Title: Top 10 Hotels in Southeast Missouri from $57 - Competitive Prices | Expedia.com

[Southeast Missouri Travel Guide](https://expedia.com/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.com/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.com/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.com/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Car Rentals in Southeast Missouri](https://expedia.com/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.com/Southeast-Missouri.d6058763.Destination-Travel-Guides)

![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Bill Dillard

![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in Southeast Missouri

Cabin

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&lodging=CABIN)

Family friendly

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&travelerType=family_friendly)

Hot tub

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&amenities=HOT_TUB)

Pet friendly

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&amenities=PETS)

Farm

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&lodging=AGRITOURISM)

Cottage

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&lodging=COTTAGE)

Pool

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&amenities=POOL)

Apart­ment

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&lodging=APARTMENT)

Waterpark

[](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-16&d1=2026-04-16&endDate=2026-04-18&d2=2026-04-18&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[Apr 2 - Apr 3](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-02&endDate=2026-04-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Apr 3 - Apr 4](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-03&endDate=2026-04-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Southeast Missouri hotels

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

[](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

Jackson

9.6/10

Exceptional

(1,000 reviews)

"Great food and pool. Clean and cozy. We will be back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Leora

$80 nightly

$85 total

Apr 27 - Apr 28

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d4a93b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/ebca14b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/61c8f623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/b6c1f98e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

French Village

9.8/10

Exceptional

(57 reviews)

"Beautiful , comfortable!! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Taniyah

$139 nightly

$150 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Cape Girardeau

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(168 reviews)

"Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Larry

$93 nightly

$105 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/2025663e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/ca85d578.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor wedding area](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/d46ce6e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/16716658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Echo Bluff State Park

[](https://www.expedia.com/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

Eminence

9.6/10

Exceptional

(236 reviews)

"The lodge was beautiful! Our room was good for our time there. We enjoyed being able to eat at the grille and relax for the weekend! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tina

$158 nightly

$167 total

Apr 26 - Apr 27

Total with taxes and fees

[](https://www.expedia.com/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1,001 reviews)

"Great room, staff and breakfast! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kenneth

$98 nightly

$110 total

Apr 8 - Apr 9

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 By Wyndham Marston

[](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

Marston

8.2/10

Very Good

(56 reviews)

"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sue

$73 nightly

$83 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/63c45b75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/e2a51dca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/5fc6e860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont Inn and Suites by Wyndham Farmington, MO

[](https://www.expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

Farmington

8.0/10

Very Good

(1,003 reviews)

"Great staff and nice accommodations "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lisa

$59 nightly

$67 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/1ca0c293.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2e166a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru By Hilton Cape Girardeau

[](https://www.expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(116 reviews)

"Hotel was very clean, quiet and has a great location! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dustin

$89 nightly

$102 total

Apr 9 - Apr 10

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/8557dc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/972e20f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/cbaecd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny Houses of French Village

[](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

French Village

10/10

Exceptional

(5 reviews)

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris

$137 nightly

$145 total

Apr 13 - Apr 14

Total with taxes and fees

[](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/0c87c756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/2b5bb07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/ab22ad5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Perryville by IHG

[](https://www.expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

Perryville

9.2/10

Wonderful

(574 reviews)

"The hotel and room were very clean. It was in a quiet area. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alice

$103 nightly

$118 total

Apr 26 - Apr 27

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,000 reviews)

"Very nice for overnight stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

$94 nightly

$108 total

Apr 9 - Apr 10

Total with taxes and fees

[](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/79ff96cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Golf](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/4175ec90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Honeysuckle Inn - Mountain View

[](https://www.expedia.com/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

Mountain View

8.6/10

Excellent

(343 reviews)

"It was a very nice hassle free stay. I will be staying here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael Grey

$106 nightly

$115 total

Apr 3 - Apr 4

Total with taxes and fees

[](https://www.expedia.com/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

![Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/e270ba08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/807f3a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/ef8850d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/504b77a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Perryville

[](https://www.expedia.com/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information)

Perryville

8.4/10

Very Good

(972 reviews)

"Great place to stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Doug

$64 nightly

$73 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/d4bc56bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Golf](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/474450fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83886d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/c44a2fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Crown Pointe Lodge, BW Signature Collection

[](https://www.expedia.com/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information)

Farmington

9.0/10

Wonderful

(602 reviews)

"Excellent staff and location was nice and quiet "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Colleen

$110 nightly

$125 total

Apr 20 - Apr 21

Total with taxes and fees

[](https://www.expedia.com/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

[](https://www.expedia.com/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

Poplar Bluff

9.2/10

Wonderful

(1,000 reviews)

"Clean, comfortable room and great staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kendra

$94 nightly

$106 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville 

[](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

Portageville

8.0/10

Very Good

(757 reviews)

"The staff was great very helpful and friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Javier

$52 nightly

$56 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin | Desk](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Wappapello

[](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information)

Williamsville

10/10

Exceptional

(1 review)

"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dyann

$77 nightly

$81 total

Apr 19 - Apr 20

Total with taxes and fees

[](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Grand Riverview Two Queen Room | Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jackpot Suite | Living area | LED TV, Netflix, Hulu, first-run movies](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(538 reviews)

"Room was perfect"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Derrick

$122 nightly

$138 total

Apr 9 - Apr 10

Total with taxes and fees

[](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Porch](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/db122c9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Double Beds | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/bca42102.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/5f391186.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/60000/60000/59960/622c9d52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Madison Inn Lodge

[](https://www.expedia.com/Farmington-Hotels-Madison-Inn-Lodge.h59960.Hotel-Information)

Fredericktown

7.6/10

Good

(298 reviews)

"Rooms were clean! Beds were comfortable, and the staff were very accommodating."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ashley

$88 nightly

$96 total

Apr 3 - Apr 4

Total with taxes and fees

[](https://www.expedia.com/Farmington-Hotels-Madison-Inn-Lodge.h59960.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d3cfa5fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/665a33a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/966bc5a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d18ea228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn By Hilton Dexter

[](https://www.expedia.com/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information)

Dexter

10/10

Exceptional

(17 reviews)

"Great stay "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ashley

$98 nightly

$110 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-16&endDate=2026-04-17&regionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Vacation Rentals in Southeast Missouri

Cabin

![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin | Desk](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Wappapello

[](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information)

Williamsville

10/10

Exceptional

(1 review)

"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."

[](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information)

Cabin

![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d4a93b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/ebca14b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/61c8f623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/b6c1f98e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

French Village

9.8/10

Exceptional

(57 reviews)

"Beautiful , comfortable!! "

[](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

Cabin

![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/7a5cb69e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/b1561176.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/51a8f2fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/ba998441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnson's Shut-ins State Park

[](https://www.expedia.com/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Middle Brook

10/10

Exceptional

(1 review)

"These newer cabins are clean and have everything you need. Highly recommend! "

[](https://www.expedia.com/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Vacation Home

![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/8557dc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/972e20f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/cbaecd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny Houses of French Village

[](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

French Village

10/10

Exceptional

(5 reviews)

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

[](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

Cabin

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/0053b39a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sam A Baker State Park

[](https://www.expedia.com/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Patterson

9.0/10

Wonderful

(6 reviews)

"Pet friendly, great staff. "

[](https://www.expedia.com/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Cottage

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/2685cfaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/13098805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/9a8a1d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/8bc2c4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 'turtle Rock' - Ironton Cabin w/ Furnished Patio!

[](https://www.expedia.com/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Ironton

10/10

Exceptional

(1 review)

"Stroller, pack n play and high chair. This was amazing "

[](https://www.expedia.com/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Aparthotel

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Perryville

9.2/10

Wonderful

(17 reviews)

"Great place to stay! "

[](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Cottage

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/77a19bc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/fc5a080b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/d2bb6aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/b5fb5a7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cottage w/ Yard, Walk to Historic Attractions

[](https://www.expedia.com/Ste-Genevieve-Hotels-Cottage-Wyard.h94958207.Hotel-Information)

Ste Genevieve

10/10

Exceptional

(1 review)

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

[](https://www.expedia.com/Ste-Genevieve-Hotels-Cottage-Wyard.h94958207.Hotel-Information)

Cottage

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/c2de0b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/7b342bdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/6a2519cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/067f95ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 40-acre Poplar Bluff Nature Lovers Paradise!

[](https://www.expedia.com/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Poplar Bluff

10/10

Exceptional

(3 reviews)

"Beautiful place enjoyed our stay"

[](https://www.expedia.com/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Cottage

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/b4a37e32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/330effe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/be36bf8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/4d1e86cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Belgrade Cottage w/ Wood-burning Stove!

[](https://www.expedia.com/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

Belgrade

10/10

Exceptional

(1 review)

[](https://www.expedia.com/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

[See all vacation rentals](https://expedia.com/Hotel-Search?startDate=2026-04-30&endDate=2026-05-03&regionId=6058763&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true)

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## Stay near popular Central United States attractions

![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg)

### Southeast Missouri State University

4.4/5 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621554122994)

![](https://images.trvl-media.com/place/6058764/b46f1ef8-a151-4a6d-a0ba-117f21235d8d.jpg)

Photo by Pat Long

### Elephant Rocks State Park

4.8/5 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648464)

![](https://images.trvl-media.com/place/183505/9493e565-66da-46c4-8222-30a8f5da22bb.jpg)

Photo by JG Morris

### Lake Wappapello

4.4/5 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648460)

![Ozark Grist Mill](https://images.trvl-media.com/place/553248621532648450/5d510200-2188-41b5-a4e9-3dcff0b33b66.jpg)

### Current River State Park

4.6/5 (20 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648450)

### Century Casino & Hotel Cape Girardeau

4.2/5 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655780)

### Century Casino Caruthersville

3.5/5 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655201)

## Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

[See all hotels in Southeast Missouri](https://www.expedia.com/Hotel-Search?startDate=2026-04-16&endDate=2026-04-17&adults=2&regionId=6058763)

![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high)

Photo by Bill Dillard

## Top Southeast Missouri Hotel Reviews

![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718_y.jpg)

### Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Great place! "

[](https://expedia.com/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"Beautiful property well staffed and maintained "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Staff was outstanding. Gym and pool were great and all the extras were very nice "

[](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5_y.jpg)

### Baymont Inn and Suites by Wyndham Farmington, MO

4/10 Poor

"Rooms with paper thin walls and doors. Heard the neighbors Tv blaring all night. The refrigerator in the room was warmer than air temperature in the room. Stay just sucked "

[](https://expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg)

### Pear Tree Inn Cape Girardeau West

6/10 Okay

"Overall the room was nice but the website say that they offer happy hour and they don’t offer anything like that they just offer popcorn ..breakfast is good overall "

[](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

8/10 Good

"Yes, breakfast was fresh. Room temperature was comfortable. Overall stay was good. Would stay there again"

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81_y.jpg)

### The Farmstead Hotel

2/10 Terrible

"AC is a joke , not cleaning rooms is disrespectful this place is a joke"

[](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Really nice rooms"

[](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn Cape Girardeau North

10/10 Excellent

"It was a clean room at a fair price. No frills but clean and staff were polite. "

[](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

## More cheap stays in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

$59 nightly

$67 total

Apr 12 - Apr 13

Total with taxes and fees

8/10 Very Good! (1,003 reviews)

[](https://expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

$65 nightly

$69 total

Apr 5 - Apr 6

Total with taxes and fees

8/10 Very Good! (1,001 reviews)

[](https://expedia.com/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

$71 nightly

$80 total

Apr 9 - Apr 10

Total with taxes and fees

9/10 Wonderful! (1,000 reviews)

[](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

$93 nightly

$105 total

Apr 12 - Apr 13

Total with taxes and fees

9/10 Wonderful! (524 reviews)

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Farmstead Hotel

778 E 3rd St Caruthersville MO

$94 nightly

$107 total

Apr 5 - Apr 6

Total with taxes and fees

8.6/10 Excellent! (530 reviews)

[](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

$105 nightly

$118 total

Apr 12 - Apr 13

Total with taxes and fees

9.4/10 Exceptional! (1,001 reviews)

[](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

## Hotels in Southeast Missouri with star-rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

2 properties

[](https://expedia.com/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

53 properties

[](https://expedia.com/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

142 properties

[](https://expedia.com/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)

## Find out more about Southeast Missouri

### Top reasons to visit Southeast Missouri

- **Outdoor Adventures:**  Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities.
- **Charming Cape Girardeau:**  Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere.
- **Historic and Cultural Experiences:**  Delve into the region's history through its historic civic buildings and local cultural attractions.
- **Excellent Golfing:**  Challenge your skills at top-notch golf courses surrounded by stunning scenery.
- **Diverse Accommodation Options:**  Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays.

### Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable.

- **[Madison Inn Lodge: ](https://www.expedia.com/Farmington-Hotels-Madison-Inn-Lodge.h59960.Hotel-Information)** Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets.
- **[Shepherd Mountain Inn: ](https://www.expedia.com/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information)** Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10\. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay.
- **[Alpaca Farm Stay: ](https://www.expedia.com/Cozy-Lakeside-Lodge-15mins-From-Arcadia.h83602829.Hotel-Information)** Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10\. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories.

### Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience.

- **[Central Fredericktown: ](https://www.expedia.com/Central-Fredericktown-Hotels.d553248635975850047.Travel-Guide-Hotels)** Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region.
- **[Annapolis: ](https://www.expedia.com/Annapolis-Hotels.d6282465.Travel-Guide-Hotels)** Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature.
- **[Des Arc: ](https://www.expedia.com/Des-Arc-Hotels.d553248634983251690.Travel-Guide-Hotels)** Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience.

### Things to do in Southeast Missouri

Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone.

**Shopping**

In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods.

**Recreation**

Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere.

**Adventure**

Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature.

**Nightlife**

Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages.

\*Distances are measured in a straight line; actual driving distances may vary depending on the route.

### Booking tips and Expedia advantages for Southeast Missouri

- **The most and least expensive months on average to stay in a hotel:**  The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
- **The most and least expensive days on average to stay in a hotel:**  The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
- **Find cheap hotels on Expedia:**  Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
- **Consider bundling your trip:**  You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal.

### Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler.

- **[K Bridge Recreation Area: ](https://www.expedia.com/K-Bridge-Recreation-Area-Hotels.0-l6282501-0.Travel-Guide-Filter-Hotels)** Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun.
- **[Millstream Gardens Conservation Area: ](https://www.expedia.com/Millstream-Gardens-Conservation-Area-Hotels.0-l553248621592517773-0.Travel-Guide-Filter-Hotels)** Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history.
- **[Madison County Courthouse: ](https://www.expedia.com/Madison-County-Courthouse-Hotels.0-l553248621592517767-0.Travel-Guide-Filter-Hotels)** This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history.

### Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain. 

| **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** |
| ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- |
| January                                                                                                          | 34.9°F (1.6°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly Low                                                                                                   | Slightly Low                                                                                                  |
| February                                                                                                         | 38.1°F (3.4°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly Low                                                                                                   | Average                                                                                                       |
| March                                                                                                            | 48.0°F (8.9°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| April                                                                                                            | 57.6°F (14.2°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Slightly High                                                                                                 |
| May                                                                                                              | 67.3°F (19.6°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| June                                                                                                             | 76.5°F (24.7°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly High                                                                                                  | Slightly High                                                                                                 |
| July                                                                                                             | 79.2°F (26.2°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly High                                                                                                  | Average                                                                                                       |
| August                                                                                                           | 77.2°F (25.1°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly High                                                                                                  | Slightly High                                                                                                 |
| September                                                                                                        | 71.6°F (22.0°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| October                                                                                                          | 59.9°F (15.5°C)                                                                                                      | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Average                                                                                                       |
| November                                                                                                         | 47.5°F (8.6°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Average                                                                                                        | Slightly Low                                                                                                  |
| December                                                                                                         | 39.4°F (4.1°C)                                                                                                       | Light Rain                                                                                                       | Mostly Sunny                                                                                                                 | Slightly Low                                                                                                   | Slightly Low                                                                                                  |

### The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)) is 96 miles away, with nearby hotels like [The Ritz-Carlton](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport ([COU](https://www.expedia.com/Columbia-Regional-Airport-Hotels.0-aCOU-0.Travel-Guide-Filter-Hotels)), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport ([MKL](https://www.expedia.com/McKellar-Sipes-Regional-Airport-Hotels.0-aMKL-0.Travel-Guide-Filter-Hotels)) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. Each hotel provides easy access to their respective airports for a seamless travel experience.

## Explore a world of travel with Expedia

- Lodging
- Flights
- Packages
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- Vacation Rentals

- [Hotels near Crane Lake Recreation Area ](https://www.expedia.com/Crane-Lake-Recreation-Area-Hotels.0-l6282499-0.Travel-Guide-Filter-Hotels)
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- [Motels in Annapolis ](https://www.expedia.com/Annapolis-Motels.d6282465-aaMotels.Travel-Guide-Accommodation)
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- [Hotels near Millstream Gardens Conservation Area ](https://www.expedia.com/Millstream-Gardens-Conservation-Area-Hotels.0-l553248621592517773-0.Travel-Guide-Filter-Hotels)
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- [Visit Piedmont ](https://www.expedia.com/Piedmont.dx3000445413)
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- [Fort Davidson State Historic Site ](https://www.expedia.com/Fort-Davidson-State-Historic-Site-Ironton.d553248621532648465.Vacation-Attraction)

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