$221 Cheap JetBlue Airways flights Santo Domingo (SDQ) to Mayagüez (MAZ)

View $221 flight on Sun, Feb 8, 2026Opens in a new window
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$221 Cheap JetBlue Airways flights Santo Domingo (SDQ) to Mayagüez (MAZ)

Prices were available within the past 7 days and start at $221 for one-way flights and $379 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Tue, Jan 27 - Sat, Jan 31
SDQ
Santo Domingo
MAZ
Mayagüez
$379 Roundtrip, found 4 days ago
$379
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Tue, Jan 27 from Santo Domingo to Mayagüez, returning Sat, Jan 31, priced at $379 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$380 Roundtrip, found 4 days ago
$380
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $380 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$381 Roundtrip, found 4 days ago
$381
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $381 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$385 Roundtrip, found 4 days ago
$385
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $385 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$386 Roundtrip, found 4 days ago
$386
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $386 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$392 Roundtrip, found 4 days ago
$392
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $392 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$393 Roundtrip, found 4 days ago
$393
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $393 found 4 days ago
JetBlue Airways
Thu, Jan 1 - Mon, Jan 12
SDQ
Santo Domingo
MAZ
Mayagüez
$398 Roundtrip, found 3 hours ago
$398
Roundtrip
found 3 hours ago
Select JetBlue Airways flight, departing Thu, Jan 1 from Santo Domingo to Mayagüez, returning Mon, Jan 12, priced at $398 found 3 hours ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$408 Roundtrip, found 4 days ago
$408
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $408 found 4 days ago
JetBlue Airways
Fri, Jan 30 - Mon, Feb 2
SDQ
Santo Domingo
MAZ
Mayagüez
$409 Roundtrip, found 4 days ago
$409
Roundtrip
found 4 days ago
Select JetBlue Airways flight, departing Fri, Jan 30 from Santo Domingo to Mayagüez, returning Mon, Feb 2, priced at $409 found 4 days ago

Alternative airports near Mayagüez

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Eugenio Maria de Hostos MAZ. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $616
MAZ
Eugenio Maria de Hostos
CheapestClosest
Average driving time to city center8 min
Flights from $616
Flights from Santo Domingo (SDQ) to Mayagüez (MAZ)
Origin airport
Las Americas Intl.
Destination airport
Eugenio María de Hostos
Distance
166 mi
*Available to One Key members.