Top 10 Hotels in Santa Cruz (from $21) 2026 - Competitive Prices

Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Learn about One Key
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Cruz

Pet friendly

Villa

Apartment

Apart hotel

Spa

Condo

Hot tub

Pool

Chalet

Cottage

Family friendly

Cabin

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Cruz hotels

A buffet with various fruits, vegetables, and beverages.

A bar area with a curved counter, shelves with bottles, and hanging wine glasses.

A person using a laptop in a hotel room with a bed, a chair, and a small table.

1. ibis Medellin

El Poblado

Yuliana

$55 nightly

$55 total

Nov 1 - Nov 2

A bedroom with a large bed, a chair, and a view through a glass door.

A garden pathway with various plants and a palm tree.

A modern bedroom with a large bed, wooden headboard, bedside tables, and a view of greenery through a window.

2. Isak Hotel & Golf Airport

Rionegro

Cristina

$75 nightly

$75 total

Oct 14 - Oct 15

A swimming pool with tiled edges, surrounded by lounge chairs and palm trees.

A traditional wooden building with a sloped roof and a balcony.

A spacious indoor venue with high ceilings and natural light, featuring wooden tables and chairs, and various floral arrangements.

A cobblestone path leading to a house with a tiled roof, surrounded by lush greenery and vibrant pink bougainvillea flowers.

3. Autenthico Sajonia Hotel Aeropuerto

Rionegro

Mabel Angela Frias

$37 nightly

$37 total

Oct 19 - Oct 20

A modern hotel room with a large bed, bedside table with a lamp, a desk with a chair, and a potted plant.

A reception area with a wooden slatted wall, a marble reception desk, and a ceiling with exposed beams and lighting.

A building facade with a large 'nnoa' sign, a window with plants, and a metal utility box on the ground.

A spacious dining area with wooden tables and chairs, surrounded by shelves with plants.

4. Moa Select

Laureles

$54 nightly

$54 total

Nov 12 - Nov 13

A modern lounge area with a blue sofa, pendant lights, a refrigerator stocked with snacks, and a chalkboard wall with food illustrations.

A modern reception area with a black counter, a digital display, and a wall decorated with food and drink illustrations.

A modern lobby with glass walls, a tiled floor, and a potted plant.

A brick building with a sign reading "ibis budget."

5. ibis budget Medellín Itagüí Metro

Itagüí

Jose

$45 nightly

$45 total

Oct 30 - Oct 31

A hotel sign with a sun emblem, a modern glass building, and flags.

A modern lobby with green sofas, a white coffee table, and a large potted plant.

A modern hotel lobby with a reception desk, seating area, and a view of the outdoors.

A rooftop terrace with lounge chairs and a large umbrella, overlooking a cityscape at dusk.

6. La Quinta by Wyndham Medellin

San Diego

Domingo

$93 nightly

$93 total

Oct 16 - Oct 17

An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.

A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.

A modern hotel entrance with a prominent sign reading "Fairfield by Marriott" and a staircase leading to the lobby.

A modern kitchen with a central island, bar stools, and a hanging plant.

7. Fairfield by Marriott Medellin Sabaneta

Sabaneta

Michael

$81 nightly

$81 total

Nov 1 - Nov 2

A rooftop pool area with a breakfast setup, including plates, cups, and juice.

An outdoor patio area with tables and chairs, a large canopy, and a brick wall.

A multi-story building with a brick facade, surrounded by lush greenery and other high-rise buildings.

A modern hotel room with a large bed, bedside tables, a sofa, and a view of the city through the window.

8. Hotel Dann Carlton Belfort Medellin

El Poblado

Christian Alvarez

$88 nightly

$88 total

Oct 18 - Oct 19

A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.

A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.

A bar area with a green wall, bar stools, and a counter with a bartender.

A spacious indoor dining area with multiple tables and chairs, large windows offering city views, and visible air ducts on the ceiling.

9. Hotel Dorado La 70

Laureles

Gregson

$83 nightly

$83 total

Nov 13 - Nov 14

A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a tray with breakfast items.

A modern reception area with a wooden reception desk, large potted plants, and a view of the outdoors through large windows.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a modern building.

A spacious living area with a leather sofa, a coffee table, and a large window with curtains.

10. Hotel Lagoon

Rionegro

Isabela

$99 nightly

$99 total

Oct 15 - Oct 16

A modern bar with a long counter, shelves with decorative items, and a coffee machine.

A city view from a high-rise room with a chair and a table.

A modern hotel lobby with a reception desk, seating area, and large windows.

A swimming pool with a glass barrier, surrounded by high-rise buildings and greenery.

11. Novotel Medellín El Tesoro

El Poblado

Oscar

$139 nightly

$139 total

Nov 6 - Nov 7

A modern building entrance with glass doors, a wooden ceiling, and potted plants.

A building with a wooden lattice facade and a sign reading 'PERGAMINO.'

An indoor seating area with tables and chairs, a large sign reading 'PERGAMINO,' and a wooden wall design.

A modern hotel room with a large bed, bedside tables, a bench, a potted plant, and a sliding door closet.

12. The Cut Hotel

El Poblado

Arturo

$56 nightly

$56 total

Nov 2 - Nov 3

A room with large windows, a patterned carpet, and a table with chairs.

A modern hotel room with a large bed, a desk, a chair, a television, and a window with a view of trees and buildings.

A modern office space with large windows, a conference table, and a view of the cityscape.

A conference room with a long table, black chairs, a white air conditioning unit, and a glass partition with a number sign.

13. Hotel BH El Poblado

El Poblado

Anthony

$85 nightly

$85 total

Nov 12 - Nov 13

A modern interior with a circular window, a seating area with a cushioned bench, and a small table.

A compact room with a desk, chair, coffee maker, and a trash bin.

A hotel room with a bed, a desk with a chair, a television, and a window with curtains.

A modern bathroom with a round mirror, a sink, a toilet, and a glass-enclosed shower.

14. Urbit Garden Hotel

Laureles

Elio Rafael

$57 nightly

$57 total

Oct 16 - Oct 17

A modern interior with a wooden ceiling, a reception desk, and a display of baked goods.

A modern hotel room with a large bed, a sitting area with a table and chairs, a bathtub, and a balcony with a view of the city.

A multi-story hotel with a prominent 'EUTOPIO' sign, featuring a modern architectural design with a mix of brick and glass facades, and balconies with greenery.

15. Eutopiq Hotel

Laureles

Ramiro

$75 nightly

$75 total

Nov 12 - Nov 13

A modern reception area with a glass door entrance, a reception desk, and seating arrangements.

A hotel room with a bed, a tray with a bottle and glasses, a red pillow, and a view of the outside through sheer curtains.

A modern interior with multiple ceiling lights, large windows, and a visible air conditioning unit.

A modern living room with a round wooden coffee table, white chairs, a sofa, and a potted plant.

16. Arame Hotel

Envigado

David

$72 nightly

$72 total

Nov 13 - Nov 14

A hotel entrance with a modern design, featuring a staircase leading to the lobby, a chandelier, and a sign indicating the hotel's name.

A gym with a treadmill, a small table with a bottle and a towel, and a spa area with candles and towels.

A modern hotel room with a large bed, a flat-screen TV, a dark-colored sofa, and a large window with curtains.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a small cabinet.

17. Hotel Egina Medellín

Laureles - Estadio

David

$66 nightly

$66 total

Nov 3 - Nov 4

A modern bedroom with a large bed, bedside table, and a view of trees through a window.

A spa area with a hot tub, seating, and plants.

A modern bathroom with a white toilet, a large sink, and a mirror above it. There are two bottles on the sink counter.

18. Soy Local Reserva Sajonia

Rionegro

Antonio

$71 nightly

$71 total

Nov 12 - Nov 13

A reflective pool with a cityscape and mountains in the background.

A modern lounge area with a sofa, chairs, and a coffee table.

A modern bedroom with a large bed, a bench, and a brick wall.

A library with bookshelves, a ladder, a round table, and a potted plant.

19. Los Patios Cool Living

Laureles

Emilio

$65 nightly

$65 total

Oct 14 - Oct 15

A row of modern, glass-roofed buildings with a garden in front featuring various colorful flowers.

A room with two beds, a table, and a chair. There is a window with curtains, and a view of greenery outside.

A reception desk with a star-shaped light fixture, a Coca-Cola refrigerator, and a vending machine.

A modern room with two beds, a large window with curtains, and artwork on the wall.

20. NEW STAR CENTER

Rionegro

Julienne

$62 nightly

$62 total

Oct 14 - Oct 15

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

10/10 Excellent

"Excelente lugar"

The Cut Hotel

10/10 Excellent

"I do not normally write reviews but I am now seeing the value it offers to other Travellers. Positives: Staff are all stellar and all speak very good English if your Spanish is not up to speed. The price for what you get in my opinion is fantastic value. The lobby of the hotel has a beautiful open air restaurant/bar attached to it and the bartenders here in particular are exceptional (coming from a guy who has worked in hospitality his whole life). There is also a small Cafe that is equally worth the visit. Surrounding streets are packed with bars and restaurants and has two options for Uber pick ups (highly recommend using Uber and not cabs, significant price difference) Negatives: Some of the rooms only look on to one another in a sort of central courtyard. I don't spend my time looking out the window so this is not an issue for me but if you are wanting a street view, you may want to specify when booking. There are two very small gyms, nothing crazy but also not unexpected from a boutique hotel. It will definitely do the trick as long as it is not too busy (more than 3 people feels a bit full) Shower Temperature control. Maybe it was just my unit, but I could only ever have an ice cold shower, or a skin melting one. If you toggle back and forth you can make it work but I would say this was this only truly noteworthy downside (also for the ladies, it is a rain shower head only so getting your hair wet may be unavoidable) Hope this helps!"

Novotel Medellín El Tesoro

10/10 Excellent

"Clean and comfortable rooms, friendly staff, good breakfast, and an excellent location. Highly recommended!"

Moa Select

10/10 Excellent

"👍"

Calle Flora Hotel by Jalo

10/10 Excellent

"El personal es muy amable, son muy atentos, el hotel es lindo, tiene un muy buen buffet, las habitaciones son lindas cómodas"

Blues Suites Medellin

10/10 Excellent

"Muy comodo"

Hotel Dorado La 70

8/10 Good

"Everything verte good and excellent the only thing I didn’t like very much was the breakfast , not a variety menu"

Hotel San Fernando Plaza

10/10 Excellent

"Hotel Súper lindo, el buffet espectacular, lo recomiendo con los ojos cerrados"

More cheap stays in Santa Cruz

Hotel Casa Malibú

Calle 32F 66 c 57 Medellín Medellin

$21 nightly

$21 total

Oct 14 - Oct 15

4.8/10 (3 reviews)

Hostal Lleras Calle 8 - Hostel

Calle 8 # 37A - 59 Medellín Antioquia

$28 nightly

$28 total

Oct 14 - Oct 15

8.4/10 Very Good! (165 reviews)

Hotel Ofix - Laureles

79-86 Calle 44 Medellín

$34 nightly

$34 total

Nov 12 - Nov 13

Autenthico Sajonia Hotel Aeropuerto

Aeropuerto Jose Maria Cordova, Km 20 Rionegro Antioquia

$37 nightly

$37 total

Oct 19 - Oct 20

Nakúa Stay + Work

8A-29 Cra. 34 Medellín Antioquia

$53 nightly

$53 total

Nov 12 - Nov 13

Masaya Medellin

43a1 Cl. 8 Medellín Antioquia

$77 nightly

$77 total

Oct 19 - Oct 20

Frequently asked questions

What is the best area to stay in Santa Cruz?

The best area to stay in Santa Cruz is the El Poblado district, particularly around Parque Lleras and the Golden Mile, as it offers a blend of upscale accommodations, dining, and entertainment options.El Poblado is known for its tree-lined streets, modern high-rises, and a wide selection of restaurants and cafes. Parque Lleras is a central square within El Poblado where many of the area's social activities are centered, while the Golden Mile (Milla de Oro) is a stretch of avenue known for its luxury hotels, shopping centers, and corporate offices. This area provides easy access to public transportation and is well-maintained.Couples often find El Poblado ideal due to its sophisticated dining experiences and lively evening scene. There are numerous restaurants offering various cuisines, from traditional Colombian to international dishes, and many establishments provide a pleasant ambiance for an evening out. The area's walkability also makes it convenient for exploring on foot.For travelers seeking a convenient base with high-quality amenities, El Poblado's Golden Mile is an excellent choice. Many hotels in this section offer modern facilities, including well-equipped fitness centers and business services.

When is the best time to go to Santa Cruz?

The best time to go to Santa Cruz, Antioquia, Colombia, is during the dry season, which runs from December to February and again from June to August. These months offer the most pleasant weather for exploring the region.During the dry season, you can expect less rainfall and more sunshine, making it ideal for outdoor activities like hiking, coffee farm tours, or simply enjoying the town's central plaza. The comfortable temperatures during these periods are particularly appealing for couples looking for a relaxed and scenic getaway.Travelers seeking a vibrant cultural experience might also consider visiting during local festivals, which often occur outside the dry season.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.

How much is the nightly rate at a Santa Cruz hotel?

Prices for hotels in Santa Cruz often vary, but you can find a great deal from $21 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia

Things to do in Medellín

Find hotels in Santa Cruz from $21

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Santa Cruz

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Cruz hotels

1. ibis Medellin

2. Isak Hotel & Golf Airport

3. Autenthico Sajonia Hotel Aeropuerto

4. Moa Select

5. ibis budget Medellín Itagüí Metro

6. La Quinta by Wyndham Medellin

7. Fairfield by Marriott Medellin Sabaneta

8. Hotel Dann Carlton Belfort Medellin

9. Hotel Dorado La 70

10. Hotel Lagoon

11. Novotel Medellín El Tesoro

12. The Cut Hotel

13. Hotel BH El Poblado

14. Urbit Garden Hotel

15. Eutopiq Hotel

16. Arame Hotel

17. Hotel Egina Medellín

18. Soy Local Reserva Sajonia

19. Los Patios Cool Living

20. NEW STAR CENTER

Top Santa Cruz Hotel Reviews

V Grand Hotel, a member of Radisson Individuals

The Cut Hotel

Novotel Medellín El Tesoro

Moa Select

Calle Flora Hotel by Jalo

Blues Suites Medellin

Hotel Dorado La 70

Hotel San Fernando Plaza

More cheap stays in Santa Cruz

Hotel Casa Malibú

Hostal Lleras Calle 8 - Hostel

Hotel Ofix - Laureles

Autenthico Sajonia Hotel Aeropuerto

Nakúa Stay + Work

Masaya Medellin

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app