$205 Cheap Flights from Fort Myers (RSW) to Panama City (PTY)

View $205 flight on Mon, Apr 27, 2026Opens in a new window

Popular airlines from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)

Cheap Flights from Fort Myers to Panama City (RSW-PTY)

Prices were available within the past 7 days and start at $205 for one-way flights and $436 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Apr 27 - Mon, May 4
RSW
Fort Myers
PTY
Panama City
$436 Roundtrip, found 2 hours ago
$436
Roundtrip
found 2 hours ago
Select Delta flight, departing Mon, Apr 27 from Fort Myers to Panama City, returning Mon, May 4, priced at $436 found 2 hours ago
American Airlines
Thu, Feb 26 - Thu, Mar 5
RSW
Fort Myers
PTY
Panama City
$440 Roundtrip, found 2 days ago
$440
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Feb 26 from Fort Myers to Panama City, returning Thu, Mar 5, priced at $440 found 2 days ago
Delta
Mon, Apr 27 - Mon, May 4
RSW
Fort Myers
PTY
Panama City
$443 Roundtrip, found 2 hours ago
$443
Roundtrip
found 2 hours ago
Select Delta flight, departing Mon, Apr 27 from Fort Myers to Panama City, returning Mon, May 4, priced at $443 found 2 hours ago
Delta
Mon, Apr 27 - Mon, May 4
RSW
Fort Myers
PTY
Panama City
$451 Roundtrip, found 2 hours ago
$451
Roundtrip
found 2 hours ago
Select Delta flight, departing Mon, Apr 27 from Fort Myers to Panama City, returning Mon, May 4, priced at $451 found 2 hours ago
Delta
Sun, May 3 - Sun, May 10
RSW
Fort Myers
PTY
Panama City
$456 Roundtrip, found 7 hours ago
$456
Roundtrip
found 7 hours ago
Select Delta flight, departing Sun, May 3 from Fort Myers to Panama City, returning Sun, May 10, priced at $456 found 7 hours ago
American Airlines
Mon, Apr 20 - Mon, Apr 27
RSW
Fort Myers
PTY
Panama City
$460 Roundtrip, found 7 hours ago
$460
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Mon, Apr 20 from Fort Myers to Panama City, returning Mon, Apr 27, priced at $460 found 7 hours ago
Delta
Mon, Feb 23 - Sun, Mar 1
RSW
Fort Myers
PTY
Panama City
$463 Roundtrip, found 1 day ago
$463
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Feb 23 from Fort Myers to Panama City, returning Sun, Mar 1, priced at $463 found 1 day ago
American Airlines
Mon, Mar 30 - Fri, Apr 3
RSW
Fort Myers
PTY
Panama City
$469 Roundtrip, found 1 day ago
$469
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Mar 30 from Fort Myers to Panama City, returning Fri, Apr 3, priced at $469 found 1 day ago
Delta
Mon, Jan 12 - Fri, Jan 16
RSW
Fort Myers
PTY
Panama City
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Jan 12 from Fort Myers to Panama City, returning Fri, Jan 16, priced at $472 found 1 day ago
United
Tue, Feb 17 - Wed, Feb 25
RSW
Fort Myers
PTY
Panama City
$644 Roundtrip, found 1 hour ago
$644
Roundtrip
found 1 hour ago
Select United flight, departing Tue, Feb 17 from Fort Myers to Panama City, returning Wed, Feb 25, priced at $644 found 1 hour ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $496
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $496
Flights from Fort Myers (RSW) to Panama City (PTY)
Origin airport
Southwest Florida Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$435
Distance
1216 mi

Fort Myers to Panama City Flights

The cheapest times to fly from Fort Myers to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Fort Myers to Panama City are during the month of April. You can find some of the cheapest flights from Fort Myers to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Fort Myers to Panama City

Sunday is one of the best days to book for cheap flights from Fort Myers to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Fort Myers to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Fort Myers to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $205 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Fort Myers to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Fort Myers to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $205 or cheap return flight from $436 from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)?
Traveling in April may help you find better deals, as it's the cheapest month for flights between RSW and PTY. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline that'll fly you from RSW to PTY, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)?
You'll have to catch a flight with a layover when traveling from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from RSW to PTY?
Typically you'll have the most choice when it comes to flights on a Friday. Tuesdays tend to be the quietest.* But this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until just before your trip to book a ticket from RSW to PTY often results in higher prices. While you may find some last-minute offers, there's no guarantee. Keep your travel schedule open for the best chance of getting a bargain.
Is it cheaper to book a RSW to PTY flight and hotel package?
Booking a RSW to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Select from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Southwest Florida Intl. Airport (RSW) to Tocumen Intl. Airport (PTY)?
You can usually reschedule or cancel your RSW to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.