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Find hotels in Southeast Missouri, MO from $51

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May 16 - May 17
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May 17 - May 18
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Compare 568 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Courtyard
Hampton Inn Cape Girardeau I 55 East
2.5 star property
9.6 out of 10, Exceptional, (619)
"Shower stall could've been cleaner, hairs around bottom of doors. Staff was excellent & so helpful! Design of room had T.V. located on side wall, would prefer direct view from bed location. "
The price is $108
$122 total
includes taxes & fees
Jun 2 - Jun 3
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Inn & Suites Jackson MO
3.0 star property
9.6 out of 10, Exceptional, (957)
"This was by far the best experience we've had with places to stay. The manger was very friendly & made sure we were taken care of. The means being included was a bonus. We will definitely stay at your hotels in the future. "
The price is $108
$114 total
includes taxes & fees
May 27 - May 28
Drury Inn & Suites Jackson MO
Lobby
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (779)
"I liked the two rooms. Having breakfast included made traveling much more convenient."
The price is $108
$122 total
includes taxes & fees
May 21 - May 22
Drury Inn & Suites Cape Girardeau
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Property amenity
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1000)
"Convenient location and newer facility compared to other area options."
The price is $108
$123 total
includes taxes & fees
Jun 2 - Jun 3
Drury Inn & Suites Sikeston, MO
Property amenity
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
2.5 star property
9.4 out of 10, Exceptional, (555)
"Friendly and clean"
The price is $121
$139 total
includes taxes & fees
May 23 - May 24
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Exterior
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 star property
9.4 out of 10, Exceptional, (126)
"When we walked in the lodge it was spotless. Very homey and clean. The staff was so kind. We will definitely be back."
The price is $179
$201 total
includes taxes & fees
Jun 9 - Jun 10
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Lobby
Drury Inn & Suites Poplar Bluff
3.0 star property
9.2 out of 10, Wonderful, (706)
"The only thing that I was disappointed with is that I did not get my rewards as a Gold Key Member!"
The price is $108
$122 total
includes taxes & fees
May 23 - May 24
Drury Inn & Suites Poplar Bluff
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn
2.5 star property
9.2 out of 10, Wonderful, (211)
"Convenient "
The price is $115
$126 total
includes taxes & fees
Jun 2 - Jun 3
Shepherd Mountain Inn
Lobby
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1001)
"We never heard another person. Staff was wonderful."
The price is $64
$72 total
includes taxes & fees
May 21 - May 22
Pear Tree Inn Cape Girardeau West
Exterior
Hampton Inn Farmington
2.5 star property
9.0 out of 10, Wonderful, (437)
"They were extremely busy at breakfast and was continually out of food and took a long time to get it refilled."
The price is $145
$166 total
includes taxes & fees
May 31 - Jun 1
Hampton Inn Farmington
BBQ/picnic area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1002)
"18 years ago, my wife and I stayed in the honeymoon suite and it was wonderful. This time, we had the opportunity to stay there with our son and it was wonderful. The staff was very friendly and immediately took care of getting us checked-in so that we could make in time for our niece’s graduation. I would recommend this hotel to anyone traveling to Cape Girardeau, MO. Blessings to you! Robert and Katherine M."
The price is $66
$75 total
includes taxes & fees
Jun 3 - Jun 4
Auburn Place Hotel And Suites
Reception
The Farmstead Hotel
2.5 star property
8.8 out of 10, Excellent, (189)
"What we liked about it was it was convenient to the casino. What we didn't like was it's in a run down area that's a little sketchy, making you feel unsafe."
The price is $105
$119 total
includes taxes & fees
May 19 - May 20
The Farmstead Hotel
Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace
Microtel Inn & Suites by Wyndham Sainte Genevieve
2.5 star property
8.8 out of 10, Excellent, (489)
"This Microtel was comfortable and clean. The local folks of Ste Genevieve make this motel a very good place to stay."
The price is $83
$92 total
includes taxes & fees
May 19 - May 20
Microtel Inn & Suites by Wyndham Sainte Genevieve
Fountain
Bullwinkles Rustic Lodge
2.5 star property
8.8 out of 10, Excellent, (152)
"everything was perfect"
The price is $84
$95 total
includes taxes & fees
May 21 - May 22
Bullwinkles Rustic Lodge
Lobby
Comfort Inn Sullivan
2.5 star property
8.8 out of 10, Excellent, (616)
"Very nice"
The price is $119
$130 total
includes taxes & fees
May 19 - May 20
Comfort Inn Sullivan
Exterior
Hampton Inn Sikeston
2.5 star property
8.8 out of 10, Excellent, (267)
"Motel off the highway. Easy on/off access"
The price is $133
$151 total
includes taxes & fees
Jun 9 - Jun 10
Hampton Inn Sikeston
Front of property
Honeysuckle Inn - Mountain View
3.0 star property
8.6 out of 10, Excellent, (190)
"Exterior of the building was a neat design. Interior of the room so what dated, but generally clean."
The price is $100
$109 total
includes taxes & fees
May 21 - May 22
Honeysuckle Inn - Mountain View
Exterior
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
2.5 star property
8.6 out of 10, Excellent, (341)
"Went for the eclipse and paid an outrageous price but otherwise a very nice hotel "
The price is $123
$139 total
includes taxes & fees
Jun 2 - Jun 3
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Hallway
Travel Inn & Suites
2.5 star property
8.4 out of 10, Very Good, (522)
"Rooms a little small. "
The price is $62
$71 total
includes taxes & fees
Jun 5 - Jun 6
Travel Inn & Suites
Exterior
Comfort Inn & Suites Sikeston I-55
2.5 star property
8.4 out of 10, Very Good, (195)
"Very good customer service. Rooms were worth the price."
The price is $92
$105 total
includes taxes & fees
May 19 - May 20
Comfort Inn & Suites Sikeston I-55
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See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More cheap stays in Southeast Missouri

Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

3265 William St, Cape Girardeau, MO
The price is $66 per night from Jun 3 to Jun 4
$66
$75 total
includes taxes & fees
Jun 3 - Jun 4
8.6/10 Excellent! (1,010 reviews)

Stay near popular Southeast Missouri attractions

Image for Meramec Caverns

Meramec Caverns

5/5(21 reviews)

Explore the great outdoors at Meramec Caverns, a lovely green space in Sullivan. While in this family-friendly area, you can enjoy the coffeehouses.

See properties
Meramec Caverns

Recent reviews of Southeast Missouri hotels
Expedia verified reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

5/5 Excellent
"This hotel is definitely not as bad as everyone says. Definitely the best food selection as for vending machines. The only bad thing would have to be the smell of the rooms. It’s an odd smell but not like dead animal odd smell"
A verified traveler stayed at Motel 6 Poplar Bluff, MO
Posted 1 day ago
Motel 6 Poplar Bluff, MO