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Southeast Missouri Vacation Rentals

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Vacation Rentals in Southeast Missouri

Terrace/patio
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

Cape Girardeau
10.0 out of 10, Exceptional, (27)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
$289 nightly
The price is $301
Dec 8 - Dec 9
Total with taxes and fees
The Twisted Sassafras Treehouse
Cabin
Sam A Baker State Park

Sam A Baker State Park

2.0 star property
Patterson
9.2 out of 10, Wonderful, (5)
"Pet friendly, great staff. "
United States
Charlie
$125 nightly
The price is $132
Dec 2 - Dec 3
Total with taxes and fees
Sam A Baker State Park
Fridge, microwave, oven, stovetop
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

New Offenburg
10.0 out of 10, Exceptional, (5)
"Relaxing setting between Farmington and St Genevieve. Both towns are rich in history and have small town charm. "
United States
Tim M.
$269 nightly
The price is $281
Nov 30 - Dec 1
Total with taxes and fees
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.
Property grounds
Micro house cabin located near Silver Mines Recreation Area.

Micro house cabin located near Silver Mines Recreation Area.

Fredericktown
10.0 out of 10, Exceptional, (76)
"This was my second visit and am planning to return again someday. Very quiet and cozy. "
United States
eric y.
Micro house cabin located near Silver Mines Recreation Area.
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!

Ste. Genevieve
10.0 out of 10, Exceptional, (270)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
$169 nightly
The price is $180
Dec 2 - Dec 3
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
Exterior detail
"Little Brick House on Main (1865)”

"Little Brick House on Main (1865)”

Ste. Genevieve
10.0 out of 10, Exceptional, (62)
"Great place to stay!"
United States
Lettitia B.
$159 nightly
The price is $159
Dec 1 - Dec 2
Total with taxes and fees
"Little Brick House on Main (1865)”
Property grounds
Collier Cabin in Pine Hollow ~ Eminence, MO

Collier Cabin in Pine Hollow ~ Eminence, MO

Birch Tree
9.6 out of 10, Exceptional, (25)
"Really awesome!!"
United States
Melinda R.
Collier Cabin in Pine Hollow ~ Eminence, MO
Fridge, microwave, oven, stovetop
Mountain View at Pickle & Perk

Mountain View at Pickle & Perk

2.5 star property
Ironton
10.0 out of 10, Exceptional, (15)
"Very cute place in beautiful area. Easy check-in, clean home, and comfy bed. The coffee shop below was really good with a beautiful patio. Location was perfect to access Elephant Rocks, Johnson Shut-ins, and Taum Sauk Mountain parks. "
United States
Amber S.
$192 nightly
The price is $202
Nov 30 - Dec 1
Total with taxes and fees
Mountain View at Pickle & Perk
Private kitchen
Cozy Cabin on the edge of town only 1/2 mile from Current River !

Cozy Cabin on the edge of town only 1/2 mile from Current River !

Van Buren
9.4 out of 10, Exceptional, (8)
"We stay here a couple times a year. In the summer to float the river and in the winter to be near relatives for the holidays. Great experience in both seasons. Very close to the river, gas, and grocery. "
United States
Shelie L.
Cozy Cabin on the edge of town only 1/2 mile from Current River !
Interior
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau
8.6 out of 10, Excellent, (48)
"Some issues with check-in. Very nice area. Lot of history."
United States
Jeffrey M.
$101 nightly
The price is $101
Nov 30 - Dec 1
Total with taxes and fees
Little Blue Cottage on Spanish
Property grounds
Charming 2 bedroom cabin on a beautiful private lake.

Charming 2 bedroom cabin on a beautiful private lake.

Ironton
9.4 out of 10, Exceptional, (16)
"Place is nice & easy to find. "
United States
Mercy
$196 nightly
The price is $196
Nov 30 - Dec 1
Total with taxes and fees
Charming 2 bedroom cabin on a beautiful private lake.
Outdoor dining
Doves Nest Guest House<br> Tranquil & Relaxing

Doves Nest Guest House<br> Tranquil & Relaxing

Ste. Genevieve
10.0 out of 10, Exceptional, (54)
"Great place. Close to everything you need for a great stay in St. Genevieve. Easy check and great host."
United States
Justin S.
Doves Nest Guest House<br> Tranquil & Relaxing
Terrace/patio
#ContemplationCabin on the Jacks Fork River!

#ContemplationCabin on the Jacks Fork River!

Summersville
10.0 out of 10, Exceptional, (70)
"Wanted an escape before starting back to school for the fall and this was exactly what we got. Easy communication with owner and got quick response. Beautiful and quiet property! Great spot on the river!"
United States
Erin A.
$339 nightly
The price is $339
Nov 30 - Dec 1
Total with taxes and fees
#ContemplationCabin on the Jacks Fork River!
Fridge, microwave, oven, stovetop
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!

Eminence
9.2 out of 10, Wonderful, (15)
"Amazing cottage! Great location for a float trip or to explore the Ozark sites. Check-in was easy, host was very accommodating, house was clean and cozy. We will definitely be back for a peaceful getaway! "
United States
Betsy S.
Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub!
3 bedrooms, iron/ironing board, WiFi, bed sheets
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

2.0 star property
Cape Girardeau
10.0 out of 10, Exceptional, (3)
"Cute place, clean and spacious. Convenient location. Very nice stay! Would stay again. "
United States
Rebecca E.
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
Beach
Your home away from home in downtown, historic Farmington!

Your home away from home in downtown, historic Farmington!

Farmington
10.0 out of 10, Exceptional, (36)
"Beautiful piece of property. Would stay here again and again. "
United States
Mary N.
Your home away from home in downtown, historic Farmington!
Fridge, microwave, oven, stovetop
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Cape Girardeau
10.0 out of 10, Exceptional, (27)
"Great property and a super host! He was super helpful and always willing to help with any questions we had. Would definitely rent here again!"
United States
Mark M.
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Outdoor dining
The Cabin on Current River with Private Gravel Bar!!

The Cabin on Current River with Private Gravel Bar!!

Van Buren
8.8 out of 10, Excellent, (28)
"Beautiful area, secluded. We enjoyed staying at this property and access to the river was as expected."
United States
Anonymous traveler
The Cabin on Current River with Private Gravel Bar!!
1 bedroom, WiFi, bed sheets, wheelchair access
Secret Sycamore– Private Stargazing Glamping Tent with Fire Pit & Open Skies

Secret Sycamore– Private Stargazing Glamping Tent with Fire Pit & Open Skies

Bunker
10.0 out of 10, Exceptional, (2)
"They were very friendly and our kids and dogs loved it. "
United States
Wesley
$120 nightly
The price is $128
Dec 1 - Dec 2
Total with taxes and fees
Secret Sycamore– Private Stargazing Glamping Tent with Fire Pit & Open Skies
Property grounds
Triple H Properties

Triple H Properties

Eminence
8.6 out of 10, Excellent, (27)
"Worked out great for friends to stay for a float trip weekend. "
United States
Kat S.
Triple H Properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

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Top Southeast Missouri Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Nice quiet night"
Stephen 1-night trip
Posted 2 days ago
Hampton Inn Sikeston

Find out more about Southeast Missouri

Everything you need to know about Southeast Missouri vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southeast Missouri vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southeast Missouri in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southeast Missouri rentals

At Expedia, we put the best Southeast Missouri vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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