$210 Cheap Flights from Knoxville (TYS) to Key West (EYW)

View $210 flight on Tue, Jan 20, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)

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Cheap Flights from Knoxville to Key West (TYS-EYW)

Prices were available within the past 7 days and start at $210 for one-way flights and $231 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Jan 20 - Tue, Jan 27
TYS
Knoxville
EYW
Key West
$231 Roundtrip, found 20 hours ago
$231
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Jan 20 from Knoxville to Key West, returning Tue, Jan 27, priced at $231 found 20 hours ago
Delta
Tue, Jan 20 - Tue, Jan 27
TYS
Knoxville
EYW
Key West
$231 Roundtrip, found 20 hours ago
$231
Roundtrip
found 20 hours ago
Select Delta flight, departing Tue, Jan 20 from Knoxville to Key West, returning Tue, Jan 27, priced at $231 found 20 hours ago
Delta
Tue, Mar 3 - Wed, Mar 18
TYS
Knoxville
EYW
Key West
$240 Roundtrip, found 2 days ago
$240
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Mar 3 from Knoxville to Key West, returning Wed, Mar 18, priced at $240 found 2 days ago
Delta
Tue, Feb 24 - Wed, Mar 4
TYS
Knoxville
EYW
Key West
$241 Roundtrip, found 4 days ago
$241
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 24 from Knoxville to Key West, returning Wed, Mar 4, priced at $241 found 4 days ago
Delta
Thu, Nov 27 - Fri, Dec 5
TYS
Knoxville
EYW
Key West
$249 Roundtrip, found 20 hours ago
$249
Roundtrip
found 20 hours ago
Select Delta flight, departing Thu, Nov 27 from Knoxville to Key West, returning Fri, Dec 5, priced at $249 found 20 hours ago
Delta
Sat, Jan 10 - Tue, Jan 13
TYS
Knoxville
EYW
Key West
$250 Roundtrip, found 2 days ago
$250
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Jan 10 from Knoxville to Key West, returning Tue, Jan 13, priced at $250 found 2 days ago
Delta
Tue, Jan 20 - Tue, Jan 27
TYS
Knoxville
EYW
Key West
$251 Roundtrip, found 20 hours ago
$251
Roundtrip
found 20 hours ago
Select Delta flight, departing Tue, Jan 20 from Knoxville to Key West, returning Tue, Jan 27, priced at $251 found 20 hours ago
American Airlines
Tue, Nov 11 - Tue, Nov 18
TYS
Knoxville
EYW
Key West
$254 Roundtrip, found 5 days ago
$254
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Nov 11 from Knoxville to Key West, returning Tue, Nov 18, priced at $254 found 5 days ago
Delta
Mon, Feb 2 - Mon, Feb 9
TYS
Knoxville
EYW
Key West
$255 Roundtrip, found 3 days ago
$255
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Feb 2 from Knoxville to Key West, returning Mon, Feb 9, priced at $255 found 3 days ago
United
Sun, Nov 23 - Wed, Nov 26
TYS
Knoxville
EYW
Key West
$567 Roundtrip, found 5 days ago
$567
Roundtrip
found 5 days ago
Select United flight, departing Sun, Nov 23 from Knoxville to Key West, returning Wed, Nov 26, priced at $567 found 5 days ago

Find the cheapest month to fly from Knoxville (TYS) to Key West (EYW)

August is typically the cheapest month to fly

From $223 - $480 per traveler.

Alternative airports near Key West

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Key West Intl. EYW. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $496
EYW
Key West Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $496
Flights from Knoxville (TYS) to Key West (EYW)
Origin airport
McGhee Tyson
Destination airport
Key West Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$230
Distance
788 mi
Average flight time
2 hours 11 mins

Knoxville to Key West Flights

The cheapest times to fly from Knoxville to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Key West are during the month of January. You can find some of the cheapest flights from Knoxville to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Key West

Sunday is one of the best days to book for cheap flights from Knoxville to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $210 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) cost?
Lock in a cheap one-way flight from $210 or cheap return flight from $231 from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
January is the cheapest month to fly from TYS to EYW. Planning your trip for the off-season is often the key to scoring lower fares.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll take you from TYS to EYW. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
Nonstop flights from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to EYW?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
To land at Key West Intl. Airport (EYW) on time, pick a flight that leaves McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) last-minute?
Holding off until right before your break to book a flight from TYS to EYW generally means paying more. While you may come across some last-minute offers, there's no guarantee. Keep your travel plans flexible for the best chance of snagging a bargain.
Is it cheaper to book a TYS to EYW flight and hotel package?
You can save money by booking a TYS to EYW flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've chosen your preferred accommodations and flights, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
If you reserved your TYS to EYW flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.