Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from $55

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Missouri hotels

Motel 6 Bonne Terre, MO

Motel 6 Bonne Terre, MO
2.0 star property
Bonne Terre
7.0 out of 10, Good, (27)
"Clean, was perfect for my one night stay in the area"
United States
Dave
$62 nightly
The price is $68
Jan 6 - Jan 7, 2026
Total with taxes and fees
Motel 6 Bonne Terre, MO

Super 8 by Wyndham Bonne Terre

Super 8 by Wyndham Bonne Terre
2.0 star property
Bonne Terre
7.0 out of 10, Good, (540)
"The room was spacious and very clean. The parking was free and close to the entrance, excellent water pressure for the shower, and the staff was friendly and professional."
United States
Raymond
$50 nightly
The price is $55
Jan 9 - Jan 10, 2026
Total with taxes and fees
Super 8 by Wyndham Bonne Terre

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
$144 nightly
The price is $153
Jan 4 - Jan 5, 2026
Total with taxes and fees
Echo Bluff State Park

Rockwood Inn

Rockwood Inn
2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (19)
"My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! "
United States
Kim
$156 nightly
The price is $177
Jan 5 - Jan 6, 2026
Total with taxes and fees
Rockwood Inn

OYO Malden Airport Inn

OYO Malden Airport Inn
2.5 star property
Malden
7.0 out of 10, Good, (68)
"Clean room, quiet. "
United States
Jennifer
$55 nightly
The price is $59
Jan 5 - Jan 6, 2026
Total with taxes and fees
OYO Malden Airport Inn

Econo Lodge Kennett

Econo Lodge Kennett
2.0 star property
Kennett
5.4 out of 10, (170)
"Yes. It Was All Good "
United States
Stephanie
$52 nightly
The price is $59
Jan 30 - Jan 31, 2026
Total with taxes and fees
Econo Lodge Kennett

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.0 out of 10, (206)
"Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors."
United States
Gary
$57 nightly
The price is $64
Jan 4 - Jan 5, 2026
Total with taxes and fees
Town House Inn Cape Giradreau

Econo Lodge Dexter

Econo Lodge Dexter
2.0 star property
Dexter
6.8 out of 10, (253)
"The stay was very nice. Animal friendly, staff is super nice and house keeping is very respectful. I appreciate everyone. "
United States
Michelle
$59 nightly
The price is $67
Jan 30 - Jan 31, 2026
Total with taxes and fees
Econo Lodge Dexter

Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (390)
"Clean room, friendly staff and quiet stay."
United States
Margo
$77 nightly
The price is $87
Jan 1 - Jan 2, 2026
Total with taxes and fees
Travelodge by Wyndham Dexter

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (577)
"Clean, friendly staff enjoyed the stay"
United States
John
$129 nightly
The price is $147
Jan 1 - Jan 2, 2026
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (104)
"It was a nice stay"
United States
Douglas
$89 nightly
The price is $102
Jan 7 - Jan 8, 2026
Total with taxes and fees
Tru By Hilton Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1003)
"Awesome stay!"
United States
Breckin
$90 nightly
The price is $102
Jan 4 - Jan 5, 2026
Total with taxes and fees
Drury Inn & Suites Cape Girardeau

Quality Inn Farmington

Quality Inn Farmington
2.5 star property
Farmington
7.6 out of 10, Good, (863)
"The staff was friendly. We had a few issues with our stay but overall was good. Love there breakfast variety "
United States
edith
$54 nightly
The price is $61
Jan 18 - Jan 19, 2026
Total with taxes and fees
Quality Inn Farmington

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (5)
"Great stay "
United States
Ashley
$106 nightly
The price is $119
Jan 9 - Jan 10, 2026
Total with taxes and fees
Hampton Inn By Hilton Dexter

OYO Hickory House Inn

OYO Hickory House Inn
2.5 star property
Dexter
5.6 out of 10, (134)
"We enjoyed every moment of our stay. Wonderful service—everyone was friendly and helpful."
United States
Albert
$57 nightly
The price is $63
Jan 29 - Jan 30, 2026
Total with taxes and fees
OYO Hickory House Inn

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.2 out of 10, Very Good, (886)
"Room was clean and spacious."
United States
George
$70 nightly
The price is $84
Jan 11 - Jan 12, 2026
Total with taxes and fees
Candlewood Suites Cape Girardeau by IHG

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (785)
"Excellent stay"
United States
Christina
$106 nightly
The price is $119
Jan 8 - Jan 9, 2026
Total with taxes and fees
Hampton Inn Cape Girardeau I 55 East

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1000)
"Room was clean , staff was friendly !"
United States
Sally
$54 nightly
The price is $61
Jan 9 - Jan 10, 2026
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO

Dexter Inn

Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (333)
"Room was nice and spacious."
United States
Rebecca
$65 nightly
The price is $73
Jan 26 - Jan 27, 2026
Total with taxes and fees
Dexter Inn

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (145)
"Lovely staff clean hotel comfortable beds "
United States
Kastriot
$88 nightly
The price is $99
Jan 8 - Jan 9, 2026
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Jan 9 - Jan 11
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Central United States attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Enjoy a range of activities from hiking in state parks to exhilarating outdoor sports tournaments.
  • Scenic Beauty: Experience stunning landscapes and picturesque views, especially vibrant during the wet months.
  • Historic Exploration: Discover charming cities and historic civic buildings that tell the region's rich story.
  • Family-Friendly Atmosphere: Southeast Missouri is perfect for families, offering relaxing strolls and memorable experiences.
  • Diverse Accommodations: Choose from a variety of inviting hotels and lodges tailored to every type of traveler.

Find great hotels near Southeast Missouri

Discover a variety of accommodation options in Southeast Missouri, where you'll find inviting hotels and lodges tailored to suit every traveler's needs. Whether you're seeking a family-friendly getaway, a business trip, or an adventure-filled vacation, the region offers top-notch services and amenities. Explore the best hotels, read reviews, and find the perfect lodging for your stay in this charming part of the Midwest.

  • Madison Inn Lodge: Located 16 miles away from Southeast Missouri, Madison Inn Lodge is a cozy motel that caters to both business and leisure travelers. With a distinctive business theme, this pet-friendly accommodation allows you to bring your furry companions along for the adventure. The lodge offers essential amenities for business travelers, including meeting facilities. Pets are welcome with certain restrictions, ensuring that everyone in the family can enjoy the stay. Experience comfort and convenience in a welcoming atmosphere at Madison Inn Lodge.
  • Shepherd Mountain Inn: Situated 21 miles from Southeast Missouri, Shepherd Mountain Inn is a hotel designed with the business traveler in mind. This property features multiple meeting rooms, making it an ideal choice for conferences and corporate gatherings. The hotel offers a professional environment with amenities tailored to support your business needs. Enjoy a restful stay in a serene setting that combines professional efficiency with comfort.
  • Alpaca Farm Stay: Just 8 miles away from Southeast Missouri, Alpaca Farm Stay offers a unique lodging experience perfect for those seeking adventure, romance, or a family getaway. This lodge features a range of exciting outdoor activities, including kayaking, fishing, and mountain biking, ensuring there's never a dull moment. Families will appreciate the shared playground for children, while couples can indulge in special romance packages. Guests can also enjoy stunning views of the mountains or lake, making it a picturesque retreat for all.

Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and scenic retreats, perfect for family-friendly vacations. Visitors can explore charming cities and neighborhoods that exude a relaxing atmosphere, ideal for leisurely strolls. With convenient locations and a welcoming vibe from friendly locals, this region is perfect for families looking to create lasting memories. Don't forget to enjoy the beautiful landscapes, especially during the wettest months when nature truly comes alive.

  • Annapolis: Located 14 miles from Southeast Missouri, Annapolis offers a blend of outdoor adventure and stunning scenery. Visitors flock here primarily in June to July and September, attracted by its recreational areas and arena entertainment facilities. Explore the nearby national state park or enjoy a leisurely day by the river and local parks. Annapolis is perfect for those seeking an active vacation filled with nature and excitement.
  • Central Fredericktown: Just 10 miles away from Southeast Missouri, Central Fredericktown is a quaint village that captivates visitors with its romantic outdoor settings. With peak travel months from May to July, it invites couples and families alike to enjoy its serene lakes and picturesque landscapes. Perfect for picnics or a relaxing day by the water, Central Fredericktown’s charm lies in its peaceful ambiance and natural beauty.
  • Des Arc: Situated 11 miles from Southeast Missouri, Des Arc is a vibrant city that comes alive during the summer months from June to August. Known for its adventurous offerings, visitors are drawn to its recreational areas, water park, and proximity to a national state park, lake, and river. Whether you’re looking for thrilling outdoor activities or a relaxing day in nature, Des Arc has something for everyone, making it an ideal getaway for adventure seekers.

Things to do near Southeast Missouri

Southeast Missouri is perfect for outdoor enthusiasts and adventure seekers. Visitors can enjoy a variety of activities including campus tours, outdoor sports tournaments, and brewery tours. The region also offers educational experiences that enhance the adventure. With its beautiful scenery and recreational areas, Southeast Missouri promises a memorable vacation filled with fun and exploration.

Shopping

Visit Red's Flea Market, located 26 miles away, offering a unique selection of local crafts and antiques in a friendly atmosphere. For a more extensive shopping experience, head to Farmington Mineral Area Shopping Center, 30 miles away, featuring a mix of entertainment, retail stores, and family-friendly options.

Recreation

Crane Lake Recreation Area offers a tranquil environment for relaxation and wellness, perfect for unwinding amidst nature. Silver Mine Recreation Area also boasts serene vibes, with scenic trails and peaceful surroundings. For sports enthusiasts, Arcadia Valley Golf Club provides an invigorating outdoor experience on the greens.

Adventure

Explore Shepherd Mountain Bike Park and Hiking Trails, located 21 miles from Southeast Missouri. Enjoy thrilling mountain biking and scenic hiking through beautiful landscapes, perfect for adrenaline seekers and nature lovers alike. Experience the adventure and stunning outdoor scenery that this park has to offer.

Nightlife

Experience the vibrant nightlife at The Blue Note in Columbia for live music or enjoy a laid-back evening at The Crossing in Cape Girardeau with craft cocktails. For dancing, head to The District in Sikeston, where you can groove to the latest hits and mingle with locals.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

To save money on your trip to Southeast Missouri, plan your visit between November and January when prices are lower. Tuesdays tend to be the cheapest days for hotel stays, while Saturdays are the most expensive. Use Expedia's search tool to find eco-friendly hotels and arrange your budget preferences. Consider booking a package that combines flights, hotels, and activities for better deals. Joining Expedia's One Key membership can also provide exclusive discounts and earn you future savings. Make the most of free activities to enhance your experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April and June to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Leverage Expedia’s search tool to customize your travel preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally-friendly hotels currently available. To discover the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Southeast Missouri with your flights and activities through an Expedia package.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and culture seekers alike, offering a variety of attractions such as urban parks, state parks, and historic civic buildings. Visitors can explore the scenic beauty and engaging experiences around Southeast Missouri State University, while also discovering nearby attractions that enhance their adventure. Whether you're looking for outdoor activities or a taste of local history, this region has something for everyone.

  • K Bridge Recreation Area: Located 17 miles from Southeast Missouri, this urban park is perfect for families looking to enjoy outdoor activities. With its city vibes, K Bridge offers picnic areas, walking trails, and playgrounds, making it an ideal spot for a fun-filled day in nature.
  • Walnut Hollow Lake: Situated 13 miles away, this picturesque lake provides a serene beach atmosphere, complete with stunning scenery. Whether you're looking for a romantic getaway or a day of swimming and sunbathing, Walnut Hollow Lake is a beautiful escape into the great outdoors.
  • Millstream Gardens Conservation Area: Just 15 miles from Southeast Missouri, this conservation area offers a blend of adventure and relaxation. With its friendly vibes and historical significance, it’s perfect for families seeking hiking trails, scenic views, and a peaceful day surrounded by nature.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4000000000000004°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnySlightly HighAverage
June76.5°F (24.700000000000003°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.200000000000003°C)Light RainMostly SunnySlightly HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1000000000000005°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

When visiting Southeast Missouri, you can fly into several major airports. St. Louis, MO (STL-Lambert-St. Louis Intl.) is 96 miles away, with nearby hotels such as The Ritz-Carlton, St. Louis and Ameristar Casino Resort and Spa, both about 7 miles from the airport. Fort Leonard Wood, MO (TBN-St. Robert Regional) is also 96 miles away, with options like Z Loft Extended Stay Hotel, located 6 miles from the airport. Additionally, Paducah, KY (PAH-Barkley Regional) is 95 miles from Southeast Missouri, offering hotels like The Respite Bed and Breakfast, which is 9 miles away. Each airport provides convenient access to quality accommodations for a comfortable stay.

Explore a world of travel with Expedia