Defiance Vacations from $383

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Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

The Latest Defiance vacation packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
 White House at Grand Central
Hampton Inn By Hilton St Louis Airport
The Knight Center at Washington University
The Cheshire
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Discover the most popular places to visit in Defiance

What to do in Defiance

Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $98 total per night from Feb 1 to Feb 2
$98 total
Feb 1 - Feb 2
Total with taxes and fees
7.8/10 Good! (1,061 reviews)
The room was clean and a nice size. Parking was easy and the front desk let us know where to park so we could see our car from the window if we wanted to.

Reviewed on Jan 1, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
$95 nightly
The price is $111 total per night from Jan 5 to Jan 6
$111 total
Jan 5 - Jan 6
Total with taxes and fees
9.2/10 Wonderful! (1,614 reviews)
Wonderful hotel staff, lovely facility.

Reviewed on Dec 31, 2025

The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $205 total per night from Jan 11 to Jan 12
$205 total
Jan 11 - Jan 12
Total with taxes and fees
8.4/10 Very Good! (1,006 reviews)
Was an amazing hotel to stay at!! Clean spacious and very nice!!! Will stay here again!!

Reviewed on Dec 31, 2025

Ameristar Casino Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Defiance Vacation Packages

Defiance Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
160
Max Temp Winter
40ºF
Max Temp Summer
90ºF
Top Sights
Augusta Winery, Montelle Winery and Chandler Hill Vineyards

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Frequently asked questions

How much does a Defiance vacation package cost?
You can grab a vacation package to this popular destination from $383 on Expedia. However, how much your vacation to Defiance costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Defiance?
If you're looking to score a cheap Defiance vacation package, consider traveling in December, January and February. You'll usually find lower rates on hotels and airfares during these quieter months — perfect for a budget-friendly break.
How many days is enough for Defiance?
Typically, a handful of days is enough to visit the top attractions during your Defiance vacation. But if you prefer to have more time to relax or take day trips, think about extending your itinerary.
How to find the best Defiance package deals?
Use Expedia's filters to find some terrific Defiance package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for Defiance package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Defiance vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Defiance vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Defiance?
If you have your Defiance vacation dates locked in, book as soon as you can to snap up some awesome deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later Defiance vacation packages?
If you're anything like us, you love discovering new places but don't love the big price tag that can come with it. That's why we've created Book Now, Pay Later vacations. With help from online lender Affirm, you can spread the overall cost of your Defiance break over 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.