Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$100 nightly
The price is $113 total per night from Jun 29 to Jun 30
$113 total
Jun 29 - Jun 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,008 reviews)
"Clean spacious king suite, friendly staff, restaurant on site, spacious breakfast area"
Reviewed on Jun 21, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$58 nightly
The price is $64 total per night from Jul 12 to Jul 13
$64 total
Jul 12 - Jul 13
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,011 reviews)
"The rooms are basic setup , the air conditioning worked great, shower was hot. Bathroom was stocked. Beds were made. Breakfast options were nice. Check in and check out were quick."
Reviewed on Jun 21, 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
$111 nightly
The price is $128 total per night from Jun 28 to Jun 29
$128 total
Jun 28 - Jun 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"
Reviewed on Jun 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (79 reviews)
"Great cozy cabin with wonderful staff to ask any questions"
Reviewed on Jun 17, 2026
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
8.8/10 Excellent! (3 reviews)
"I had a reservation for 4 nights, also received a confermation and itinerary number from hotes.com, but upon arrival I found that hotels.cim never made the reservation with the place I was staying. The place i was supposed to stay at were as accommodating as they could be, tried to find me a place ..."
Reviewed on Jun 19, 2026
Johnson's Shut-ins State Park
148 Taum Sauk Trail Middle Brook MO
Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...
10/10 Exceptional! (3 reviews)
"Nice property"
Reviewed on Apr 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Elephant Rocks State Park
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Big Spring
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Lake Wappapello
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Alley Spring State Park
You can take time to visit Alley Spring State Park during your travels to Eminence. Wander the riverfront or discover the area's waterfalls.
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
100% of travellers recommend
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- Johnson's Shut-ins State Park
- Mark Twain National Forest
- Century Casino & Hotel Cape Girardeau
- Ozark National Scenic Riverways
- Elephant Rocks State Park
- Current River
- Alley Spring & Mill
- Current River State Park
- Century Casino Caruthersville
- Rocky Falls
- Southeast Missouri State University
- Echo Bluff State Park
- Big Spring
- Lake Wappapello
- Hawn State Park
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- K Bridge Recreation Area
- Pickle Springs Natural Area
- Round Spring Cave
- Persimmon Ridge Winery
- Riverfront Bridge Park
- St. Francois State Park
- Big River
- Villa Antonio Winery
- Washington State Park
- National Shrine of Our Lady of the Miraculous Medal
