Top 10 Hotels in Santa Cruz (from $21) 2026 - Competitive Prices

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Our top choices for Santa Cruz hotels

A buffet with various fruits, vegetables, and beverages.

A modern outdoor seating area with a mix of tables and sofas, surrounded by lush green plants and a metal fence.

A person using a laptop in a hotel room with a bed, a chair, and a small table.

1. ibis Medellin

El Poblado

Yuliana

$55 nightly

$55 total

Oct 18 - Oct 19

A swimming pool with tiled edges, surrounded by lounge chairs and palm trees.

A spacious indoor venue with high ceilings and natural light, featuring wooden tables and chairs, and various floral arrangements.

A bedroom with a wooden ceiling, a brick wall, a bed with pillows, a nightstand, and a chair.

A traditional wooden building with a sloped roof and a balcony.

2. Autenthico Sajonia Hotel Aeropuerto

Rionegro

Mabel Angela Frias

$29 nightly

$29 total

Oct 26 - Oct 27

A rooftop pool area with a breakfast setup, including plates, cups, and juice.

A multi-story building with a brick facade, surrounded by lush greenery and other high-rise buildings.

A hotel lobby with a reception desk, a large potted plant, a check-in counter, and a seating area.

An outdoor patio area with tables and chairs, a large canopy, and a brick wall.

3. Hotel Dann Carlton Belfort Medellin

El Poblado

Christian Alvarez

$85 nightly

$85 total

Nov 16 - Nov 17

A bedroom with a large bed, a chair, and a view through a glass door.

A garden pathway with various plants and a palm tree.

A modern bedroom with a large bed, wooden headboard, bedside tables, and a view of greenery through a window.

A modern glass structure with a roof, surrounded by a well-maintained lawn and trees.

4. Isak Hotel & Golf Airport

Rionegro

Juwan

$80 nightly

$80 total

Oct 23 - Oct 24

A hotel room with two beds, a TV, a balcony with a city view, and artwork on the walls.

A multi-story building with a modern architectural design, featuring large windows and a brick facade.

A hotel room with a bed, a small table with chairs, a coffee maker, and a view of the city through the window.

5. Urbit Social Lofts

Laureles

Marloane

$49 nightly

$49 total

Nov 17 - Nov 18

A modern building entrance with glass doors, a wooden ceiling, and potted plants.

An indoor seating area with tables and chairs, a large sign reading 'PERGAMINO,' and a wooden wall design.

A modern hotel room with a large bed, bedside tables, a bench, a potted plant, and a sliding door closet.

A gym with wooden floors, weight racks, and exercise equipment.

6. The Cut Hotel

El Poblado

Arturo

$50 nightly

$50 total

Oct 19 - Oct 20

A modern bar with a long counter, shelves with decorative items, and a coffee machine.

A modern hotel lobby with a reception desk, seating area, and large windows.

A restaurant with multiple tables and chairs, large windows offering a view of mountains and cityscape, and indoor plants.

A city view from a high-rise room with a chair and a table.

7. Novotel Medellín El Tesoro

El Poblado

Haydee

$146 nightly

$146 total

Nov 7 - Nov 8

A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.

A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.

A spacious indoor dining area with multiple tables and chairs, large windows offering city views, and visible air ducts on the ceiling.

A bar area with a green wall, bar stools, and a counter with a bartender.

8. Hotel Dorado La 70

Laureles

Gregson

$91 nightly

$91 total

Oct 19 - Oct 20

An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.

A modern living area with a sofa, ottomans, and a dining area with chairs and a table.

A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.

A modern kitchen with a central island, bar stools, and a hanging plant.

9. Fairfield by Marriott Medellin Sabaneta

Sabaneta

Michael

$81 nightly

$81 total

Nov 1 - Nov 2

A modern lounge area with a blue sofa, pendant lights, a refrigerator stocked with snacks, and a chalkboard wall with food illustrations.

A modern interior with a blue sofa, a hanging chair, a vending machine, and a refrigerator stocked with beverages.

A brick building with a sign reading "ibis budget."

A modern reception area with a black counter, a digital display, and a wall decorated with food and drink illustrations.

10. ibis budget Medellín Itagüí Metro

Itagüí

Jose

$37 nightly

$37 total

Oct 24 - Oct 25

A hotel sign with a sun emblem, a modern glass building, and flags.

A rooftop terrace with lounge chairs and a large umbrella, overlooking a cityscape at dusk.

A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.

A modern lobby with green sofas, a white coffee table, and a large potted plant.

11. La Quinta by Wyndham Medellin

San Diego

Domingo

$84 nightly

$84 total

Oct 30 - Oct 31

A reflective pool with a cityscape and mountains in the background.

A modern bedroom with a large bed, a bench, and a brick wall.

A library with bookshelves, a ladder, a round table, and a potted plant.

A modern lounge area with a sofa, chairs, and a coffee table.

12. Los Patios Cool Living

Laureles

Emilio

$65 nightly

$65 total

Oct 21 - Oct 22

A tall building with a modern design, featuring large windows and a sign that reads "SPRING SELECT EST 2025".

A woman standing by a spa tub with a window and plants in the background.

A rooftop terrace with potted plants, a tiled floor, and a cityscape view in the background.

A bar area with shelves of wine bottles and glasses, decorated with green foliage.

13. Hotel Ryo 74B Suites by Growing Group

Laureles

Neil

$40 nightly

$40 total

Oct 26 - Oct 27

A swimming pool with lounge chairs and umbrellas, surrounded by modern buildings.

A hotel lobby with a reception desk, a chandelier, a piano, and a large mirror.

A hotel room with a large bed, bedside lamps, a desk with a computer, and a view of the city at night.

A modern dining area with a glass-top table, surrounded by chairs, and a chandelier.

14. Hotel San Fernando Plaza

El Poblado

Julio

$78 nightly

$78 total

Oct 18 - Oct 19

A modern bedroom with a large bed, a small table, and a chair.

A reception area with a modern design, featuring a white reception desk, a white sofa, and a mural of tropical plants.

A modern hotel room with a large bed, a desk with chairs, a TV, and a view of the outdoors.

A modern kitchen with a built-in island, wooden cabinets, and a bar stool.

15. Firenze Lofts

La América

Ricky

$54 nightly

$54 total

Oct 18 - Oct 19

A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a tray with breakfast items.

A modern reception area with a wooden reception desk, large potted plants, and a view of the outdoors through large windows.

A dining table with a plate of food, wine glasses, and a bottle of wine.

A spacious living area with a leather sofa, a coffee table, and a large window with curtains.

16. Hotel Lagoon

Rionegro

Vanessa

$122 nightly

$122 total

Oct 22 - Oct 23

A modern reception area with a glass door entrance, a reception desk, and seating arrangements.

A gym with exercise equipment, a punching bag, and a view of the city through large windows.

A modern interior with multiple ceiling lights, large windows, and a visible air conditioning unit.

A modern living room with a round wooden coffee table, white chairs, a sofa, and a potted plant.

17. Arame Hotel

Envigado

David

$77 nightly

$77 total

Nov 17 - Nov 18

A modern bedroom with a large bed, bedside table, and a view of trees through a window.

A spa area with a hot tub, seating, and plants.

A modern living space with a central island, a dining area, and a kitchen.

18. Soy Local Reserva Sajonia

Rionegro

Antonio

$68 nightly

$68 total

Oct 20 - Oct 21

A building with a bar area, outdoor seating, and a visible name 'LUSSAC'.

A modern hotel room with a large bed, a bedside table with a lamp, a glass-enclosed balcony, and a bathtub.

A hallway with wooden paneling, a chair, and a polished marble floor.

A buffet with various food items and utensils.

19. Hotel Park 10

El Poblado

David

$106 nightly

$106 total

Nov 3 - Nov 4

A modern interior with a wooden ceiling, a reception desk, and a display of baked goods.

A modern hotel room with a large bed, a sitting area with a table and chairs, a large window with a view of buildings, and a hot tub.

A modern hotel room with a large bed, a sitting area with a table and chairs, a bathtub, and a balcony with a view of the city.

20. Eutopiq Hotel

Laureles

Ramiro

$78 nightly

$78 total

Nov 15 - Nov 16

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Top Santa Cruz Hotel Reviews

Hotel Provenza Garden

10/10 Excellent

"The location of the hotel is right in the middle of all of the disco and bars and restaurants. Most of the businesses close at 2 AM, but a few are open until 4 AM. Also, off of the main strip, that no cars allowed to be on, the city is extremely lively as well."

Hotel Dorado La 70

10/10 Excellent

"Todo en orden. Excelente servicio al cliente. Se debe mejorar el desayuno con mas variedad. Y se le debe orientar al huesped cuando le entregan el cuarto a verificar los suministros de la nevera antes de firmar. Por todo lo demas excelente!!!! 10 de 10!!!"

Moa Select

8/10 Good

"Best shower I have ever had! Rooms small but clean and tidy. No free water this had to be paid for. Breakfast had 4 options but small portions such as one rasher of bacon. Location was too far away for hotel trip pick ups. We always had to catch a taxi. Friendly and helpful staff."

Marquee Hotel

10/10 Excellent

"I loved the hotel and its location! Walking around the city was very pleasant. Hotel gives earplugs to minimize streets noise and worked very well. . Breakfast was good, the lunch and dinner seams like frozen food and I didn’t like them. Outside of hotel has better quality food. I want to go back to Medellin soon. Beautiful city"

Novotel Medellín El Tesoro

10/10 Excellent

"Per previous rating; customer service was excellent; the staff met my various request promptly; the service transportation that was used and the personnel they used was professional and excelled my expectations at all time, as well as the hotel . I will recommend Novotel to all my friends . As always Thank you to the Novotel Team! Until next time ."

La Quinta by Wyndham Medellin

10/10 Excellent

"Muy buena experiencia."

Calle Flora Hotel by Jalo

10/10 Excellent

"The staff was nice and very helpful when asked for recommendations. Definitely will be staying here again."

The Click Clack Hotel Medellin

10/10 Excellent

"Muy bonito hotel , moderno"

Dann Carlton Medellin Hotel

10/10 Excellent

"Staff was very friendly and professional. Continental breakfast which is included in our stay was excellent."

More cheap stays in Santa Cruz

Hotel Casa Malibú

Calle 32F 66 c 57 Medellín Medellin

$21 nightly

$21 total

Oct 26 - Oct 27

4.8/10 (3 reviews)

Hostal Lleras Calle 8 - Hostel

Calle 8 # 37A - 59 Medellín Antioquia

$28 nightly

$28 total

Oct 18 - Oct 19

8.4/10 Very Good! (165 reviews)

Hotel Ofix - Laureles

79-86 Calle 44 Medellín

$29 nightly

$29 total

Nov 16 - Nov 17

Autenthico Sajonia Hotel Aeropuerto

Aeropuerto Jose Maria Cordova, Km 20 Rionegro Antioquia

$29 nightly

$29 total

Oct 26 - Oct 27

Nakúa Stay + Work

8A-29 Cra. 34 Medellín Antioquia

$59 nightly

$59 total

Nov 17 - Nov 18

Masaya Medellin

43a1 Cl. 8 Medellín Antioquia

$77 nightly

$77 total

Oct 20 - Oct 21

Frequently asked questions

What is the best area to stay in Santa Cruz?

The best area to stay in Santa Cruz is the El Poblado district, particularly around Parque Lleras and the Golden Mile, as it offers a blend of upscale accommodations, dining, and entertainment options.El Poblado is known for its tree-lined streets, modern high-rises, and a wide selection of restaurants and cafes. Parque Lleras is a central square within El Poblado where many of the area's social activities are centered, while the Golden Mile (Milla de Oro) is a stretch of avenue known for its luxury hotels, shopping centers, and corporate offices. This area provides easy access to public transportation and is well-maintained.Couples often find El Poblado ideal due to its sophisticated dining experiences and lively evening scene. There are numerous restaurants offering various cuisines, from traditional Colombian to international dishes, and many establishments provide a pleasant ambiance for an evening out. The area's walkability also makes it convenient for exploring on foot.For travelers seeking a convenient base with high-quality amenities, El Poblado's Golden Mile is an excellent choice. Many hotels in this section offer modern facilities, including well-equipped fitness centers and business services.

When is the best time to go to Santa Cruz?

The best time to go to Santa Cruz, Antioquia, Colombia, is during the dry season, which runs from December to February and again from June to August. These months offer the most pleasant weather for exploring the region.During the dry season, you can expect less rainfall and more sunshine, making it ideal for outdoor activities like hiking, coffee farm tours, or simply enjoying the town's central plaza. The comfortable temperatures during these periods are particularly appealing for couples looking for a relaxed and scenic getaway.Travelers seeking a vibrant cultural experience might also consider visiting during local festivals, which often occur outside the dry season.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.

How much is the nightly rate at a Santa Cruz hotel?

Prices for hotels in Santa Cruz often vary, but you can find a great deal from $21 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Find hotels in Santa Cruz from $21

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Santa Cruz

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Cruz hotels

1. ibis Medellin

2. Autenthico Sajonia Hotel Aeropuerto

3. Hotel Dann Carlton Belfort Medellin

4. Isak Hotel & Golf Airport

5. Urbit Social Lofts

6. The Cut Hotel

7. Novotel Medellín El Tesoro

8. Hotel Dorado La 70

9. Fairfield by Marriott Medellin Sabaneta

10. ibis budget Medellín Itagüí Metro

11. La Quinta by Wyndham Medellin

12. Los Patios Cool Living

13. Hotel Ryo 74B Suites by Growing Group

14. Hotel San Fernando Plaza

15. Firenze Lofts

16. Hotel Lagoon

17. Arame Hotel

18. Soy Local Reserva Sajonia

19. Hotel Park 10

20. Eutopiq Hotel

Top Santa Cruz Hotel Reviews

Hotel Provenza Garden

Hotel Dorado La 70

Moa Select

Marquee Hotel

Novotel Medellín El Tesoro

La Quinta by Wyndham Medellin

Calle Flora Hotel by Jalo

The Click Clack Hotel Medellin

Dann Carlton Medellin Hotel

More cheap stays in Santa Cruz

Hotel Casa Malibú

Hostal Lleras Calle 8 - Hostel

Hotel Ofix - Laureles

Autenthico Sajonia Hotel Aeropuerto

Nakúa Stay + Work

Masaya Medellin

Frequently asked questions

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