Top 10 Hotels in Santa Cruz (from $21) 2026 - Competitive Prices

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Our top choices for Santa Cruz hotels

A modern bathroom with a sink, mirror, towel rack, and hairdryer.

A bar area with a curved counter, shelves with bottles, and hanging wine glasses.

A buffet with various fruits, vegetables, and beverages.

A modern outdoor seating area with a mix of tables and sofas, surrounded by lush green plants and a metal fence.

1. ibis Medellin

El Poblado

Yuliana

$57 nightly

$57 total

Oct 24 - Oct 25

A swimming pool with tiled edges, surrounded by lounge chairs and palm trees.

A traditional wooden building with a sloped roof and a balcony.

A bedroom with a wooden ceiling, a brick wall, a bed with pillows, a nightstand, and a chair.

A cobblestone path leading to a house with a tiled roof, surrounded by lush greenery and vibrant pink bougainvillea flowers.

2. Autenthico Sajonia Hotel Aeropuerto

Rionegro

Mabel Angela Frias

$37 nightly

$37 total

Oct 19 - Oct 20

A hotel room with two beds, a TV, a balcony with a city view, and artwork on the walls.

A multi-story building with a modern architectural design, featuring large windows and a brick facade.

A reception area with a brick wall, wooden tables, wicker pendant lights, and a reception desk.

A hotel room with a bed, a small table with chairs, a coffee maker, and a view of the city through the window.

3. Urbit Social Lofts

Laureles

Richard

$49 nightly

$49 total

Oct 12 - Oct 13

A bedroom with a large bed, a chair, and a view through a glass door.

A garden pathway with various plants and a palm tree.

A modern glass structure with a roof, surrounded by a well-maintained lawn and trees.

4. Isak Hotel & Golf Airport

Rionegro

Cristina

$69 nightly

$69 total

Oct 13 - Oct 14

An outdoor patio area with wicker furniture, a brick floor, and a view of a building with large windows and indoor lighting.

A modern kitchen with a central island, bar stools, and a hanging plant.

A modern kitchen area with wooden cabinets, a countertop, and a fruit bowl.

A modern hotel entrance with a prominent sign reading "Fairfield by Marriott" and a staircase leading to the lobby.

5. Fairfield by Marriott Medellin Sabaneta

Sabaneta

Michael

$77 nightly

$77 total

Oct 31 - Nov 1

A hotel sign with a sun emblem, a modern glass building, and flags.

A rooftop terrace with lounge chairs and a large umbrella, overlooking a cityscape at dusk.

A neatly arranged bedroom with a bed, bedside table, and a desk with a chair.

A modern lobby with green sofas, a white coffee table, and a large potted plant.

6. La Quinta by Wyndham Medellin

San Diego

Domingo

$93 nightly

$93 total

Oct 10 - Oct 11

A rooftop pool area with a breakfast setup, including plates, cups, and juice.

A hotel lobby with a reception desk, a large potted plant, a check-in counter, and a seating area.

A modern hotel room with a large bed, bedside tables, a sofa, and a view of the city through the window.

A multi-story building with a brick facade, surrounded by lush greenery and other high-rise buildings.

7. Hotel Dann Carlton Belfort Medellin

El Poblado

Christian Alvarez

$73 nightly

$73 total

Oct 18 - Oct 19

A modern interior with a wooden ceiling, a reception desk, and a display of baked goods.

A multi-story hotel with a prominent 'EUTOPIO' sign, featuring a modern architectural design with a mix of brick and glass facades, and balconies with greenery.

A modern hotel room with a large bed, a sitting area with a table and chairs, a large window with a view of buildings, and a hot tub.

A modern hotel room with a large bed, a sitting area with a table and chairs, a bathtub, and a balcony with a view of the city.

8. Eutopiq Hotel

Laureles

Luis Alfonso

$64 nightly

$64 total

Oct 14 - Oct 15

A modern reception area with a glass door entrance, a reception desk, and seating arrangements.

A gym with exercise equipment, a punching bag, and a view of the city through large windows.

A modern interior with multiple ceiling lights, large windows, and a visible air conditioning unit.

A hotel room with a bed, a tray with a bottle and glasses, a red pillow, and a view of the outside through sheer curtains.

9. Arame Hotel

Envigado

David

$68 nightly

$68 total

Nov 8 - Nov 9

A modern bar with a long counter, shelves with decorative items, and a coffee machine.

A modern hotel lobby with a reception desk, seating area, and large windows.

A city view from a high-rise room with a chair and a table.

A swimming pool with a glass barrier, surrounded by high-rise buildings and greenery.

10. Novotel Medellín El Tesoro

El Poblado

Oscar

$137 nightly

$137 total

Nov 6 - Nov 7

A room with large windows, a patterned carpet, and a table with chairs.

A gym with two people using stationary bikes, a treadmill, and a rowing machine.

A conference room with a long table, black chairs, a white air conditioning unit, and a glass partition with a number sign.

A modern office space with large windows, a conference table, and a view of the cityscape.

11. Hotel BH El Poblado

El Poblado

Anthony

$84 nightly

$84 total

Nov 8 - Nov 9

A hotel room with a balcony overlooking a cityscape, a bed with patterned pillows, and a painting of a flower on the wall.

A spacious indoor dining area with multiple tables and chairs, large windows offering city views, and visible air ducts on the ceiling.

A modern hotel room with a large bed, a cityscape mural on the wall, a wooden headboard, and a walk-in closet.

A casino with multiple slot machines and chairs arranged in rows.

12. Hotel Dorado La 70

Laureles

Gregson

$79 nightly

$79 total

Nov 9 - Nov 10

A modern interior with a circular window, a seating area with a cushioned bench, and a small table.

A hotel room with a bed, a desk with a chair, a television, and a window with curtains.

A modern bathroom with a round mirror, a sink, a toilet, and a glass-enclosed shower.

A compact room with a desk, chair, coffee maker, and a trash bin.

13. Urbit Garden Hotel

Laureles

Elio Rafael

$56 nightly

$56 total

Oct 13 - Oct 14

A modern lounge area with a blue sofa, pendant lights, a refrigerator stocked with snacks, and a chalkboard wall with food illustrations.

A modern interior with a blue sofa, a hanging chair, a vending machine, and a refrigerator stocked with beverages.

A modern lobby with glass walls, a tiled floor, and a potted plant.

A brick building with a sign reading "ibis budget."

14. ibis budget Medellín Itagüí Metro

Itagüí

Maria

$44 nightly

$44 total

Oct 25 - Oct 26

A modern building entrance with glass doors, a wooden ceiling, and potted plants.

A gym with wooden floors, weight racks, and exercise equipment.

A modern hotel room with a large bed, bedside tables, a bench, a potted plant, and a sliding door closet.

A building with a wooden lattice facade and a sign reading 'PERGAMINO.'

15. The Cut Hotel

El Poblado

Arturo

$50 nightly

$50 total

Oct 13 - Oct 14

A modern hotel room with a large bed, a wooden headboard, a bedside table with a lamp, and a tray with breakfast items.

A modern reception area with a wooden reception desk, large potted plants, and a view of the outdoors through large windows.

A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a modern building.

A spacious living area with a leather sofa, a coffee table, and a large window with curtains.

16. Hotel Lagoon

Rionegro

Isabela

$127 nightly

$127 total

Nov 3 - Nov 4

A row of modern, glass-roofed buildings with a garden in front featuring various colorful flowers.

A reception desk with a star-shaped light fixture, a Coca-Cola refrigerator, and a vending machine.

A modern room with two beds, a large window with curtains, and artwork on the wall.

A small, single-story building with a sloped roof, numbered 1 and 2, indicating separate units. A concrete staircase leads to a door with a glass panel, revealing a bed and a wall-mounted light fixture.

17. NEW STAR CENTER

Rionegro

Julienne

$61 nightly

$61 total

Oct 10 - Oct 11

A modern outdoor pool area with a wooden deck, lounge chairs, and a table with umbrellas.

A modern indoor pool area with wooden decking, a hot tub, and a view of the surrounding greenery.

A modern meeting room with a wooden table, black chairs, and a potted plant.

A modern hotel lobby with a long reception desk, seating area, and a large window.

18. Movich Hotel Las Lomas

Rionegro

Anuradha

$130 nightly

$130 total

Nov 6 - Nov 7

A hotel entrance with a modern design, featuring a staircase leading to the lobby, a chandelier, and a sign indicating the hotel's name.

A hotel dining area with multiple tables and chairs, a skylight, and artwork on the walls.

A gym with a treadmill, a small table with a bottle and a towel, and a spa area with candles and towels.

A modern living room with a flat-screen TV, a sofa, a coffee table, and a small cabinet.

19. Hotel Egina Medellín

Laureles - Estadio

Chad

$65 nightly

$65 total

Nov 4 - Nov 5

A reflective pool with a cityscape and mountains in the background.

A library with bookshelves, a ladder, a round table, and a potted plant.

A modern hotel room with a large bed, a wooden desk, a black curtain, a brick accent wall, and a balcony with plants.

A modern lounge area with a sofa, chairs, and a coffee table.

20. Los Patios Cool Living

Laureles

Emilio

$65 nightly

$65 total

Oct 15 - Oct 16

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Top Santa Cruz Hotel Reviews

Heiss Hotel By Jalo

10/10 Excellent

"Great location and nice place"

Calle Flora Hotel by Jalo

8/10 Good

"The location was great. The downside is they let drunks and protistutes loitering at the hotel entrance."

Hashtag 98 Hotel By Jalo

10/10 Excellent

"Todo excelente me encantó el lugar. Creo que la chica de la recepción se llama Vanesa o Valeria no recuerdo su nombre cabello color rubio, una dama súper empatica demasiado servicial, excelente servicio. Cuando vuelva a Colombia definitivamente me hospedaría en este lugar. Gracias ❤️"

Urbit Social Lofts

10/10 Excellent

"Every was great"

Hotel Dorado La 70

8/10 Good

"Los desayunos son muy simple, siempre el mismo menú. Los huevos siempre fríos independientemente a hora que vayas. Las frutas siempre es un corte de papaya y sandía . El área para desayunar es algo incómoda. Los empleados son muy atentos"

Moa Select

10/10 Excellent

"Limpieza 100% Desayuno bueno pero al estilo colombiano El staff muy ateneo y diligente Aire acondicionado 100% Habitación muy bonita"

The Click Clack Hotel Medellin

10/10 Excellent

"Amazing"

Dann Carlton Medellin Hotel

10/10 Excellent

"I didn't like the snacks n beverages that we have to pay if you get some"

Hotel Provenza Garden

8/10 Good

"Buena relacion precio-calidad"

More cheap stays in Santa Cruz

Hotel Casa Malibú

Calle 32F 66 c 57 Medellín Medellin

$21 nightly

$21 total

Oct 14 - Oct 15

4.8/10 (3 reviews)

Hostal Lleras Calle 8 - Hostel

Calle 8 # 37A - 59 Medellín Antioquia

$25 nightly

$25 total

Oct 17 - Oct 18

8.4/10 Very Good! (165 reviews)

Hotel Ofix - Laureles

79-86 Calle 44 Medellín

$33 nightly

$33 total

Nov 9 - Nov 10

Autenthico Sajonia Hotel Aeropuerto

Aeropuerto Jose Maria Cordova, Km 20 Rionegro Antioquia

$37 nightly

$37 total

Oct 19 - Oct 20

Nakúa Stay + Work

8A-29 Cra. 34 Medellín Antioquia

$60 nightly

$60 total

Oct 12 - Oct 13

Masaya Medellin

43a1 Cl. 8 Medellín Antioquia

$75 nightly

$75 total

Oct 19 - Oct 20

Frequently asked questions

What is the best area to stay in Santa Cruz?

The best area to stay in Santa Cruz is the El Poblado district, particularly around Parque Lleras and the Golden Mile, as it offers a blend of upscale accommodations, dining, and entertainment options.El Poblado is known for its tree-lined streets, modern high-rises, and a wide selection of restaurants and cafes. Parque Lleras is a central square within El Poblado where many of the area's social activities are centered, while the Golden Mile (Milla de Oro) is a stretch of avenue known for its luxury hotels, shopping centers, and corporate offices. This area provides easy access to public transportation and is well-maintained.Couples often find El Poblado ideal due to its sophisticated dining experiences and lively evening scene. There are numerous restaurants offering various cuisines, from traditional Colombian to international dishes, and many establishments provide a pleasant ambiance for an evening out. The area's walkability also makes it convenient for exploring on foot.For travelers seeking a convenient base with high-quality amenities, El Poblado's Golden Mile is an excellent choice. Many hotels in this section offer modern facilities, including well-equipped fitness centers and business services.

When is the best time to go to Santa Cruz?

The best time to go to Santa Cruz, Antioquia, Colombia, is during the dry season, which runs from December to February and again from June to August. These months offer the most pleasant weather for exploring the region.During the dry season, you can expect less rainfall and more sunshine, making it ideal for outdoor activities like hiking, coffee farm tours, or simply enjoying the town's central plaza. The comfortable temperatures during these periods are particularly appealing for couples looking for a relaxed and scenic getaway.Travelers seeking a vibrant cultural experience might also consider visiting during local festivals, which often occur outside the dry season.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Santa Cruz.

How much is the nightly rate at a Santa Cruz hotel?

Prices for hotels in Santa Cruz often vary, but you can find a great deal from $21 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Find hotels in Santa Cruz from $21

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Santa Cruz

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Cruz hotels

1. ibis Medellin

2. Autenthico Sajonia Hotel Aeropuerto

3. Urbit Social Lofts

4. Isak Hotel & Golf Airport

5. Fairfield by Marriott Medellin Sabaneta

6. La Quinta by Wyndham Medellin

7. Hotel Dann Carlton Belfort Medellin

8. Eutopiq Hotel

9. Arame Hotel

10. Novotel Medellín El Tesoro

11. Hotel BH El Poblado

12. Hotel Dorado La 70

13. Urbit Garden Hotel

14. ibis budget Medellín Itagüí Metro

15. The Cut Hotel

16. Hotel Lagoon

17. NEW STAR CENTER

18. Movich Hotel Las Lomas

19. Hotel Egina Medellín

20. Los Patios Cool Living

Top Santa Cruz Hotel Reviews

Heiss Hotel By Jalo

Calle Flora Hotel by Jalo

Hashtag 98 Hotel By Jalo

Urbit Social Lofts

Hotel Dorado La 70

Moa Select

The Click Clack Hotel Medellin

Dann Carlton Medellin Hotel

Hotel Provenza Garden

More cheap stays in Santa Cruz

Hotel Casa Malibú

Hostal Lleras Calle 8 - Hostel

Hotel Ofix - Laureles

Autenthico Sajonia Hotel Aeropuerto

Nakúa Stay + Work

Masaya Medellin

Frequently asked questions

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