Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$99 nightly
The price is $112 total per night from Nov 15 to Nov 16
$112 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,001 reviews)
"Best breakfast I’ve had in a long time at a hotel. The variety was nice too!"
Reviewed on Nov 4, 2026
Hampton Inn Poplar Bluff
2420 Crestwood Dr Poplar Bluff MO
$89 nightly
The price is $100 total per night from Dec 6 to Dec 7
$100 total
Dec 6 - Dec 7
Total with taxes and fees
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$54 nightly
The price is $62 total per night from Nov 11 to Nov 12
$62 total
Nov 11 - Nov 12
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (119 reviews)
"Limpio,muy fácil el check in cómodo y limpio."
Reviewed on Nov 2, 2026
Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve MO
Stay at this vacation home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
10/10 Exceptional! (160 reviews)
"Visited for the weekend with my wife to celebrate our anniversary. The Silo Farm Haus was absolutely perfect! The views of the rolling farmland were gorgeous. Inside was cozy and beautifully decorated. We had a wonderful time and would highly recommend staying here if you get the chance."
Reviewed on Oct 19, 2026
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions Poplar Bluff History Museum and North Main Street Historic District are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Southeast Missouri hotel availability
Stay near popular Southeast Missouri attractions
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
96% of travellers recommend
Tour The Ozarks Private Springfield Brewery Tour
$214
per adult
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- Visit Fredericktown
- Visit Park Hills
- Visit Ironton
- Walnut Hollow Lake
- Visit Perryville
- Visit Oran
- Visit Piedmont
- Visit Annapolis
- Visit Middle Brook
- Visit Jackson
- Visit Valles Mines
- Adults Only Vacation Packages Southeast Missouri
- Visit Desloge
- Yoga Vacation Packages Southeast Missouri
- Visit Belleview
- Visit Lesterville
- Visit Cape Girardeau
- Visit Van Buren
- Visit Black
- Visit Farmington
- Visit Pilot Knob
- Visit St. Francois County
- Visit Cadet
- Crane Lake Recreation Area
- Visit Poplar Bluff
- Visit New Offenburg
- Visit Bonne Terre
- Visit Wappapello
- Patterson Vacations
- Visit Leadwood
- Visit Dutchtown
- Visit Ellington
- Visit Caledonia
- Visit Marble Hill
- Visit Potosi
- Johnson's Shut-ins State Park
- United Rental Cars in Southeast Missouri
- Hertz Rental Cars in Southeast Missouri
- Top Rent a Car Rental Cars in Southeast Missouri
- Localiza Colombia Rental Cars in Annapolis
- Discount Car Rentals Rental Cars in Southeast Missouri
- Car rental Annapolis
- Car rental Central Fredericktown
- First-Car Rental Cars in Southeast Missouri
- Mississippi River
- Shawnee National Forest
- Mark Twain National Forest
- Johnson's Shut-ins State Park
- Century Casino & Hotel Cape Girardeau
- Elephant Rocks State Park
- Southeast Missouri State University
- Ozark National Scenic Riverways
- Taum Sauk Mountain State Park
- Century Casino Caruthersville
- Current River
- Lake Wappapello
- Echo Bluff State Park
- Alley Spring & Mill
- Current River State Park
- Big Spring
- Hawn State Park
- Rocky Falls
- Riverfront Park
- Bonne Terre Mine
- Fort Davidson State Historic Site
- St. Joe State Park
- Hunter Valley Winery
- National Shrine of Our Lady of the Miraculous Medal
- Black River Coliseum
- Meramec River
- St. Francois State Park
- Kennett Country Club
