Set off the coast of Nicaragua in the Caribbean Sea, San Andrés is an idyllic Colombian island that's celebrated for its white-sand beaches, swaying palm trees, and water that shifts from blue and green into lilac. This UNESCO “Seaflower” Biosphere Reserve boasts stingray snorkeling, vibrant scuba diving, quiet cays, and a botanical garden.

Capital of Colombia's Bolívar region, Cartagena is a picturesque port city on the Caribbean coast, famed for its UNESCO-listed Old Town that dates to the 16th century. Come for the cobblestone streets lined with charming colonial buildings, but stay for its historic churches, mighty fortress, and immersive fusion cuisine.

Home to three majestic monoliths on the banks of the Inírida River, Mavecure appeals to those with an adventurous spirit. Part of the ancient Guyana Shield, deep in the Amazon rainforest, this geological region offers a truly remote vacation. Meet the Almidon Indigenous community, spot freshwater dolphins, and hike the lush Mataven jungle.