The illuminated Gateway Arch at night with a city skyline in the background.

Clayton Vacations from $363

Book a Hotel + Flight or Car together to unlock savings

Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

The Latest Clayton Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
    Dec 29 - Dec 31

    The Wildwood Hotel + Flight

    Wildwood
    2 nights
    3.5 star property
    9.2/10 - Wonderful (1,684 reviews)
    Roundtrip • Atlanta (ATL) - St. Louis (STL)
    ATL - STL • Nonstop STL - ATL • Nonstop
    $516
    $363
    per traveler
    found 22 hours ago
    The Wildwood Hotel
  • A wooden cabin with a porch overlooking a lake, dock, and boats.
    Jan 1 - Jan 3

    Buddy's Harbor + Flight

    Lake Ozark
    2 nights
    2.5 star property
    9.4/10 - Exceptional (51 reviews)
    Roundtrip • Tampa (TPA) - St. Louis (STL)
    TPA - STL • 1 stop STL - TPA • 1 stop
    $639
    $565
    per traveler
    found 1 day ago
    Buddy's Harbor
  • A rooftop restaurant with round tables, chairs, and a view of the city.
    Jan 12 - Jan 14

    Moonrise Hotel + Flight

    Delmar Loop
    2 nights
    4.0 star property
    9.0/10 - Wonderful (2,056 reviews)
    "But expensive"
    Reviewed November 15, 2026
    Roundtrip • New York (NYC) - St. Louis (STL)
    LGA - STL • Nonstop STL - LGA • Nonstop
    $575
    $511
    per traveler
    found 1 day ago
    Moonrise Hotel
  • A marina with docked boats, a small dockside building, and a road with vehicles.
    Jan 1 - Jan 3

    Alhonna Resort LLC + Flight

    Lake Ozark
    2 nights
    3.0 star property
    8.8/10 - Excellent (376 reviews)
    "If you have question after hours, just read the instructions you receive.\nChecking in 😊"
    Reviewed November 1, 2026
    Roundtrip • Tampa (TPA) - St. Louis (STL)
    TPA - STL • 1 stop STL - TPA • 1 stop
    $668
    $599
    per traveler
    found 1 day ago
    Alhonna Resort LLC
  • A balcony with a view of a lake and forest.
    Jan 1 - Jan 3

    WorldMark Lake of the Ozarks + Flight

    Osage Beach
    2 nights
    3.0 star property
    9.4/10 - Exceptional (432 reviews)
    "Nice place to stay. Private balcony viewing lake."
    Reviewed November 11, 2026
    Roundtrip • Tampa (TPA) - St. Louis (STL)
    TPA - STL • 1 stop STL - TPA • 1 stop
    $655
    $591
    per traveler
    found 1 day ago
    WorldMark Lake of the Ozarks

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Learn more about Clayton
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

A large airplane suspended in a net structure in an urban setting with modern buildings in the background.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Discover the most popular places to visit in Clayton

Chapel of St. Timothy And St. Titus, Concordia Seminary

Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
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What to do near Clayton

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travelers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
See all activities near Clayton

Clayton Hotel Deals

A hotel room with two beds, a desk, a chair, and a television.

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
8.8 out of 10, Excellent, (3,529 reviews)
"My room was clean and the staff were helpful and kind. Housekeeping did walk into my room while I was sleeping. The pool is always out of order and there were NO LIGHTS in the garage, so it was dark, dangerous and scary! The hotel was also noisy."
$105 nightly
The price is $122
Dec 6 - Dec 7
Total with taxes and fees
Clayton Plaza Hotel & Extended Stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Clayton
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.