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Our top choices for De Soto hotels

GrandStay Hotel & Suites

GrandStay Hotel & Suites
2.5 star property
Historic Downtown La Crosse
9.0 out of 10, Wonderful, (1,058 reviews)
"Our room was clean, bed comfy and common areas were very welcoming."
United States
Abigail
7 days ago
$119 nightly
The price is $137
Apr 13 - Apr 14
Total with taxes and fees
GrandStay Hotel & Suites

Radisson Hotel La Crosse

Radisson Hotel La Crosse
3.5 star property
Historic Downtown La Crosse
8.8 out of 10, Excellent, (1,043 reviews)
"The restaurant looked very nice. The river view was extremely wonderful."
United States
Cathy
December 10th, 2025
$110 nightly
The price is $126
Apr 23 - Apr 24
Total with taxes and fees
Radisson Hotel La Crosse

The Charmant Hotel

The Charmant Hotel
4.0 star property
Historic Downtown La Crosse
9.6 out of 10, Exceptional, (1,003 reviews)
"Had a great stay. Very nice atmosphere."
United States
Daniel
2 days ago
$189 nightly
The price is $217
Apr 26 - Apr 27
Total with taxes and fees
The Charmant Hotel

Pearl Street Hotel & Suites

Pearl Street Hotel & Suites
2.5 star property
Historic Downtown La Crosse
8.0 out of 10, Very Good, (441 reviews)
"Room was clean. This location is super convenient."
United States
Kristie
15 days ago
$89 nightly
The price is $102
May 12 - May 13
Total with taxes and fees
Pearl Street Hotel & Suites

Scenic Valley Motel

Scenic Valley Motel
2.0 star property
Lansing
8.2 out of 10, Very Good, (119 reviews)
"Beds were firm. The price was great."
United States
Chrystal
$94 nightly
The price is $105
Apr 24 - Apr 25
Total with taxes and fees
Scenic Valley Motel

AmericInn by Wyndham La Crosse Riverfront-Conference Center

AmericInn by Wyndham La Crosse Riverfront-Conference Center
2.5 star property
Northside
7.6 out of 10, Good, (1,003 reviews)
"Great pool area, lots of fun for the kids."
United States
Mark
17 days ago
$88 nightly
The price is $102
Apr 13 - Apr 14
Total with taxes and fees
AmericInn by Wyndham La Crosse Riverfront-Conference Center

Country Inn & Suites by Radisson, La Crosse, WI

Country Inn & Suites by Radisson, La Crosse, WI
2.5 star property
Northside
8.8 out of 10, Excellent, (1,007 reviews)
"Property are very clean. Breakfast is great. Patio are an extra perk."
United States
Michelle
7 days ago
$80 nightly
The price is $92
Apr 14 - Apr 15
Total with taxes and fees
Country Inn & Suites by Radisson, La Crosse, WI

Gundersen Hotel & Suites

Gundersen Hotel & Suites
2.5 star property
Powell-Poage-Hamilton
9.4 out of 10, Exceptional, (1,001 reviews)
"Hotel was clean, well appointed and staff was very helpful."
United States
Michael
18 days ago
$153 nightly
The price is $176
May 8 - May 9
Total with taxes and fees
Gundersen Hotel & Suites

Waterfront Hotel

Waterfront Hotel
3.0 star property
Prairie Du Chien
9.2 out of 10, Wonderful, (909 reviews)
"The hotel is very charming inside from the chocolate chip cookies."
United States
Darla
1 day ago
$116 nightly
The price is $129
Apr 19 - Apr 20
Total with taxes and fees
Waterfront Hotel

Hampton Inn & Suites La Crosse Downtown

Hampton Inn & Suites La Crosse Downtown
2.5 star property
Historic Downtown La Crosse
9.6 out of 10, Exceptional, (1,004 reviews)
"Very clean establishment. Staff was top notch. Room was amazing."
United States
Christine
21 days ago
$99 nightly
The price is $114
Apr 19 - Apr 20
Total with taxes and fees
Hampton Inn & Suites La Crosse Downtown

Courtyard by Marriott La Crosse

Courtyard by Marriott La Crosse
3.0 star property
Historic Downtown La Crosse
9.0 out of 10, Wonderful, (565 reviews)
"Enjoyed the patio right on the river."
United States
Ashley
19 days ago
$110 nightly
The price is $126
Apr 19 - Apr 20
Total with taxes and fees
Courtyard by Marriott La Crosse

Country Inn & Suites by Radisson, Prairie du Chien

Country Inn & Suites by Radisson, Prairie du Chien
3.0 star property
Prairie Du Chien
8.4 out of 10, Very Good, (1,003 reviews)
"Clean rooms Staff was awesome Big slide only open."
United States
Joseph
10 days ago
$90 nightly
The price is $100
May 3 - May 4
Total with taxes and fees
Country Inn & Suites by Radisson, Prairie du Chien

Super 8 by Wyndham La Crosse

Super 8 by Wyndham La Crosse
2.5 star property
Northside
8.0 out of 10, Very Good, (1,004 reviews)
"Rooms are always clean, great staff, quiet, and mostly reasonably priced."
United States
Corey
9 days ago
$65 nightly
The price is $75
Apr 19 - Apr 20
Total with taxes and fees
Super 8 by Wyndham La Crosse

Boarders Inn & Suites by Cobblestone Hotels – Waukon

Boarders Inn & Suites by Cobblestone Hotels – Waukon
3.5 star property
Waukon
8.0 out of 10, Very Good, (458 reviews)
"The room was very clean. It was typical of a hotel breakfast."
United States
Richard
October 21st, 2025
$72 nightly
The price is $81
Apr 19 - Apr 20
Total with taxes and fees
Boarders Inn & Suites by Cobblestone Hotels – Waukon

AmericInn by Wyndham Prairie du Chien

AmericInn by Wyndham Prairie du Chien
2.0 star property
Prairie Du Chien
8.0 out of 10, Very Good, (603 reviews)
"The staff were very friendly. Had a wonderful waffle. We would stay again."
United States
Jenny
4 days ago
$65 nightly
The price is $72
Apr 29 - Apr 30
Total with taxes and fees
AmericInn by Wyndham Prairie du Chien

Home2 Suites by Hilton La Crosse

Home2 Suites by Hilton La Crosse
3.0 star property
Historic Downtown La Crosse
9.4 out of 10, Exceptional, (861 reviews)
"It is an amazing hotel and very clean. Everything was amazing."
United States
Cindy
6 days ago
$99 nightly
The price is $114
May 3 - May 4
Total with taxes and fees
Home2 Suites by Hilton La Crosse

Spark by Hilton La Crosse Onalaska

Spark by Hilton La Crosse Onalaska
2.5 star property
Onalaska
8.6 out of 10, Excellent, (128 reviews)
"Very impressed with this hotel."
United States
Damian
7 days ago
$74 nightly
The price is $85
Apr 26 - Apr 27
Total with taxes and fees
Spark by Hilton La Crosse Onalaska

Best Western Plus LaCrescent / LaCrosse

Best Western Plus LaCrescent / LaCrosse
2.5 star property
La Crescent
9.2 out of 10, Wonderful, (535 reviews)
"Everyone was nice, a great dog friendly place."
United States
Courtney
5 days ago
$101 nightly
The price is $113
Apr 19 - Apr 20
Total with taxes and fees
Best Western Plus LaCrescent / LaCrosse

Fairfield Inn & Suites by Marriott La Crosse Downtown

Fairfield Inn & Suites by Marriott La Crosse Downtown
3.0 star property
Historic Downtown La Crosse
9.2 out of 10, Wonderful, (820 reviews)
"Great location to concert venue, shopping and food."
United States
Brooke
21 days ago
$107 nightly
The price is $123
Apr 26 - Apr 27
Total with taxes and fees
Fairfield Inn & Suites by Marriott La Crosse Downtown

Quality Inn La Crosse North

Quality Inn La Crosse North
2.5 star property
Northside
7.8 out of 10, Good, (1,001 reviews)
"This place was a great value."
United States
Bart
October 16th, 2025
$63 nightly
The price is $72
Apr 19 - Apr 20
Total with taxes and fees
Quality Inn La Crosse North
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Where to stay in and around De Soto

Nestled in scenic Wisconsin, De Soto offers outdoor adventures and a welcoming atmosphere reminiscent of Florida. Explore nearby hot springs for relaxation, or embark on hiking trails that reveal stunning landscapes. Experience family-friendly activities and immerse yourself in the area's rich culture.

Lansing

Discover Lansing, a charming getaway perfect for families and nature enthusiasts looking for adventure. With its stunning outdoor scenery, visitors can explore the nearby French Creek Wildlife Management Area and enjoy various hiking trails. The picturesque lake and river provide a serene backdrop for relaxation. Located about 4 miles by car from De Soto, Lansing offers easy access to its attractions, making it a smart choice for your next vacation.

Ferryville

If you are a family or nature enthusiast, look no further than Ferryville, which features stunning outdoor scenery and adventure opportunities. The area offers easy access to beautiful spots like Big Lake and local landmarks such as the Immaculate Conception - Wexford Church and Black Hawk Bridge, perfect for exploration. With Ferryville located about 7 miles by car from De Soto, it makes for a seamless travel experience. Choosing Ferryville for your stay ensures a memorable getaway immersed in nature.

New Albin

Immerse yourself in New Albin, where outdoor enthusiasts can easily access stunning natural attractions and family-friendly activities. This charming city offers a perfect blend of adventure and relaxation, with highlights like Big Lake for fishing fun, the serene Romance Prairie State Natural Area for hiking, and the Lansing Wildlife Management Area for nature exploration. Located about 17 miles by car from De Soto, New Albin makes an excellent choice for a weekend getaway, ensuring memorable experiences for all visitors.

Retreat

Experience the charm of Retreat, a delightful hub for families and nature enthusiasts eager to explore the beauty of De Soto. With attractions like Big Lake for serene waterfront activities, the picturesque Romance Prairie State Natural Area for outdoor adventures, and the tranquil Romance Woods for peaceful strolls, there’s something for everyone. Nestled in De Soto, Retreat offers easy access to these local gems, making it a smart choice for your next getaway.

Eagle Mountain

Travelers seeking a family-friendly getaway will find Eagle Mountain to be the ideal base for their vacation, featuring stunning natural scenery and outdoor activities. Nestled about 10 miles by car from De Soto, this charming neighborhood offers access to a recreational area, golf course, and nearby attractions like Big Lake and the Black Hawk Bridge. With visitor numbers peaking in July and September to October, Eagle Mountain is a smart choice for those looking to immerse themselves in Wisconsin's beautiful landscapes.

Stay near popular attractions around De Soto

Discover the charm of De Soto, where outdoor adventures and stunning scenery await. Explore local parks, relax by the lake, and indulge in family-friendly activities. Whether you're seeking romance or adventure, De Soto offers an unforgettable experience for every traveler.

Learn more about De Soto

Perched along the Mississippi River, De Soto offers scenic overlooks where bald eagles soar above the water during migration seasons. Explore the nearby Blackhawk Park for fishing and camping, or time your visit for the annual Labor Day celebration with its small-town parade and festivities.

 Hernando de Soto Bridge - Memphis Tennessee at night

Top De Soto Hotel Reviews

More cheap stays in De Soto

Hotels in De Soto with star-rating

Find out more about De Soto

Top reasons to visit De Soto

  • Outdoor Adventure: De Soto is perfect for outdoor enthusiasts, offering hiking trails and beautiful landscapes for exploration.
  • Fishing Opportunities: Enjoy fantastic fishing experiences with local species available in the area's waters.
  • Scenic Drives: Drive along the Wisconsin Great River Road for breathtaking views of the region's natural beauty.
  • Bluff Country Exploration: Discover the enchanting Bluff Country, ideal for hiking and outdoor activities.
  • Charming Accommodations: Choose from a variety of unique hotels, including pet-friendly and agritourism options.

Find great hotels near De Soto

Explore a variety of hotel accommodations in De Soto, Wisconsin, catering to adventurous travelers and those seeking a unique historic-themed experience. Whether you prefer pet-friendly options or agritourism properties, De Soto offers a range of choices to suit your needs. Discover the best hotels and enjoy a memorable stay in this charming area.

  • AmericInn by Wyndham Viroqua: AmericInn by Wyndham Viroqua is a budget-friendly hotel offering a comfortable stay with a guest rating of 8.2 out of 10. Located 19 miles from De Soto, this property is perfect for business travelers seeking convenience. Guests appreciate the modern amenities, including complimentary breakfast, an indoor pool, and a well-equipped business center. The welcoming atmosphere and attentive staff make it a reliable choice for those looking for a practical stay with essential comforts.
  • Boarders Inn & Suites by Cobblestone Hotels – Waukon: With a guest rating of 8.0 out of 10, Boarders Inn & Suites by Cobblestone Hotels – Waukon is a 3.5-star hotel situated 18 miles from De Soto. Ideal for business travelers, this hotel combines comfort and functionality. Guests enjoy spacious rooms equipped with microwaves and refrigerators, a complimentary breakfast, and a fitness center to maintain their routine. The inviting lobby and friendly staff create an atmosphere that enhances both relaxation and productivity during your stay.
  • Driftless Escape – Secluded Luxury Lodge on Stream with Hot Tub: Driftless Escape is a hidden gem located just 6 miles from De Soto, boasting an impressive guest rating of 9.6 out of 10. This lodge is designed for adventure enthusiasts and pet owners, offering a unique blend of luxury and nature. Guests can indulge in outdoor activities such as hiking, fishing, and swimming, while the hot tub provides a perfect way to unwind after a day of exploration. With a pet-friendly policy and a serene riverside setting, this lodge is ideal for those looking to connect with nature and enjoy a tranquil getaway.

Where to stay in and around De Soto

De Soto, Wisconsin, is a haven for outdoor enthusiasts and families alike, offering stunning views and friendly local charm. Explore the scenic Wisconsin Great River Road, where breathtaking landscapes await. Discover the enchanting Bluff Country, perfect for hiking and adventure. Enjoy the rich history and welcoming atmosphere of the De Soto area, making your vacation both memorable and enriching. Whether you're seeking adventure or relaxation, De Soto has something for everyone.

  • Lansing: Located a mere 4 miles from De Soto, Lansing is a charming city that attracts visitors year-round, with peak travel times in June to July and September. Known for its outdoor adventures and stunning scenery, Lansing offers a host of recreational activities, including hiking trails and access to beautiful lakes and rivers. The nearby national state park provides a perfect backdrop for outdoor enthusiasts looking to immerse themselves in nature. Whether you’re seeking a peaceful retreat or an adrenaline-filled adventure, Lansing has something for everyone.
  • Retreat: Nestled within the area of De Soto, Retreat is a quaint village that welcomes travelers at any time of the year. With peak visitor numbers in July to August and October, Retreat is an ideal spot for those seeking a romantic getaway or family-friendly entertainment. The village features educational and recreational areas, including playgrounds perfect for kids. Visitors can enjoy picturesque lakes and a community-focused event conference venue, making it a great choice for both relaxation and social gatherings.
  • Ferryville: Just 7 miles away from De Soto, Ferryville is a delightful city that draws visitors with its natural beauty and adventure opportunities. The travel experience here is rich with outdoor activities, particularly during the summer months of June to July and in September. With access to hiking trails and recreational areas, Ferryville is perfect for those who love to explore the great outdoors. The proximity to rivers and lakes, along with the nearby national state park, ensures that every visit is filled with scenic views and memorable experiences.

Things to do in De Soto

De Soto, Wisconsin, is perfect for outdoor enthusiasts seeking adventure and stunning scenery. Visitors can explore a variety of recreational areas, enjoy hiking trails, and access beautiful landscapes. Fishing is also a highlight, offering fantastic opportunities to catch local species. Whether you're looking to hike, fish, or simply enjoy nature, De Soto has something for everyone to experience and enjoy.

Shopping

In De Soto, you'll find charming local shops offering unique gifts and souvenirs. If you're up for a drive, check out the nearby Prairie du Chien Shopping Center for more variety, including big-name retailers and local boutiques to enhance your shopping experience.

Recreation

In De Soto, the Driftless Wellness Retreat provides rejuvenating yoga sessions and holistic spa treatments amidst serene surroundings. Explore the scenic landscapes while hiking or biking along the Mississippi River, and enjoy peaceful moments by the water, making it an ideal destination for relaxation and self-care.

Adventure

Explore the scenic beauty of the Mississippi River on a kayaking adventure, offering stunning views and a chance to spot local wildlife. For hiking enthusiasts, the nearby Kickapoo Valley Reserve has trails that meander through lush landscapes, providing a perfect opportunity for outdoor exploration and photography.

Nightlife

In De Soto, the nightlife is laid-back yet inviting, with local bars like The River View Tavern offering live music and friendly atmospheres. For a more casual vibe, enjoy drinks at the nearby Riverside Restaurant, where you can unwind and savor the scenic views of the Mississippi River.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for De Soto

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in De Soto are November to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in De Soto is Monday. The most expensive day to stay in De Soto is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and eco-friendly hotels currently available. To find the best prices and deals, sort the price filter from low to high.
  • Consider bundling your trip: You can save money by combining your De Soto hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near De Soto

De Soto, Wisconsin, is a great destination for outdoor enthusiasts and families seeking adventure and scenic beauty. With popular attractions like parks and urban spaces, visitors can immerse themselves in nature while enjoying cultural experiences. Whether you're looking to relax in a park or explore local libraries, there's something for everyone in and around De Soto.

  • Immaculate Conception - Wexford Church: Located 11 miles from De Soto, this charming church offers a serene atmosphere steeped in culture. Its beautiful architecture and peaceful surroundings make it a perfect spot for reflection and appreciation of local history.
  • Big Lake: Just 2 miles away, Big Lake is a picturesque destination for outdoor lovers. Whether you're looking to relax on the beach, enjoy a romantic sunset, or take in the stunning scenery, this lake has something for everyone.
  • Romance Woods: Situated 11 miles from De Soto, Romance Woods is perfect for adventure seekers. Explore its lush trails and immerse yourself in nature, making it an ideal spot for hiking and discovering the beauty of the forest.

Best time to go to De Soto

The best time to visit De Soto can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in De Soto falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature in De Soto falls in January, visitor numbers are slightly low and weather is mostly cloudy with no rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January17.4°F (-8.1°C)No RainMostly CloudySlightly LowSlightly Low
February19.8°F (-6.8°C)No RainMostly CloudyAverageAverage
March34.5°F (1.4°C)Light RainMostly CloudyAverageAverage
April45.5°F (7.5°C)Light RainMostly CloudySlightly HighAverage
May57.9°F (14.4°C)Light RainMostly SunnySlightly HighSlightly High
June68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
July72.0°F (22.2°C)Light RainMostly SunnySlightly HighAverage
August70.3°F (21.3°C)Light RainMostly SunnyAverageAverage
September63.3°F (17.4°C)Light RainMostly SunnyAverageSlightly High
October49.6°F (9.8°C)Light RainMostly SunnyAverageSlightly High
November36.7°F (2.6°C)Light RainMostly SunnySlightly LowSlightly Low
December25.0°F (-3.9°C)Light RainMostly CloudySlightly LowSlightly Low

The nearest major airports for your trip to De Soto

When planning your trip to De Soto, Wisconsin, you can consider three major airports. La Crosse Municipal Airport (LSE) is the closest, located 31 miles away. Good hotel options nearby include The Charmant Hotel and Radisson Hotel La Crosse, both about 4 miles from the airport, with 24-hour shuttle services available. Rochester International Airport (RST) is 73 miles away, with hotels like The Towers At Kahler Grand Hotel and EVEN Hotel Rochester, both 8 miles from the airport. Finally, Dane County Regional Airport (MSN) is 95 miles away, featuring hotels like The Edgewater and DoubleTree by Hilton Madison East, both conveniently accessible with various transportation services.

Frequently asked questions

What is the best area to stay in De Soto?
The best area to stay in De Soto is directly within the village center, particularly along or near Main Street.

This area serves as the heart of De Soto, offering convenient access to local businesses and the Mississippi River. Main Street, also known as Wisconsin Highway 35, runs through the village and provides easy navigation. While De Soto is a small community, staying in the village center means you're close to everything it has to offer.

Families looking for a laid-back experience will find this area suitable. The proximity to the Mississippi River provides opportunities for outdoor activities like fishing or enjoying the river views.
What are the most romantic hotels in De Soto for couples?
For a romantic getaway in De Soto, consider The River View Lodge Sun Set Views over Looking Mississippi River Romantic.

This highly-rated lodge boasts a superb 10.0 review score and offers several features ideal for couples. Guests can enjoy private outdoor spaces such as a deck, patio, porch, or balcony, some of which provide beautiful sunset views over the Mississippi River. The lodge also includes a kitchen, a hot tub, and a fireplace, creating a cozy and intimate atmosphere for a special stay.
What are the best hotels in De Soto near Mississippi River?
For hotels in De Soto near the Mississippi River, The River View Lodge Sun Set Views over Looking Mississippi River Romanticis a good option.

This lodge, with a superb 10.0 rating, offers a relaxed stay with amenities such as a kitchen, a deck or patio, a porch or lanai, and a balcony, all of which provide opportunities to enjoy the views. It is located 267.3 miles from the Mississippi River.
When is the best time to go to De Soto?
The best time to visit De Soto is during the summer and fall months, from June through October, when the weather is most pleasant for outdoor activities.

Summer in De Soto offers warm temperatures ideal for exploring the Mississippi River and surrounding bluffs. This is a great time for families to enjoy fishing, boating, or picnicking in the local parks along the riverfront. The longer daylight hours also allow for more time to discover the area's natural beauty.

Fall brings cooler temperatures and the vibrant colors of autumn foliage, making it a particularly scenic time for couples. Driving along the Great River Road offers picturesque views, and local orchards often open for apple picking.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in De Soto.
How can I save on a De Soto hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible De Soto hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a De Soto hotel?
Prices for hotels in De Soto often vary, but you can find a great deal from $67 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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