Title: Visit Santa Isabel do Rio Negro: 2026 Travel Guide for Santa Isabel do Rio Negro, Amazonas | Expedia.com [Hotels in Santa Isabel do Rio Negro](https://expedia.com/Santa-Isabel-Do-Rio-Negro-Hotels.d553248634664628244.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel do Rio Negro](https://expedia.com/Santa-Isabel-Do-Rio-Negro-Vacation-Rentals.d553248634664628244.Travel-Guide-VacationRentals)[Car Rentals in Santa Isabel do Rio Negro](https://expedia.com/Car-Rentals-In-Santa-Isabel-Do-Rio-Negro.d553248634664628244.Car-Rental-Guide)[Santa Isabel do Rio Negro Vacation Packages](https://expedia.com/Santa-Isabel-Do-Rio-Negro.d553248634664628244.Destination-Travel-Guides) # Santa Isabel do Rio Negro ## Travel Guide ## Visit Santa Isabel do Rio Negro Things to do ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248634664628244) - Santa Isabel do Rio Negro Hotel Deals - Vacation Rentals in Santa Isabel do Rio Negro ![Rede Andrade Amazônia](https://images.trvl-media.com/lodging/38000000/37110000/37107500/37107402/5e655d97_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rede Andrade Amazônia Av. Getúlio Vargas 227 Manaus AM $28 nightly $29 total Mar 9 - Mar 10 Total with taxes and fees Stay at this hotel in Manaus. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ... 7.8/10 Good! (928 reviews) Friendly staff specially at the restaurant during breakfast Reviewed on Oct 9, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F9%2F2026&endDate=3%2F10%2F2026&selected=37107402&PinnedHotelID=37107402&HadPinnedHotel=true®ionId=553248634664628244) ![Hotel Express Vieiralves](https://images.trvl-media.com/lodging/6000000/5410000/5401300/5401230/e7c96934_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Express Vieiralves Rua Rio Branco, s/n Manaus AM Book a stay at this business-friendly hotel in Manaus. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Parque Ecologico ... 8.2/10 Very Good! (957 reviews) Easy chek in and out. Reviewed on Nov 24, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=3%2F7%2F2026&endDate=3%2F8%2F2026&selected=5401230&PinnedHotelID=5401230&HadPinnedHotel=true®ionId=553248634664628244) [](https://expedia.com/Hotel-Search?startDate=3%2F7%2F2026&endDate=3%2F8%2F2026&selected=5401230&PinnedHotelID=5401230&HadPinnedHotel=true®ionId=553248634664628244) ![Hotel Intercity Manaus](https://images.trvl-media.com/lodging/6000000/5800000/5794700/5794682/52dbff01_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Intercity Manaus Rua Professor Marciano Armond, 544 Manaus AM $61 nightly $62 total Feb 27 - Feb 28 Total with taxes and fees Book a stay at this business-friendly hotel in Manaus. Enjoy free breakfast, free WiFi, and 24-hour room service. Our guests praise the helpful staff in our ... 8.4/10 Very Good! (940 reviews) Service great. Rooms very nice. Reviewed on Feb 15, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=5794682&PinnedHotelID=5794682&HadPinnedHotel=true®ionId=553248634664628244) [See all 264 properties in Amazonas](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F22%2F2026&endDate=2%2F23%2F2026®ionId=6052622) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Flat em Tropical Executive Hotel](https://images.trvl-media.com/lodging/113000000/112290000/112286600/112286537/8a557902_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Flat em Tropical Executive Hotel Av. Coronel Teixeira, 1320 Manaus AM Stay at this aparthotel in Manaus. Enjoy free WiFi, a steam room, and a garden. Popular attractions Ponta Negra Beach and Ponta Negra Shopping are located ... 8.2/10 Very Good! (11 reviews) The only good thing is the view of the pool to the river Reviewed on Jun 12, 2025 [](https://expedia.com/Manaus-Hotels-Flat-Em-Tropical-Executive-Hotel.h112286537.Hotel-Information) ![Hotel Residencial Manaus](https://images.trvl-media.com/lodging/79000000/78400000/78399400/78399356/a035c93e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Residencial Manaus 145 Rua Dallas Manaus AM Stay at this aparthotel in Manaus. Enjoy free WiFi, free parking, and air conditioning. Popular attractions Mindu Municipal Park and Parque do Mindú are located ... 8.2/10 Very Good! (25 reviews) Foi boa, gratidão por nos acolher. Reviewed on Aug 9, 2025 [](https://expedia.com/Manaus-Hotels-Hotel-Residencial-Manaus.h78399356.Hotel-Information) ![Tropical Executive Suit 1006](https://images.trvl-media.com/lodging/112000000/111160000/111153900/111153806/w1200h1060x0y0-bd1b6aa8_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tropical Executive Suit 1006 1320 Avenida Coronel Teixeira Manaus AM Stay at this aparthotel in Manaus. Enjoy free WiFi, 10 beach bars, and a 24-hour front desk. Popular attractions Ponta Negra Beach and Moon Beach are located ... 8/10 Very Good! (1 review) It was great I live nearby but the hotel is good and the pool is excellent. Reviewed on Jun 20, 2025 [](https://expedia.com/Manaus-Hotels-Tropical-Executive-Residence-Hotel.h111153806.Hotel-Information) [See all 264 properties in Amazonas](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6052622&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Isabel do Rio Negro hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2026-02-21&endDate=2026-02-22)[Feb 21 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2026-02-21&endDate=2026-02-22) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2026-02-22&endDate=2026-02-23)[Feb 22 - Feb 23](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2026-02-22&endDate=2026-02-23) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026)[Feb 27 - Mar 1](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634664628244&startDate=2%2F27%2F2026&endDate=3%2F1%2F2026) ### Popular places to visit #### Pico da Neblina Commune with nature and explore the great outdoors at Pico da Neblina during your travels in Santa Isabel do Rio Negro. Discover the mountain views while you're in the area. [](https://expedia.com/Pico-Da-Neblina-Santa-Isabel-do-Rio-Negro.d553248621562483867.Vacation-Attraction) - Cities near Santa Isabel do Rio Negro - Places of interest [Cocuy](https://expedia.com/Cocuy.dx836918575718596608)[Casiquiare](https://expedia.com/Casiquiare.dx836918955040989184) - [Pico da Neblina ](https://expedia.com/Pico-Da-Neblina-Santa-Isabel-do-Rio-Negro.d553248621562483867.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app