Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A town square with historic buildings, a church, and a bell tower.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
See properties

Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

$33
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

$126
per adult
100% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
The Best of Tuscany in One Day Sightseeing Tour

The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery

$78
per adult
98% of travellers recommend
The Best of Tuscany Tour: Siena, San Gimignano, Pisa and Lunch at a Winery
Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$23
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Michaelangelo's David

Accademia timed-entry Ticket with Instant Delivery & Priority Access

$47
per adult
94% of travellers recommend
Accademia timed-entry Ticket with Instant Delivery & Priority Access
Florence: Dome Climb Ticket & Duomo Complex 3-Day Pass

Florence: Brunelleschi’s Dome Entry Ticket and Duomo Complex

$61
per adult
94% of travellers recommend
Florence: Brunelleschi’s Dome Entry Ticket and Duomo Complex
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
$149 nightly
The price is $180 total per night from Aug 10 to Aug 11
$180 total
Aug 10 - Aug 11
Total with taxes and fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (686 reviews)
"Beautiful, clean, amazing breakfast, really nice staff. 10/10 recommendation"

Reviewed on Jul 7, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
$123 nightly
The price is $151 total per night from Aug 11 to Aug 12
$151 total
Aug 11 - Aug 12
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (276 reviews)
"Clean room with good location and air conditioner Shops and restaurants nearby"

Reviewed on Jul 10, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
$78 nightly
The price is $101 total per night from Aug 2 to Aug 3
$101 total
Aug 2 - Aug 3
Total with taxes and fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"

Reviewed on May 12, 2026

UNA Hotels Vittoria Firenze
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
$85 nightly
The price is $108 total per night from Jul 20 to Jul 21
$108 total
Jul 20 - Jul 21
Total with taxes and fees
Stay at this guesthouse in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (228 reviews)
"Air climatisé qui ne fonctionnait pas vraiment Lits inconfortables Ventilateur hors d’état car tellement sale, nous avons dû le nettoyer nous-mêmes"

Reviewed on Jul 5, 2026

Foresteria Valdese di Firenze - Casa per Ferie
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
$157 nightly
The price is $188 total per night from Jul 14 to Jul 15
$188 total
Jul 14 - Jul 15
Total with taxes and fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (1,136 reviews)
"An absolute gem in Florence! Palazzo Mannaioni Suites was amazing, from the ideal location and beautiful room views to the exceptional staff. As first-time visitors to Italy, my wife and I spent a lot of time researching where to stay, and this property lived up to every rave review. The bed was ..."

Reviewed on Jul 10, 2026

Palazzo Mannaioni Suites
Torre di Bellosguardo

Torre di Bellosguardo

4 out of 5
Via Roti Michelozzi 2 Florence FI
$557 nightly
The price is $629 total per night from Jul 14 to Jul 15
$629 total
Jul 14 - Jul 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (103 reviews)
"This was by far the best hotel I have ever stayed at, as someone who travels solo often sometimes you are just looking for some peace and not having to do everything on your own. I am in awe of the property. If you are looking for privacy, story book views, and gardens this is the place to be. The ..."

Reviewed on Oct 29, 2025

Torre di Bellosguardo
See all 514 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Cathedral of Santa Maria del Fiore and Piazza della Signoria are a few top attractions in Historic Centre of Florence. Hop around the city on the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop and check out the area's fascinating museums, stunning cathedral, and stunning river views.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Cathedral of Santa Maria del Fiore and Piazza del Duomo are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Signoria and Uffizi Gallery are top sights worth seeing.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito

Choose one or more items to build your trip:

Explore a world of travel with Expedia