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Southeast Missouri Vacation Rentals

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Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7

Our top choices for Southeast Missouri vacation rentals

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

1. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (113 reviews)
"The stay here gets better every time."
United States
cynthia
$159 nightly
The price is $181
Oct 15 - Oct 16
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A hot tub in a covered outdoor area with a view of a swimming pool and a wooden play structure in the background.

2. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
Fredericktown
10.0 out of 10, Exceptional, (14 reviews)
"This was one of the best stays we have ever had! The owners Cathy and Richard are absolutely incredible! They go above and beyond to make sure you have the best time possible! The amities are just non stop! I 100% recommend and will definitely be back!"
United States
Lexis
$200 nightly
The price is $212
Oct 15 - Oct 16
Total with taxes and fees
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
A rustic log cabin with a stone foundation, surrounded by trees and a wooden fence.

3. Sam A Baker State Park

Sam A Baker State Park
2.0 star property
Patterson
9.0 out of 10, Wonderful, (6 reviews)
"Pet friendly, great staff. "
United States
Charlie
$150 nightly
The price is $159
Oct 15 - Oct 16
Total with taxes and fees
Sam A Baker State Park
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

4. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.8 out of 10, Exceptional, (9 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
$98 nightly
The price is $112
Oct 15 - Oct 16
Total with taxes and fees
The Atrium - A Boutique Hotel
A cabin interior with a loft bed, a chair, and a ceiling fan.

5. Hillside Cabin #2 Annapolis, MO Black River

Hillside Cabin #2 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (65 reviews)
"The cabin was very nice but looks a little un loved. 6 nights no tv in the evening and no reply. Looks like no one is doing up keep on the place. We did love how close we were to the river and the store. Very quite and private property. Shower curtain had a lot of mildew build up. Would give it 4 stars if it was cleaner and everything worked."
United States
Tim S.
$219 nightly
The price is $219
Oct 15 - Oct 16
Total with taxes and fees
Hillside Cabin #2 Annapolis, MO Black River
A compact kitchen with wooden cabinets, a large TV, and various kitchen utensils hanging on the wall.

6. FS Rental #4 Annapolis, MO Black River

FS Rental #4 Annapolis, MO Black River
Annapolis
9.4 out of 10, Exceptional, (10 reviews)
"Loved the cabin and the outdoor seating area. Definitely recommend for anyone traveling in the area. "
United States
Corey M.
$210 nightly
The price is $210
Oct 15 - Oct 16
Total with taxes and fees
FS Rental #4 Annapolis, MO Black River
A cozy cabin-style room with a wooden interior, a sofa, a dining table, and a kitchen area.

7. Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!
Patterson
9.6 out of 10, Exceptional, (12 reviews)
"Easy check in, very quiet, very calming and relaxing. Overall great stay and great property manager. "
United States
Wyatt S.
$115 nightly
The price is $121
Nov 2 - Nov 3
Total with taxes and fees
Cozy hobby farm cabin under the stars!
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

8. Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.4 out of 10, Exceptional, (22 reviews)
"Beautiful place and staff was amazing!"
United States
Grace
$295 nightly
The price is $338
Oct 15 - Oct 16
Total with taxes and fees
Urban Lofts
A table with two chairs under a large tree with a potted plant on it.

9. Pickleball Cafe & Micro Hotel

Pickleball Cafe & Micro Hotel
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great place to get away. Loved the coffee . "
United States
Craig C.
$215 nightly
The price is $233
Oct 18 - Oct 19
Total with taxes and fees
Pickleball Cafe & Micro Hotel
A kitchen with wooden cabinets, a toaster, and a dishwasher.

10. Lake Road Cabin C — Million Dollar Ozark View!

Lake Road Cabin C — Million Dollar Ozark View!
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Great cabin. Very quiet area. Nice fire pit."
United States
Heather the Librarian
$168 nightly
The price is $179
Oct 20 - Oct 21
Total with taxes and fees
Lake Road Cabin C — Million Dollar Ozark View!
A kitchen with wooden cabinets, a central island with stools, a microwave, a refrigerator, and a stove.

11. Hillside Cabin #1 Annapolis, MO Black River

Hillside Cabin #1 Annapolis, MO Black River
Annapolis
9.6 out of 10, Exceptional, (41 reviews)
"Very grateful for this safe clean cabin. We were there during the terrible Black River flooding and thankfully this cabin was in safe high ground. "
United States
Leslie
$254 nightly
The price is $254
Oct 15 - Oct 16
Total with taxes and fees
Hillside Cabin #1 Annapolis, MO Black River
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.

12. Mountain View at Pickle & Perk

Mountain View at Pickle & Perk
Ironton
10.0 out of 10, Exceptional, (30 reviews)
"Perfect getaway, great experience. Hosts are phenomenal, food and coffee drinks are excellent. Highly recommend."
United States
Anonymous traveler
$191 nightly
The price is $207
Oct 15 - Oct 16
Total with taxes and fees
Mountain View at Pickle & Perk
A modern room with a large window, two chairs, a small wooden table, and a view of a forest.

13. RIVER and SKY Cabin; Hot Tub

RIVER and SKY Cabin; Hot Tub
Fredericktown
9.4 out of 10, Exceptional, (6 reviews)
"Great getaway"
United States
Anonymous traveler
$236 nightly
The price is $250
Oct 18 - Oct 19
Total with taxes and fees
RIVER and SKY Cabin; Hot Tub
A kitchen with wooden cabinets, a microwave, a coffee maker, a stove, and a sink.

14. Clearwater Lake, cabin minutes from Bluff View Marina & boat dock

Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
Piedmont
10.0 out of 10, Exceptional, (48 reviews)
"Would stay here again"
United States
Steve A.
$140 nightly
The price is $147
Oct 15 - Oct 16
Total with taxes and fees
Clearwater Lake, cabin minutes from Bluff View Marina & boat dock
A window with a vase of flowers and a book on a wooden table.

15. The Sutton House 2 blocks from Main Street & Courthouse Square

The Sutton House 2 blocks from Main Street & Courthouse Square
Ironton
10.0 out of 10, Exceptional, (64 reviews)
"This property is beautiful and everything is thought of for the guests. The hosts were amazing. It is close to wonderful state parks. My family had a great time. I would stay here again!"
United States
Jennifer D.
$192 nightly
The price is $208
Oct 28 - Oct 29
Total with taxes and fees
The Sutton House 2 blocks from Main Street & Courthouse Square
A cozy living room with a brown leather sofa, a small table with a lamp, and a wooden floor. A kitchen with wooden cabinets and a dining area with a table and chairs are visible in the background.

16. Small Town Lodge - Annapolis, MO Black River

Small Town Lodge - Annapolis, MO Black River
Annapolis
8.4 out of 10, Very good, (9 reviews)
"Owner communicated well and the place was a nice clean place for us to stay "
United States
Jeremy H.
$253 nightly
The price is $253
Oct 15 - Oct 16
Total with taxes and fees
Small Town Lodge - Annapolis, MO Black River
A dining area with a table and chairs, wooden cabinets, and a kitchen with an archway.

17. Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.

Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
Lesterville
9.0 out of 10, Wonderful, (20 reviews)
"Ellen is a Very communicative and helpful host. Property looks even better in person than in the pictures. Enjoyable stay!"
United States
Robert H.
$479 nightly
The price is $503
Oct 15 - Oct 16
Total with taxes and fees
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
A porch with four green Adirondack chairs, a small table, and string lights.

18. *State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch

*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
Ironton
10.0 out of 10, Exceptional, (41 reviews)
"Great place to stay!"
United States
Derek R.
$287 nightly
The price is $309
Oct 20 - Oct 21
Total with taxes and fees
*State Parks*Bungalow*CoffeeBar*Pet Friendly*Porch
A wooden deck with two Adirondack chairs and a hammock.

19. Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (6 reviews)
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
United States
Chris
$347 nightly
The price is $370
Oct 15 - Oct 16
Total with taxes and fees
Tiny Houses of French Village
A spacious living room with a fireplace, a ceiling fan, and a large window.

20. AV Bungalows #1 with Loft

AV Bungalows #1 with Loft
Arcadia
9.6 out of 10, Exceptional, (5 reviews)
"The host was incredibly responsive and helpful. And for full transparency, we did not ask the host about this while we were there; however, the hot water in the showers was lukewarm at best. The hot water in the rest of the home was very warm. Also, the loft area was such a unique space. The kids loved it! Unfortunately, we were there when temperatures were in the single digits, so we needed to run the heat. ALL of it settled in the loft, leaving it much cooler everywhere else. The layout and...
United States
Tina T.
$273 nightly
The price is $294
Oct 15 - Oct 16
Total with taxes and fees
AV Bungalows #1 with Loft
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Wonderful experience. We will return."
Terry 1-night trip
Posted 1 hour ago
Pear Tree Inn Cape Girardeau West

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southeast Missouri in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $105 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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