The illuminated Gateway Arch at night with a city skyline in the background.

Clayton Vacations from $363

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Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

The Latest Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Dec 29 - Dec 31
The Wildwood Hotel + Flight
Wildwood
2 nights
3.5 star property
9.2/10 - Wonderful (1,685 reviews)
"This was our second stay at this property in 3 weeks. Great experience. Booked a king suite & was upgraded upon check-in. Very polite, efficient & courteous staff. Easy check-in, easy access. Great location in Wildwood many services within walking distance."
Reviewed November 15, 2026
Roundtrip • Atlanta (ATL) - St. Louis (STL)
ATL - STL • Nonstop STL - ATL • Nonstop
~~$516~~
$363
per traveler
found 1 day ago
The Wildwood Hotel
Jan 8 - Jan 11
Remodeled and Inviting Free EV + Flight
Fenton
3 nights
2.0 star property
9.0/10 - Wonderful (4 reviews)
Roundtrip • Atlanta (ATL) - St. Louis (STL)
ATL - STL • Nonstop STL - ATL • 1 stop
~~$749~~
$569
per traveler
found 3 hours ago
Remodeled and Inviting Free EV
Jan 8 - Jan 11
The Cheshire + Flight
Richmond Heights
3 nights
4.0 star property
8.8/10 - Excellent (1,005 reviews)
Roundtrip • Atlanta (ATL) - St. Louis (STL)
ATL - STL • Nonstop STL - ATL • 1 stop
~~$657~~
$544
per traveler
found 3 hours ago
The Cheshire
Jan 8 - Jan 11
Landing Furnished Apartments near Gateway Arch + Flight
Downtown West
3 nights
3.0 star property
Roundtrip • Atlanta (ATL) - St. Louis (STL)
ATL - STL • Nonstop STL - ATL • 1 stop
~~$697~~
$609
per traveler
found 3 hours ago
Landing Furnished Apartments near Gateway Arch
Jan 8 - Jan 11
The West End + Flight
Central West End
3 nights
2.0 star property
8.6/10 - Excellent (717 reviews)
"The hotel was clean and parking was great. Still haven't gotten my deposit back and its been a week!"
Reviewed November 15, 2026
Roundtrip • Atlanta (ATL) - St. Louis (STL)
ATL - STL • Nonstop STL - ATL • 1 stop
~~$470~~
$415
per traveler
found 3 hours ago
The West End

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton

The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

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A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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A large airplane suspended in a net structure in an urban setting with modern buildings in the background.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

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Discover the most popular places to visit in Clayton

Chapel of St. Timothy And St. Titus, Concordia Seminary

Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.

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