
Isla Grande Vacations from $610
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Your Isla Grande Vacation
With a Isla Grande vacation package, say goodbye to endless planning and hello to stress-free adventure. Every detail of your getaway has been taken care of before you go, so you can enjoy each moment discovering this lively city. If taking in the sights is a priority during your trip to Isla Grande, be sure to swing by famous attractions like Isla Mamey and Portobelo National Park. Whoever you're heading away with and whatever you want to spend, your dream Isla Grande vacation is just a few clicks away with Expedia.
The Latest Isla Grande vacation packages
Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B
Price was $957, price is now $610 per person
$610
per person
Jun 8 - Jun 13
found 14 hours ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
9.8/10 Exceptional! (64 reviews)
excellent breakfast every day and varied menu. nice room, had a a fridge and coffee maker, sitting area and very clean pool. walkable to beach and few restaurants - beach was very nice.
Reviewed on Mar 22, 2026

Mahogany Suites
Price was $1,218, price is now $721 per person
$721
per person
May 26 - May 31
found 1 day ago
Roundtrip flight included
Georgetown (GEO) to Panama City (PTY)
9.4/10 Exceptional! (6 reviews)
This is a very nice gated country club. It has great amenities and the apartment is in excellent condition and very comfortable. We only had one issue and that was with the dryer not working, which we didn’t discover until we had already washed a load of clothes. There isn’t a lobby that is staffed at this location, and it’s not clear who to contact with issues. The “check-in” occurred at the security gate as you arrive to the country club. But despite the lack of clear instructions you get when booking, I still recommend this place, especially if you have more than a one night stay, and would stay here again.
Reviewed on Mar 16, 2026

Central Hotel Panama Casco Viejo
Casco Viejo
Price was $1,748, price is now $1,214 per person
$1,214
per person
Jun 11 - Jun 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,000 reviews)
Such a beautiful hotel!!! I chose it because of the stair case but was floored when I saw it in person. Gorgeous, peaceful.It was a dream fantasy come to fruition!!! The location perfect. Few feet away from the presidential plaza. There was something happening everyday right outside the hotel all the time. The staff so welcoming, breakfast was delicious. The city the people. I cannot say enough Panama and its people. So welcoming. I will definitely stay there again and longer. It was like staying in a movie. I see why our people move there and why citizens rarely move out this country
Reviewed on Mar 20, 2026

Radisson Riviera Panama
Price was $994, price is now $745 per person
$745
per person
May 30 - Jun 6
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
8.6/10 Excellent! (118 reviews)
This hotel has a great beach location. Although we couldn't go into the ocean because of jellyfish allegedly. The sea is best for surfing and water sports not so much relaxing. Pools were fine. The rooms were in need of repairs, first room we found mold and they didn't move us until the next day. Second room was better but showers were leaking, air conditioner smelt of mildew. There is only one restaurant and the food was good but the service was slow, the server had to come back many times to re-take our order. Generally staff was friendly. due to the rooms I wouldn't stay here again, I would probably rent an Air B&B in the area instead next time.
Reviewed on Mar 23, 2026
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View all tripsIsla Grande Hotel Deals

Hotel Cocotal
La Guaira Isla Grande Provincia de Colón
$97 nightly
The price is $107 total per night from Apr 6 to Apr 7
$107 total
Apr 6 - Apr 7
Total with taxes and fees

HOTEL ISLA GRANDE
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
4.8/10 (8 reviews)
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.
Reviewed on Feb 4, 2026

Ordovician Beach Resort
Isla Grande Isla Grande Colon
$500 nightly
The price is $549 total per night from Mar 26 to Mar 27
$549 total
Mar 26 - Mar 27
Total with taxes and fees
10/10 Exceptional! (9 reviews)
The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.
Reviewed on Feb 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Isla Grande Vacation Packages
Isla Grande Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Max Temp Winter | 80ºF |
Max Temp Summer | 85ºF |
Top Sights | Blanca Beach, Portobelo National Park and Mirador Perú |
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