$244 Cheap Flights from Des Moines (DSM) to Ithaca (ITH)

View $244 flight on Thu, Nov 6, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Ithaca, NY (ITH-Tompkins Regional)

Cheap Flights from Des Moines to Ithaca (DSM-ITH)

Prices were available within the past 7 days and start at $244 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Oct 21 - Tue, Oct 28
DSM
Des Moines
ITH
Ithaca
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 21 from Des Moines to Ithaca, returning Tue, Oct 28, priced at $259 found 2 days ago
Delta
Wed, Oct 22 - Tue, Oct 28
DSM
Des Moines
ITH
Ithaca
$324 Roundtrip, found 2 days ago
$324
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 22 from Des Moines to Ithaca, returning Tue, Oct 28, priced at $324 found 2 days ago
Delta
Sat, Oct 25 - Tue, Oct 28
DSM
Des Moines
ITH
Ithaca
$364 Roundtrip, found 2 days ago
$364
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Oct 25 from Des Moines to Ithaca, returning Tue, Oct 28, priced at $364 found 2 days ago
Delta
Wed, Oct 22 - Thu, Oct 30
DSM
Des Moines
ITH
Ithaca
$389 Roundtrip, found 2 days ago
$389
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 22 from Des Moines to Ithaca, returning Thu, Oct 30, priced at $389 found 2 days ago
Delta
Fri, Oct 24 - Tue, Oct 28
DSM
Des Moines
ITH
Ithaca
$407 Roundtrip, found 2 days ago
$407
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 24 from Des Moines to Ithaca, returning Tue, Oct 28, priced at $407 found 2 days ago
Delta
Sat, Oct 25 - Thu, Oct 30
DSM
Des Moines
ITH
Ithaca
$429 Roundtrip, found 2 days ago
$429
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Oct 25 from Des Moines to Ithaca, returning Thu, Oct 30, priced at $429 found 2 days ago
Delta
Thu, Oct 23 - Tue, Oct 28
DSM
Des Moines
ITH
Ithaca
$439 Roundtrip, found 2 days ago
$439
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Oct 23 from Des Moines to Ithaca, returning Tue, Oct 28, priced at $439 found 2 days ago
Delta
Tue, Oct 21 - Mon, Oct 27
DSM
Des Moines
ITH
Ithaca
$443 Roundtrip, found 2 days ago
$443
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Oct 21 from Des Moines to Ithaca, returning Mon, Oct 27, priced at $443 found 2 days ago
Delta
Fri, Oct 24 - Thu, Oct 30
DSM
Des Moines
ITH
Ithaca
$472 Roundtrip, found 2 days ago
$472
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 24 from Des Moines to Ithaca, returning Thu, Oct 30, priced at $472 found 2 days ago
United
Fri, Oct 24 - Mon, Oct 27
DSM
Des Moines
ITH
Ithaca
$611 Roundtrip, found 2 days ago
$611
Roundtrip
found 2 days ago
Select United flight, departing Fri, Oct 24 from Des Moines to Ithaca, returning Mon, Oct 27, priced at $611 found 2 days ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH) cost?
Snag a cheap one-way flight from $244 or cheap return flight from $259 from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH)?
The cheapest month to fly from DSM to ITH is October, when demand is low. Off-peak season is generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH)?
To find the cheapest airline flying from DSM to ITH, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH)?
There aren't any daily direct flights available from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from DSM to ITH?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH)?
To reach Tompkins Regional Airport (ITH) on schedule, choose a flight that takes off from Des Moines Intl. Airport (DSM) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH) last-minute?
Holding off until just before your departure to book a flight from DSM to ITH generally means paying more. While you may find some last-minute deals, there's no guarantee. Be flexible with your travel plans to boost your chances of getting a bargain.
Is it cheaper to book a DSM to ITH flight and hotel package?
You'll generally save money by securing a DSM to ITH flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your ideal flights and accommodations, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Tompkins Regional Airport (ITH)?
If you booked your DSM to ITH flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Tompkins Regional
Roundtrip price
$259
Distance
883 mi

Book with confidence

Book with confidence

Des Moines to Ithaca Flights

The cheapest times to fly from Des Moines to Ithaca

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Ithaca are during the month of October. You can find some of the cheapest flights from Des Moines to Ithaca with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Ithaca

Sunday is one of the best days to book for cheap flights from Des Moines to Ithaca: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Ithaca

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Ithaca in 2025. You can also book with separate airlines for your outbound and return journeys, from $244 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Ithaca flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Ithaca airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Ithaca Flights

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*Available to One Key members.