Ohio River Scenic Byway Vacations from $359

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Your Ohio River Scenic Byway Vacation

Our Ohio River Scenic Byway vacation packages take the hassle out of travel planning. Whether you're visiting to enjoy its history or something else, adventure awaits wherever you turn in this destination. Get your trip to Ohio River Scenic Byway off to an unforgettable start by making Clarksville your first stop. This city is a favorite with visitors from all over the globe. When it's time to stop dreaming and start traveling, Expedia will help turn your Ohio River Scenic Byway vacation into a reality.

The Latest Ohio River Scenic Byway vacation packages

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Louisville Airport
Hotel Indigo Pittsburgh East Liberty by IHG
Crowne Plaza Louisville Airport Expo Ctr by IHG
Belterra Casino Resort
21c Museum Hotel Cincinnati
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Ohio River Scenic Byway Hotel Deals

Hyatt Regency Cincinnati

Hyatt Regency Cincinnati

4 out of 5
151 West Fifth Street, Cincinnati, OH
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $190 total per night from Sep 7 to Sep 8
$190 total
Sep 7 - Sep 8
Total with taxes and fees
Hyatt Regency Cincinnati
Hilton Cincinnati Netherland Plaza

Hilton Cincinnati Netherland Plaza

4 out of 5
35 W 5th St, Cincinnati, OH
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $157 total per night from Sep 15 to Sep 16
$157 total
Sep 15 - Sep 16
Total with taxes and fees
Hilton Cincinnati Netherland Plaza
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
140 North Fourth Street, Louisville, KY
$118 nightly
The price is $139 total per night from Sep 3 to Sep 4
$139 total
Sep 3 - Sep 4
Total with taxes and fees
8.8/10 Excellent! (3,423 reviews)
"Buisness Friendly shops nearby"

Reviewed on Aug 29, 2025

Galt House Hotel Trademark Collection by Wyndham
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.