Clayton Vacations from $470
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Royal Sonesta Chase Park Plaza St. Louis
Central West End
Price was $636, price is now $470 per person
$470
per person
Jul 8 - Jul 11
found 1 day ago
Roundtrip flight included
Dallas (DFW) to St. Louis (STL)
9/10 Wonderful! (1,003 reviews)
This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.
Reviewed on May 4, 2026
Alhonna Resort LLC
Save 100% on your flight
Price was $1,052, price is now $747 per person
$747
per person
Jul 21 - Jul 27
found 1 day ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
8.8/10 Excellent! (264 reviews)
The sraff was amazing needed help fixing my trolling motor the maintenance man was so helpful and the room was amazing
Reviewed on Apr 30, 2026
Hilton Garden Inn Chesterfield
Price was $1,047, price is now $785 per person
$785
per person
Jun 12 - Jun 18
found 1 hour ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.4/10 Very Good! (818 reviews)
Room decent but customer service was excellent. Breakfast should be free
Reviewed on May 4, 2026
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Price was $915, price is now $718 per person
$718
per person
Jun 25 - Jun 29
found 1 day ago
Roundtrip flight included
Dallas (DAL) to St. Louis (STL)
8.8/10 Excellent! (1,034 reviews)
Amazing location and area . Easy to get around and property was clean and organized
Reviewed on May 4, 2026
Courtyard by Marriott St. Louis Downtown/Convention Center
Downtown St. Louis
Price was $908, price is now $730 per person
$730
per person
Jun 25 - Jun 29
found 1 day ago
Roundtrip flight included
Dallas (DAL) to St. Louis (STL)
9/10 Wonderful! (1,004 reviews)
Location, location, location...
Reviewed on May 3, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$99 nightly
The price is $116 total per night from May 10 to May 11
$116 total
May 10 - May 11
Total with taxes and fees
8.8/10 Excellent! (3,185 reviews)
Great location
Reviewed on May 4, 2026
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
$499 nightly
The price is $583 total per night from May 10 to May 11
$583 total
May 10 - May 11
Total with taxes and fees
9.2/10 Wonderful! (566 reviews)
When we arrived it was really loud hard to hear customer service as karaoke was going on.
Reviewed on Apr 27, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $168 total per night from May 17 to May 18
$168 total
May 17 - May 18
Total with taxes and fees
9/10 Wonderful! (299 reviews)
Great hotel.
Reviewed on May 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(483 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.