Clayton Vacations from $186
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Royal Relax Inn
$186
per person
Nov 12 - Nov 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6/10 (215 reviews)
I didn’t stay there because when I got there, he tried my card three times and it did not go through, which really made no sense to me. I drove 20 miles down the road got to quality Inn and had no problem with my credit card..
Reviewed on Oct 1, 2026
The Wildwood Hotel
$385
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,672 reviews)
We were there for three days. Every single person was helpful. The only downside for us was the lack of choices for the breakfast. After the first day, we went out to breakfast at other locations.
Reviewed on Oct 2, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
4 out of top 10 points of interest in this area
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
Downtown West
2 out of top 10 points of interest in this area
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$94 nightly
$110 total
Oct 25 - Oct 26
Total with taxes and fees
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$128 nightly
$150 total
Oct 11 - Oct 12
Total with taxes and fees
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$152 nightly
$179 total
Oct 11 - Oct 12
Total with taxes and fees
8.8/10 Excellent! (783 reviews)
"The Meridian is clearly an upscale business hotel. The room is modern, comfortable and clean. The hotel is very well equipped with amenities. There's parking with fees but the location is not parking friendly"
Reviewed on Oct 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Clayton attractions
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
Shaw Park Tennis Center
Catch an event at Shaw Park Tennis Center during your trip to St. Louis. Check out the shops and top-notch restaurants in this family-friendly area.
Things to do
StL's Signature "Sights and Bites" - Private Tour in St. Louis
$175
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
$15
per traveler
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- Christ Church Cathedral
- St. Louis Zoo
- Pagoda Circle
- St. Louis Cathedral
- Tower Grove Park
- Chapel of St. Timothy And St. Titus
- St. Louis Walk of Fame
- Wainwright Building
- Grant's Farm
- St. Louis Science Center
- Saint Louis Galleria Mall
- Chaifetz Arena
- Eads Bridge
- Missouri History Museum
- The MOTO Museum
- St. Alphonsus Liguori Catholic Church
- City Museum
- Fox Theater
- Cathedral Basilica of St. Louis
- Gateway Arch National Park
- St. Louis Art Museum
- Washington Avenue Historic District
- Busch Stadium
- Visit St. Louis
- Old Post Office
- Jewel Box
- Downtown St. Louis Vacations
- St. Louis City Hall
- Samuel Cupples House
- Citygarden Sculpture Park
- Washington University in St. Louis
- Museum at the Gateway Arch
- Meeting of the Waters Fountain
- The Muny Theater
- Gateway Arch
- Magic House - St. Louis Children's Museum
- St. Mary of Victories Catholic Church
- Eugene Field House & St. Louis Toy Museum
- Citygarden
- St. Louis Vacations
- Tivoli Theatre
- St. Louis Aquarium at Union Station
- Sky Zone Indoor Trampoline Park - St. Louis
- Missouri Botanical Gardens and Arboretum
- Bruno David Gallery
- Cabanne House
- Brentwood Vacations
- Forest Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.