Title: Visit Sainte-Reine: 2026 Travel Guide for Sainte-Reine, Bourgogne-Franche-Comté | Expedia.com [Hotels in Sainte-Reine](https://expedia.com/Sainte-Reine-Hotels.d553248634539797095.Travel-Guide-Hotels)[Vacation Rentals in Sainte-Reine](https://expedia.com/Sainte-Reine-Vacation-Rentals.d553248634539797095.Travel-Guide-VacationRentals)[Car Rentals in Sainte-Reine](https://expedia.com/Car-Rentals-In-Sainte-Reine.d553248634539797095.Car-Rental-Guide)[Sainte-Reine Vacation Packages](https://expedia.com/Sainte-Reine.d553248634539797095.Destination-Travel-Guides) # Sainte-Reine ## Travel Guide ## Visit Sainte-Reine ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248634539797095) - Sainte-Reine Hotel Deals - Vacation Rentals in Sainte-Reine ![Hôtel Akena Besançon](https://images.trvl-media.com/lodging/26000000/25160000/25153300/25153287/17ddd389_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hôtel Akena Besançon Rue Victor Considérant Chemaudin Doubs Stay at this hotel in Chemaudin. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Besançon Loop Trail and Micropolis Conference ... 9.2/10 Wonderful! (464 reviews) Quite a lot noise from the road- from rooms pointing against the main road- anything else was fine Reviewed on Sep 11, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&selected=25153287&PinnedHotelID=25153287&HadPinnedHotel=true®ionId=553248634539797095) [](https://expedia.com/Hotel-Search?startDate=2%2F28%2F2026&endDate=3%2F1%2F2026&selected=25153287&PinnedHotelID=25153287&HadPinnedHotel=true®ionId=553248634539797095) ![B&B HOTEL Besançon Valentin](https://images.trvl-media.com/lodging/100000000/99110000/99109800/99109793/ea28875b_edited_cefc_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### B&B HOTEL Besançon Valentin Zac Valentin Ouest Miserey-Salines Bourgogne-Franche-Comté $73 nightly $85 total Feb 21 - Feb 22 Total with taxes and fees Stay at this hotel in Miserey-Salines. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Pelote Tower and Musée des Beaux-Arts et ... 8.8/10 Excellent! (159 reviews) Almost perfect The hotel is recent and clean. The room was spacious enough. The mattress and pillows were comfy. The parking lot is big with wide parking spaces. But due to the general breakdown the air conditioning didn't work the night we stayed (during the heat wave). I cannot say that it was very hot in the ... Reviewed on Jun 2, 2025 [](https://expedia.com/Hotel-Search?startDate=2%2F21%2F2026&endDate=2%2F22%2F2026&selected=99109793&PinnedHotelID=99109793&HadPinnedHotel=true®ionId=553248634539797095) ![ibis Vesoul](https://images.trvl-media.com/lodging/1000000/10000/5600/5582/7bf0ce9a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### ibis Vesoul Rue Jean Georges Girard Vesoul Haute-Saone $91 nightly $102 total Feb 15 - Feb 16 Total with taxes and fees Book a stay at this business-friendly hotel in Vesoul. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Sport Bowling Vesoul and ... 7.2/10 Good! (235 reviews) A sleepless night!!! The room was small. Bathroom was very compact and had a drainage smell. The bathroom door handle was loose causing a problem getting in and out. The air con was great but when switched off it would rattle intermittently which meant we had an awful night’s sleep. Main door to first floor squeaked ... Reviewed on Sep 1, 2025 [](https://expedia.com/Hotel-Search?startDate=2%2F15%2F2026&endDate=2%2F16%2F2026&selected=5582&PinnedHotelID=5582&HadPinnedHotel=true®ionId=553248634539797095) [See all 148 properties in Sainte-Reine](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F15%2F2026&endDate=2%2F16%2F2026®ionId=553248634539797095) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Large family home in the country - sleeps 8](https://images.trvl-media.com/lodging/122000000/121340000/121338300/121338292/8f288cac_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Large family home in the country - sleeps 8 Saint-Seine-sur-Vingeanne Côte-d'Or Stay at this vacation home in Saint-Seine-sur-Vingeanne. Enjoy in-room fireplaces. Popular attraction Vignoble Boirin is located nearby. [](https://expedia.com/Saint-Seine-Sur-Vingeanne-Hotels-Vrbo-Property.h121338292.Hotel-Information) ![Country house with private spa pets welcome](https://images.trvl-media.com/lodging/115000000/114740000/114736600/114736564/w2048h1062x0y0-f204be87_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Country house with private spa pets welcome Broye-les-Loups-et-Verfontaine Haute-Saône Book a stay at this family-friendly vacation home in Broye-les-Loups-et-Verfontaine. Enjoy a garden, laundry facilities, and patios. Popular attraction Vignoble ... 10/10 Exceptional! (2 reviews) Location conforme à la description avec un espace extérieur permettant de jouer pour les enfants, se reposer et manger quand le temps le permet. Le lieu est calme et agréable. Les contacts avec les propriétaires sont très cordiaux. Ils sont très disponibles et soucieux de notre bien-être. Je recommande ... Reviewed on Aug 1, 2025 [](https://expedia.com/Broye-Les-Loups-Et-Verfontaine-Hotels-Vrbo-Property.h114736564.Hotel-Information) ![Love Room](https://images.trvl-media.com/lodging/115000000/114730000/114725700/114725627/1450048a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Love Room Échenoz-le-Sec Haute-Saône Stay at this apartment in Mailley - Vellefaux. Enjoy free WiFi and a hot tub. [](https://expedia.com/Echenoz-Le-Sec-Hotels-Love-Room-Saonoise-In-The-Countryside.h114725627.Hotel-Information) [See all properties in Sainte-Reine](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248634539797095&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Sainte-Reine hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2026-02-14&endDate=2026-02-15)[Feb 14 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2026-02-14&endDate=2026-02-15) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2026-02-15&endDate=2026-02-16)[Feb 15 - Feb 16](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2026-02-15&endDate=2026-02-16) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026)[Feb 20 - Feb 22](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248634539797095&startDate=2%2F20%2F2026&endDate=2%2F22%2F2026) - Cities near Sainte-Reine - Places of interest [Vellexon-Queutrey-et-Vaudey](https://expedia.com/Vellexon-Queutrey-Et-Vaudey.dx6023166)[Seveux-Motey](https://expedia.com/Seveux-Motey.dx687962051508224000) - [Espace le Festi'Val ](https://expedia.com/Espace-Le-FestiVal-Arc-les-Gray.d553248622924610359.Vacation-Attraction) - [La Cure Des Arts ](https://expedia.com/La-Cure-Des-Arts-Preigney.d553248629175280533.Vacation-Attraction) - [Castle of Champlitte ](https://expedia.com/Castle-Of-Champlitte-Champlitte.d6320239.Vacation-Attraction) - [Ludolac ](https://expedia.com/Ludolac-Vaivre-et-Montoille.d553248626383870403.Vacation-Attraction) - [Vignoble Boirin ](https://expedia.com/Vignoble-Boirin-Broye-les-Loups-et-Verfontaine.d553248621561950306.Vacation-Attraction) - [La Cave se Rebiffe ](https://expedia.com/La-Cave-Se-Rebiffe-Marnay.d553248621532505365.Vacation-Attraction)