$1,055 Cheap Flights from San Diego (SAN) to São Tomé Island (TMS)

View $1,055 flight on Wed, Feb 11, 2026Opens in a new window

Popular airlines from San Diego Intl. Airport (SAN) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from San Diego to São Tomé Island (SAN-TMS)

Prices were available within the past 7 days and start at $1,055 for one-way flights and $3,246 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

TAP Portugal
Wed, Feb 11 - Fri, Feb 27
SAN
San Diego
TMS
São Tomé Island
$3,246 Roundtrip, found 5 days ago
$3,246
Roundtrip
found 5 days ago
Select TAP Portugal flight, departing Wed, Feb 11 from San Diego to São Tomé Island, returning Fri, Feb 27, priced at $3,246 found 5 days ago

Frequently asked questions

How much does a flight from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS) cost?
Snag a cheap one-way flight from $1,055 or cheap return flight from $3,246 from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS)?
February is the least expensive month to fly from SAN to TMS. Traveling during an off-peak travel window is often the key to finding better deals on flights.
What is the cheapest airline that flies from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest SAN to TMS flight.
How many flights per day from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS)?
You'll need to take a flight with a layover when traveling from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from SAN to TMS?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS)?
To land at Sao Tome Intl. Airport (TMS) on schedule, book a flight that leaves from San Diego Intl. Airport (SAN) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS) last-minute?
Booking your plane ticket from SAN to TMS shortly before your journey is typically more expensive. However, if there's some wiggle room with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a SAN to TMS flight and hotel package?
Compared with arranging hotels and flights separately, booking a SAN to TMS flight and hotel package with Expedia could result in significant savings. Better yet, managing everything in one place takes the hassle out of planning your trip. Simply secure your flights and select from our wide range of stays, then customize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from San Diego Intl. Airport (SAN) to Sao Tome Intl. Airport (TMS)?
It's usually possible to reschedule or cancel your SAN to TMS flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Travel information

Origin airport
San Diego Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$3,246
Distance
8135 mi

Book with confidence

Book with confidence

San Diego to São Tomé Island Flights

The cheapest times to fly from San Diego to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Diego to São Tomé Island are during the month of February. You can find some of the cheapest flights from San Diego to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Diego to São Tomé Island

Sunday is one of the best days to book for cheap flights from San Diego to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Diego to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Diego to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,055 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Diego to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Diego to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

San Diego to São Tomé Island Flights
*Available to One Key members.