Flights to Silicon Valley from Des Moines - $120

View $120 flight on Wed, Oct 8, 2025Opens in a new window

Popular airlines from Des Moines to Silicon Valley

  • United

    United

  • American Airlines

    American Airlines

  • Delta

    Delta

  • Southwest Airlines

    Southwest Airlines

  • Frontier Airlines

    Frontier Airlines

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Cheap Flights from Des Moines to Silicon Valley (DSM-SJC)

Prices were available within the past 7 days and start at $120 for one-way flights and $228 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Oct 8 - Wed, Oct 22
DSM
Des Moines
SFO
San Francisco
$228 Roundtrip, found 7 hours ago
$228
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Wed, Oct 8 from Des Moines to San Francisco, returning Wed, Oct 22, priced at $228 found 7 hours ago
Frontier Airlines
Thu, Sep 4 - Sat, Sep 6
DSM
Des Moines
SFO
San Francisco
$238 Roundtrip, found 15 hours ago
$238
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Thu, Sep 4 from Des Moines to San Francisco, returning Sat, Sep 6, priced at $238 found 15 hours ago
American Airlines
Wed, Oct 1 - Wed, Oct 8
DSM
Des Moines
SFO
San Francisco
$271 Roundtrip, found 4 days ago
$271
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Oct 1 from Des Moines to San Francisco, returning Wed, Oct 8, priced at $271 found 4 days ago
Southwest Airlines
Wed, Oct 1 - Wed, Oct 8
DSM
Des Moines
SFO
San Francisco
$276 Roundtrip, found 4 days ago
$276
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Wed, Oct 1 from Des Moines to San Francisco, returning Wed, Oct 8, priced at $276 found 4 days ago
Delta
Wed, Oct 8 - Wed, Oct 22
DSM
Des Moines
SFO
San Francisco
$281 Roundtrip, found 7 hours ago
$281
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Oct 8 from Des Moines to San Francisco, returning Wed, Oct 22, priced at $281 found 7 hours ago
United
Wed, Sep 24 - Sun, Sep 28
DSM
Des Moines
SFO
San Francisco
$292 Roundtrip, found 12 hours ago
$292
Roundtrip
found 12 hours ago
Select United flight, departing Wed, Sep 24 from Des Moines to San Francisco, returning Sun, Sep 28, priced at $292 found 12 hours ago

Find the cheapest month to fly from Des Moines (DSM) to San Jose (SJC)

August is typically the cheapest month to fly

From $235 - $2,629 per traveler.

Graph displaying average flight prices per month

Alternative airports

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to San Francisco Intl. SFO. Flights from $527
SFO
San Francisco Intl.
Flights from $527
Select flight to Norman Y. Mineta San Jose Intl. SJC. Cheapest option available. Flights from $511
SJC
Norman Y. Mineta San Jose Intl.
Cheapest
Flights from $511
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