Title: Santa Isabel Vacation Rentals from $282: Search Short-Term Rentals | Expedia.com [Santa Isabel Travel Guide](https://expedia.com/Santa-Isabel.dx6203540)[Hotels in Santa Isabel](https://expedia.com/Santa-Isabel-Hotels.d6203540.Travel-Guide-Hotels)[Flights to Santa Isabel](https://expedia.com/Cheap-Flights-To-Santa-Isabel.d6203540.Travel-Guide-Flights)[Car Rentals in Santa Isabel](https://expedia.com/Car-Rentals-In-Santa-Isabel.d6203540.Car-Rental-Guide)[Santa Isabel Vacation Packages](https://expedia.com/Santa-Isabel.d6203540.Destination-Travel-Guides) ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg) ### Bundle & Save Get more, spend less whenever you see Bundle & Save deals - ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg) ### OneKeyCash Earn OneKeyCash on all your eligible bookings - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg) ### Upfront pricing We are not like the others - we include taxes and fees ## Check prices for these dates In two weeks [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 17 - Jul 19](https://www.expedia.com/Hotel-Search?regionId=6203540&startDate=2026-07-17&endDate=2026-07-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Isabel vacation rentals ![Front of property](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/1c2dafbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, 2 Double Beds, Ocean View, Overwater | Individually decorated, individually furnished](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/d8c32202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, white sand](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/633fd22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Cabin, 2 Double Beds, Ocean View, Overwater | Terrace/patio](https://images.trvl-media.com/lodging/47000000/46950000/46948400/46948372/2e9ab169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Paradise Over the Water Cabins in San Blas [](https://www.expedia.com/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) Narganá 6.0/10 (1 review) "29/22 i stay with my family for three nights and 4 days the beds are not comfortable and the fan doesn't work the bathroom need cleaning, the worst part is the sandflyies we got bitten all over our bodies, the owners can do better with proper new nets and fan and maybe spray the place, after the first night we want to leave so bad. The island is not so bad its peaceful and claim but after the bites we could take it we were prepared with bug spray but it was not enough for the bugs. The island... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dominik $266 nightly $282 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/El-Porvenir-Hotels-Newly-Built-Paradise-Cabins-In-San-Blas.h46948372.Hotel-Information) ![Beach nearby, beach towels](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/a2a99590.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/6f230b81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/da467749.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/bed98230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Exclusive sailboat for 2 people all inclusive in San Blas islands [](https://www.expedia.com/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information) Guna Yala 10/10 Exceptional (1 review) "Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Grazia B. $606 nightly $606 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/803cd264.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/b3c05fe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/9304c3cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/72000000/71150000/71141100/71141036/c41bafb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Catamaran experience in paradise [](https://www.expedia.com/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information) Guna Yala Comarca $915 nightly $915 total Mar 30 - Mar 31 Total with taxes and fees [](https://www.expedia.com/San-Blas-Islands-Hotels-Catamaran-Experience-In-Paradise.h71141036.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-12&endDate=2026-04-13®ionId=6203540&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Villas [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-06-26&d1=2026-06-26&endDate=2026-06-29&d2=2026-06-29&lodging=VILLA) Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-06-26&d1=2026-06-26&endDate=2026-06-29&d2=2026-06-29&lodging=VACATION_HOME) Cottages [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-06-26&d1=2026-06-26&endDate=2026-06-29&d2=2026-06-29&lodging=COTTAGE) Houseboats [](https://www.expedia.com/Hotel-Search?destination=Santa+Isabel%2C+Col%C3%B3n%2C+Panama®ionId=6203540&latLong=9.539417%2C-79.195937&adults=2&startDate=2026-06-26&d1=2026-06-26&endDate=2026-06-29&d2=2026-06-29&lodging=HOUSE_BOAT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Vacation-Rentals.d6203540.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSanta-Isabel-Vacation-Rentals.d6203540.Travel-Guide-VacationRentals) ## Top Santa Isabel Hotel Reviews ![Private Ocean-Front Cabin with private bathroom on San Blas Island](https://images.trvl-media.com/lodging/38000000/37770000/37767000/37766985/a23e7585_y.jpg) ### Private Ocean-Front Cabin with private bathroom on San Blas Island 10/10 Excellent "Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door. " [](https://expedia.com/San-Blas-Islands-Hotels-Cabins-In-Diablo-Island.h37766985.Hotel-Information) ![BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES](https://images.trvl-media.com/lodging/31000000/30800000/30792300/30792236/e39b72a8_y.jpg) ### BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES 10/10 Excellent "This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. " [](https://expedia.com/Palenque-Hotels-Palenque-Spectacular-Caribbean-Ocean-Front-Property-In-Panama.h30792236.Hotel-Information) ![Exclusive sailboat for 2 people all inclusive in San Blas islands](https://images.trvl-media.com/lodging/114000000/113060000/113058600/113058539/a2a99590_y.jpg) ### Exclusive sailboat for 2 people all inclusive in San Blas islands 10/10 Excellent "Anita e Federico sono state il valore aggiunto in queste isole meravigliose. La loro disponibilita, le loro attenzioni, i sorridenti contatti di Anita con la popolazione dei Guna e la cucina superlativa di Federico hanno reso speciale la nostra vacanza che ha soddisfatto appieno le nostre aspettative. Discreta e deliziosa la presenza della gattina (la principessa di bordo) Shanu. Grazie di tutto!" [](https://expedia.com/Ailigandi-Hotels-Vrbo-Property.h113058539.Hotel-Information) ![Caribbean getaway: beach cottage just on the sand](https://images.trvl-media.com/lodging/72000000/71150000/71150000/71149949/ddaf5491_y.jpg) ### Caribbean getaway: beach cottage just on the sand 10/10 Excellent "The beach view was perfect! I loved hearing the waves all day and throughout the night. My dog and I enjoyed everything and felt very comfortable. " [](https://expedia.com/Palenque-Hotels-Caribbean-Getaway-Beach-Cottage-Just-On-The-Sand.h71149949.Hotel-Information) ## Find out more about Santa Isabel **Everything you need to know about Santa Isabel vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Santa Isabel vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Santa Isabel. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Isabel in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $282 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Santa Isabel rentals** At Expedia, we put the best Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Isabel vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Santa Isabel ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals) - [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals) - [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals) - [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals) - [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals) - [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals) - [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals) - [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals) - [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals) - [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals) - [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals) - [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations) - [Cabin Rentals in Santa Isabel ](https://expedia.com/Santa-Isabel-Cabins.d6203540-aaCabins.Travel-Guide-Accommodation) ## Frequently asked questions ### Are there vacation rentals in Santa Isabel? ### What are some of the best vacation rentals that Santa Isabel has to offer? ### What’s there to see and do in Santa Isabel? ### What’s a vacation rental in Santa Isabel like? ### Expedia's Latest Trends Hotels - [Pet-friendly Hotels in Maria Chiquita](https://expedia.com/Maria-Chiquita-Hotels-Pet-Friendly-Hotel.0-0-d6344217-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels in Puerto Lindo](https://expedia.com/Puerto-Lindo-Hotels.d3000007427.Travel-Guide-Hotels) - [All-inclusive Resorts in Colon](https://expedia.com/Colon-Hotels-All-Inclusive-Hotel.0-0-d601867-tAllinclusiveHotel.Travel-Guide-Filter-Hotels) - [Hotels in Colon](https://expedia.com/Colon-Hotels.d601867.Travel-Guide-Hotels) - [Hotels near Gatun Locks](https://expedia.com/Gatun-Locks-Hotels.0-l6078509-0.Travel-Guide-Filter-Hotels) - [Resorts & Hotels with Spas in Gamboa](https://expedia.com/Gamboa-Hotels-Spa-Hotel.0-0-d6025059-tSpaHotel.Travel-Guide-Filter-Hotels) - [Hotels in Portobelo](https://expedia.com/Portobelo-Hotels.d6145607.Travel-Guide-Hotels) - [Hotels in Isla Grande](https://expedia.com/Isla-Grande-Hotels.d6053183.Travel-Guide-Hotels) - [Adults Only Resorts & Hotels in Colon](https://expedia.com/Colon-Hotels-Adults-Only-Resorts.0-0-d601867-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) Flights - [Flights to Colon](https://expedia.com/Cheap-Flights-To-Colon.d601867.Travel-Guide-Flights) - [Flights to Isla Grande](https://expedia.com/Cheap-Flights-To-Isla-Grande.d6053183.Travel-Guide-Flights) - [Colon Flights](https://expedia.com/lp/flights/601867/flights-from-colon) Cars - [Car rentals in Gamboa](https://expedia.com/Car-Rentals-In-Gamboa.d6025059.Car-Rental-Guide) - [Car rentals in Puerto Lindo](https://expedia.com/Car-Rentals-In-Puerto-Lindo.d3000007427.Car-Rental-Guide) - [Car rentals in Colon](https://expedia.com/Car-Rentals-In-Colon.d601867.Car-Rental-Guide) - [Hertz Car Rentals In Colon](https://expedia.com/Hertz-Car-Rentals-In-Colon.d601867-c40.Car-Rental-Guide-Suppliers) Activities - [Things to do in Maria Chiquita](https://expedia.com/Things-To-Do-In-Maria-Chiquita.d6344217.Travel-Guide-Activities) - [Things to do in Portobelo](https://expedia.com/Things-To-Do-In-Portobelo.d6145607.Travel-Guide-Activities) - [Things to do in Colon](https://expedia.com/Things-To-Do-In-Colon.d601867.Travel-Guide-Activities) - [Things to do in Gamboa](https://expedia.com/Things-To-Do-In-Gamboa.d6025059.Travel-Guide-Activities) Packages - [Safarick's Zoo](https://expedia.com/Safaricks-Zoo-Maria-Chiquita.d553248621574431161.Vacation-Attraction) - [Nombre de Dios Vacation](https://expedia.com/Nombre-De-Dios.d3000462548.Destination-Travel-Guides) - [Colon Vacation](https://expedia.com/Colon.d601867.Destination-Travel-Guides) - [Real Aduana de Portobelo](https://expedia.com/Real-Aduana-De-Portobelo-Portobelo.d553248621532964863.Vacation-Attraction) General - [Visit Isla Grande](https://expedia.com/Isla-Grande.dx6053183) - [Visit Colon](https://expedia.com/Colon.dx601867) - [Visit Fort Sherman](https://expedia.com/Fort-Sherman.dx6223313) - [Visit Cativa](https://expedia.com/Cativa.dx553248623142874455) - [Visit La Guaira](https://expedia.com/La-Guaira.dx3000439511) - [Visit Limón](https://expedia.com/Limon.dx829297944220938240)