Title: Visit Eastern Panama: Best of Eastern Panama Tourism | Expedia Travel Guide - Expedia.com [Hotels in Eastern Panama](https://expedia.com/Eastern-Panama-Hotels.d6246114.Travel-Guide-Hotels)[Vacation Rentals in Eastern Panama](https://expedia.com/Eastern-Panama-Vacation-Rentals.d6246114.Travel-Guide-VacationRentals)[Flights to Eastern Panama](https://expedia.com/Cheap-Flights-To-Eastern-Panama.d6246114.Travel-Guide-Flights)[Car Rentals in Eastern Panama](https://expedia.com/Car-Rentals-In-Eastern-Panama.d6246114.Car-Rental-Guide)[Eastern Panama Vacation Packages](https://expedia.com/Eastern-Panama.d6246114.Destination-Travel-Guides) # Eastern Panama ## Travel Guide ![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. #BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![50 Shades of blue. Sailing through the San Blas Islands in Panama lets you experience a pure paradise and crystal clear water. You can buy fresh fish and other seefood drirectly from local fishermen. If you want you can also play Robinson Crusoe on islands with literally only one palm tree. #BVSBlue](https://images.trvl-media.com/place/6246376/42fe0cae-c805-47d5-a705-ee119c68d58c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![A Kuna Yala man headed out to fish. If you have ever dreamed of spending a night or two on a small, private island, check out Kuna Yala. If you don't like roughing it a little bit, this might not be for you. There are cabins with flushing toilets but no electricity and the shower water is rather cool. Great place to get away from crowds and unplug though. #islands #peaceful #Adventure #water #ocean #boat #trovember](https://images.trvl-media.com/place/6246376/d3a402eb-8cb8-4f70-9be6-1b7fe662551a.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![A definite bucketlist place to visit if ever in #Panama. #SanBlas](https://images.trvl-media.com/place/6246376/a6346c00-8b9f-4941-bebd-cae3909ada84.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Secluded island in the Guna Yala region of Panama](https://images.trvl-media.com/place/829297845969362944/4b998afd-12f7-4a39-bbc7-d387cdb43caf.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Eastern Panama Things to do - Eastern Panama Hotel Deals - Vacation Rentals in Eastern Panama ![HOTEL ISLA GRANDE ](https://images.trvl-media.com/lodging/120000000/119950000/119947200/119947185/9e6abf31_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### HOTEL ISLA GRANDE Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National ... 4.6/10 (6 reviews) Although I gave this hotel a medium rating I enjoyed myself. This is a rough almost close to camping hotel. I must have not seen the message about bringing soap wash clothes, hand towel, tissue actually everything. The water does not get cold and there was a party set up just outside the window lasting ... Reviewed on Sep 19, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F21%2F2026&endDate=2%2F22%2F2026&selected=119947185&PinnedHotelID=119947185&HadPinnedHotel=true®ionId=6246114) [](https://expedia.com/Hotel-Search?startDate=2%2F21%2F2026&endDate=2%2F22%2F2026&selected=119947185&PinnedHotelID=119947185&HadPinnedHotel=true®ionId=6246114) ![Hotel Cocotal](https://images.trvl-media.com/lodging/117000000/116790000/116790000/116789972/c828cfe9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Cocotal La Guaira Isla Grande Provincia de Colón $98 nightly $108 total Feb 8 - Feb 9 Total with taxes and fees Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located ... 8.8/10 Excellent! (7 reviews) Excelente hospedaje lo mejor la amabilidad de José Ángel y los demás muchachos... Con decirles que hasta te llevan a la habitación si te has tomado algunos tragos.. recomendada al 100 Reviewed on Jan 7, 2026 [](https://expedia.com/Hotel-Search?startDate=2%2F8%2F2026&endDate=2%2F9%2F2026&selected=116789972&PinnedHotelID=116789972&HadPinnedHotel=true®ionId=6246114) ![Konsenda San Blas](https://images.trvl-media.com/lodging/100000000/99080000/99079700/99079675/3f55d468_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Konsenda San Blas Llano Cartí Km 11 El Llano Panamá Province $42 nightly $47 total Mar 5 - Mar 6 Total with taxes and fees Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden. 10/10 Exceptional! (1 review) wonderful eco lodge in the forest. Easy to reach by car, just on the main road. Paths to walk, excellent meals. A very good option if you need to relax before and after visiting Sab Blas, but worth the trip on its own, beautiful landscape. Reviewed on Mar 6, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F5%2F2026&endDate=3%2F6%2F2026&selected=99079675&PinnedHotelID=99079675&HadPinnedHotel=true®ionId=6246114) [See all 177 properties in Eastern Panama](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F8%2F2026&endDate=2%2F9%2F2026®ionId=6246114) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Private Over the Water Cabin on San Blas Island](https://images.trvl-media.com/lodging/38000000/37720000/37715900/37715808/f17df0ed_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Private Over the Water Cabin on San Blas Island 9.542876, -78.899058 Narganá San Blas Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime ... 7/10 Good! (6 reviews) Very nice. And I liked the food Reviewed on Aug 14, 2025 [](https://expedia.com/San-Blas-Islands-Hotels-Cabins-Over-The-Water-Wailidup-Island.h37715808.Hotel-Information) ![San Blas Private Beach Cabin](https://images.trvl-media.com/lodging/47000000/46960000/46955900/46955891/a97a9ec2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### San Blas Private Beach Cabin Nusatupo Narganá Guna Yala Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ... [](https://expedia.com/San-Blas-Islands-Hotels-San-Blas-Private-Beach-Cabin.h46955891.Hotel-Information) ![San Blas Private Oceanfront Cabin](https://images.trvl-media.com/lodging/47000000/46960000/46955400/46955399/287bc182_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### San Blas Private Oceanfront Cabin C5W9 4M Nusatupo Narganá Guna Yala Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). [](https://expedia.com/San-Blas-Private-Oceanfront-Cabin.h46955399.Hotel-Information) [See all properties in Eastern Panama](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=6246114&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Eastern Panama hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2026-02-07&endDate=2026-02-08)[Feb 7 - Feb 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2026-02-07&endDate=2026-02-08) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2026-02-08&endDate=2026-02-09)[Feb 8 - Feb 9](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2026-02-08&endDate=2026-02-09) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)[Feb 13 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=6246114&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026) ### Popular places to visit ![Secluded island in the Guna Yala region of Panama](https://images.trvl-media.com/place/829297845969362944/4b998afd-12f7-4a39-bbc7-d387cdb43caf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Isla Diablo Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area. [](https://expedia.com/Isla-Diablo-Nargana.d951034527519002624.Vacation-Attraction) #### Isla Chichime Commune with nature and explore the great outdoors at Isla Chichime during your travels in San Blas Islands. Take in the festivals while you're in the area. [](https://expedia.com/Isla-Chichime-Nargana.d951034147716386816.Vacation-Attraction) #### Museum of the Kuna Nation You can spend an afternoon studying the exhibits at Museum of the Kuna Nation in Narganá. Stroll along the seaside or experience the area's festivals. [](https://expedia.com/Museum-Of-The-Kuna-Nation-Nargana.d553248621579133546.Vacation-Attraction) ## Cities near Eastern Panama ![Islands of San Blas , Panama; Shutterstock ID 687617053; Purchase Order: -](https://images.trvl-media.com/place/6024116/aba78afe-1be5-4d43-bdc0-318dfbedec76.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### San Blas Islands ![Isla Grande Panama Tropen Strand](https://images.trvl-media.com/place/6053183/3ddb22e8-2245-453b-b3ca-3467e9b3943f.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Isla Grande ![#lifeatexpedia Beautiful Portobelo is full of history and culture. Located on the Caribbean coast it has a variety of world class attractions. The historic town of Portobelo is one of the most scenic spots in Panama. Set on a turquoise Caribbean bay, it was Spanish Empires' s trade epicenter in the 16th and 17th century. Don´t miss the Portobello Fortress and the Cristo Negro Church! ](https://images.trvl-media.com/place/6145607/ff6a8501-0761-475b-9eb5-4aa1941844ac.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Portobelo ![Scenic Coiba Island Aerial View](https://images.trvl-media.com/place/6203540/c7b068e1-573b-4f4f-9d2b-445d757c301a.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Santa Isabel - Cities near Eastern Panama - Places of interest [San Blas Islands](https://expedia.com/San-Blas-Islands.dx6024116)[Isla Grande](https://expedia.com/Isla-Grande.dx6053183)[Portobelo](https://expedia.com/Portobelo.dx6145607)[Santa Isabel](https://expedia.com/Santa-Isabel.dx6203540)[Puerto Lindo](https://expedia.com/Puerto-Lindo.dx3000007427)[Playon Chico](https://expedia.com/Playon-Chico.dx3000007429)[El Porvenir](https://expedia.com/El-Porvenir.dx3000007455)[Armila](https://expedia.com/Armila.dx3000007477)[Isla Tigre](https://expedia.com/Isla-Tigre.dx3000379099)[Meteti](https://expedia.com/Meteti.dx3000437845)[La Guaira](https://expedia.com/La-Guaira.dx3000439511)[Nombre de Dios](https://expedia.com/Nombre-De-Dios.dx3000462548)[Miramar](https://expedia.com/Miramar.dx553248623282266307)[Palenque](https://expedia.com/Palenque.dx553248623282267036)[Santa Fe](https://expedia.com/Santa-Fe.dx553248623287535268)[Tupile](https://expedia.com/Tupile.dx553248635963618492)[Carti](https://expedia.com/Carti.dx553248635974498100)[Playa Chiquita](https://expedia.com/Playa-Chiquita.dx553248635975847835)[Mandinga](https://expedia.com/Mandinga.dx553248635975856894)[Nusatupo](https://expedia.com/Nusatupo.dx553248635996711305)[Camogantí](https://expedia.com/Camoganti.dx829297382853201920)[Paya](https://expedia.com/Paya.dx829297452726095872)[Púcuro](https://expedia.com/Pucuro.dx829297458059177984)[Boca de Cupe](https://expedia.com/Boca-De-Cupe.dx829297466781212672)[Yape](https://expedia.com/Yape.dx829297475935293440) - [Cayos Holandeses ](https://expedia.com/Cayos-Holandeses-Guna-Yala.d553248621579133545.Vacation-Attraction) - [Isla Mamey ](https://expedia.com/Isla-Mamey-Colon.d553248623454093160.Vacation-Attraction) - [Portobelo National Park ](https://expedia.com/Portobelo-National-Park-Colon.d6252836.Vacation-Attraction) - [Museum of the Kuna Nation ](https://expedia.com/Museum-Of-The-Kuna-Nation-Nargana.d553248621579133546.Vacation-Attraction) - [Porvenir Museum ](https://expedia.com/Porvenir-Museum-Nargana.d553248621532964866.Vacation-Attraction) - [Colon Free Zone ](https://expedia.com/Colon-Free-Zone-Barrio-Sur.d6078503.Vacation-Attraction) - [Blanca Beach ](https://expedia.com/Blanca-Beach-Portobelo.d6286205.Vacation-Attraction) - [Chagres National Park ](https://expedia.com/Chagres-National-Park-Panama.d6252818.Vacation-Attraction) - [Playa La Angosta ](https://expedia.com/Playa-La-Angosta-Colon.d553248635998074269.Vacation-Attraction) - [Darien National Park ](https://expedia.com/Darien-National-Park-Panama.d6078494.Vacation-Attraction) - [Real Aduana de Portobelo ](https://expedia.com/Real-Aduana-De-Portobelo-Portobelo.d553248621532964863.Vacation-Attraction) - [Fuerte San Fernando ](https://expedia.com/Fuerte-San-Fernando-Portobelo.d553248621532964860.Vacation-Attraction) - [Chepo Regional Hospital ](https://expedia.com/Chepo-Regional-Hospital-Chepo.d553248622838221964.Vacation-Attraction) - [Limon Bay ](https://expedia.com/Limon-Bay-Colon.d6035251.Vacation-Attraction) - [San Felipe Church ](https://expedia.com/San-Felipe-Church-Portobelo.d6253121.Vacation-Attraction) - [Chepo Youth Recreation Center ](https://expedia.com/Chepo-Youth-Recreation-Center-Chepo.d553248622838221961.Vacation-Attraction) - [Chagres River ](https://expedia.com/Chagres-River-Panama.d740477249562820608.Vacation-Attraction) - [Galeta Island Marine Education Center ](https://expedia.com/Galeta-Island-Marine-Education-Center-Colon.d6253111.Vacation-Attraction) - [Mirador Perú ](https://expedia.com/Mirador-Peru-Portobelo.d553248621532964859.Vacation-Attraction) - [Fuerte San Jerónimo ](https://expedia.com/Fuerte-San-Jeronimo-Portobelo.d553248621532964862.Vacation-Attraction) - [San Cristobal Church ](https://expedia.com/San-Cristobal-Church-Chepo.d553248622838221957.Vacation-Attraction) - [Fuerte Santiago ](https://expedia.com/Fuerte-Santiago-Portobelo.d553248621532964861.Vacation-Attraction) - [Safarick's Zoo ](https://expedia.com/Safaricks-Zoo-Maria-Chiquita.d553248621574431161.Vacation-Attraction) - [Pirre Station ](https://expedia.com/Pirre-Station-La-Palma.d553248621532964867.Vacation-Attraction) - [Gatun Eco Adventures ](https://expedia.com/Gatun-Eco-Adventures-Nueva-Providencia.d553248621532619397.Vacation-Attraction) - [Área Silvestre de Narganá ](https://expedia.com/Area-Silvestre-De-Nargana-Panama-Province.d553248621532964873.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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