Santo Spirito Vacations

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Your Santo Spirito Vacation

Experience the best that Santo Spirito has to offer with a tailor-made Santo Spirito vacation package. From its walking and views to its culture, you'll quickly fall for the charms of this residential neighborhood. Not sure what to do during your trip to Santo Spirito? Nearby attractions like Piazza Santo Spirito, Santo Spirito Basilica and Brancacci Chapel are good places to begin. Expedia is here to put your travel plans into action. Book your perfect Santo Spirito vacation today.

The Latest Santo Spirito Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Astro Mediceo

Hotel Astro Mediceo

3 out of 5
Santissima Annunziata
per person
Jul 15 - Jul 19
found 21 hours ago
Roundtrip non-stop flight included
San Francisco (SFO) to Florence (FLR)
8.8/10 Excellent! (316 reviews)
Great little bar and bar area with an amazing bar tender who will give a master class on Italian alcohol. Breakfast was good. Staff was all very friendly. Street parking in the blue lines is the only parking, which we found a spot a few blocks down. Not a lot of retail or restaurants in the immediate area, which we were fine with as we had a car. Quiet at night. A good night of sleep.

Reviewed on May 31, 2024

Aurum Uffizi

Aurum Uffizi

4 out of 5
Santa Croce
per person
Jul 15 - Jul 19
found 21 hours ago
Roundtrip non-stop flight included
San Francisco (SFO) to Florence (FLR)
8/10 Very Good! (890 reviews)
Great location for attractions and dining options

Reviewed on Jun 11, 2024

Hotel La Scaletta Al Ponte Vecchio

Hotel La Scaletta Al Ponte Vecchio

3 out of 5
Oltrarno
per person
Jul 15 - Jul 19
found 21 hours ago
Roundtrip non-stop flight included
San Francisco (SFO) to Florence (FLR)
8.6/10 Excellent! (622 reviews)
We loved everything at La Scaletta! The best thing is the Sky Bar and roof top restaurant! Wide variety of excellent food and drinks, super conveniently located at a few steps away from Ponte Vecchio.

Reviewed on Jun 13, 2024

Hotel Lombardia

Hotel Lombardia

3 out of 5
Duomo
per person
Jul 15 - Jul 19
found 21 hours ago
Roundtrip non-stop flight included
San Francisco (SFO) to Florence (FLR)
8.6/10 Excellent! (122 reviews)
Apologies if I misspell Loren’s name! Loren was exceptional! He went out of his way to help with our luggage! After he noticed I had mobility issues, he switched us from the 4th floor to the 1st floor. Beyond accommodating! Grazie mille, Loren!

Reviewed on Jun 10, 2024

Hotel Albani Firenze

Hotel Albani Firenze

4 out of 5
Santa Maria Novella
per person
Jul 15 - Jul 19
found 21 hours ago
Roundtrip non-stop flight included
San Francisco (SFO) to Florence (FLR)
8.8/10 Excellent! (1,000 reviews)
Great service from wonderful staff. Convenient to everything we wanted to see but especially convenient to the train station. Highly recommend!!

Reviewed on Jun 9, 2024

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

5 out of top 10 points of interest in this area
5/5(2,214 area reviews)

Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence.

Find hotel + flight trips in Duomo

Santo Spirito Hotel Deals

Hotel Horto Convento
Hotel Horto Convento
4 out of 5
Viale Ariosto, 13, Florence
Fully refundableReserve now, pay when you stay
The price is $234 per night from Jun 16 to Jun 17
$234
$273 total
includes taxes & fees
Jun 16 - Jun 17
9.6/10 Exceptional! (372 reviews)
Historic and modern
"Beautiful old building, modernized and comfortable. The room was spacious, the bathroom and shower large and luxurious. Great firm mattress"

Reviewed on Jun 8, 2024

Hotel Horto Convento
UNAHOTELS Vittoria Firenze
UNAHOTELS Vittoria Firenze
4 out of 5
Via Pisana 59, Florence, FI
Fully refundableReserve now, pay when you stay
The price is $114 per night from Jul 7 to Jul 8
$114
$140 total
includes taxes & fees
Jul 7 - Jul 8
8.4/10 Very Good! (985 reviews)
"Hip and modern hotel. Loved the breakfast and bar options. Would stay again."

Reviewed on Jun 11, 2024

UNAHOTELS Vittoria Firenze
Palazzo Mannaioni Suites
Palazzo Mannaioni Suites
4 out of 5
Via Maffia 9 - 17r, Florence, FI
9.2/10 Wonderful! (892 reviews)
"The property was lovely, but the air conditioning in the room did not seem to be fully functioning and as a result the room was a bit stuffy. Other than that, this was a great property and had very responsive and accommodating staff, would recommend!"

Reviewed on Jun 2, 2024

Get rates
Palazzo Mannaioni Suites
See all 435 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santo Spirito vacation package cost?
From just $1,485. Yes, you read that right. Our Santo Spirito packages are the best way to make your dollar go further. Bundle your favorite hotels, flights and rental car and explore this wonderful destination.
How do I get a cheap travel package to Santo Spirito?
If you love scoring a bargain, bundle your bookings into a Santo Spirito vacation package. Whether you need hotels, flights, activities or rental cars, you can book everything in one place. You’ll have endless choice at your fingertips as well. Expedia has more than 550 partner airlines and 1,000,000 hotels across the globe to choose from. Fly with who you want, stay in a place you like and save precious dollars — now that’s the ideal getaway!
What are the top hotels in Santo Spirito?
Reserve a room at Sweet Home Campuccio, 2 Double Bedrooms In San Frediano. It’s one of this area’s most sought-after hotels. Another well-known option in Santo Spirito is Residenza Oltrarno, An Elegant Apartment In The Historic Center Of Florence.
How far in advance should I book my Santo Spirito vacation?
To score cheap prices, book as soon as you can. Airlines typically release tickets, along with some of the lowest fares, up to a year in advance. Hotels, activities and car rental should also be booked early to avoid disappointment. If you were hoping for a last-minute getaway in Santo Spirito, there are always lots of great deals on Expedia. Check them out now!
What does an Expedia Santo Spirito travel package include?
Rental cars, flights and hotels, or any combination of the three — it’s totally up to you. Whether you’re headed to Santo Spirito with the entire family or enjoying a solo break, there’s a bundle to match every budget and style. Once you’ve made your booking, why not add on a couple of tours as well?
What should I know before booking a Santo Spirito travel package?
Locking in all the parts of your trip together is one of the best ways to save. Combine car rentals, airfares and hotels into a neat little package. But you’re not restricted to hotels. Expedia features all sorts of properties, including vacation rentals like oceanfront condos and city residences. The list goes on!
Can I choose my airline with a Santo Spirito Expedia vacation package?
Yes — and it’s simple too. Expedia has access to more than 550 partner airlines all over the world. Our vacation packages give you the freedom to pick from available flights, hotels and activities that suit you.
If I'm not able to travel, can I cancel my Santo Spirito vacation package?
If your vacation plans in Santo Spirito have been upended, it’s a relief to know that it is possible to cancel your booking. If you made your booking within the last 24 hours, you may be eligible for a refund. If your booking is older than that, your airline, hotel or car rental company may charge a fee. For more details, check our Customer Service Portal.

Discover the most popular places to visit in Santo Spirito

Image for Piazza Santo Spirito

Piazza Santo Spirito

5/5(1 review)

Learn about the local history of San Frediano with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and stunning cathedral in this vibrant area.

Piazza Santo Spirito
Image for Porta Romana

Porta Romana

4/5(14 reviews)

Find out about the history of San Frediano when you take a trip to Porta Romana. Amble around this vibrant area's riverfront or experience its acclaimed art scene.

Porta Romana
Image for Brancacci Chapel

Brancacci Chapel

A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.

Brancacci Chapel

Things to do

Image for Pisa & Tuscany in one day - Small group

Pisa & Tuscany in one day - Small group

$173
Per adult
Pisa & Tuscany in one day - Small group
Image for Tuscan Country Bike Tour with Wine and Olive Oil Tastings

Tuscan Country Bike Tour with Wine and Olive Oil Tastings

$96
Per adult
Tuscan Country Bike Tour with Wine and Olive Oil Tastings
Image for Private and authentic cooking class experience with family

Private and authentic cooking class experience with family

$103
Per adult
Private and authentic cooking class experience with family
See all activities in Florence

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.