Defiance Vacations from $358
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Your Defiance Vacation
Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.
The Latest Defiance vacation packages
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
Price was $536, price is now $358 per person
$358
per person
Sep 12 - Sep 14
found 2 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.2/10 Wonderful! (1,663 reviews)
We were welcomed by a lovely person named Genna at the front desk who was so kind. The room was great - very clean and spacious. The grounds and building seem very well taken care of. This was a blind find on our way through the area. We sure lucked out with such a fantastic stay!
Reviewed on Jun 29, 2026
Hermann Grain Bins BNB
Price was $1,510, price is now $1,205 per person
$1,205
per person
Sep 6 - Sep 11
found 11 hours ago
Roundtrip non-stop flight included
New York (JFK) to St. Louis (STL)
6/10 (2 reviews)
It was so comfortable and uniquely and beautifully decorated! There was so many awesome areas to explore inside and outside of the Grain Bins. Food provided for breakfast was fresh and hot. There was perfectly cooked bacon, scrambled eggs and really moist corn muffins with homemade mango preservers! We were welcomed with fresh, homemade plum bread. Instructions for everything available to utilize and operate were easy to understand. I can’t wait to go back and I will tell all my friends and family about this unique and relaxing place.
Reviewed on May 22, 2026
Moonrise Hotel
Delmar Loop
Price was $470, price is now $394 per person
$394
per person
Sep 12 - Sep 14
found 2 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,981 reviews)
The manager Andre along with the rest of the staff was great and helpful. The staff were polite and answered all questions and were respectful and professional.
Reviewed on Jun 30, 2026
The Knight Center at Washington University
Price was $441, price is now $370 per person
$370
per person
Sep 12 - Sep 14
found 2 hours ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9.4/10 Exceptional! (583 reviews)
A hidden gem! Will absolutely stay here again. Quiet, clean, great staff, the breakfast was decent in a fun pub setting. Easy in/out access. Wish I had found this sooner.
Reviewed on Jun 29, 2026
What to do in Defiance
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
St. Louis Premium Small Group Tour With Arch & River Cruise
$161
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Defiance Hotel Deals
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $109 total per night from Jul 1 to Jul 2
$109 total
Jul 1 - Jul 2
Total with taxes and fees
7.8/10 Good! (1,395 reviews)
"Overall the staff was great. We did ask some staff we saw for towels since the pool area had none. The EVS asked a staff member we could not see who mumbled something we could not hear, she replied to them “she’s standing right there” to which I heard from unseen person a very loud annoyed sigh. ..."
Reviewed on Jun 30, 2026
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
$114 nightly
The price is $133 total per night from Jul 2 to Jul 3
$133 total
Jul 2 - Jul 3
Total with taxes and fees
8.6/10 Excellent! (2,203 reviews)
"We stayed for 5 nights for a competition. Check in and front desk were extremely friendly and helpful. I know we are attached to a casino but the smoke smell hits you when you get to elevators. The main areas were pretty maintained; however corners and behind doors need attention. Our room was okay, ..."
Reviewed on Jun 29, 2026
The Wildwood Hotel
2801 Fountain Pl Wildwood MO
$108 nightly
The price is $126 total per night from Jul 20 to Jul 21
$126 total
Jul 20 - Jul 21
Total with taxes and fees
9.2/10 Wonderful! (1,675 reviews)
"Great Staff"
Reviewed on Jun 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Defiance Vacation Packages
Defiance Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 160 |
Max Temp Winter | 40ºF |
Max Temp Summer | 90ºF |
Top Sights | Augusta Winery, Montelle Winery and Chandler Hill Vineyards |
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Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
