San Diego Resort
Harbor Island
United States
James
$183 nightly
$210 total
Oct 25 - Oct 26
Total with taxes and fees
Sheraton San Diego Resort
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.
A spacious lobby with a high ceiling, a large sectional sofa, multiple seating areas, and a modern chandelier.
An outdoor patio area with seating arrangements, including sofas, chairs, and round tables.
A spacious lobby with large windows, curved ceiling, and comfortable seating areas.

6. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
Downtown San Diego
United States
James
$230 nightly
$267 total
Oct 25 - Oct 26
Total with taxes and fees
Omni San Diego Hotel at the Ballpark
An outdoor lounge area with seating, a fire feature, and a pool in the background.
A stone wall with a neon sign that reads "Tom & Jerry."
A spacious lobby with a bar area, leather armchairs, and a reception desk.
A modern restaurant with multiple seating areas, including booths and tables. There are hanging lights and a variety of plants.

7. Town and Country San Diego

Town and Country San Diego
Mission Valley
United States
Nelly
$207 nightly
$238 total
Nov 10 - Nov 11
Total with taxes and fees
Town and Country San Diego
A bar area with a glass ceiling, a central bar counter, and multiple stools.
A large swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a striped facade.
A checkered floor with round tables and chairs, a patterned ceiling, and large windows.
A dimly lit room with patterned walls, a wooden table, and a chair.

8. Lafayette Hotel & Club

Lafayette Hotel & Club
University Heights
United States
Laurie
$248 nightly
$285 total
Nov 16 - Nov 17
Total with taxes and fees
Lafayette Hotel & Club
An aerial view of a resort with multiple swimming pools, lounge areas, and palm trees.
A bar area with a long counter, multiple stools, and hanging wicker lamps.
A modern hotel with a prominent circular tower and a glass facade.
A marina with numerous boats docked, a large ship in the background, and a modern building with balconies.

9. Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
Downtown San Diego
United States
LaTonya
$326 nightly
$378 total
Oct 29 - Oct 30
Total with taxes and fees
Marriott Marquis San Diego Marina
An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.
A spacious lobby with a central seating area, a staircase, and a view of the hallway leading to the entrance.
A modern dining area with a large table, chairs, and hanging plants.
A grand lobby with a marble floor, a central table with floral arrangements, a staircase, and potted plants.

10. DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
Mission Valley
United States
Laura
$144 nightly
$165 total
Nov 8 - Nov 9
Total with taxes and fees
DoubleTree by Hilton Hotel San Diego - Mission Valley
A cozy outdoor seating area with wicker furniture, a fire pit, and a bar with a city view.
A bar area with stools, a sofa set, a fire pit, and a television mounted on the wall.
A modern lobby with a sofa set, armchairs, a small table, and a green wall with plants.
A multi-story hotel with a modern architectural design, featuring a prominent curved structure and a rooftop terrace.

11. Hilton San Diego Gaslamp Quarter

Hilton San Diego Gaslamp Quarter
Downtown San Diego
United States
Cliff
$232 nightly
$269 total
Oct 25 - Oct 26
Total with taxes and fees
Hilton San Diego Gaslamp Quarter
An outdoor dining area with tables and chairs, a fire feature, and a bar area with a stone wall and shelves.
A hotel entrance with a covered outdoor seating area, palm trees, and a car parked in front.
A swimming pool with lounge chairs and umbrellas, surrounded by trees and a tall building in the background.
A spacious indoor lounge area with a central fire feature, multiple seating arrangements, and a bar area.

12. San Diego Marriott La Jolla

San Diego Marriott La Jolla
University City
United States
Josh
$185 nightly
$213 total
Oct 30 - Oct 31
Total with taxes and fees
San Diego Marriott La Jolla
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a modern building.
A hotel room with a large bed, a desk with a laptop, a chair, a TV, and a view of a bridge and water.
A rooftop dining area with multiple round tables, palm trees, and a view of the sea.
A spacious lobby with modern furniture, large windows, and a unique ceiling design.

13. Hilton San Diego Bayfront

Hilton San Diego Bayfront
Downtown San Diego
United States
Jason
$253 nightly
$293 total
Oct 25 - Oct 26
Total with taxes and fees
Hilton San Diego Bayfront
An outdoor seating area with chairs and a fire feature, overlooking a body of water and a distant mountain range.
A spacious living area with a wooden table, a sofa, and a chair, overlooking a scenic view of a body of water and hills.
A wedding aisle with white chairs and floral decorations leading to a decorated arch.
A hotel room with a large bed, a TV, a desk with a lamp, and a view of a lake and mountains.

14. Lakehouse Resort

Lakehouse Resort
Lake San Marcos
United States
Nicole
$138 nightly
$149 total
Nov 2 - Nov 3
Total with taxes and fees
Lakehouse Resort
A hotel with a large swimming pool, multiple water slides, and a well-lit outdoor area with lounge chairs and umbrellas.
A modern hotel with a pool area, palm trees, and a well-lit courtyard.
An outdoor patio area with wooden pergola, tables, chairs, and a bar with shelves of bottles.
A spacious indoor area with a high ceiling, large windows, and a variety of seating arrangements including tables and chairs.

15. Gaylord Pacific Resort & Convention Center

Gaylord Pacific Resort & Convention Center
Chula Vista
United States
Rabb
$324 nightly
$375 total
Oct 23 - Oct 24
Total with taxes and fees
Gaylord Pacific Resort & Convention Center
A hotel room with a sofa, two armchairs, a TV, a desk, and a large window with a view of a stadium.
A modern office space with two monitors, a desk, chairs, and a plant.
A bar area with a refrigerator stocked with beverages, coffee dispensers, and a bottle of sweet syrup.
A conference room with a long table, chairs, and glassware.

16. Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG
Downtown San Diego
United States
Angel
$207 nightly
$240 total
Oct 25 - Oct 26
Total with taxes and fees
Hotel Indigo San Diego-Gaslamp Quarter by IHG
A modern building with multiple windows, outdoor seating, and a chessboard.
A Hampton Inn & Suites by Hilton building with a covered entrance and a prominent sign.
A spacious indoor area with a pool table, seating, and a staircase.
A modern hotel reception area with a marble counter, a 'Welcome to Hampton' sign, and a reception desk.

17. Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town

Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
Point Loma
United States
Tammy
$161 nightly
$185 total
Nov 1 - Nov 2
Total with taxes and fees
Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town
A hotel room with a balcony, a TV mounted on the wall, a round wooden table with two white chairs, and a grey sofa.
A spacious lobby with a modern design, featuring a mix of seating options including sofas and chairs, a coffee table, and a decorative wall with abstract art.
A large building with a central dome and a reflection in the water.
A dining area with a long wooden table set for multiple guests, surrounded by dark blue chairs.

18. The Westin San Diego Gaslamp Quarter

The Westin San Diego Gaslamp Quarter
Downtown San Diego
Canada
Franco
$224 nightly
$260 total
Oct 25 - Oct 26
Total with taxes and fees
The Westin San Diego Gaslamp Quarter
A swimming pool with palm trees and a mountain in the background.
A modern lounge area with dark-toned seating, a central coffee table, and a stone accent wall.
A modern hotel with a prominent entrance, multiple floors, and a landscaped area with palm trees and a bridge.
A modern bar area with a long counter, multiple stools, and a variety of bottles on shelves.

19. Sycuan Casino Resort

Sycuan Casino Resort
El Cajon
United States
Sarah
$116 nightly
$127 total
Nov 17 - Nov 18
Total with taxes and fees
Sycuan Casino Resort
A lobby with a staircase, a round seating area, a wicker chair, and a large stained glass window.
A rooftop terrace with a striped awning, potted plants, and a view of the cityscape.
A spacious lobby with a central walkway, seating areas on either side, and large windows providing views of the city.
A rooftop bar with a bartender, potted plants, and a city view.

20. Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter
Downtown San Diego
United States
Rosie
$136 nightly
$158 total
Oct 25 - Oct 26
Total with taxes and fees
Palihotel San Diego Gaslamp Quarter
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Santee.
Pendry San Diego

Pendry San Diego

550 J Street San Diego CA
$342 nightly
$397 total
Nov 8 - Nov 9
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Pendry San Diego
L'Auberge Del Mar

L'Auberge Del Mar

1540 Camino Del Mar Del Mar CA
$445 nightly
$503 total
Oct 25 - Oct 26
Total with taxes and fees
8.8/10 Excellent! (886 reviews)
L'Auberge Del Mar
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

326 Broadway San Diego CA
$237 nightly
$276 total
Nov 8 - Nov 9
Total with taxes and fees
The US Grant, a Luxury Collection Hotel, San Diego
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santee

Hikers and nature lovers flock to Mission Trails Regional Park for its 60 miles of scenic trails and stunning views. Santee Lakes Recreation Preserve offers family-friendly fishing, camping, and paddle boating where you'll spot turtles sunning themselves on logs.

See all hotels in Santee
A calm river flowing through a rocky landscape with lush greenery and trees in the background.

Top Santee Hotel Reviews

Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Make sure you read the parking sign as you enter in regards to pricing. everything else was great. The room was clean. The beds were comfortable. The staff was great. We didn’t have time to eat breakfast in the morning so we were able to DoorDash Starbucks. We had a wedding to go to so we were running a little behind. Other than that, it was a great place to stay and I would stay there again."
Jacquelyn 2-night trip
Posted 1 hour ago
Sheraton San Diego Resort
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

10/10 Excellent
"It was a great stay and thank you for having friendly staff."
Stephanie M 1-night trip
Posted 10 hours ago
Hard Rock Hotel San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

10/10 Excellent
"Love the location but you get a lot of street noise and airport noise from planes taking off."
Frank 3-night trip
Posted 11 hours ago
Wyndham San Diego Bayside
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

10/10 Excellent
"Alexa at front desk was amazing. Plus the property was perfectly located for all attractions, well maintained and plenty of food options. Would definitely recommend this hotel!"
LaTonya 1-night trip
Posted 23 hours ago
Marriott Marquis San Diego Marina

Find out more about Santee

Santee Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santee, California are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santee 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santee. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santee, California, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santee hotels offer everything your heart desires.

Frequently asked questions

What are the best 4-star hotels in Santee?
Expedia travelers enjoy staying at Sycuan Casino Resort. From its handy amenities to its friendly staff, every feature of this 4-star hotel in Santee is designed to deliver an incredible vacation experience.
How much does it cost to stay in a 4-star hotel in Santee?
Expedia can help you quickly track down the perfect 4-star hotel for your vacation in Santee. Use our handy filter tool to fine-tune your search by things like amenities, budget and hotel star rating and get access to awesome deals in a few clicks.
  • Search for the lowest price from $276
What's the difference between 5-star and 4-star hotels in Santee?
Give yourself the luxury treatment during your Santee getaway by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities like complimentary bathrobes, large beds and plenty more. A 5-star hotel will go above and beyond to make your trip an even more indulgent and memorable one. 24-hour front desk, elegant furnishings and gourmet dining are only the start of the exclusive conveniences and services you'll likely get access to.

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