Santa Isabel Vacations from $991

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The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was $1,864, price is now $991 per person
$991
per person
Sep 10 - Sep 15
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,008 reviews)
Love the breakfast and the rooms were amazing

Reviewed on Jul 5, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Save 100% on your flight
Price was $1,902, price is now $1,127 per person
$1,127
per person
Aug 25 - Sep 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,570 reviews)
The staff was very helpful the hotel was nice and clean. Wonderful hotel I would definitely recommend

Reviewed on Jul 6, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,611, price is now $1,039 per person
$1,039
per person
Aug 25 - Sep 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,815 reviews)
Very beautiful and convenient in every way possible.

Reviewed on Jul 6, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was $1,580, price is now $1,049 per person
$1,049
per person
Aug 25 - Sep 1
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (5,679 reviews)
The breakfast buffet is amazing,more variety that the cruise’s buffet

Reviewed on Jul 6, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

4 out of 5
Casco Viejo
Price was $1,872, price is now $1,321 per person
$1,321
per person
Sep 12 - Sep 17
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026

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Santa Isabel Hotel Deals

Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
Fully refundableReserve now, pay when you stay
$1,895 nightly
The price is $2,099 total per night from Jul 7 to Jul 8
$2,099 total
Jul 7 - Jul 8
Total with taxes and fees
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Get rates
Private Ocean-Front Cabin with private bathroom on San Blas Island
Private wood Cabins on San Blas island - private bathroom

Private wood Cabins on San Blas island - private bathroom

2 out of 5
Wailidup Island Narganá Guna Yala
Get rates
Private wood Cabins on San Blas island - private bathroom
See all 39 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
260
Max Temp Winter
80ºF
Max Temp Summer
80ºF

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $991 on Expedia for your Santa Isabel getaway. However, factors like the season, choice of hotel and length of stay will determine how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
You can typically find lower prices and better availability in August, November and December. Take a look at our cheap Santa Isabel vacation packages and you could land some excellent off-season deals.
How many days is enough for Santa Isabel?
Typically, a handful of days is enough to visit the major attractions during your Santa Isabel vacation. However, if you want to have some time to kick back or go on day trips, consider extending your itinerary.
How to find the best Santa Isabel package deals?
Finding a cheap Santa Isabel package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can personalize your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Isabel package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Isabel vacation as a package?
You can enjoy significant savings on your Santa Isabel break by booking a personalized vacation package. Click on the "Package" heading, then select your travel dates and destination to browse some great airfares and hotel prices. Bundle everything into a great-value package and you can save hundreds of dollars. Consider adding a rental car and you may score a better deal.
When to book a vacation package to Santa Isabel?
Enjoy incredible bargains by reserving your flights early with Expedia. If spontaneity is more your style, take advantage of our last-minute deals for a spur-of-the-moment Santa Isabel getaway.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Set off on your dream escape to Santa Isabel with help from our Book Now, Pay Later vacations. There's no need to save up or hold off until your next paycheck — we've partnered with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans mean you can split the cost across 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snap up travel deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.