Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$96 nightly
The price is $108 total per night from May 14 to May 15
$108 total
May 14 - May 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,007 reviews)
Loved the evening meal/drinks!
Reviewed on May 6, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$57 nightly
The price is $62 total per night from Jun 7 to Jun 8
$62 total
Jun 7 - Jun 8
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,008 reviews)
Staff was very friendly and free breakfast was great. The room was fine enough, but a bit run down.
Reviewed on May 4, 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from May 12 to May 13
$128 total
May 12 - May 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,007 reviews)
Nice stay staff and amenities were exe
Reviewed on May 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (65 reviews)
Wonderful location and attentive staff. Perfect getaway.
Reviewed on May 5, 2026
Johnson's Shut-ins State Park
148 Taum Sauk Trail Middle Brook MO
Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...
10/10 Exceptional! (3 reviews)
Nice property
Reviewed on Apr 30, 2026
Unbeatable convenience in amazing Eminence!
Eminence MO
Stay at this vacation home in Eminence. Enjoy laundry facilities, patios, and air conditioning. Popular attractions Roy L. Beck Municipal Golf Course and Mahan ...
10/10 Exceptional! (23 reviews)
Unbeatable location. Will definitely be back!
Reviewed on Apr 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Popular places to visit
Elephant Rocks State Park
5/5(13 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
4.5/5(78 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Current River State Park
4/5(5 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Lake Wappapello
4/5(18 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Big Spring
5/5(2 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Hawn State Park
5/5(4 reviews)
You can take time to visit Hawn State Park during your travels to Ste Genevieve. Discover the area's coffeehouses or seek out the golf courses.
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
100% of travellers recommend
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- Crane Lake Recreation Area
- Walnut Hollow Lake
- Visit Annapolis
- Silver Mine Recreation Area
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- Madison County Courthouse
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- K Bridge Recreation Area
- Visit Piedmont
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- Mark Twain National Forest
- Johnson's Shut-ins State Park
- Current River
- Ozark National Scenic Riverways
- Elephant Rocks State Park
- Century Casino & Hotel Cape Girardeau
- Southeast Missouri State University
- Century Casino Caruthersville
- Current River State Park
- Lake Wappapello
- Alley Spring & Mill
- Echo Bluff State Park
- Taum Sauk Mountain State Park
- Rocky Falls
- Big Spring
- Washington State Park
- Trail of Tears State Park
- Hawn State Park
- National Shrine of Our Lady of the Miraculous Medal
- Cape Splash Family Aquatic Center
- Riverfront Bridge Park
- Round Spring Cave
- Pickle Springs Natural Area
- Bonne Terre Mine
- Fort de Chartes
- Villa Antonio Winery
