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$449 Cheap Flights from Florence (FLO) to Fort Wayne (FWA)

View $449 flight on Tue, Aug 25, 2026Opens in a new window

Popular airlines from Florence, SC (FLO-Florence Regional) to Fort Wayne Intl. Airport (FWA)

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Cheap Flights from Florence to Fort Wayne (FLO-FWA)

Prices were available within the past 7 days and start at $449 for one-way flights and $610 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$610 Roundtrip, found 3 days ago
$610
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $610 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$677 Roundtrip, found 3 days ago
$677
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $677 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$684 Roundtrip, found 3 days ago
$684
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $684 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$746 Roundtrip, found 3 days ago
$746
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $746 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$770 Roundtrip, found 3 days ago
$770
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $770 found 3 days ago
American Airlines
Thu, Aug 20 - Thu, Aug 27
FLO
Florence
FWA
Fort Wayne
$777 Roundtrip, found 4 days ago
$777
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 20 from Florence to Fort Wayne, returning Thu, Aug 27, priced at $777 found 4 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$791 Roundtrip, found 3 days ago
$791
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $791 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$805 Roundtrip, found 3 days ago
$805
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $805 found 3 days ago
American Airlines
Fri, Oct 30 - Tue, Nov 3
FLO
Florence
FWA
Fort Wayne
$813 Roundtrip, found 3 days ago
$813
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Florence to Fort Wayne, returning Tue, Nov 3, priced at $813 found 3 days ago
American Airlines
Thu, Aug 20 - Thu, Aug 27
FLO
Florence
FWA
Fort Wayne
$870 Roundtrip, found 4 days ago
$870
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 20 from Florence to Fort Wayne, returning Thu, Aug 27, priced at $870 found 4 days ago
American Airlines
Thu, Aug 20 - Thu, Aug 27
FLO
Florence
FWA
Fort Wayne
$901 Roundtrip, found 4 days ago
$901
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Aug 20 from Florence to Fort Wayne, returning Thu, Aug 27, priced at $901 found 4 days ago

Frequently asked questions

How much does a flight from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) cost?
You can find cheap one-way flights from $449 and cheap return flights from $610 Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) with Expedia. One-way flights usually range from $437 to $498. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
The cheapest month to fly from FLO to FWA is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
Enter FLO to FWA and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
American Airlines is the only carrier that flies from Florence, SC (FLO) to Fort Wayne, IN (FWA). Use Expedia's flight search tool to compare airlines on this route and find our cheapest option for your trip. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
To find a cheap flight from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
The earliest flight from Florence, SC (FLO) to Fort Wayne, IN (FWA) typically departs at around 5:15 AM, operated by American Airlines. This seasonal service is available in January, and an early departure can help you make the most of your day in Fort Wayne. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
The busiest day for flights from Florence Regional (FLO) to Fort Wayne Intl. (FWA) is a Sunday, with around 3 flights. This gives you plenty of options for your travel plans. A major airline on this route is American Airlines.
What are the most popular departure times for flights from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
The most popular departure times for flights from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) are in the early afternoon, from noon to 3pm. About 50% of passengers prefer this time window. American Airlines offers flights during this window. This timing is favored as it allows for a relaxed start to your travel day.
How long does it take to fly from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
Flights from FLO to FWA with one stop typically take around 6 hours 30 minutes, covering approximately 556 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
Select the "Business class" and "First class" filters when looking for FLO to FWA flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) flight with Expedia?
It's easy to earn miles on a Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Fort Wayne from Florence Regional (FLO)?
If you're planning to travel to Fort Wayne from Florence Regional (FLO), you can fly into Fort Wayne Intl. (FWA) Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) at the last minute?
Typically, booking a last minute flight from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) flight and hotel package?
Securing a Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) Fort Wayne Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.)?
If you booked your Florence, SC (FLO-Florence Regional) to Fort Wayne, IN (FWA-Fort Wayne Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Florence Regional
Destination airport
Fort Wayne Intl.
Roundtrip price
$609
Distance
556 mi

Book with confidence

Florence to Fort Wayne Flights

The cheapest times to fly from Florence to Fort Wayne

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Florence to Fort Wayne are during the month of October. You can find some of the cheapest flights from Florence to Fort Wayne with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Florence to Fort Wayne

Sunday is one of the best days to book for cheap flights from Florence to Fort Wayne: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Florence to Fort Wayne

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Florence to Fort Wayne in 2026. You can also book with separate airlines for your outbound and return journeys, from $449 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Florence to Fort Wayne flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Florence to Fort Wayne airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Florence to Fort Wayne Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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