Clayton Vacations from $160
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Riverport
$160
per person
Oct 13 - Oct 16
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.6/10 Good! (1,015 reviews)
This hotel was dirty. There was hair in the sheets, mold on the shower curtain, the ice buckets were missing that tops and dirty, etc. Do not recommend.
Reviewed on Sep 7, 2026
Remodeled and Inviting Free EV
$325
per person
Oct 23 - Oct 26
found 3 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (2 reviews)
It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it
Reviewed on Aug 7, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
St. Charles Historic District
Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
Downtown West
2 out of top 10 points of interest in this area
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$104 nightly
$121 total
Oct 5 - Oct 6
Total with taxes and fees
9/10 Wonderful! (3,395 reviews)
"Very nice hotel! All the staff were wonderful and the parking garage was one of the cleanest I've ever seen. The breakfast was really tasty and the waitstaff were very attentive. It was my first time in the St. Louis area and Mr. Aaron at registration was very kind and helpful. He gave me some recommendations ..."
Reviewed on Sep 8, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$122 nightly
$142 total
Sep 13 - Sep 14
Total with taxes and fees
9.2/10 Wonderful! (394 reviews)
"It was very clean and nice property, beautiful room, located on a calm and secure part of the town, staff were ok but not super friendly, breakfast was just fine not more. You may find street parking space but they offer Valet parking option only for $32 per night."
Reviewed on Sep 8, 2026
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$130 nightly
$154 total
Sep 13 - Sep 14
Total with taxes and fees
8.8/10 Excellent! (1,008 reviews)
"Property is not good. It is very old and dirty."
Reviewed on Sep 8, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Clayton attractions
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
Shaw Park Tennis Center
Catch an event at Shaw Park Tennis Center during your trip to St. Louis. Check out the shops and top-notch restaurants in this family-friendly area.
Things to do
Beignet Cooking Class at a Trendy Local Café in St. Louis
$75
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Dome at America’s Center
- Hotels near Gateway Arch
- Clayton Hotels
- St. Louis Hotels
- Hotels with Free Airport Shuttle in St. Louis
- Extended Stay Hotels in St. Louis
- Casino Hotels in St. Louis
- Hotels with Free Breakfast in St. Louis
- Cabin Rentals in St. Louis
- Hotels near Lambert-St. Louis Intl.
- Hotels near Enterprise Center
- Cheap Hotels in St. Louis
- St. Charles Hotels
- Hotels near Busch Stadium
- Downtown St. Louis Hotels
- Flights from Fort Lauderdale (FLL) to St. Louis (STL)
- Flights from Portland (PDX) to St. Louis (STL)
- Flights from San Diego (SAN) to St. Louis (STL)
- Flights from New York (JFK) to St. Louis (STL)
- Flights from New York (LGA) to St. Louis (STL)
- Flights from Washington (DCA) to St. Louis (STL)
- Flights from Kansas City (MCI) to St. Louis (STL)
- Flights from Nashville (BNA) to St. Louis (STL)
- Flights from Phoenix (PHX) to St. Louis (STL)
- Flights from Orlando (MCO) to St. Louis (STL)
- Flights from Denver (DEN) to St. Louis (STL)
- Flights to St. Louis
- Flights from Lambert-St. Louis Intl.
- Flights from Raleigh (RDU) to St. Louis (STL)
- Flights from Atlanta (ATL) to St. Louis (STL)
- Flights from Philadelphia (PHL) to St. Louis (STL)
- Flights from Cincinnati (CVG) to St. Louis (STL)
- Flights from Seattle (SEA) to St. Louis (STL)
- Flights from Salt Lake City (SLC) to St. Louis (STL)
- Flights from Los Angeles (LAX) to St. Louis (STL)
- Flights from San Francisco (SFO) to St. Louis (STL)
- Flights from Chicago (ORD) to St. Louis (STL)
- Flights from Indianapolis (IND) to St. Louis (STL)
- Flights from Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
- Flights from Austin (AUS) to St. Louis (STL)
- Flights from Las Vegas (LAS) to St. Louis (STL)
- Flights from Tampa (TPA) to St. Louis (STL)
- Flights from Charlotte (CLT) to St. Louis (STL)
- Flights from Boston (BOS) to St. Louis (STL)
- Flights from Miami (MIA) to St. Louis (STL)
- Flights from Houston (IAH) to St. Louis (STL)
- Flights from Dallas (DFW) to St. Louis (STL)
- Flights from Detroit (DTW) to St. Louis (STL)
- Flights from Minneapolis (MSP) to St. Louis (STL)
- Christ Church Cathedral
- St. Louis Zoo
- Pagoda Circle
- St. Louis Cathedral
- Tower Grove Park
- Chapel of St. Timothy And St. Titus
- St. Louis Walk of Fame
- Wainwright Building
- Grant's Farm
- St. Louis Science Center
- Saint Louis Galleria Mall
- Chaifetz Arena
- Eads Bridge
- Missouri History Museum
- The MOTO Museum
- St. Alphonsus Liguori Catholic Church
- City Museum
- Fox Theater
- Cathedral Basilica of St. Louis
- Gateway Arch National Park
- St. Louis Art Museum
- Washington Avenue Historic District
- Busch Stadium
- Visit St. Louis
- Old Post Office
- Jewel Box
- Downtown St. Louis Vacations
- St. Louis City Hall
- Samuel Cupples House
- Citygarden Sculpture Park
- Washington University in St. Louis
- Museum at the Gateway Arch
- Meeting of the Waters Fountain
- The Muny Theater
- Gateway Arch
- Magic House - St. Louis Children's Museum
- St. Mary of Victories Catholic Church
- Eugene Field House & St. Louis Toy Museum
- Citygarden
- St. Louis Vacations
- Tivoli Theatre
- St. Louis Aquarium at Union Station
- Sky Zone Indoor Trampoline Park - St. Louis
- Missouri Botanical Gardens and Arboretum
- Bruno David Gallery
- Cabanne House
- Brentwood Vacations
- Forest Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.