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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,004 reviews)
"Clean room, friendly staff, good breakfast and dinner variety,large open parking, clean pool and exercise room. All around great stay. "
United States
Jeremy
$80 nightly
The price is $85
Jun 17 - Jun 18
Total with taxes and fees
Drury Inn & Suites Jackson MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (66 reviews)
"I had a great time with my mom there!"
United States
Lily
$133 nightly
The price is $143
Jun 16 - Jun 17
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (184 reviews)
"Nice room, good breakfast "
United States
KENNETH
$93 nightly
The price is $105
May 28 - May 29
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.4 out of 10, Exceptional, (249 reviews)
"Always a wonderful experience when staying here"
United States
James
$177 nightly
The price is $188
May 18 - May 19
Total with taxes and fees
Echo Bluff State Park

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (353 reviews)
"We stayed one night. For a small town, it's a decent Inn to stay. Could there be updates to the rooms, yes, but overall it was okay. Will we stay again? Unsure."
United States
Wanda
$106 nightly
The price is $115
May 18 - May 19
Total with taxes and fees
Honeysuckle Inn - Mountain View

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,004 reviews)
"We found this property to be everything someone would hope for in an overnight stay away from home."
United States
Richard
$100 nightly
The price is $113
May 25 - May 26
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (840 reviews)
"Nice quiet overnight stay."
United States
Tammy
$93 nightly
The price is $105
May 31 - Jun 1
Total with taxes and fees
Hampton Inn Poplar Bluff

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (572 reviews)
"I ALWAYS stay here when I come to Cape! Wonderful, great place!"
United States
Audra
$120 nightly
The price is $135
May 24 - May 25
Total with taxes and fees
The Riverview

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (125 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
$93 nightly
The price is $106
Jun 17 - Jun 18
Total with taxes and fees
Tru By Hilton Cape Girardeau

Arcadia Academy

Arcadia Academy
3.0 star property
Arcadia
9.8 out of 10, Exceptional, (12 reviews)
"We enjoyed ourselves we've been to plenty of places but we had a great excellent time people the room the food and it was great we will be back¡!!!"
United States
John
$144 nightly
The price is $156
May 18 - May 19
Total with taxes and fees
Arcadia Academy

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
"Great travel hotel from Texas to Chicago."
United States
Sally
$111 nightly
The price is $128
May 25 - May 26
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,003 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
United States
Stephanie
$94 nightly
The price is $106
May 31 - Jun 1
Total with taxes and fees
Drury Inn & Suites Poplar Bluff

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (585 reviews)
"Breakfast was great. Fresh coffee, pancake maker so good. "
United States
Kristin
$101 nightly
The price is $116
May 21 - May 22
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.8 out of 10, Exceptional, (30 reviews)
"The property was clean and the staff was friendly. "
United States
Shelia
$96 nightly
The price is $108
May 24 - May 25
Total with taxes and fees
Hampton Inn By Hilton Dexter

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (550 reviews)
"felt safe stayed only in hotel was clean and quiet and felt safe."
United States
Michael
$86 nightly
The price is $97
May 19 - May 20
Total with taxes and fees
The Farmstead Hotel

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (902 reviews)
"Nice overnight stop over"
United States
Douglas
$105 nightly
The price is $119
May 24 - May 25
Total with taxes and fees
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (78 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
$110 nightly
The price is $125
May 28 - May 29
Total with taxes and fees
Fairfield Inn & Suites by Marriott Sikeston

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very Good, (998 reviews)
"Enjoyed our stay "
United States
Cynthia
$69 nightly
The price is $79
May 27 - May 28
Total with taxes and fees
Super 8 by Wyndham Perryville

Current River Inn

Current River Inn
3.0 star property
Van Buren
8.2 out of 10, Very Good, (174 reviews)
"This was the cutest little place to stay. The people are friendly, room was clean, and it was safe. I would stay here again. "
United States
Jennifer
$97 nightly
The price is $105
May 18 - May 19
Total with taxes and fees
Current River Inn

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (742 reviews)
"Wonderful restaurant and rooms "
United States
Robert
$93 nightly
The price is $105
May 24 - May 25
Total with taxes and fees
Holiday Inn Poplar Bluff by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

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Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities.
  • Charming Cape Girardeau: Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere.
  • Historic and Cultural Experiences: Delve into the region's history through its historic civic buildings and local cultural attractions.
  • Excellent Golfing: Challenge your skills at top-notch golf courses surrounded by stunning scenery.
  • Diverse Accommodation Options: Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays.

Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable.

  • Madison Inn Lodge: Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets.
  • Shepherd Mountain Inn: Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay.
  • Alpaca Farm Stay: Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories.

Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience.

  • Central Fredericktown: Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region.
  • Annapolis: Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature.
  • Des Arc: Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience.

Things to do in Southeast Missouri

Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone.

Shopping

In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods.

Recreation

Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere.

Adventure

Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature.

Nightlife

Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal.

Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler.

  • K Bridge Recreation Area: Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun.
  • Millstream Gardens Conservation Area: Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history.
  • Madison County Courthouse: This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.7°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.2°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport (STL) is 96 miles away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport (COU), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport (MKL) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. Each hotel provides easy access to their respective airports for a seamless travel experience.

Why book with Expedia?

  • Flexible booking

    On Expedia, you can find plenty of hotels with flexible cancellation in Southeast Missouri using the “Fully refundable property” search filter. Just be sure to always double-check each hotel's cancellation policy before booking.

  • Book now and pay later

    With countless book now, pay later options, there's no need to wait till payday to grab a deal. Use the “Reserve now, pay later” search filter to view all properties available with this payment option in Southeast Missouri.

  • Hotel comparison

    Thanks to the handy “Compare properties” tool on Expedia, you can compare hotels in Southeast Missouri side by side with just a few clicks.

  • Member prices

    Join Expedia's loyalty program, One Key, for free and unlock Member Prices and rewards on select hotels worldwide. Simply log in when you search and look out for the blue savings label.

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