$879 Cheap TAP Portugal flights Madrid (MAD) to São Tomé Island (TMS)

Landing cheap one-way TAP Portugal flights from MAD to TMS from $879 on Expedia couldn't be simpler --- just filter by "Price (lowest to highest)." Or check out our budget-friendly return fares from $1,062 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for TAP Portugal flights from MAD to TMS about one month before you want to go. The most affordable time to book an international flight is usually 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. No matter your itinerary or ticket type, the best day of the week to book international airfare is usually Sunday. Friday can be the most expensive. Travelers booking on a Sunday can save an average of 17% compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from MAD to TMS with TAP Portugal, filter your results by "Morning" and "Early Morning." Booking an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.