Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$99 nightly
The price is $112 total per night from Feb 8 to Feb 9
$112 total
Feb 8 - Feb 9
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,000 reviews)
Trash cans didn’t have trash bags
Reviewed on Jan 26, 2026
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $117 total per night from Feb 16 to Feb 17
$117 total
Feb 16 - Feb 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (494 reviews)
Room was clean and staff were all nice. Overall it was a good experience. My only complaint is how small the shower was. I would assume not all of the rooms have that small of a shower.
Reviewed on Jan 26, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$54 nightly
The price is $61 total per night from Feb 13 to Feb 14
$61 total
Feb 13 - Feb 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,000 reviews)
Clean room and nice staff
Reviewed on Jan 26, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (49 reviews)
Absolutely perfect stay! Beautiful clean cabin, fantastic views, so private and lovely. The amenities were great, and from beginning to end our stay was everything we wanted.
Reviewed on Feb 1, 2026
Johnson's Shut-ins State Park
148 Taum Sauk Trail Middle Brook MO
Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...
10/10 Exceptional! (1 review)
These newer cabins are clean and have everything you need. Highly recommend!
Reviewed on Nov 5, 2025
"Little Brick House on Main (1865)”
Ste. Genevieve MO
Stay at this vacation home in Ste Genevieve. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions Felix Valle House State Historic ...
10/10 Exceptional! (65 reviews)
We had a wonderful stay and enjoy the property, the shops in town and the dining. We visited Chateau Sainte Genevieve winery and loved the tour and the wines.
Reviewed on Jan 11, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Popular places to visit
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Elephant Rocks State Park
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Big Spring
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Hawn State Park
You can take time to visit Hawn State Park during your travels to Ste Genevieve. Discover the area's coffeehouses or seek out the golf courses.
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- Crane Lake Recreation Area
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- Visit Annapolis
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- Madison County Courthouse
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- K Bridge Recreation Area
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- Mark Twain National Forest
- Johnson's Shut-ins State Park
- Isle Casino Cape Girardeau
- Ozark National Scenic Riverways
- Southeast Missouri State University
- Elephant Rocks State Park
- Current River
- Century Casino Caruthersville
- Lake Wappapello
- Alley Spring & Mill
- Bonne Terre Mine
- Taum Sauk Mountain State Park
- Current River State Park
- Echo Bluff State Park
- Hawn State Park
- Big Spring
- Rocky Falls
- National Shrine of Our Lady of the Miraculous Medal
- Riverfront Bridge Park
- Round Spring Cave
- Trail of Tears State Park
- Pickle Springs Natural Area
- Riverfront Park
- Villa Antonio Winery
- Fort de Chartes
- Hunter Valley Winery
