Title: Isla Grande Vacation Rentals from $108: Search Short-Term Rentals | Expedia.com

[Isla Grande Travel Guide](https://expedia.com/Isla-Grande.dx6053183)[Hotels in Isla Grande](https://expedia.com/Isla-Grande-Hotels.d6053183.Travel-Guide-Hotels)[Flights to Isla Grande](https://expedia.com/Cheap-Flights-To-Isla-Grande.d6053183.Travel-Guide-Flights)[Things to do in Isla Grande](https://expedia.com/Things-To-Do-In-Isla-Grande.d6053183.Travel-Guide-Activities)[Car Rentals in Isla Grande](https://expedia.com/Car-Rentals-In-Isla-Grande.d6053183.Car-Rental-Guide)[Isla Grande Vacation Packages](https://expedia.com/Isla-Grande.d6053183.Destination-Travel-Guides)

![Palm trees forest and houses in Isla Grande shore. Colon province, Panama, Caribbean, Central America.](https://images.trvl-media.com/place/6053183/8bba6d27-3102-43e6-89e4-9ef59409f2b6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6053183/8bba6d27-3102-43e6-89e4-9ef59409f2b6.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=6053183&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Isla Grande vacation rentals

![Beach](https://images.trvl-media.com/lodging/121000000/120070000/120061100/120061071/95ace113.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/121000000/120070000/120061100/120061071/14bad027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/121000000/120070000/120061100/120061071/551ebe2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120070000/120061100/120061071/30f0b989.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Deluxe Beachfront 4-bedroom house in Colón Province

[](https://www.expedia.com/Isla-Grande-Hotels-Deluxe-Beachfront-4-Bedroom-House-In-Colon-Province.h120061071.Hotel-Information)

Colón Province

$384 nightly

$384 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Isla-Grande-Hotels-Deluxe-Beachfront-4-Bedroom-House-In-Colon-Province.h120061071.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/104000000/103640000/103636800/103636720/1649bd69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/104000000/103640000/103636800/103636720/073e10ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103640000/103636800/103636720/7ad3ced9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103640000/103636800/103636720/07d64ddb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabaña La Punta op het Strand!!

[](https://www.expedia.com/Cabana-La-Punta-Op-Het-Strand.h103636720.Hotel-Information)

Colón Province

$170 nightly

$170 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Cabana-La-Punta-Op-Het-Strand.h103636720.Hotel-Information)

![On the beach, sun loungers, beach towels](https://images.trvl-media.com/lodging/75000000/74060000/74054900/74054867/w1064h805x0y11-7ae51d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/75000000/74060000/74054900/74054867/1ac172a0_edited_9bc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, stereo](https://images.trvl-media.com/lodging/75000000/74060000/74054900/74054867/ad3a9028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/75000000/74060000/74054900/74054867/5a781682_edited_8afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### BEAUTIFUL APARTMENT IN FRONT OF THE SEA

[](https://www.expedia.com/Portobelo-Hotels-BEAUTIFUL-APARTMENT-IN-FRONT-OF-THE-SEA.h74054867.Hotel-Information)

Portobelo

8.0/10

Very Good

(3 reviews)

"All of it! Gabriel is a marvelous host; absolutely above and beyond. The house is lovely, very unique, and the location, right on the water, superb. We'll be back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosa M.

$177 nightly

$177 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Portobelo-Hotels-BEAUTIFUL-APARTMENT-IN-FRONT-OF-THE-SEA.h74054867.Hotel-Information)

![Marina](https://images.trvl-media.com/lodging/109000000/108570000/108562100/108562093/de84a70a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/109000000/108570000/108562100/108562093/9f704818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108570000/108562100/108562093/a6aae70d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/109000000/108570000/108562100/108562093/1e44d7b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Despierta sobre el mar 

[](https://www.expedia.com/Puerto-Lindo-Hotels-Despierta-Sobre-El-Mar.h108562093.Hotel-Information)

Garrote

6.0/10

(1 review)

$100 nightly

$108 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Puerto-Lindo-Hotels-Despierta-Sobre-El-Mar.h108562093.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/116000000/115840000/115832800/115832785/9bf6774d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115840000/115832800/115832785/ea8360be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/116000000/115840000/115832800/115832785/bde6b74f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/116000000/115840000/115832800/115832785/23785068.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

[](https://www.expedia.com/Maria-Chiquita-Hotels-Bala-Bliss-Charming-2-Bedroom-Apartment-With-WiFi.h115832785.Hotel-Information)

Maria Chiquita

6.8/10

(3 reviews)

"Well-appointed apartment, view of the ocean, big pool, fast Internet, attentive security. We had a great time here, thanks!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Will

$145 nightly

$145 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Maria-Chiquita-Hotels-Bala-Bliss-Charming-2-Bedroom-Apartment-With-WiFi.h115832785.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06&regionId=6053183&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Villas

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VILLA)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Isla+Grande%2C+Col%C3%B3n%2C+Panama&regionId=6053183&latLong=9.634628%2C-79.562556&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APARTMENT)

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## Top Isla Grande Hotel Reviews

![La Posada del Buzo](https://images.trvl-media.com/lodging/91000000/90300000/90295300/90295300/984fa3bd_y.jpg)

### La Posada del Buzo

8/10 Good

"Our stay there was VERY enjoyable. We had a clean, comfortable room though it could use some updating. Staff was exceptionally friendly and helpful. Excellent location - quiet yet close to town. Tasty food with breakfast being the best. I would definitely recommend this hotel to other travelers."

[](https://expedia.com/Portobelo-Hotels-Hotel-Panama-Dive-Adventure.h90295300.Hotel-Information)

![Casa Congo - Rayo Verde - Restaurante](https://images.trvl-media.com/lodging/16000000/15370000/15362800/15362713/0ae07404_y.jpg)

### Casa Congo - Rayo Verde - Restaurante

10/10 Excellent

"Great staff. Loved the balcony in our room, Ray Congo, with hammock overlooking the water. Lots to do!"

[](https://expedia.com/Portobelo-Hotels-Casa-Congo-Rayo-Verde-Restaurante.h15362713.Hotel-Information)

![Ordovician Beach Resort](https://images.trvl-media.com/lodging/104000000/103770000/103761600/103761591/9a39b281_y.jpg)

### Ordovician Beach Resort

10/10 Excellent

"The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed."

[](https://expedia.com/Ordovician-Beach-Resort.h103761591.Hotel-Information)

![Ranchos de Chalia](https://images.trvl-media.com/lodging/106000000/105450000/105444000/105443903/fedfb071_y.jpg)

### Ranchos de Chalia

10/10 Excellent

"Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth"

[](https://expedia.com/Puerto-Lindo-Hotels-Ranchos-De-Chalia.h105443903.Hotel-Information)

![HOTEL ISLA GRANDE ](https://images.trvl-media.com/lodging/120000000/119950000/119947200/119947185/9e6abf31_y.jpg)

### HOTEL ISLA GRANDE 

4/10 Poor

"This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces."

[](https://expedia.com/Isla-Grande-Hotels-HOTEL-ISLA-GRANDE.h119947185.Hotel-Information)

![Ciel y Miel ](https://images.trvl-media.com/lodging/97000000/96740000/96735000/96734959/272cbe65_y.jpg)

### Ciel y Miel 

10/10 Excellent

"The views from this mountain-top boutique hotel are extraordinary."

[](https://expedia.com/Cacique-Hotels-Ciel-Y-Miel.h96734959.Hotel-Information)

![ScubaPortobelo](https://images.trvl-media.com/lodging/113000000/112180000/112177900/112177814/7b25d479_y.jpg)

### ScubaPortobelo

2/10 Terrible

"Even if I have paid and I had a printed confirmation the hôtel didn’t have m’y name. I had to pay in double "

[](https://expedia.com/Portobelo-Hotels-ScubaPortobelo.h112177814.Hotel-Information)

![Villa Bella Portobelo](https://images.trvl-media.com/lodging/95000000/94910000/94906500/94906459/805a9c7d_y.jpg)

### Villa Bella Portobelo

2/10 Terrible

"Serviette encore mouillé drap pas changer plancher très sale accueil douteux "

[](https://expedia.com/Portobelo-Hotels-Villa-Bella-Portobelo.h94906459.Hotel-Information)

![BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES](https://images.trvl-media.com/lodging/31000000/30800000/30792300/30792236/e39b72a8_y.jpg)

### BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent

"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "

[](https://expedia.com/Palenque-Hotels-Palenque-Spectacular-Caribbean-Ocean-Front-Property-In-Panama.h30792236.Hotel-Information)

## Find out more about Isla Grande

**Everything you need to know about Isla Grande vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Isla Grande vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Isla Grande vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Isla Grande vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Isla Grande. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Isla Grande in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Isla Grande rentals**

At Expedia, we put the best Isla Grande vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Isla Grande rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Isla Grande vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Isla Grande. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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## Frequently asked questions

### Can I find vacation rentals in Isla Grande?

### What are some of the best vacation home rentals in Isla Grande?

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### Expedia's Latest Trends

Hotels

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- [Puerto Lindo Hotels](https://expedia.com/Puerto-Lindo-Hotels.d3000007427.Travel-Guide-Hotels)
- [Colon All-inclusive Resorts](https://expedia.com/Colon-Hotels-All-Inclusive-Hotel.0-0-d601867-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Colon Hotels](https://expedia.com/Colon-Hotels.d601867.Travel-Guide-Hotels)
- [Blanca Beach hotels](https://expedia.com/Blanca-Beach-Hotels.0-l6286205-0.Travel-Guide-Filter-Hotels)
- [Buenaventura Beach Hotels](https://expedia.com/Buenaventura-Hotels-Beach-Hotel.0-0-d3000409855-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Gamboa Resorts & Hotels with Spas](https://expedia.com/Gamboa-Hotels-Spa-Hotel.0-0-d6025059-tSpaHotel.Travel-Guide-Filter-Hotels)
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- [Santa Isabel Beach Hotels](https://expedia.com/Santa-Isabel-Hotels-Beach-Hotel.0-0-d6203540-tBeachHotel.Travel-Guide-Filter-Hotels)

Flights

- [Flights to Colon](https://expedia.com/Cheap-Flights-To-Colon.d601867.Travel-Guide-Flights)
- [Flights from Colon](https://expedia.com/lp/flights/601867/flights-from-colon)

Cars

- [Car rentals in Puerto Lindo](https://expedia.com/Car-Rentals-In-Puerto-Lindo.d3000007427.Car-Rental-Guide)
- [Car rentals in Colon](https://expedia.com/Car-Rentals-In-Colon.d601867.Car-Rental-Guide)
- [Hertz Car Rentals In Colon](https://expedia.com/Hertz-Car-Rentals-In-Colon.d601867-c40.Car-Rental-Guide-Suppliers)

Activities

- [Things to do in Maria Chiquita](https://expedia.com/Things-To-Do-In-Maria-Chiquita.d6344217.Travel-Guide-Activities)
- [Things to do in Portobelo](https://expedia.com/Things-To-Do-In-Portobelo.d6145607.Travel-Guide-Activities)
- [Things to do in Colon](https://expedia.com/Things-To-Do-In-Colon.d601867.Travel-Guide-Activities)
- [Things to do in Gamboa](https://expedia.com/Things-To-Do-In-Gamboa.d6025059.Travel-Guide-Activities)

Packages

- [Safarick's Zoo](https://expedia.com/Safaricks-Zoo-Maria-Chiquita.d553248621574431161.Vacation-Attraction)
- [Trip to Nombre de Dios](https://expedia.com/Nombre-De-Dios.d3000462548.Destination-Travel-Guides)
- [Trip to Colon](https://expedia.com/Colon.d601867.Destination-Travel-Guides)
- [Real Aduana de Portobelo](https://expedia.com/Real-Aduana-De-Portobelo-Portobelo.d553248621532964863.Vacation-Attraction)

General

- [Visit Colon](https://expedia.com/Colon.dx601867)
- [Visit Fort Sherman](https://expedia.com/Fort-Sherman.dx6223313)
- [Visit Gamboa](https://expedia.com/Gamboa.dx6025059)
- [Visit La Guaira](https://expedia.com/La-Guaira.dx3000439511)
- [Visit Cativa](https://expedia.com/Cativa.dx553248623142874455)
- [Visit Limón](https://expedia.com/Limon.dx829297944220938240)

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