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Cherokee Vacation Rentals

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Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Cherokee vacation rentals

A covered patio with two wicker chairs, a blue rug, and a potted plant.

1. The 72 Rendezvous

The 72 Rendezvous
Cherokee
$282 nightly
The price is $302
Oct 12 - Oct 13
Total with taxes and fees
The 72 Rendezvous
A modern kitchen with a stainless steel refrigerator, black cabinets, a brick wall, and wooden flooring.

2. Iuka Downtown Historic King Loft B

Iuka Downtown Historic King Loft B
Iuka
10.0 out of 10, Exceptional, (4 reviews)
"Property was exactly as described. We enjoyed our weekend and would not hesitate to stay again. When we arrived, we texted with Cooper to get the code and he responded right away."
United States
Kelly K.
$198 nightly
The price is $212
Oct 12 - Oct 13
Total with taxes and fees
Iuka Downtown Historic King Loft B
A small, dark-colored building with a covered patio area, wooden chairs, and a bench.

3. Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka

Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka
Iuka
9.6 out of 10, Exceptional, (4 reviews)
"Super cute tiny home and really close to JP Coleman boat ramp. I would stay again and again!"
United States
EMILY B.
$180 nightly
The price is $193
Oct 12 - Oct 13
Total with taxes and fees
Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka
A cozy cabin interior with wooden walls, a white door, a sofa, a dining table, and a kitchen area.

4. Country Bliss

Country Bliss
Tishomingo
10.0 out of 10, Exceptional, (26 reviews)
"Love this place"
United States
Randall S.
$159 nightly
The price is $170
Oct 12 - Oct 13
Total with taxes and fees
Country Bliss
A small, two-story wooden structure with a red door and a porch.

5. The Gypsy Queen

The Gypsy Queen
Tishomingo
9.6 out of 10, Exceptional, (4 reviews)
"Cute funky fun little cottage. We loved it"
United States
Ashley P.
$203 nightly
The price is $217
Oct 12 - Oct 13
Total with taxes and fees
The Gypsy Queen
A wooden deck with wicker furniture and a table overlooking a body of water.

6. Perfect lake front cottage! Now with stairs to the water!

Perfect lake front cottage! Now with stairs to the water!
Waterloo
9.8 out of 10, Exceptional, (133 reviews)
"Wonderful stay! Great views at a cozy cabin!"
United States
Andrew A.
$333 nightly
The price is $365
Oct 13 - Oct 14
Total with taxes and fees
Perfect lake front cottage! Now with stairs to the water!
A living room with a blue sofa, a coffee table, a television, and a dining area with a table and chairs.

7. Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!

Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!
Florence
10.0 out of 10, Exceptional, (1 review)
"We really enjoyed our stay. The host was very accommodating and the area was nice quite and very close to everything to do in the area."
United States
David L.
$161 nightly
The price is $182
Oct 12 - Oct 13
Total with taxes and fees
Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!
A kitchen with white cabinets, a coffee maker, a bowl of coffee pods, and a window with sheer curtains.

8. Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake

Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake
Sheffield
9.4 out of 10, Exceptional, (8 reviews)
"Nice clean property. Conveniently located within 2-20 mins of shopping and restaurants."
United States
Kristy
Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake
A rustic wooden cabin with a balcony, surrounded by trees and a fire pit area.

9. Fern Hollow Treehouse, rustic escape cozy romantic

Fern Hollow Treehouse, rustic escape cozy romantic
Tishomingo
9.8 out of 10, Exceptional, (44 reviews)
"Beautiful and unique place to stay! The outdoor bathhouse was a great way to cool off from the humidity! Bring your mosquito repellent!!"
United States
Mel L.
$254 nightly
The price is $272
Oct 18 - Oct 19
Total with taxes and fees
Fern Hollow Treehouse, rustic escape cozy romantic
A living room with a brick wall, a ceiling fan, a sofa, and a coffee table.

10. Iuka Historic Downtown King Loft C

Iuka Historic Downtown King Loft C
Iuka
10.0 out of 10, Exceptional, (5 reviews)
"Wonderful place to stay"
United States
Sherry B.
$215 nightly
The price is $230
Oct 12 - Oct 13
Total with taxes and fees
Iuka Historic Downtown King Loft C
A living room with two sofas, a fireplace, a television, and a window with curtains.

11. The Cozy Cottage of Florence!

The Cozy Cottage of Florence!
Florence
8.8 out of 10, Excellent, (14 reviews)
"The cottage was comfortable and very centrally located"
United States
Sarah K.
$252 nightly
The price is $285
Oct 20 - Oct 21
Total with taxes and fees
The Cozy Cottage of Florence!
A living room with a TV mounted on the wall, a ceiling fan, a wooden floor, and a door leading to another room.

12. Charming 2-bedroom house with AC, WiFi in wonderful Florence

Charming 2-bedroom house with AC, WiFi in wonderful Florence
Florence
8.8 out of 10, Excellent, (6 reviews)
"Adorable house, great location, awesome host, very comfortable "
United States
Jamie S.
$243 nightly
The price is $275
Oct 13 - Oct 14
Total with taxes and fees
Charming 2-bedroom house with AC, WiFi in wonderful Florence
A kitchen with white cabinets, a double sink, and a window with blinds.

13. ReNew At JW's & bring your Dog too!

ReNew At JW's & bring your Dog too!
East Florence
9.4 out of 10, Exceptional, (13 reviews)
"The house is laid out very well, and the neighborhood is close to everything and quiet at night. The fenced yard was perfect for the pups. We would stay here again."
United Kingdom
Nicole L.
$165 nightly
The price is $186
Oct 13 - Oct 14
Total with taxes and fees
ReNew At JW's & bring your Dog too!
A wooden swing chair under a covered area overlooking a lake with a dock and trees in the background.

14. Stenson Hollow Lake Condo

Stenson Hollow Lake Condo
Muscle Shoals
9.6 out of 10, Exceptional, (115 reviews)
"The view of the lake was nice and we enjoyed seeing the fireflies at night"
United States
Wayne
$195 nightly
The price is $211
Oct 12 - Oct 13
Total with taxes and fees
Stenson Hollow Lake Condo
A cabin with a porch, a small deck, and a gravel yard.

15. BRAND NEW !! Cozy 1-bedroom cabin near PICKWICK LAKE with room for boat parking

BRAND NEW !! Cozy 1-bedroom cabin near PICKWICK LAKE with room for boat parking
Iuka
$156 nightly
The price is $167
Oct 17 - Oct 18
Total with taxes and fees
BRAND NEW !! Cozy 1-bedroom cabin near PICKWICK LAKE with room for boat parking
A rustic wooden interior with a dining table and chairs, a hanging light fixture, and a door with a window.

16. The Loft on Main

The Loft on Main
Belmont
9.8 out of 10, Exceptional, (19 reviews)
"Can't say enough good things about this place.... LOVED IT!!"
United States
Mark
$169 nightly
The price is $181
Oct 12 - Oct 13
Total with taxes and fees
The Loft on Main
A compact kitchen with white cabinets, stainless steel appliances, and a dining area with a rustic table and stools.

17. Crossroads to Pickwick Cabin SMOOTH SAILING

Crossroads to Pickwick Cabin SMOOTH SAILING
Iuka
9.8 out of 10, Exceptional, (27 reviews)
"Very cute place and convenient for our trip. "
United States
Tammy
$207 nightly
The price is $222
Oct 12 - Oct 13
Total with taxes and fees
Crossroads to Pickwick Cabin SMOOTH SAILING
A compact RV kitchen with a central island, built-in cabinets, and a sofa in the living area.

18. Crossroads to Pickwick Glamping

Crossroads to Pickwick Glamping
Iuka
9.8 out of 10, Exceptional, (11 reviews)
"Was very clean, the host was very nice, Made our trip really enjoyable"
United States
sharon
$179 nightly
The price is $192
Oct 15 - Oct 16
Total with taxes and fees
Crossroads to Pickwick Glamping
A dining area with a round wooden table, black chairs, a brick fireplace, and a vintage car display.

19. 3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital

3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital
Muscle Shoals
9.6 out of 10, Exceptional, (75 reviews)
"Property very nice, pool was wonderful, community safe and friendly, home was well supplied we had a fabulous time."
United States
Danyela Ranae L.
$309 nightly
The price is $339
Oct 12 - Oct 13
Total with taxes and fees
3-bedroom w/pool and all the comforts of home in Muscle Shoals-recording capital
A modern kitchen with dark cabinets, a central island, stainless steel appliances, pendant lighting, and a decorative rug.

20. Emerald Hour Loft: 2 mins from UNA

Emerald Hour Loft: 2 mins from UNA
Florence
9.8 out of 10, Exceptional, (6 reviews)
"Perfect location and great Accommodations. Host was easy to contact and plan to stay again if available. ."
United States
Andrea
$233 nightly
The price is $264
Oct 13 - Oct 14
Total with taxes and fees
Emerald Hour Loft: 2 mins from UNA
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cherokee Hotel Reviews

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

10/10 Excellent
"Good room, breakfast was not good, but overall a nice stay"
john 1-night trip
Posted 6 hours ago
Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Find out more about Cherokee

Everything you need to know about Cherokee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cherokee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cherokee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Cherokee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cherokee. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Cherokee in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $181 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Cherokee rentals

At Expedia, we put the best Cherokee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cherokee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cherokee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cherokee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find vacation rentals in Cherokee?

Yes, you can find vacation rentals near popular points of interest in Cherokee, or you can select a secluded option if you're looking for a relaxing stay.

What are some of the best vacation rentals in Cherokee?

Rustic Cabin overlooking Pickwick Lake: This Cherokee vacation home rental is located on a lake and offers a barbecue grill, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. Our travelers also rate RIVERTON LAKESIDE COTTAGE ON PICKWICK LAKE as a favorite home for rent in Cherokee.

How many vacation rentals are there in Cherokee?

Choose from 6 Expedia vacation rentals in Cherokee for a memorable vacation.

What can I see and do in Cherokee?

Pickwick Lake and Tennessee River are a couple of lovely local spots to get outside and enjoy nature. Cane Creek Canyon Nature Preserve and Ivy Green are a couple of places you'll find in the larger area.

What are vacation rentals like in Cherokee?

Vacation rentals are privately owned accommodations you can reserve for several days or longer in Cherokee. Vacation rentals offer amenities like WiFi and washers and dryers so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for family trips.