Clayton Vacations from $273
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Your Clayton Vacation
Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.
The Latest Clayton Vacation Packages
Price found within the past 48 hours. Click for updated prices.
HoteLumiere at the Arch - A Caesars Rewards Destination
Downtown St. Louis
Save 100% on your flight
Price was $389, price is now $273 per person
$273
per person
Jun 24 - Jun 27
found 21 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
6.8/10 (1,006 reviews)
Staff was generally unfriendly, odd smell about the place
Reviewed on Apr 12, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $754, price is now $392 per person
$392
per person
Jun 24 - Jun 27
found 22 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,624 reviews)
Lots of very helpful staff. Usually 2 at the desk at a time.
Reviewed on Apr 18, 2026
The Cheshire
Save 100% on your flight
Price was $447, price is now $296 per person
$296
per person
Jun 24 - Jun 27
found 22 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.6/10 Excellent! (1,011 reviews)
The bar was the perfect spot for a nightcap! Breakfast was also good, though there wasn't much seating available.
Reviewed on Apr 18, 2026
Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
Save 100% on your flight
Price was $680, price is now $472 per person
$472
per person
Jun 24 - Jun 27
found 22 hours ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,023 reviews)
This hotel had a very elegant modern vibe while encapsulating the big city bustle, it was very convenient to the stadiums, the arch and the river. The only downfall which is not their fault is the dilapidated hotel right across the street, definitely an eyesore but hopefully the city will have an amazing opportunity to revitalize that area! But back to this idea hotel, it was very clean and comfortable!
Reviewed on Apr 15, 2026
Where to stay in Clayton
Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
Downtown St. Louis
3 out of top 10 points of interest in this area
4/5(4,044 area reviews)
Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$96 nightly
The price is $112 total per night from Apr 19 to Apr 20
$112 total
Apr 19 - Apr 20
Total with taxes and fees
9/10 Wonderful! (3,155 reviews)
Front desk is extremely slow.
Reviewed on Apr 18, 2026
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
$499 nightly
The price is $583 total per night from Apr 19 to Apr 20
$583 total
Apr 19 - Apr 20
Total with taxes and fees
9.2/10 Wonderful! (564 reviews)
Friendly staff and very clean room.
Reviewed on Apr 15, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
$135 nightly
The price is $159 total per night from May 10 to May 11
$159 total
May 10 - May 11
Total with taxes and fees
8.8/10 Excellent! (709 reviews)
Parking went up to $35 night. Small, tight hotel Parking garage, but it was secure. Ice machine in floor Wasn’t working, bar area was nice.
Reviewed on Apr 3, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Clayton
Washington University in St. Louis
4.5/5(483 reviews)
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
Chapel of St. Timothy And St. Titus, Concordia Seminary
Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed theater scene or attend a sporting event.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
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- St. Louis Zoo
- Chapel of St. Timothy And St. Titus
- St. Louis Art Museum
- Washington University in St. Louis
- Saint Louis Galleria Mall
- St. Louis Walk of Fame
- Visit Richmond Heights
- Tivoli Theatre
- The Muny Theater
- Turtle Playground
- Jewel Box
- Missouri History Museum
- The Focal Point
- Brentwood Vacations
- Visit University City
- Pagoda Circle
- Cabanne House
- Car rentals near Washington University in St. Louis
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.