East Seneca Vacations from $235

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Your East Seneca Vacation

Say bye-bye to the stress of planning and hello to a East Seneca vacation package. With your travel details organized before you leave, you can focus on discovering this city, starting with Downtown Buffalo, which is great for nightlife, shopping and bars and pubs. A trip to East Seneca is a superb opportunity to sightsee. Check out well-known attractions like Highmark Stadium, Buffalo and Erie County Botanical Gardens and Walden Galleria Mall. Don't put off exploring this city any longer. The ultimate East Seneca vacation is a few clicks away with Expedia.

The Latest East Seneca Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Garden Place Hotel

Garden Place Hotel

3.5 out of 5
Price was $333, price is now $235 per person
$235
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
7.8/10 Good! (1,861 reviews)
A lot of renovations need to be done to the rooms. Also, the smell is not appealing and t smells like a hospital.

Reviewed on Sep 8, 2025

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Save 100% on your flight
Price was $484, price is now $279 per person
$279
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
8/10 Very Good! (2,625 reviews)
The outdoor patio section was nice just needs a couple more tv.s King room was nice and having Wingnutz right there and speedway is a plus.

Reviewed on Sep 8, 2025

La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

3 out of 5
Save 100% on your flight
Price was $509, price is now $348 per person
$348
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
7.8/10 Good! (1,263 reviews)
Had a great stay. When in Buffalo I would stay again!

Reviewed on Sep 8, 2025

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
Price was $404, price is now $284 per person
$284
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
7.4/10 Good! (2,072 reviews)
Overall, was good. Not great.

Reviewed on Sep 8, 2025

Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
Price was $439, price is now $311 per person
$311
per person
Dec 5 - Dec 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Buffalo (BUF)
7.8/10 Good! (1,723 reviews)
Nice place to stay for the Bills games! Judy makes the best breakfast in the morning

Reviewed on Sep 8, 2025

Where to stay in East Seneca

Find the best East Seneca areas and neighborhoods for the activities you enjoy most. Learn more about East Seneca
Buffalo showing a city, a monument and a skyscraper

Downtown Buffalo

4 out of top 10 points of interest in this area
4/5(1,204 area reviews)

Experience the city's rich culture with visits to the oldest urban parks system in the US, Albright–Knox Art Gallery, and Shea's Performing Arts Center. Enjoy annual festivals and explore nearby universities.

Find hotels in Downtown Buffalo

East Seneca Hotel Deals

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St, Buffalo, NY
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $134 total per night from Sep 10 to Sep 11
$134 total
Sep 10 - Sep 11
Total with taxes and fees
Buffalo Airport Hotel
M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave, Buffalo, NY
Fully refundableReserve now, pay when you stay
$93 nightly
The price is $106 total per night from Sep 10 to Sep 11
$106 total
Sep 10 - Sep 11
Total with taxes and fees
M Hotel Buffalo
Hyatt Regency Buffalo / Hotel and Conference Center

Hyatt Regency Buffalo / Hotel and Conference Center

3.5 out of 5
Two Fountain Plaza, Buffalo, NY
Fully refundableReserve now, pay when you stay
$145 nightly
The price is $169 total per night from Sep 29 to Sep 30
$169 total
Sep 29 - Sep 30
Total with taxes and fees
Hyatt Regency Buffalo / Hotel and Conference Center
See all 761 properties in East Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in East Seneca

A nice day for a walk in the fall by the pillars. #universityatbuffalo#buffalo #ub #college #hiking #lake #berries #fall

University At Buffalo - North Campus

Explore the campus of University At Buffalo - North Campus, a top college in Amherst. Experience the area's entertainment choices and acclaimed theater scene.

University At Buffalo - North Campus
Buffalo Zoo

Buffalo Zoo

See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains.

Buffalo Zoo
The USS Little Rock and the submarine, USS Croaker just to the left. Both are open for tours.

Buffalo and Erie County Naval and Military Park

After visiting Buffalo and Erie County Naval and Military Park, make a plan to see the other sights and activities in Buffalo. Experience the area's entertainment choices or attend a hockey game.

Buffalo and Erie County Naval and Military Park

Things to do

The Station Master

Niagara Falls USA and Underground Railroad Heritage Tour

$125
per adult
Niagara Falls USA and Underground Railroad Heritage Tour
Welcome to the Pan-American Exposition.

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

$13
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Niagara Falls Self-Guided Driving Audio Tour from Toronto

Niagara Falls Self-Guided Driving Audio Tour from Toronto

$17
per traveler
Niagara Falls Self-Guided Driving Audio Tour from Toronto
See all activities in Buffalo
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.